Gene 22258 (Tetrahymena)

22258

Species: Tetrahymena
Alias: TTHERM_00218310, 3701.m00044, 22258, 18.m00284, 513, PreTt22258
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
22258.AA Protein None 526 None Fasta, JSON
22258.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
22258.NA RNA None 1581 None Fasta, JSON

Protein domain

Protein domains of 22258.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22258.AA CDPK 60-316 57 7.2e-188 581.03 In-house 1-271 (271) Show / Hide 
Range on Protein: 60-316
Range on HMM: 1-271/271
Sequence Identity: 57% (155 aa)

TLMNPPLGKGAFGEVRRAVHK-QTQILR-AVKIISKQQTPKEEQ-IRLKNEVEILKSLDHPNIIKVFEFYQDTRFLYIVTE--LCQGGELFDKIIDEKQF
. ....||||.||.||...|| .|.. | |.|||.| . ...|| ....||.||||.||||||||..||||| .. |||.|  .| ||||||.||....|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGA----LIKLVDFGTSIAYNPQ-----EKMKQQFGTPYYIAPEVLERKYDNKCDIWSCG
|| .||..|.||| |||||||.||.||||||||||..|.|...     ||..|.|||  ....     .||.|..|||||||||||..||. ||||||||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILYILLCGYPPFNGSSDQMITDKVKLGKFGFDTDEWNYVSKEAKEFICKMLEKDPKKRISAYDALNDPWI
|||||||||||||.| .|| | .||| ||. |. .||. .|.|||  |.|||..|||||.|| .||..||.
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 22258.AA CAMK1 59-316 46 1.4e-185 544.5 In-house 1-276 (276) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-276/276
Sequence Identity: 46% (128 aa)

YTLMNPPLGKGAFGEVRRAVHKQT---QILRAVKIIS-KQQTPKEEQ---IRLKNEVEILKS---LDHPNIIKVFEFYQDTRFLYIVTELCQGGELFDKI
| ...  .|.|||.||....||.|   .   |.|.|. |... |...    .|.||.||.|.   .||||||| .|.|......|.|.||..||||||.|
YEFGK-EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

IDEKQFTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGALIK--LVDFGTSIAYNPQE-KMKQQFGTPYYIAPEVLERK----YDNKCDI
.. ...||..|...|||||.||.|.|||.|.||||||||.||....... ||  . ||| |  ....| .||...|||.|.||||||.|    ||..||.
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSCGVILYILLCGYPPFNGSS-DQMITDKVKLGKFGFDTDEWNYVSKE-AKEFICKMLEKDPKKRISAYDALNDPWI
||.|||.||||||||||.... |.....|.| ....|....|...|.. ||.||..|||.|||||......||.|||
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 22258.AA CAMK 65-316 29 4.8e-134 434.64 In-house 1-425 (425) Show / Hide 
Range on Protein: 65-316
Range on HMM: 1-425/425
Sequence Identity: 29% (126 aa)

PLGKGAFGEVRRAVHKQTQ------------ILRAVKIISKQQTP--------------------------KEEQIRLKNEVEILKS-------LDHPNI
 ||.|.||.|....||.|.               |.|||.|.. .                           . . ....|.||.|.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKVFEFYQDTRF-------------------LYIVT---ELCQGGEL----FDKIIDEKQ---------------FTENKAAETMKQILGAVNYCHSKNI
|| .|.|.|...                   .|.|.   |.|.||||    ||.|.. ..               |||  |.  ..||. ||.||||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPENILYESNKPG--------------ALIKLVDFGTSIAYNP------------------------QEKMKQQFGTPYYIA-PEVLERK-----
.||||||||||. .|...              . ||..||| .. ..|                         .||| ..|||.|.| ||||..|     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDNKCDIWSCGVILYILLCGYPPFNGS-------------SDQMITDKVKLGKFGFDTDE------------WNYVSKE--------AKE
          |. |||.|||||||||.|||||||.|.             .|. .  |.. ||. |. ..            |. .|.|        .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FICKMLEKDPKKRISAYDALNDPWI
.|.|||..||.||... ..||.||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22258.AA Ciliate-E2a 59-316 45 3.2e-131 388.48 In-house 1-275 (275) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-275/275
Sequence Identity: 45% (126 aa)

YTLMNPPLGKGAFGEVRRAVHKQTQIL-RAVKIISKQQTPKEEQIRLKNEVEILKSLDHPNIIKVFEFYQDTRFLYIVTELCQGGELFDKIIDEKQFTEN
| . .  .|||.|| |. | ||||    ...|.| | .  |...  ..||. |...|||||||| .|.|.| . .|.|.|.|.||||.|||.  |.|.|.
YKFIK-KIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--KAAETMKQIL-GAVNYCHSKNICHRDLKPENILYE---SNK-PGALIKLVDFGTSIAY--NPQEKMKQQFGTPYYIA------PEVLERK-YDNKCDI
  .... |.|.|  ...|.|..|| ||||||||||..   .|. . . ||..|||..  .  . ...|.|. |||.|.|      .|||..| || |||.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

WSCGVILYILLCGYPPFNGSSDQMITDKVKLGKFGFDTDE-WNYVSKEAKEFICKMLEKDPKKRISAYDALNDPWI
||||||.||||||.|||.| . . |  ..|  |. |.  | |...|||.| .. |||||||||||.| .|||.|| 
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 22258.AA S_TKc 59-316 40 8.20000000001e-108 365.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-231/231
Sequence Identity: 40% (112 aa)

YTLMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQTPKEEQIRLKNEVEILKSLDHPNIIKVFEFYQDTRFLYIVTELCQG--GELFDKIIDEKQ---
|.... ..||||||.|....|| |. . |.|||.         .....|..|||. .||||.| ....||  .||.|.|.| |  |.||| | . .    
YEILR-KIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGALIKLVDFGTSIAYNPQEKMKQQFGTPYYIAPEVLERKYDN-KCDIWSCGVILY
   |.|  |.  |.||. |..||||..|.||||||||||  .      ||. ||| .  .      . . |||.|.|||||  .|.  |||.||||.|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILY

ILLCGYPPFNGSSDQMITDKVKLGKFGFDTDEWNYVSKEAKEFICKMLEKDPKKRISAYDALN-------DPWI
..|||||||    .||. .|..              |.|||.||.|.|.|||.||..| .||.       .||.
EMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22258.AA CAMKL 59-316 36 1.5e-107 344.28 In-house 1-297 (297) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-297/297
Sequence Identity: 36% (110 aa)

YTLMNPPLGKGAFGEVRRAVH-KQTQILRAVKIISKQQTPKEEQIR-------------LKNEVEILKSLD---HPNIIKVFEFYQDTRF------LYIV
|..    ||||.||.|. |.| . |..  |.||| |. . ......             .. |..|.|.|.   |||||| .| ... ..      .|.|
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

TELCQGGE--LFDKIIDEKQ----FTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNK-PGALIKLVDFGTSIAYNP-----QEKMKQQFGTP
.|.|.|||  |||.|. ..     ..|. |    .||. |||||||..|.|||.||||||  .|.     ||..||| |. | |      .|.| . |.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

YYIAPEVLER--K-YD-NKCDIWSCGVILYILLCGYPPFNGSSDQ-----MITDKVKLGKFGFDTD-EWNYVSKEAKEFICKMLEKDPKKRISAYDALND
 | |||....  | ||  | |||||||||| ..||| ||.. ...      |  . .  . |   .  |..|| ... .| |||...|.||... . .|.
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWI
|| 
PWM
Kinase 22258.AA RAD53 61-316 37 7e-106 316.42 In-house 2-305 (305) Show / Hide 
Range on Protein: 61-316
Range on HMM: 2-305/305
Sequence Identity: 37% (115 aa)

LMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQ-----TPK-EEQIRLKNEVEILKSLDHPNIIKVFEFYQDT-RFLYIVTELCQGGELFDKIIDEKQ
.|.  ||.|.||.|..|. | |    |.|||.|..     .       .. ||||||| | ||.||. ....... . .|.| ||  |||||.||.. | 
YMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKR

----FTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGA---------------LIKLVDFGTSIAYNPQEKMKQQFGTPYYIAPEVLERK
    |.|... .. .|.. ||.| |...||||||||||||..... .                |||. ||| | .   .. ||   ||| | ||||.  |
CQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSK

----------------YDNKCDIWSCGVILYILLCGYPPFNGSSDQ-----MITDKVKL-GKFGFDTDEWNYVSKEAKEFICKMLEKDPKKRISAYDALN
                |  |.|.|| |.||||.|||||||  ...|      . ...|  ||..|.. .|  .| ||| .| .||  ||.||... .|||
GHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALN

DPWI
 ||.
HPWM
Kinase 22258.AA MAPKAPK 60-316 36 2e-102 317.93 In-house 1-292 (292) Show / Hide 
Range on Protein: 60-316
Range on HMM: 1-292/292
Sequence Identity: 36% (108 aa)

TLMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQTPKEEQIRLKNEVEILKSL-DHPNIIKVFEFYQD----TRFLYIVTELCQGGELFDKIID--EK
.| .  || |. | |...|||.|.   ||||. .|..   . .|  .|||...   .||||... ... .     . .|.| |. .|||||..| .  .|
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKAR--REVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHK

QFTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGALIKLVDFGTSIA-------YNP--QEKMKQQFGTPYYIAPEVLER-K----YDNK
 ||| .|.. ||.|  || ..||.|| ||||||||||...... . .|| |||             |  . ...   .||||.||||... |    || .
HFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKS

CDIWSCGVILYILLCGYPPFNGSSD--QMITD--------------KVKLGKFGFDTDEWNYVSKEAKEFICKMLEKDPKKRISAYDALNDPWI
||.|| |||.||.||||||| .. .  ..  |              . . |.. | . ||  .|.|||  | |.| .||..|... . .| |||
CDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase 22258.AA Pkinase 59-316 35 1.2e-101 348.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

YTLMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQTPKEEQIRLKN--EVEILKSLDHPNIIKVFEFYQDTRFLYIVTELCQGG----ELFDKII--D
|..   ..|.|.||.|....|| |... |||||.|. . ....... .  |..|.|.|.||||.. .....| . .|.|.|.|.||    .||| |   .
YHIG-RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EKQF--TENKAAETMKQILGAVNYCHSKNICHRDLKPENILYE-SNKPGALIKLVDFGTSIA--YNPQEKMKQQFGTPYYIAPEVLE--RKYDNKCDIWS
.. |  .|. .   |.||| ...||||..|.||||||||||.   . ..| .|. ||| .    | ... |.   |||.|.||||.   ..|. |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

CGVILYILLCGYPPFNGS------SDQMITDKVKLGKFGFDTDEWNYVS-----------------KEAKEFICKMLEKDPKKRISAYDALNDPWI
||.|||..|||.||| |.      ... . .... ... || ..|. .|                 .|.|.||...|.||||||..| ..|..||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 22258.AA CAMK-Unique 59-316 29 4.1e-101 334.55 In-house 1-363 (363) Show / Hide 
Range on Protein: 59-316
Range on HMM: 1-363/363
Sequence Identity: 29% (107 aa)

YTLMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQTPKEEQIR------------------LKNEVEILKSLDHPNIIKVFEF----YQDTR------
|.. . ..|.|.||.|...  . |  ..|.|.. ||    . |.                   ||.|..|.|..|||||||....    ..| .      
YKMHR-IIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------FLYIVTELCQGGELFDKIID--------------------EKQFTE--NKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKP----
          .|||.|.||||.|||.|..                    . .|.|  . ..  | ..| ||.| ||..| |||||.|||.. .. .    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------GALIKLVDFGTSIAYN-PQEK--MKQQFGTPYYIAP--------------EVLE-RKYDNKC----DIWSCGVILYILLCGYPPFNGSSDQ
            ||| ||| .  ||  ..   |.   |||.|.||              ||.. ..|| .|    ||||.|||.|..|||.|||..... 
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------MITDKVKLGKF-GFDTDEWNY---VSKEAKEFICKMLEKDPKKRISAYDALNDPWI
         | .. . |..  ||.. |.    .|.||| |. . .. ||..|.||  .|  .||
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 22258.AA Ciliate-E2 60-316 30 2.7e-98 332.84 In-house 1-365 (365) Show / Hide 
Range on Protein: 60-316
Range on HMM: 1-365/365
Sequence Identity: 30% (115 aa)

TLMNPPLGKGAFGEVRRAVHKQTQILR------------------AVKIISKQQTPKEEQIRLKNEVEILK----------------SLDHPNIIKVFEF
   .  .|.|.|| |... ....| .                   ..||. . .  | . . .|.|  |..                .|.|||||| .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DTRFLYIVTELCQGGELFDKII------------DEKQFTENKAAETMKQILG---------------AVNYCHSKN-ICHRDLKPENILYESNKP
.|  |.  .|.|.|.||||.||| |.            | |.|||..... |||||                |..|.|||| |.|||.||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

GALIKLVDFGTSIAYNPQ----------EKMKQQF-----------------------GTPYYIAPEVLERK----------YDNKCDIWSCGVILYILL
   ||..|||.|  |...          ..... .                       |||.| |||.|..|          || ||||||.|||||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGYPPFNGSSDQMITDKVKLGKFGFDTDE--------------WNYVSKEAKEFICK----MLEKDPKKRIS-AYDALNDPWI
.|.|||         .. | .|. |.  |              |...|.|.| .| |    ||.|||.|||. . ..|| ||.
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22258.AA Ciliate-E2-Unclassified 66-316 31 2.7e-85 289.7 In-house 7-352 (352) Show / Hide 
Range on Protein: 66-316
Range on HMM: 7-352/352
Sequence Identity: 31% (110 aa)

LGKGAFGEVRRAVHKQTQILRAVKIIS-------KQQTPK---------EEQIRLKNEVE--------ILKSLDHPNIIKVFEFYQDTRFLYIVTELCQG
.|.|.||.|....||... . | |...       ||.  |         ....   . ..        ||....||.|.| |.  ||.  .|||.|.|.|
IGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEG

GELFDKIIDEKQ-----------------FTENKAA-----ETMKQILGAVNYCHSKN-ICHRDLKPENILYESNKPGALIKLVDFGTSIAYN-------
|.|.. | . |.                 |||..|.       ..||| . .|.|.|| |.|||.||||||. .|.    ||. ||| |. |.       
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDT

---------PQEKMKQQFGTPYYI----APEVLER-KYDNK----CDIWSCGVILYILLCGYPPFNG-SSDQ---------------MITDKVKLGKFGF
         .|..|... |||.|.    |||||.. .||..    |||||.||||| .| ||.||.. ...|               .. .. | ... |
NQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQF

DTDEW----NYVSKEAKEFIC----KMLEKDPKKRISAYDALNDPWI
.  .|      .|.|||.||     |||.|.|.|||.. ..|| ||.
PKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22258.AA Pkinase_Tyr 59-144 32 9.7e-16 53.93 Pfam 1-94 (270) Show / Hide 
Range on Protein: 59-144
Range on HMM: 1-94/270
Sequence Identity: 32% (31 aa)

YTLMNPPLGKGAFGEVRRAVHK----QTQILRAVKIISKQQTPKEE--QIRLKNEVEILKSL-DHPNIIKVFEFYQ-DTRF--LYIVTELCQGGEL
 |..   ||.||||||.... |    .|.|  |||.. |... .|.  .  . .|..|.|.| .||||..       . .   .|||.|....| |
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 22258.AA TyrKc 60-319 23 2.6e-15 24.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 60-319
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

TLMNPPLGKGAFGEVRRAVHKQTQILRAVKIISKQQTPKEEQIRLKNEVEILKSL--DHPNIIKVFEFYQDT-------RFLYIVTELCQGGELFDKIID
  ..  || ||||||.... |   |  ||| . .       .  . .| .|...|  .||||.. .    .          |.||.|.. .| | | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EKQ-FTENKAAETMKQILGAVNYCHSKNICHRDLKPENILYESNKPGALIKLVDFGTSIAYNPQ-------EKMKQQF--GTP-----YYIAPEVL-ERK
 .  ..  .  . . ||    .| ||||. ||||   |.|. .|.    .|  ||| | .           .  ...   |.         |||.. ..|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDNKCDIWSCGVILY-ILLCGYPPFNG-----SSDQMITDKVKLGKFGFDTDEWNY--------VSKEAKEFICKMLEKDPKKRISAYDALNDPWIQKY
.  | |.|| || .. |.  | .|  |      |.| .  .|| |.     .   .         ..|  . . .  . ||..| .  .      ... 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Efhand 22258.AA efhand 366-394 31 6e-07 29.85 Pfam 1-29 (29) Show / Hide 
Range on Protein: 366-394
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELLKIFQALDTNRDGRLSREELINGYRKI
|| ..|. .|...||....||......|.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22258.AA EFh 366-394 24 1e-06 29.49 SMART 1-29 (29) Show / Hide 
Range on Protein: 366-394
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

ELLKIFQALDTNRDGRLSREELINGYRKI
|. ..|. .|...||... ||.. . ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22258.AA efhand 406-434 20 0.00016 20.97 Pfam 1-29 (29) Show / Hide 
Range on Protein: 406-434
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

EVNRIMNAVDTNHSGSIDYTEWVMATINR
|...... .|....| ||. |.. .  . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22258.AA EFh 406-434 20 0.001922 18.4 SMART 1-29 (29) Show / Hide 
Range on Protein: 406-434
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

EVNRIMNAVDTNHSGSIDYTEWVMATINR
|...... .|....| ||. |....  . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22258.AA efhand 442-470 34 4e-07 30.49 Pfam 1-29 (29) Show / Hide 
Range on Protein: 442-470
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

RLDVAFKMFDKDGSGTLSIDEIRDLFGNQ
.|. .||.|||||.|.....| .... ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22258.AA EFh 442-470 34 9.6e-07 29.65 SMART 1-29 (29) Show / Hide 
Range on Protein: 442-470
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

RLDVAFKMFDKDGSGTLSIDEIRDLFGNQ
 .. .|.||||||.|... .| .|.. . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 22258.AA EFh 477-505 51 2.1e-08 35.17 SMART 1-29 (29) Show / Hide 
Range on Protein: 477-505
Range on HMM: 1-29/29
Sequence Identity: 51% (15 aa)

VWREMLTEADDNGDGQISFKEFKDMMLKL
 ..||  ..| .|||.|.|.|||||| .|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22258.AA efhand 477-505 51 3.7e-08 34.26 Pfam 1-29 (29) Show / Hide 
Range on Protein: 477-505
Range on HMM: 1-29/29
Sequence Identity: 51% (15 aa)

VWREMLTEADDNGDGQISFKEFKDMMLKL
 ..||  |.| .|||.|.|.||..|| ||
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL