Gene 16214 (Tetrahymena)
16214
Sequence
Protein domains of 16214.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CNMP_binding | 16214.AA | cNMP_binding | 53-135 | 17 | 0.009194 | 12.07 | Pfam | 13-91 (91) | Show / Hide |
Range on Protein: 53-135 Range on HMM: 13-91/91 Sequence Identity: 17% (15 aa) KGIQSSRLGIIMKGKVKIQSSNNGKKKQYHENKMVLRPGDKIGAESMLLEK-ANLFSLIVETEELVLLEIEKYFFDRCIRQLES .| ..... |. .||||. . . . | .|.||| .| ... .. .. .. .. ....|.. |.....| . QGDPCDHFYIVLSGKVKVYK-DEDGREQ---ILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE |
|||||||||
| CNMP_binding | 16214.AA | cNMP_binding | 169-296 | 18 | 3.3e-09 | 34.23 | Pfam | 1-91 (91) | Show / Hide |
Range on Protein: 169-296 Range on HMM: 1-91/91 Sequence Identity: 18% (24 aa) KISFQNNEVVYSQDQASYAIYIVLHGKFQVQQRFQDDTDQFMDQVSICSDNQEGTPNLRKQQSLDQSSFFSNTTTLKIRTVETYEIFGEEEIMDMR-QRN ..... .||...|.... .||||.||..| . .| | ..... ..||| .... . | VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ------------------------------------ILGFLGPGDFFGEMALFTNQNPRT STVVCLQDCSEVLVIRPVIYKSCILKDDA ||| | || |...| .... .. . ATVVALTDC-ECWRIPREDFRQLMQQHPE |
|||||||||
| Kinase | 16214.AA | CDPK | 882-1141 | 51 | 6.2e-178 | 550.09 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-271/271 Sequence Identity: 51% (139 aa) FDDKIKLGTGHYSEVYKIKDKLKD-VYR-AMKIINKKKIPFNEK-ESFLREIKILKKLDHPNILKLYEFLEDSDNYYLITE--FCEGKELFDVIQDNCEN .. | .||.||...|.|.|.|.|. ..| |||||.|......|. ..|..||.|||.||||||.|.||| .|..|||...| .|.| ||||.|..... YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH- LTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNN---YIIKLVDWGIGSDFGSN----DSTLNQKCGTPYYAAPEVIKKKYNEKCDIWST .|||. |.|..|||. ..|.|||.|.|||.|||||. ...|... |.||..|||. .|..| | ...|.|||||| ||||..||||||||||| FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSC GVILYTLLVSEIPFGGDSTTDIILNVLKGKYDLKGQEWNKVSDEAKDLVQKMLNYEYENRISAEEALQHPWF |||||.||. . ||.|.. .|. .| ||||...|.||...|||||||..|||.|....|.||..||||||| GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
|||||||||
| Kinase | 16214.AA | Ciliate-E2a | 882-1141 | 43 | 2.9e-121 | 358.67 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-275/275 Sequence Identity: 43% (119 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNE--KESFLREIKILKKLDHPNILKLYEFLEDSDNYYLITEFCEGKELFDVIQDNCENLTE .. . |.|.| . ||. . | .|||...| |. .. ||.| .||.|...||||||.||||. || .||||..|.|||.||.| |. . . .| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE -KDIASIVQQIL-QSLAYAHSNKIMHRDIKPENIMVQ-TDKNN--NYIIKLVDWGIGSDFGSNDS-TLNQKCGTPYYAA------PEVIKKK-YNEKCDI ..|..| ||.| | |.| |...|||||.|||||. .||. | ||..|.| . .. ... . ||||||.| | .||.|.| | .|||. IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM WSTGVILYTLLVSEIPFGGDSTTDIILNVLKGKYDLKGQE-WNKVSDEAKDLVQKMLNYEYENRISAEEALQHPWF || |||.|.||. . || | ....|. .. | |.|. ..| |.|.|.|.|||..|||.. ..||.|..||.|||| WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
|||||||||
| Kinase | 16214.AA | CAMK | 887-1141 | 25 | 1.9e-116 | 376.91 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 887-1141
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)
KLGTGHYSEVYKIKDKLKD------------VYRAMKIINKKKIPFNE--------------------------KESFLREIKILKK-------LDHPNI
.||.| ...|.. ..|. . |.|||.|||.. .. .....|||.|.|| ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LKLYEFLED-------------------SDNYYLIT---EFCEGKEL----FDVIQDNCEN--------------LTEKDIASIVQQILQSLAYAHSNKI
.||||. || ...|... |.|.| || || |... . .||.. . ...||.. ..| ||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
MHRDIKPENIMVQTDKNNN-------------YIIKLVDWGIGSDFGSN-----------------------DSTLNQKCGTPYYAA-PEVIKKK-----
.|||.|||||......... . ||..|.| | .. . .. ||||.|.| |||...|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
----------YNEKCDIWSTGVILYTLLVSEIPFGGDSTTDIIL-------------NVLKGKYDLKGQE------------WNKVSDE--------AKD
|..|||.|| |||||..|. . || ||. .|. ...||||| . |...||| .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
LVQKMLNYEYENRISAEEALQHPWF
|..|||... |.|...|..|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | 16214.AA | S_TKc | 882-1141 | 34 | 1.1e-102 | 348.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-231/231 Sequence Identity: 34% (96 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEKESFLREIKILKKLDHPNILKLYEFLEDSDNYYLITEFCEG--KELFDVIQDNCEN--- .. |.| | ...||| ..| . . |.|||. |...|||.|||| .|||| |||.. .| |..|...|.|.| .|||.|... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDFGSNDSTLNQKCGTPYYAAPEVIKKKYNE-KCDIWSTGVIL ..| .......||.. |.| ||..|.|||.|||||.. . ||. | |. . . ||||.| ||||. .|. |||.|| |.|| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL YTLLVSEIPFGGDSTTDIILNVLKGKYDLKGQEWNKVSDEAKDLVQKMLNYEYENRISAEEALQ-------HPWF | .|. . || . . ...... |.||||...|.|... |.|..| |||| |||| YEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 16214.AA | CAMK-Unique | 884-1141 | 26 | 1.1e-93 | 309.68 | In-house | 2-363 (363) | Show / Hide |
Range on Protein: 884-1141
Range on HMM: 2-363/363
Sequence Identity: 26% (97 aa)
DKIK-LGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEKES------------------FLREIKILKKLDHPNILKLYEF----LEDSD--------
.... .|.| ...||. .|. . .|.|...|.. . . . ||. |.|..|||||.|||.. .|..
KMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLII
-------NYYLITEFCEGKELFDVIQDN-------------------CENLTE--KDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTD--------
..|...|.|.|..|||.||.. ..| |...|.|..|. .||.||..| |||.|.|||||..
KTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHR
--KNN--NYIIKLVDWGIGSDFGSNDST--LNQKCGTPYYAAP--------------EVIK-KKYNEKC----DIWSTGVILYTLLVSEIPFGGDSTT--
... |. ||| |.|. .. .| . . ||||.|.|| |||. .| ..| |||| |||.|..|. . || ...
DFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRD
------DIILNVLKGKY-DLKGQEWNK---VSDEAKDLVQKMLNYEYENRISAEEALQHPWF
|. . .||.| ... . |. .|.||||.|.. .... |.||.|.|.|.|.
YENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
|
|||||||||
| Kinase | 16214.AA | Ciliate-E2 | 882-1141 | 28 | 3.1e-93 | 316.07 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-365/365 Sequence Identity: 28% (109 aa) FDDKIKLGTGHYSEVYKIKDKLKDV------------------YRAMKIINKKKIPFNEKESFLREIKILK----------------KLDHPNILKLYEF .. |.|.| .. ||| |..... . ..||...| . |..|....||.|.. .|.||||.|.||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC LE--DSDNYYLITEFCEGKELFDVIQDNCEN----------LTEKDIASIVQQILQ---------------SLAYAHSNK-IMHRDIKPENIMVQTDKNN . | .|.||..|.|.|..||| |..|. . .||| |. | .|||| | | ||.. |.|||||||||.. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ NYIIKLVDWGIGSDFGSN-------------------------------DSTLNQKCGTPYYAAPEVIKKK----------YNEKCDIWSTGVILYTLLV ||..|.|. .. . . . |. ||||.| |||....| |..|||||| ||||| .| ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF SEIPFGGDSTTDIILNVLKGKYDLKGQE--------------WNKVSDEAKDLVQK----MLNYEYENRIS-AEEALQHPWF . || . . ...|.|. .| |.|.|.|.||| .| ||... |.||. .|..|.|||| GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 16214.AA | Pkinase | 882-1141 | 33 | 1.2e-88 | 305.66 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-293/293 Sequence Identity: 33% (98 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEKESFLR--EIKILKKLDHPNILKLYEFLEDSDNYYLITEFCEGK----ELFDVIQ-DNC . . |.| | ...||| ..| |.|||.|... ..... .| ||.|.|.|.||||..||.. ||.|..|...|.||| .|||.|. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH ENL--TEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDF-GSNDSTLNQKCGTPYYAAPEVIK--KKYNEKCDIWST .. .|... ... |||. |.| ||..|.|||.|||||.. . ... ..|. |.|. | |.| .. ||||.|.|||||. ..| |.|.|| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVILYTLLVSEIPFGGD------STTDIILNVLKGKYDLKGQEWNKVS-----------------DEAKDLVQKMLNYEYENRISAEEALQHPWF |.||| .| . || |. . .| ........ ..|. .| .|.||.. ..|.. . |..||..|||||| GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 16214.AA | CAMKL | 888-1141 | 32 | 1.4e-88 | 282.75 | In-house | 7-297 (297) | Show / Hide |
Range on Protein: 888-1141 Range on HMM: 7-297/297 Sequence Identity: 32% (97 aa) LGTGHYSEVYKIKD-KLKDVYRAMKIINKKKIPFNEKESFL-------------REIKILKKLD---HPNILKLYEFLEDSDN------YYLITEFCEGK ||.|....| .. .. . |.|||.|||| ... . |||.|.|.|. |||| |||| .|.... .||..| |.| LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG E--LFDVIQ-DNCEN--LTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDFGSN----DSTLNQKCGTPYYAAPEV | ||| |. . . ..|.. . .||. ..| ||..| |||||||||.. ..|| ||..| | . . . . .|. ||.| |.|||. EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI IKK--K-YN-EKCDIWSTGVILYTLLVSEIPFGGDST-----TDIILNVLKGKYDLKGQ-EWNKVSDEAKDLVQKMLNYEYENRISAEEALQHPWF ... | |. | |||| |||||.... . || .|. ..| . .| . . . |..|| ...|| .|||. | |..... ..|||. FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | 16214.AA | CAMK1 | 882-1141 | 36 | 2.5e-88 | 256.86 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-276/276 Sequence Identity: 36% (102 aa) FDDKIKLGTGHYSEVYKIKDKLK---DVYRAMKIIN-KKKIPFNEK---ESFLREIKILKK---LDHPNILKLYEFLEDSDNYYLITEFCEGKELFDVIQ . . ..|.| ||||. ..| . . |.|.|. || . .. |....|| |.|| .||||| |.||. |. . .||..| . | |||| | YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV DNCENLTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIK--LVDWGIGSDFGSNDSTLNQKCGTPYYAAPEVIKKK----YNEKCD .. .| |||| . |..|||. . | ||. |.|||.||||. || .. .|| . | |. |.... .. . ||||.| ||||.. | | .|| EK-GNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLY-YDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD IWSTGVILYTLLVSEIPFGGDS-TTDIILNVLKGKYDLKGQEWNKVSDE-AKDLVQKMLNYEYENRISAEEALQHPWF .|| |||.|.||. || ... . ..|..|. .|...||. |||.. .||. . ..|...|..|.|||. MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
|||||||||
| Kinase | 16214.AA | Ciliate-E2-Unclassified | 882-1141 | 27 | 9.7e-82 | 277.86 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-352/352 Sequence Identity: 27% (98 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEKESF----------LREIK-------------ILKKLDHPNILKLYEFLEDSDNYYLIT . ..|.| ...||| ..| .. | |||...|..| . . . ..| ||. ..||.|.|... .| .| |... YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EFCEGKELFDVIQD-------------NCEN---LTEKDIA-----SIVQQILQSLAYAHSNK-IMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDFGS |.|||..|.. |.. |... .||. .. . |||| | | |... | |||||||||... ... || ||. |.|| . .. EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQ N---------------DSTLNQKCGTPYYA----APEVIKK-KYN----EKCDIWSTGVILYTLLVSEIPFGGDSTTD----------------IILNVL | . ....||||.| ||||... .|. .|||||| ||||| .| . ||.. . .. .. | . NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK KGKYDLKGQEW----NKVSDEAKDLVQ----KMLNYEYENRISAEEALQHPWF ..... . ..| ..|.||||... |||.. ..||..|..|.|||| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | 16214.AA | RAD53 | 882-1141 | 31 | 6.8e-80 | 237.55 | In-house | 1-305 (305) | Show / Hide |
Range on Protein: 882-1141 Range on HMM: 1-305/305 Sequence Identity: 31% (97 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIP------FNEKESFLREIKILKKLDHPNILKLYEFLED-SDNYYLITEFCEGKELFDVIQDNC .. .||.|....|.. ..| |.|||.|||. .. .... .|..||||| ||.| ..|.. .. ...||.. |. .| |||. | .| YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK EN---LTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQ-TDKNN-------------NYIIKLVDWGIGSDFGSNDSTLNQKCGTPYYAAPEVIK . ..| .. . |.. .. | |.| | |||.||||| .|... . .||. | | | | ...| .. |||| | ||||| RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGL-SKFVGEGSFMKTMCGTPQYVAPEVIT KK----------------YNEKCDIWSTGVILYTLLVSEIPFGGD-----STTDIILNVLK-GKYDLKGQEWNKVSDEAKDLVQKMLNYEYENRISAEEA .| |. |.|.|| |.|||..| ||. | ..... ... ||| .| ..|.|||||...||. . |.|....|| SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA LQHPWF |.|||. LNHPWM |
|||||||||
| Kinase | 16214.AA | RSK | 885-1141 | 32 | 2.3e-70 | 240.08 | In-house | 2-278 (278) | Show / Hide |
Range on Protein: 885-1141 Range on HMM: 2-278/278 Sequence Identity: 32% (89 aa) KIK--LGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEK--ESFLREIKILKKLD-HPNILKLYEFLEDSDNYYLITEFCEGKELFDVIQDNCEN--L | . .| | .. . |. .. .. . |||...|.|| ..| . ..|..||. ||.| .|.. .. . |||.|.|.| |||. .| . KVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCF TEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDF-GSNDSTLNQKCGTPYYAAPEVIK----KK-YNEKCDIWSTGV .|.. . . .| . . |. .| |||.|||||. .. |. |||.| | | .. . .. |.| |.|||..| .. ... ||.|| || SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV ILYTLLVSEIPFGG---DSTTDIILNVLKGKYDLKGQEWNKVSDEAKDLVQKMLNYEYENRIS-----AEEALQHPWF ..|..|. || | .. .|. ...|||..|.. .|...|.|||||..||| . ..|.. ||| .||||| LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
| Kinase | 16214.AA | TyrKc | 882-1148 | 24 | 4.1e-16 | 37.75 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 882-1148 Range on HMM: 1-280/280 Sequence Identity: 24% (73 aa) FDDKIKLGTGHYSEVYKIKDKLKDVYRAMKIINKKKIPFNEKESFLREIKILKKL--DHPNILKLYEFLEDS-------DNYYLITEFCEGKELFDVIQD . ||| |.. |||| . | .| | | ... . .| |.||..|..|| .||||..|| .. . .....|.... | | ... ITLGKKLGEGAFGEVYKGTWK-IQV--AVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK NCENLTEKDIASIVQQILQSLAYAHSNKIMHRDIKPENIMVQTDKNNNYIIKLVDWGIGSDFGSND-------STLNQK---CGTP----YYAAPEVI-K . ..|. || |. || . .| ||... |||. |..| .. ..| | | | .. .| .. .| .| |||.| . HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY KKYNEKCDIWSTGVILYTLLVS-EIPFGG-----DSTTDIILNVLKGKYDLKGQE-----WNKVSDEAKDLVQKMLNYEYENRISAEEALQHPWFKQINQ .|...| |.|| || .. .. . | | | ...| .| .|.. . .. .|| .. .. ... |.| | |..| . GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR---------PTFSEIHE KL .. CF |
|||||||||
| Kinase | 16214.AA | Pkinase_Tyr | 909-1006 | 29 | 4.5e-13 | 44.89 | Pfam | 32-137 (270) | Show / Hide |
Range on Protein: 909-1006 Range on HMM: 32-137/270 Sequence Identity: 29% (32 aa) AMKIINKKKIPFNE--KESFLREIKILKKL-DHPNILKLYEFLE-DSDN--YYLITEFCEGKELFDVIQDN---CENLTEKDIASIVQQILQSLAYAHSN | |.. | . . .|.|.||.||.|.| .||||..|| ... .|...|.... | | ... ..|| ||. .. .|| . ..| .|. AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK KIMHRDI .. |||. NCIHRDL |
|||||||||
| Efhand | 16214.AA | efhand | 1189-1217 | 34 | 1.8e-05 | 24.44 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1189-1217 Range on HMM: 1-29/29 Sequence Identity: 34% (10 aa) EFSQTFKQLDENGDGQLSKAEIMNGYKKV |. . ||..| .|||.... | ....||. ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
|||||||||
| EFh | 16214.AA | EFh | 1189-1217 | 31 | 9.3e-05 | 23.05 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 1189-1217 Range on HMM: 1-29/29 Sequence Identity: 31% (9 aa) EFSQTFKQLDENGDGQLSKAEIMNGYKKV || . |. .| .|||.... | . . |.. EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
|||||||||
| Efhand | 16214.AA | efhand | 1226-1254 | 27 | 1e-06 | 28.97 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1226-1254 Range on HMM: 1-29/29 Sequence Identity: 27% (8 aa) EVNKIFDQIDVNQSGFIDYTEFITAVIDD |....|...|....|.||. ||.... . ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
|||||||||
| EFh | 16214.AA | EFh | 1226-1254 | 27 | 4e-06 | 27.78 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 1226-1254 Range on HMM: 1-29/29 Sequence Identity: 27% (8 aa) EVNKIFDQIDVNQSGFIDYTEFITAVIDD |....|. .|.. .|.||. ||.... EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
|||||||||
| Efhand | 16214.AA | efhand | 1262-1290 | 41 | 2.9e-07 | 31.02 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1262-1290 Range on HMM: 1-29/29 Sequence Identity: 41% (12 aa) KLRKAFSLFDKDGDGYITQQEIQNVLGVG .|...|..|||||||||. .| .... ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
|||||||||
| EFh | 16214.AA | EFh | 1262-1290 | 37 | 2e-06 | 28.82 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 1262-1290 Range on HMM: 1-29/29 Sequence Identity: 37% (11 aa) KLRKAFSLFDKDGDGYITQQEIQNVLGVG .....|..|||||||||. .| . .. EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
|||||||||
| Efhand | 16214.AA | efhand | 1297-1325 | 37 | 9.8e-08 | 32.72 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1297-1325 Range on HMM: 1-29/29 Sequence Identity: 37% (11 aa) TWTKIVAEVDENGDGQVSFEEFKKIMQTL . .. .|.| .|||...||||...|..| ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
|||||||||
| EFh | 16214.AA | EFh | 1297-1325 | 37 | 1.8e-07 | 32.08 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 1297-1325 Range on HMM: 1-29/29 Sequence Identity: 37% (11 aa) TWTKIVAEVDENGDGQVSFEEFKKIMQTL . .. ...| .|||...|||||..|..| EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
|||||||||