Gene 23071 (Tetrahymena)

23071

Species: Tetrahymena
Alias: 33, PreTt23071, 23071, 7.m00520, TTHERM_00106700
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
23071.NA RNA None 1722 None Fasta, JSON
23071.AA Protein None 573 None Fasta, JSON
23071.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of 23071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23071.AA CAMK-Unique 85-360 36 6.8e-162 538.39 In-house 1-363 (363) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-363/363
Sequence Identity: 36% (135 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKK-----NKLIQ------------------TDNELELLKRLDHPNIIRIFDF----YQDEE-------
|.....||.|.||.||...||||. ..|.|..||     .|..|                  ...|....|..||||||...|.    ..|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------DFYIITEYIEGGCLFDEIQKLSKRYFNFSIIKFDFNISLKKLKQQFNE--YHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQE--
        ..||..||..||.|||.|||....|||| |||||||| ||.....|.|  ...|.|||..|.||.|.||..|||||||.||....|....  
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNF-IIKFDFNI-LKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

---------SRYHVKVIDWGLSVLVEHNQKLH---IDCGTSYFKAP--------------EVIN-RCYDEKC----DLWSCGALMYELLSGCPPFDAETD
         |..|.|..|.||.....||.. |   ..|||....||              |||| .|||..|    |.||.|..||..|.||||||.|..
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

D--------EIEEKILQGGY-SLPTEYFGG---VSVEAIDLLKKLLTYIPSFRISAKQALEHSWF
|        ||.|.|..|.| ........|   .|.||.|..|...|..|..|.|||..|||.|.
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 23071.AA CAMK 90-360 23 3.4e-107 346.54 In-house 1-425 (425) Show / Hide 
Range on Protein: 90-360
Range on HMM: 1-425/425
Sequence Identity: 23% (105 aa)

VIGEGGFGVVYKVLDRETK------------LIKAMKRLKKN-------------------------------KLIQTDNELELLKR-------LDHPNI
..|.|.||.|... ...|.               |.| ..|.                               .. .  .|.|..|.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRIFDFYQD-------------------EEDFYIIT---EYIEGGCL----FDEIQKLSKRYFNFSIIKFDFNISLKKLKQQ--------FNEYHACQIM
|.....|.|                   ....|...   ||..||.|    || |.. ......| .              |        |.|  |....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-D--------------QFDIVERGRFTEREARRYF

QQILMAVNYAHSINIVHRDLKAENVLIQYNEQESR------------YHVKVIDWGLSVLVEH------------------------NQKLHIDCGTSYF
.||. ||.| || |||||||| ||.|...|. .|             . .|.||.|..  ...                        .||..  ||| ..
RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

KA-PEVINRC---------------YDEKCDLWSCGALMYELLSGCPPFDAE-------------TDDEIEEKILQGGYSLPTEYFGG------------
 | |||.|..               |..||| |||| ..| .|.|.|||...             .| |. |||..| |. | .|| .            
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDD

VSVE--------AIDLLKKLLTYIPSFRISAKQALEHSWF
.| |        ..||..|.|.. |. |....|.|.| |.
ISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 23071.AA Ciliate-E2a 85-360 34 1.9e-94 278.41 In-house 1-275 (275) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-275/275
Sequence Identity: 34% (102 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKKNKLIQTD-------NELELLKRLDHPNIIRIFDFYQDEEDFYIITEYIEGGCLFDEIQKLSKRYFN
|... .||.| ||.||..  ..|.  .||| ..| |. |..       ||. ....|||||||.....|.||  .|...||.||| |.|.|..  .  ..
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

FSIIKFDFNISLKKLKQQFNEYHACQIMQQIL-MAVNYAHSINIVHRDLKAENVLIQYNEQESR--YHVKVIDWGLSVLV--EHNQKLHIDCGTSYFKA-
                    .. .|.||||.|  ...| |. ||.||||| ||.|.  . ..|     .|.||.||.  .    .....  ||| .. | 
--------------------IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAP

-----PEVINRC-YDEKCDLWSCGALMYELLSGCPPFDAETDDEIEEKILQGGYSLPTEY-FGGVSVEAIDLLKKLLTYIPSFRISAKQALEHSWF
     .||...  ||.|||.||||. .| ||.|.|||...| .|| ... .  ...     .  .| |..||.||.| . |. ||.|.|||.| ||
EVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 23071.AA S_TKc 85-360 34 6e-89 302.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-231/231
Sequence Identity: 34% (100 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKKNKLIQTDNELELLKRLDHPNIIRIFDFYQDEEDFYIITEYIEG--GCLFDEIQKLSKRYFNFSIIK
||.|..||.|.||.|||. ...|. | |.|..|    ... .|...||. .||||....|..|| ...|...||..|  | ||| |.|  ..        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH--------

FDFNISLKKLKQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVKVIDWGLSVLVEHNQKLHIDCGTSYFKAPEVINRCYDE-
        .|...|.| ||. .|.||. |..| || .|.||||| ||.|.         |.|..| ||. ..      .  ||| .. ||||.   |.  
--------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKC

KCDLWSCGALMYELLSGCPPFDAETDDEIEEKILQGGYSLPTEYFGGVSVEAIDLLKKLLTYIPSFRISAKQALE-------HSWF
||| |||| ..||.|.|.|||.  ..... .||.              | ||.|...|.|.. |. |..| .||.       | ||
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23071.AA CAMK1 85-360 34 1e-84 246.2 In-house 1-276 (276) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-276/276
Sequence Identity: 34% (104 aa)

YEKLEVIGEGGFGVVYKVLDRET---KL---IKAM--KR-LKKNKL---IQTDNELELLK---RLDHPNIIRIFDFYQDEEDFYIITEYIEGGCLFDEIQ
||  ..||.| |..||.. ..||   .    ||..  |. .||..     . .||.| .|   ..|||||| ....|.....||...|.. || ||| | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KLSKRYFNFSIIKFDFNISLKKLKQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVK--VIDWGLSVLVEHNQ-KLHIDCGT
.                        ...| .|. ||.||| ||.| || .||||||| || |  |  ..    .|  ..| |||  ..|.  ..   |||
EKG----------------------NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLL--YYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGT

SYFKAPEVINR----CYDEKCDLWSCGALMYELLSGCPPFDAET-DDEIEEKILQGGYSLPTEYFGGVSVE-AIDLLKKLLTYIPSFRISAKQALEHSWF
 .. ||||...     || .||.||.|   | || |.||| .|. |.|. |||. . |  |. ... .| . | |..|..|.  |. |....|.|.| |.
PGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 23071.AA Ciliate-E2 85-360 25 1e-80 274.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-365/365
Sequence Identity: 25% (103 aa)

YEKLEVIGEGGFGVVYKVLDRETK-----------------------LIKAMKRLKKNKLIQTDNELELLK----------------RLDHPNIIRIFDF
|.....||.|.||.|||. .....                        |.|||..|||...|. .|. ...                .|.|||||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DEEDFYIITEYIEGGCLFDEIQ---KLSKRYFNFSIIKFDFNISLKKLKQQFNEYHACQIMQQIL---------------MAVNYAHSIN-IVHRD
.|  |.. .|...||..|| ||| |.   | ..  ..            |   ..|.|.....||.|||                |..| || | |.|||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRD

LKAENVLIQYNEQESRYHVKVIDWGLSV-----------LVEHNQKLHID----------------------CGTSYFKAPEVINRC----------YDE
.| ||.|.          .|.||.|||            ..... ..                         ||| ...|||..|.           ||.
IKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KCDLWSCGALMYELLSGCPPFDAETDDEIEEKILQGGYSLPTE--------------YFGGVSVEAIDLLKK----LLTYIPSFRIS-AKQALEHSWF
|||.||.| ..||.|.| |||        ...|.|. ...| .               .  .| |..||.||    .| . |. ||. ..|.|.| ||
KCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 23071.AA Pkinase 85-360 31 3.2e-77 267.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKKNKLIQTDN-------ELELLKRLDHPNIIRIFDFYQDEEDFYIITEYIEGG----CLFDEIQKLSK
|.....||.|.||.|||  .. |  | |.|..|| .     .       |....|||.||||.|..|...|. . |...|| |||     ||| |.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

RYFNFSIIKFDFNISLKKLKQQF--NEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVKVIDWGLSVL--VEHNQKLHIDCGTSYF
                 . .  |   | ... .| ||| ...| || .|.||||| ||.||  | . .  .||..|.||. .    .|. ..  |||...
-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWY

KAPEVIN--RCYDEKCDLWSCGALMYELLSGCPPFDAE------TDDEIEEKILQGGYSLPTEYFGGVS-----------------VEAIDLLKKLLTYI
 |||||.  . |. |.| |||| ..||.|.| |||. .      ..... ..|... .. . ..   .|                  |..|..|..|.. 
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PSFRISAKQALEHSWF
|. |..|.|.|.| ||
PKKRPTAEQILQHPWF
Kinase 23071.AA CDPK 193-360 49 7.4e-77 235.29 In-house 97-271 (271) Show / Hide 
Range on Protein: 193-360
Range on HMM: 97-271/271
Sequence Identity: 49% (87 aa)

KQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQES--RYHVKVIDWGLSVLVEHN-----QKLHIDCGTSYFKAPEVINRCYDEKCDL
| .|.|  |..||.||| ||||.|| |||||||| ||.| ....  |   | .||||||.|   ..|     .|.   ||| |  ||||... |.||||.
KGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDI

WSCGALMYELLSGCPPFDAETDDEIEEKILQGGYSLPTEYFGGVSVEAIDLLKKLLTYIPSFRISAKQALEHSWF
||||  .| ||.| ||| ...| || ||.  | ||.  . .  .|.||.|| .|.|.| |  |.|| |||.| ||
WSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 23071.AA CAMKL 85-360 30 6e-74 235.33 In-house 1-297 (297) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-297/297
Sequence Identity: 30% (97 aa)

YEKLEVIGEGGFGVVYKVLD-RETKLIKAMKRLKKNKLI----QTDN--------------ELELLKRLD---HPNIIRIFDFYQDEED------FYIIT
|. ....|.|.||.|   .. | |.   |.| ..|.|.      ..|              | ...|.|.   |||||.... ....|       .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYIEGGC--LFDEIQKLSKRYFNFSIIKFDFNISLKKLKQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVKVIDWGLSVLV
||..||   ||| |.|  .|                   . . |  |... .||. |||| || .|||||.|.||.|. .|  .    .|.|| |.| . 
EYCSGGEMDLFDYIVKHGHRR------------------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMY

E-H----NQKLHIDCGTSYFKAPEVINR--C-YD-EKCDLWSCGALMYELLSGCPPFDAETDD-------EIEEKILQGGYSLPTEYFGGVSVEAIDLLK
. .    .|||.. ||.  . |||....    ||  | | |||| ..| .. |  |||..|.        . ..|| .| |  |  |.  || ...||..
RPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYH--VS-DCRDLIR

KLLTYIPSFRISAKQALEHSWF
|.|.  |. |....| ..| |.
KMLQVNPEKRPTIHQIMNHPWM
Kinase 23071.AA Ciliate-E2-Unclassified 85-360 26 1.8e-70 240.42 In-house 1-352 (352) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-352/352
Sequence Identity: 26% (99 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKKNKLIQ---------------TDNELE-------------LLKRLDHPNIIRIFDFYQDEEDFYIIT
|.....||.||||.|||. ....|.. ||| .||.. .                . |...             .|. ..||.|.. |.  ||.. .||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYIEGGCLFDEIQKLSK---RYFNFSIIKFDFNISLKKL-------KQQFNEYHAC-----QIMQQILMAVNYAHSIN-IVHRDLKAENVLIQYNEQESR
||.||| |.. |.| .|                   ...       ...| |..|.     ... ||| . .| |. | |.|||.| ||.|.. | .  .
EYCEGGDLWQYIKKRKKQKQK---------------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--N

YHVKVIDWGLSVLVEHN----------------QKLHIDCGTSYFK----APEVINR-CYD----EKCDLWSCGALMYELLSGCPPFDAETDDE------
|..|.||.|.|   . |                |...  ||| ...    ||||. .  ||    .||| ||.| ..||.| | .||.......      
YYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLIT

----------IEEKILQGGYSLPTEYF----GGVSVEAIDLLK----KLLTYIPSFRISAKQALEHSWF
          ....|.|. .. | . .     ..| ||.|...    |.| . |. ||...|.|.| ||
QWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23071.AA RSK 189-360 35 4.9e-53 182.52 In-house 92-278 (278) Show / Hide 
Range on Protein: 189-360
Range on HMM: 92-278/278
Sequence Identity: 35% (68 aa)

LKKLKQQ--FNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVKVIDWGLSVL--VEHNQKLHIDCGTSYFKAPEVIN----RC-Y
|.| |.   | |  ||..| .| .|| . |.  |.||||| ||.|    .  .. |.|..| |.. .   .|||...  |.|  . |||...    .. .
LQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES--NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH

DEKCDLWSCGALMYELLSGCPPFDA---ETDDEIEEKILQGGYSLPTEYFGGVSVEAIDLLKKLLTYIPSFRIS-----AKQALEHSWF
|. ||.|| |.||||.|.||||| .   .. .|| ..|..| .||. .    .| || ||..|.|.  |. |..     |.. ..|.||
DKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 23071.AA MARK 201-360 40 6.5e-49 158.12 In-house 106-262 (262) Show / Hide 
Range on Protein: 201-360
Range on HMM: 106-262/262
Sequence Identity: 40% (67 aa)

ACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNE-QESRYHVKVIDWGLSVLVEHNQKLHIDCGTSYFKAPEVIN-RCYD-EKCDLWSCGALMYELLS
| .| .||. |||| ||.||||||.|.||.||  |  .     .| || |.|. .. .||| . |||  . |||... . ||  | | ||.| ..| ...
ARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNH----NIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVC

GCPPFDAET--DDEIEEKILQGGYSLPTEYFGGVSVEAIDLLKKLLTYIPSFRISAKQALEHSWF
|. |||. |  . |...||| | |. |.     ||.|. .|...|||  |. |..... ..|.|.
GYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 23071.AA CDPK 85-173 42 9.6e-35 104.15 In-house 1-99 (271) Show / Hide 
Range on Protein: 85-173
Range on HMM: 1-99/271
Sequence Identity: 42% (42 aa)

YEKLEVIGEGGFGVVYKVLDR-ETKLIK-AMKRLKKNKLIQTD------NELELLKRLDHPNIIRIFDFYQDEEDFYIITE--YIEGGCLFDEIQKLSK
| . .|.|.|.||.|.|| ..  |. .. |||  .|..... .      ||.|.|| |||||||.|. |||||  .||..|  | .|| ||| |.  ..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH
Kinase 23071.AA MARK 85-175 33 1.9e-21 67.02 In-house 1-100 (262) Show / Hide 
Range on Protein: 85-175
Range on HMM: 1-100/262
Sequence Identity: 33% (33 aa)

YEKLEVIGEGGFGVVYKVLDRETKLIKAMKRLKKNKLIQ------TDNELELLKRLDHPNIIRIFDFYQ--DEED-FYIITEYIEGGCLFDEIQKLSKRY
|. | .||.|....|...... |.   | | ..|.||           |.|..|.|||||||. |.  .  .|.  .|.| ||..|| |.| |.. ....
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR
Kinase 23071.AA RSK 88-170 37 1.9e-17 60.65 In-house 1-94 (278) Show / Hide 
Range on Protein: 88-170
Range on HMM: 1-94/278
Sequence Identity: 37% (35 aa)

LEVIGEGGFGVVYKVLDR---ETKLIKAMKRLKKNKLIQTD-------NELELLKRLD-HPNIIRIFDFYQDEEDFYIITEYIEGGCLFDEIQK
|.| |.||.| |. .       |. | ||| |||.|..|..        | . |.|   ||.|.. .. .|.|. .|.|.||..|| ||. .||
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQK
Kinase 23071.AA TyrKc 85-360 22 9.9e-17 47.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 85-360
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YEKLEVIGEGGFGVVYK-VLDRETKLIKAMKRLKKNKLIQTDNELELLKRL--DHPNIIRIFDFYQDE-------EDFYIITEYIEGGCLFDEIQKLSKR
 ......||| ||.||| ...    .  | | ||....    .|......|  .||||.|..    ..       |  .|..|| ..|.| | ..|  ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YFNFSIIKFDFNISLKKLKQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLIQYNEQESRYHVKVIDWGLSVLVEHN------QKLHID----C
                     ..  . .... ||    .| || |..|||| | |.|.  |      .||. | |||  ...       ..        .
---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

GT--SYFK--APEVI-NRCYDEKCDLWSCGALMYELLSGCPPFDAE------TDDEIEEKILQGGYSLPTEY-----FGGVSVEAIDLLKKLLTYIPSFR
|      .  |||.|  ... .| | || | .|.|... . .   .      ...|. |.. ||..  . ..     | . . |  .. |.   . |. |
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

ISAKQALEHSWF
 . ..   |. |
PTFSEI--HECF
Kinase 23071.AA Pkinase_Tyr 85-232 28 5.5e-11 37.83 Pfam 1-144 (270) Show / Hide 
Range on Protein: 85-232
Range on HMM: 1-144/270
Sequence Identity: 28% (46 aa)

YEKLEVIGEGGFGVVYKVLDR----ETKLIKAMKRLKKNKLIQTD-------NELELLKRL-DHPNIIRIFDFYQ-DEED--FYIITEYIEGGCLFDEIQ
 ......||| ||.|||   .    .||.  | | | |..  . .       .|....| | .||||.|       ..|    ||..|| ..|.| |  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KLSKRYFNFSIIKFDFNISLKKLKQQFNEYHACQIMQQILMAVNYAHSINIVHRDLKAENVLI
| .                    ||...  . .|. .|| .. .| .|.|..|||| | |.|.
KHR------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV
Kinase 23071.AA Pkinase_Tyr 271-322 36 0.030441 8.22 Pfam 182-236 (270) Show / Hide 
Range on Protein: 271-322
Range on HMM: 182-236/270
Sequence Identity: 36% (20 aa)

APEVIN-RCYDEKCDLWSCGALMYELLSGC-PP-FDAETDDEIEEKILQGGYSLP
|||.|| . . .| | || | ||.|... .  | .   .. |. |.| . || .|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
Efhand 23071.AA efhand 409-437 37 3.2e-07 30.86 Pfam 1-29 (29) Show / Hide 
Range on Protein: 409-437
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

QLTNLFNQIDKDQDGKISHEEMAQALKSV
.| ..|...|||.||.|. ||. ...|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 23071.AA EFh 409-437 37 1e-06 29.42 SMART 1-29 (29) Show / Hide 
Range on Protein: 409-437
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

QLTNLFNQIDKDQDGKISHEEMAQALKSV
..  .|. .||| ||.|. ||. ...||.
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 23071.AA EFh 459-487 24 1.7e-05 25.54 SMART 1-29 (29) Show / Hide 
Range on Protein: 459-487
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

EISEIINHIDFNQNGEIEYTEFLVAAMRK
|. |.....| . .|.|.. ||... ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 23071.AA efhand 459-487 24 2.7e-05 23.77 Pfam 1-29 (29) Show / Hide 
Range on Protein: 459-487
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

EISEIINHIDFNQNGEIEYTEFLVAAMRK
|. |.....| ...|.|.. ||. . ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 23071.AA efhand 495-523 37 6e-06 26.3 Pfam 1-29 (29) Show / Hide 
Range on Protein: 495-523
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

FLYKVFDIFDKDGDGFISLQEVKDKLQNN
 | ..|..|||||||.|...| .. ... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 23071.AA EFh 495-523 41 6.6e-05 23.55 SMART 1-29 (29) Show / Hide 
Range on Protein: 495-523
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

FLYKVFDIFDKDGDGFISLQEVKDKLQNN
 . ..|..|||||||.|...| || ... 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 23071.AA EFh 533-561 31 3e-06 28.18 SMART 1-29 (29) Show / Hide 
Range on Protein: 533-561
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

VWNQIIKEVDEDGDKEISFDEFKSIINTY
 ........| ||| .|.|.||| .. . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 23071.AA efhand 533-561 34 3e-06 27.36 Pfam 1-29 (29) Show / Hide 
Range on Protein: 533-561
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

VWNQIIKEVDEDGDKEISFDEFKSIINTY
 .....||.| ||| .|.|.||.... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL