Gene 25228 (Tetrahymena)

25228

Species: Tetrahymena
Alias: 336.m00018, 726, PreTt25228, 25228, TTHERM_01344710
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
25228.AA Protein None 497 None Fasta, JSON
25228.kin_dom Protein Kinase Domain None 296 None Fasta, JSON
25228.NA RNA None 1494 None Fasta, JSON

Protein domain

Protein domains of 25228.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25228.AA CDPK 28-323 49 1.9e-200 620.2 In-house 1-271 (271) Show / Hide 
Range on Protein: 28-323
Range on HMM: 1-271/271
Sequence Identity: 49% (154 aa)

IDPKKVLGSGTYGMVFKAKKK-GTKITR-AIKQIPKKKVKNQE---RFQREIEIMSSLDHPNIIKLYETFEDDKNIYLVMELDWWFARQSFLQQKMALEN
.. |||||.|..|.|.|.|.| .|...| |.|.|||..||..|   .|..||||...||||||||.||...|.||.|.|||                   
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVME-------------------

NPNQFHLNSGQIYLKNIFLIQKRVCEGGELFDRIIERGFFSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDS----PIKVIDFGLSKNF
                     ...|.||||||.|||.| |.| .|. |..||..|.|||||. | ||||||||.||..|.|||    .|||||.|.||.|
---------------------TEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKF

DHN-----QAMTTKAGTPYYISPEVLQGKYDESCDIWSGGVILYILLSGNPPFYGDTDPEILEAVKKGQFSFDIPEFQSVSQEAQDLIRKMITT-PDKRL
|.|     . |....||||||.|||||.||.|.||||| ||||||||.| |||||..| ||.|.||||..||..||....|.||.||||||... |.||.
DQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRM

KSFEVLNHPWM
.. ..|.|||.
SAQQALQHPWF
Kinase 25228.AA CAMK 33-323 30 3.9e-128 415.26 In-house 1-425 (425) Show / Hide 
Range on Protein: 33-323
Range on HMM: 1-425/425
Sequence Identity: 30% (142 aa)

VLGSGTYGMVFKAKKK-GTKITR-----------AIKQIPKKKVK----------------------------NQERFQREIEIMSS-------LDHPNI
.||.|..| |.... |  |. .|           ||| |.|||.|                            ......||||||..       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYETFED-------------------DKNIYLVMELDWWFARQSFLQQKMALENNPNQFHLNSGQIYLKNIFLIQKRVCEGGEL----FDRIIERGF-
|||||..||                   ||..|.|||                                       .   |.||||    ||.|.|.|  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME---------------------------------------IMEYCSGGELFDDLFDYIVEHGCY

--------------FSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDSP--------------IKVIDFGLSKNFDH-------------
              |.| .||..| || .|..||||. | |||||||| |. ...|||.              ||.||||... ||.             
GEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGG

-----------NQAMTTKAGTPYYIS-PEVLQGK---------------YDESCDIWSGGVILYILLSGNPPFYGD-------------TDPEILEAVKK
           .| |.|  |||.|.. ||||.||               |...||.|| ||||||.|.| ||||||             .|.|..| ..|
EMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK

GQFSFDIPEFQSVS--------------------QEAQDLIRKMITT-PDKRLKSFEVLNHPWM
|...|. |.|  .|                    ||..|||||| .. |.||..  ..||||||
GKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 25228.AA CAMK1 147-323 50 4.2e-106 309.43 In-house 90-276 (276) Show / Hide 
Range on Protein: 147-323
Range on HMM: 90-276/276
Sequence Identity: 50% (95 aa)

CEGGELFDRIIERGFFSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDSPIK--VIDFGLSKNFDHNQ-AMTTKAGTPYYISPEVLQGK-
. ||||||||.|.|...| |||.|  || .|..|.||| | |||||||| |. .| .||.||  ..|||||| |||.   |.|  |||.|. |||| .| 
VTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK

---YDESCDIWSGGVILYILLSGNPPFYGDT-DPEILEAVKKGQFSFDIPEFQSVSQE-AQDLIRKMITT-PDKRLKSFEVLNHPWM
   || .||.|| |||.|||| | ||||... |.|..| .||... |. |.. ..| . | |.|..|..  | ||.   ..||||| 
DKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 25228.AA Ciliate-E2a 147-323 45 2.7e-88 260.02 In-house 81-275 (275) Show / Hide 
Range on Protein: 147-323
Range on HMM: 81-275/275
Sequence Identity: 45% (88 aa)

CEGGELFDRIIERG-FFSE-VDARTIFTQIM-QAINYCHSKSISHRDLKPENFLFL--TKHDD--SPIKVIDFGLSKNF--DHNQAMTTKAGTPYYIS--
||||||.|.|.. . ||.|  ... |  |.  |...|.|.. | ||||||||.||    | ..  | ||.|||||....  | .. | .| |||.|.   
CEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPE

----PEVLQGK-YDESCDIWSGGVILYILLSGNPPFYGDTDPEILEAVKKGQFSFDIPE-FQSVSQEAQDLIRKMITT-PDKRLKSFEVLNHPWM
    .|||..| ||..||.|| |||.||||.| |||.| |  |||. .|| ...|..|| .. .|.|..||..||    | ||..  . |||||.
VLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 25228.AA S_TKc 28-323 33 2.2e-87 297.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-323
Range on HMM: 1-231/231
Sequence Identity: 33% (104 aa)

IDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKVKNQERFQREIEIMSSLDHPNIIKLYETFEDDKNIYLVMELDWWFARQSFLQQKMALENNPNQF
 .  ...|.|..| |.|...|.|.   |||.|.       |...|||.|... .||||.|||..|.| ...|.|||.                       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEY-----------------------

HLNSGQIYLKNIFLIQKRVCEG--GELFDRIIERGF------FSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDSPIKVIDFGLSKNFD
                   |.|  |.|||.| .||       |.| .|| .. || .|..||||. | |||||||| |. .      ||..||||.. . 
-------------------CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-

HNQAMTTKAGTPYYISPEVLQGKYDE-SCDIWSGGVILYILLSGNPPFYGDTDPEILEAVKKGQFSFDIPEFQSVSQEAQDLIRKMIT-TPDKRLKSFEV
     ||  |||.|..||||  .|.  .||.|| |.|||..|.| |||.  .. .... ..              |.|| |.|||. .  |.||.   |.
-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EA

LN-------HPWM
|.       |||.
LQDEWDIKCHPWF
Kinase 25228.AA RAD53 148-323 35 1.3e-70 209.37 In-house 88-305 (305) Show / Hide 
Range on Protein: 148-323
Range on HMM: 88-305/305
Sequence Identity: 35% (78 aa)

EGGELFDRIIERGF----FSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDS---------------PIKVIDFGLSKNFDHNQAMTTKA
.|||||..|. ..     |.| .....| |.  |..| |.. |.|||||||| |. .. ..                 ||. ||||||. .  . |.|  
TGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMC

GTPYYISPEVLQGK----------------YDESCDIWSGGVILYILLSGNPPFY-GDTD----PEILEAVKK-GQFSFDIPEFQSVSQEAQDLIRKMIT
||| |  |||. .|                |  ..|.|| |.||||.|.| |||  ..|.    . . | .|. | ..|. |.  ..|.||.|||..|..
GTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLC

T-PDKRLKSFEVLNHPWM
  |.||.   |.||||||
VDPEKRYTIDEALNHPWM
Kinase 25228.AA CAMKL 147-323 40 6.1e-70 222.35 In-house 103-297 (297) Show / Hide 
Range on Protein: 147-323
Range on HMM: 103-297/297
Sequence Identity: 40% (81 aa)

CEGGE--LFDRIIERGF----FSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDSPIKVIDFGLSKNFD-H----NQAMTTKAGTPYYIS
|.|||  |||.|...|     ..| .|| .|.||. |.|||||. | |||.|||| |.  ...   ||.||||.|  .. .    .| ..|  |.| | .
CSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMA

PEVLQG--K-YD-ESCDIWSGGVILYILLSGNPPFYGDTDP------EILEAVKKGQFSFDIPEFQSVSQEAQDLIRKMITT-PDKRLKSFEVLNHPWM
||..||  | ||    |||| ||||| .. |. || .||..        ..  |. .  . .| . .|| ...|||||| .. |.|| .  ...|||||
PEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 25228.AA CAMK-Unique 147-323 30 2.1e-68 224.88 In-house 117-363 (363) Show / Hide 
Range on Protein: 147-323
Range on HMM: 117-363/363
Sequence Identity: 30% (76 aa)

CEGGELFDRIIE--------------------RGFFSE--VDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHD-------------DSPIKVID
|.||.||| |..                    .| |||   |...|.... .|..| ||..| |||||.|| .. .  .             .. ||..|
CQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCD

FGLSKNFDHNQAMT---TKAGTPYYISP--------------EVLQ-GKYDESC----DIWSGGVILYILLSGNPPFYGDTDP--------EILEAVKKG
|||.. ..||.. .   |  |||.|..|              ||.   .||. |    |||| |||.|..|.|.|||......        ||.|. .||
FGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKG

QF-SFDIPEFQS---VSQEAQDLIRKMITTP-DKRLKSFEVLNHPWM
.. .|| . ...   .|||| |.. .  |.  |.|... | | |.| 
DYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 25228.AA Pkinase 147-323 35 4e-65 227.47 Pfam 82-293 (293) Show / Hide 
Range on Protein: 147-323
Range on HMM: 82-293/293
Sequence Identity: 35% (76 aa)

CEGG----ELFDRII--ERGFF--SEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFL-TKHDDSPIKVIDFGLSKN--FDHNQAMTTKAGTPYYIS
||||    .|||.|   ..| |  || ... ...|| ....||||..| ||||||||.|.  . | |...|..||||.|     .|. ||| .|||.|..
CEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMA

PEVLQ--GKYDESCDIWSGGVILYILLSGNPPFYGD------TDPEILEAVKKGQFSFDIPEFQSVS-----------------QEAQDLIRKMITT-PD
|||..   .|. ..|.|| |.|||..|.|.|||.|.      .. .... .......||.|.  |.|                 .|..|.|.....  | 
PEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

KRLKSFEVLNHPWM
||.   ..|.|||.
KRPTAEQILQHPWF
Kinase 25228.AA Ciliate-E2 147-323 31 6.1e-65 221.86 In-house 116-365 (365) Show / Hide 
Range on Protein: 147-323
Range on HMM: 116-365/365
Sequence Identity: 31% (84 aa)

CEGGELFDRIIERGFFS-----------EVDARTIFTQIMQ---------------AINYCHSKS-ISHRDLKPENFLFLTKHDDSPIKVIDFGLSKNFD
|.||.|||.|...  ..           |  ...|..|| |               |..|.|||  | |||.|||| ||        ||.|||||||..|
CQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYD

-----------HNQAMTTK----------------------AGTPYYISPEVLQGK----------YDESCDIWSGGVILYILLSGNPPFYGDTDPEILE
           ..  |  |                      .|||.| .||.|.||          ||..||||| |||||..|.|.|||        ..
DDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQ

AVKKGQFSFDIPE--------------FQSVSQEAQDLIRK-----MITTPDKRLK-SFEVLNHPWM
  |.....|. ||              ....|||..|||.|     .   |.||.    ..|||||.
QIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 25228.AA RSK 147-323 40 4e-63 216.03 In-house 83-278 (278) Show / Hide 
Range on Protein: 147-323
Range on HMM: 83-278/278
Sequence Identity: 40% (80 aa)

CEGGELFDRIIERGF---FSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDD-SPIKVIDFGLSKNF--DHNQAMTTKAGTPYYISPEVLQ
|.|||||... ....   ||| .|. .. .|  |. . |.. | |||||||| |.  .  .   ||..|||..| |  |||| . |  .|  |. ||.| 
CRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLK

----GK-YDESCDIWSGGVILYILLSGNPPFYG---DTDPEILEAVKKGQFSFDIPEFQSVSQEAQDLIRKMIT-TPDKRLK-----SFEVLNHPWM
    .. .|..||.|| ||..| .|.|.|||.|   ..  ||.. ..||.||...|. |..||||.|||||| .  | |||.       |...|||.
RANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 25228.AA MARK 147-323 42 5.6e-56 181.55 In-house 84-262 (262) Show / Hide 
Range on Protein: 147-323
Range on HMM: 84-262/262
Sequence Identity: 42% (80 aa)

CEGGELFDRIIER--GFFSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDS---PIKVIDFGLSKNFDHNQAMTTKAGTPYYISPEVLQG
..||||.|.|...  |  .| .||.||.||  |.||||||.| |||.|||| |     |.     || ||||.|  .  .|  .|  ||| | .||....
ASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI----DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLK

K-YD-ESCDIWSGGVILYILLSGNPPFYGDT--DPEILEAVKKGQFSFDIPEFQSVSQEAQDLIRKMITT-PDKRLKSFEVLNHPWM
| ||    |||| ||.||....|. || |||  . |. . . .|...  || .  || |...||....|. |..| .  |...||||
KPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD--IPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 25228.AA Ciliate-E2a 26-104 45 5.5e-37 106.43 In-house 1-80 (275) Show / Hide 
Range on Protein: 26-104
Range on HMM: 1-80/275
Sequence Identity: 45% (38 aa)

YDIDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKVKNQE----RFQREIEIMSSLDHPNIIKLYETFEDDKNIYLVMEL
|..  .|..|.|..| |..|..|.|.  .|.| . | |  .|.     |..|| ||..|||||||||||..||..|.|||||.
YKF--IKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEY
Kinase 25228.AA CAMK1 26-104 41 4.2e-35 99.43 In-house 1-89 (276) Show / Hide 
Range on Protein: 26-104
Range on HMM: 1-89/276
Sequence Identity: 41% (38 aa)

YDIDPKKVLGSGTYGMVFKAKKKGT---KITRAIKQIP-KKKVKN-----QERFQREIEIMSS---LDHPNIIKLYETFEDDKNIYLVMEL
| .  .|..|.|. . |.....| |   .   ||| |  || .|.     ||....||||| .   .|||||||.|| .|.|. .||||||
YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMEL
Kinase 25228.AA CAMKL 26-104 37 5.7e-28 86.23 In-house 1-102 (297) Show / Hide 
Range on Protein: 26-104
Range on HMM: 1-102/297
Sequence Identity: 37% (39 aa)

YDIDPKKVLGSGTYGMVFKAKK-KGTKITRAIKQIPKKKVK----------------NQERFQREIEIMSSLD---HPNIIKLYETFEDDKN------IY
|.| .  .|| |..| |  |.  . |..  ||| | ||| .                .. | .|||.||..|.   |||||||||..|....      ||
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

LVMEL
||||.
LVMEY
Kinase 25228.AA MARK 30-104 41 1.1e-25 81.12 In-house 3-83 (262) Show / Hide 
Range on Protein: 30-104
Range on HMM: 3-83/262
Sequence Identity: 41% (34 aa)

PKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKV---KNQERFQREIEIMSSLDHPNIIKLYETFE--DDKN-IYLVMEL
 .|..| |.|. | .|  | |..  ||| ..|.|    .. . ..||||||..|||||||||....|  . .. |||.||.
MLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEY
Kinase 25228.AA CAMK-Unique 28-104 25 9.8e-25 78.41 In-house 1-116 (363) Show / Hide 
Range on Protein: 28-104
Range on HMM: 1-116/363
Sequence Identity: 25% (29 aa)

IDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKVKNQERFQ--------------------REIEIMSSLDHPNIIKLYET----FEDDK-------
..  ...|.|..|.|.... . |.  .|.| . |....|  . |                    ||..|. ..|||||||||..    |.|.|       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NIYLVMEL
        ..|.|||.
IKTPRALPYMYIVMEY
Kinase 25228.AA RAD53 26-104 38 1.2e-24 69.89 In-house 1-86 (305) Show / Hide 
Range on Protein: 26-104
Range on HMM: 1-86/305
Sequence Identity: 38% (34 aa)

YDIDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKK--------VKNQERFQREIEIMSSLDHPNIIKLYETFED-DKNIYLVMEL
|...  |.|||| .| | .|..| |  . |||.| |||         |. .....|.||.  | ||.||..|. |.. .|. |.|.||
YYMS--KELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLEL
Kinase 25228.AA Pkinase 28-104 41 1.5e-24 87.93 Pfam 1-81 (293) Show / Hide 
Range on Protein: 28-104
Range on HMM: 1-81/293
Sequence Identity: 41% (34 aa)

IDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKVKNQER--FQR--EIEIMSSLDHPNIIKLYETFEDDKNIYLVMEL
.  ....|||..| |.|...||| .. |.|.|.|.. | ...    |  ||.|| .|.||||..||..|||...||.|||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEY
Kinase 25228.AA Ciliate-E2 28-104 26 2.6e-23 76.89 In-house 1-115 (365) Show / Hide 
Range on Protein: 28-104
Range on HMM: 1-115/365
Sequence Identity: 26% (30 aa)

IDPKKVLGSGTYGMVFKAKKKGTKI-----------------------TRAIKQIPKKKVKNQERFQREIE-------------IMSSLDHPNIIKLYET
..  |..|.|..| |.|.|.. ..                          |.|.. |........ ....              |...|.||||||.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DDKNIYLVMEL
|.  ||.|||||||.
FQEKDDNNIYLVMEY
Kinase 25228.AA Pkinase_Tyr 28-104 37 2.7e-17 59.19 Pfam 1-88 (270) Show / Hide 
Range on Protein: 28-104
Range on HMM: 1-88/270
Sequence Identity: 37% (33 aa)

IDPKKVLGSGTYGMVFKAKKK----GTKITRAIKQIPKKKVKNQ---ERFQREIEIMSSL-DHPNIIKLYETFE-DDKN--IYLVMEL
|   |.||.| .|.|.|.. |    .|||. |.| .. .  . |   | | ||..||..| .||||..||     ...   ||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY
Kinase 25228.AA RSK 31-104 31 4.6e-17 59.2 In-house 1-82 (278) Show / Hide 
Range on Protein: 31-104
Range on HMM: 1-82/278
Sequence Identity: 31% (26 aa)

KKVLGSGTYGMVFKAKKK---GTKITRAIKQIPKKKVKN----QERFQREIEIMSSLD-HPNIIKLYETFEDDKNIYLVMEL
 |||| | || ||  .|.    |.   | |.. |.|...    ...  .|..|..    ||.|..|...|.... .||.||.
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEY
Kinase 25228.AA TyrKc 28-323 22 2.4e-15 25.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-323
Range on HMM: 1-280/280
Sequence Identity: 22% (76 aa)

IDPKKVLGSGTYGMVFKAKKKGTKITRAIKQIPKKKVKNQERFQREIEIMSSL--DHPNIIKLYETFEDD-------KNIYLVMELDWWFARQSFLQQKM
|  .|.||.| .| |.|.. |   |. |.| . . .   .| | ||..||..|  .||||..||    ..       . ...|||.  . . ...|. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

ALENNPNQFHLNSGQIYLKNIFLIQKRVCEGGELFDRIIERGFFSEVDARTIFTQIMQAINYCHSKSISHRDLKPENFLFLTKHDDSPIKVIDFGLSKNF
                                           ..  |   . .|| .  .| ||| . ||||   | |   .|    .|. |||||.. 
PK-----------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDI

DHN-------QAMTTKA--GTP-----YYISPEVL-QGKYDESCDIWSGGVILY-ILLSGNPPFYG-----DTDPEILEAVKKGQFSFDIPE-----FQS
..        .  ..|   |.         .||..  ||. .  |.|| || .. |.  | .| .|      .. |..| ||.|      |.     |  
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC

VSQEAQDLIRKMITT-PDKRLKSFEVLNHPWM
 ..|  .....     |..|  .|. . |  .
CPDEMYQIMKQCWHEDPEDRP-TFSEI-HECF
Efhand 25228.AA efhand 369-397 31 4e-06 27.01 Pfam 1-29 (29) Show / Hide 
Range on Protein: 369-397
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLGRLFRQLDKNGDGVLTIDEIKEGLSGT
.| ..|...||.||| ....| .|... .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 25228.AA EFh 369-397 31 0.000148 22.38 SMART 1-29 (29) Show / Hide 
Range on Protein: 369-397
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLGRLFRQLDKNGDGVLTIDEIKEGLSGT
.. ..|| .||.||| .. .| |....  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 25228.AA EFh 404-432 34 1.6e-07 32.23 SMART 1-29 (29) Show / Hide 
Range on Protein: 404-432
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

EIKKVIESIDTDGSGKIDYTEFLAATMEK
|.|.... .|.||.|.||. ||... ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 25228.AA efhand 404-432 34 2.7e-07 31.11 Pfam 1-29 (29) Show / Hide 
Range on Protein: 404-432
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

EIKKVIESIDTDGSGKIDYTEFLAATMEK
|.|.... .|.||.|.||. ||... ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 25228.AA efhand 440-453 35 29.160715 1.71 Pfam 1-14 (29) Show / Hide 
Range on Protein: 440-453
Range on HMM: 1-14/29
Sequence Identity: 35% (5 aa)

KLIQAFKMLDLDDN
.| ..||..| | .
ELKEMFKEFDKDGD
EFh 25228.AA EFh 465-493 41 3.8e-10 40.94 SMART 1-29 (29) Show / Hide 
Range on Protein: 465-493
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

YWDQMIQEVDKNGDGEIDYSEFREMMNTI
 ...|....||.|||.||. ||..|| ..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 25228.AA efhand 465-493 48 2.3e-09 38.71 Pfam 1-29 (29) Show / Hide 
Range on Protein: 465-493
Range on HMM: 1-29/29
Sequence Identity: 48% (14 aa)

YWDQMIQEVDKNGDGEIDYSEFREMMNTI
 ...|..|.||.|||.||. ||.||| ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL