Gene 19206 (Tetrahymena)

19206

Species: Tetrahymena
Alias: PreTt19206, 19206, 85.m00199, 3725.m00090, 350, TTHERM_00616570
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
19206.AA Protein None 529 None Fasta, JSON
19206.kin_dom Protein Kinase Domain None 265 None Fasta, JSON
19206.NA RNA None 1590 None Fasta, JSON

Protein domain

Protein domains of 19206.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19206.AA CDPK 36-300 50 4.6e-185 572.28 In-house 1-271 (271) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-271/271
Sequence Identity: 50% (139 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKI--YMLQRELEVLKTLDHPNIIKFYETYHDKMYIHFVME--YCPGGDLFEYVAN
||| ..||||.||.|......|..|..|    .|.|.| |.|||||   .....|.|.||.||||||||.||.|.|......|||  || ||.||.|...
YKIKKVLGKGHFGQVRKVKHKQKTNQER----VAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIE

KGPLEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSW---DIKIIDFGLSRQFNSN----DKKHMSVVGTPLYVAPEIIGEKNYEKECD
||...|.|||.||....|||...||.||||||||||||||.||...||   .||.||.|.|..|..|    |||..  .|||.|.|||..  | |...||
KGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCD

NWSLGVIMYILLSGREPFYAKSLKEVYDKIRNQRYDFNDSCWENITKQAKDLISKLLTVDPKKRFTCEQALKHQWF
.||.|||.||||.|. |||.|. .|...|.....|.|.. .|..|...|||||.|.|..|||||....|||.|.||
IWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 19206.AA CAMK1 36-300 45 1.8e-134 393.37 In-house 1-276 (276) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-276/276
Sequence Identity: 45% (127 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTIL-KDRVKDKI----YMLQRELEVLKT---LDHPNIIKFYETYHDKMYIHFVMEYCPGGDLFE
|......|.|.|. |.|.| .. |     .| .||| |  |. .| |     ..|..|.|..|.   .|||||||||| | .......|||.. ||.||.
YEFGKEIGRGAFSEVYLCTHKETQ--T-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

YVANKGPLEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIK--IIDFGLSRQFNSNDKKHMSVVGTPLYVAPEIIGE---KNYEKE
 .  ||   | .|. |||...||| ..|||.||||||||||.|. .||  | .||  |.|||||..|.... .   ..||| |||||..     | | |.
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDS-KIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKA

CDNWSLGVIMYILLSGREPFYAKS-LKEVYDKIRNQRYDFNDSCWENITKQ-AKDLISKLLTVDPKKRFTCEQALKHQWF
|| || ||| |||| | .|||...  .| ..|| .  |.|    | || .| |||.|...|.||||||.||||.|.| |.
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 19206.AA Ciliate-E2a 36-300 42 2.2e-132 391.97 In-house 1-275 (275) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-275/275
Sequence Identity: 42% (120 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKI---YMLQRELEVLKTLDHPNIIKFYETYHDKMYIHFVMEYCPGGDLFEYVANK
||.| ..|||.||||.||. .|      ..| ||.| . | .  ..      ...|.  ...||||||||.||.| |. .. .||||| ||.|...  ..
YKFIKKIGKGNFGSVYLAQHKQ------TGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQC

G-PLEE-FEAAQIMKKLFS-AVAHIHSKNIVHRDLKPENILFTSKDKTS---WDIKIIDFGLSRQFNSNDK-KHMSVVGTPLYVAPEIIGEKN------Y
.   || .|...||..|.. .....|..||.|||||||||||....|.|    |||||||||........| .  . .||| |||||..  |       |
KRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQY

EKECDNWSLGVIMYILLSGREPFYAKSLKEVYDKIRNQRYDFNDSC-WENITKQAKDLISKLLTVDPKKRFTCEQALKHQWF
 . || ||.|||.||||.|. ||..|. .|.  ....  .|||..  ||...|..|||..|.| .|||||.|..|||.|.||
DTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 19206.AA CAMK 41-300 29 8.9e-129 417.35 In-house 1-425 (425) Show / Hide 
Range on Protein: 41-300
Range on HMM: 1-425/425
Sequence Identity: 29% (124 aa)

QLGKGSFGSVKLATYRQGQNDRRE------KKLFAIKTILKDRVKD---------------------------KIYMLQRELEVLKT-------LDHPNI
.||.|||| |||.. .. ... |.      .. .||| | |...||                           .  ...||.|..|.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYETYHD-------------------KMYIHFVM---EYCPGG----DLFEYVANKGP---------------LEEFEAAQIMKKLFSAVAHIHSKNI
||.||.| |                   ......||   |||.||    |||.|.  .|.               ..| ||..... . |||...||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILFTSKDKTS-------------WDIKIIDFGLSRQFNSN-----------------------DKKHMSVVGTPLYVA-PEIIGEKN----
|||||||||||...... |             ..|||||||....|...                       ..|   ..||| |.| ||..  |     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YEKECDNWSLGVIMYILLSGREPFYAK-------------SLKEVYDKIRNQRYDFNDSC------------WENITKQ--------AKD
          | ..|| ||.|||.||.|.|. |||..             ...| . ||.. .||| ..             | .|...        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISKLLTVDPKKRFTCEQALKHQWF
||.|.|.|||.||.|.||.|.|.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19206.AA CAMK-Unique 36-300 29 2.1e-110 365.7 In-house 1-363 (363) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-363/363
Sequence Identity: 29% (110 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKIYML-------------------QRELEVLKTLDHPNIIKFYET----YHDKM-
|| .  .|.|.|| |. ..      || ..|..|.| . | ... |.. .                    ||....|..|||||||.|..    ..|.  
YKMHRIIGHGNFGHVYECM------DRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKY

--------------YIHFVMEYCPGGDLFEYVAN--------------------KGPLEE--FEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKD
              |.. |||||.|||||....                     .|...|   ....|| .| ||||. ||..|||||||.|||.. .  
PLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSF

K------------TSWDIKIIDFGLSRQFNSNDKKH--MSVVGTPLYVAP--------------EIIGEKNYEKEC----DNWSLGVIMYILLSGREPFY
|              |.||..||||....|.| . |   ...|||.|.||              |.|..  |   |    | ||||||||..|.|. ||.
KDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFD

AKSLK--------EVYDKIRNQRY-DFNDSCWEN---ITKQAKDLISKLLTVDPKKRFTCEQALKHQWF
. . .        | ...|.  .| .|  . |.    |...|||.. ...||||..| .....|.|||.
CECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 19206.AA S_TKc 36-300 35 4.2e-106 359.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-231/231
Sequence Identity: 35% (99 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKIYMLQRELEVLKTLDHPNIIKFYETYHDKMYIHFVMEYCPG--GDLFEYVANKG
|.|. ..|||.||.|.... .        ....||| |          ...||...||  .||||.|.|....|  ....|||||.|  ||||.|  ..|
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

P------LEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIKIIDFGLSRQFNSNDKKHMSVVGTPLYVAPEIIGEKNYEK-ECDNW
.      . | .|. .|. ...|....||..|.||||||||||...       |||.||||.||.       ....||| |.|||..    | | .|| |
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGVIMYILLSGREPFYAKSLKEVYDKIRNQRYDFNDSCWENITKQAKDLISKLLTVDPKKRFTCEQALK-------HQWF
|.|.|.|..|.|. ||.   ......||.              ...|||.|.|.|..||.|| |. .||.       |.||
SCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19206.AA Ciliate-E2 36-300 29 1.1e-103 350.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-365/365
Sequence Identity: 29% (114 aa)

YKIISQLGKGSFGSVKLA-TYRQGQN----------------DRREKKLFAIKTILKDR---VKDKIYMLQ---------RELEVLKTLDHPNIIKFYET
||.| ..|.|.||||...  ......                .   .|..|.|.. |.    .| .|....          |...|..|.||||||.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YH--DKMYIHFVMEYCPGGDLFEYVANK-----------GPLEEFEAAQIMKKLFS---------------AVAHIHSKN-IVHRDLKPENILFTSKDKT
.   |. .| .||||| |||||.|  |.           ... |.|...|||....               |. ..|||| |.|||.|||||||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SWDIKIIDFGLSRQFN-----------SNDKKHMS---------------------VVGTPLYVAPEIIGEKN---------YEKECDNWSLGVIMYILL
   |||||||||....           .. ..  .                     ..||| |.||||.. |.         | ..|| ||||||.|..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGREPFYAKSLKEVYDKIRNQRYDFNDSC--------------WENITKQAKDLISK----LLTVDPKKRFT-CEQALKHQWF
.|. ||        ...| .. .||.  .              |.......||||.|    .| .||.||.|  ||.|.|.||
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19206.AA Pkinase 36-300 33 1.2e-102 352.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-293/293
Sequence Identity: 33% (102 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKI-YMLQR--ELEVLKTLDHPNIIKFYETYHDKMYIHFVMEYCPGG----DLFEY
|.|....|.||||.|.... .  .       ..|.|.| |.. |..  . . |  |....| |.||||...|....|| .|..|||||.||    |||.|
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

VA--NKGPL--EEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIKIIDFGLSRQF-NSNDKKHMSVVGTPLYVAPEIIG-EKNYEKE
.   ..|..  .| |.  .|. ........||..|.||||||||||. ... .. ..||.||||..|| . |.   ....||| |.|||.|   . | ..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

CDNWSLGVIMYILLSGREPFYAK------SLKEVYDKIRNQRYDFNDSCWENIT-----------------KQAKDLISKLLTVDPKKRFTCEQALKHQW
.| ||.|.|.|..|.|| ||. .      . ......|.  ...|. . | .|                  . .||.|...|..||||| |.||.|.| |
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 19206.AA CAMKL 36-300 34 3.9e-101 323.5 In-house 1-297 (297) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-297/297
Sequence Identity: 34% (107 aa)

YKIISQLGKGSFGSVKLATY-RQGQNDRREKKLFAIKTILKDRVK-DKIYM-------------LQRELEVLKTLD---HPNIIKFYETY-------HDK
|.|. .||||||| |||||  |        ..  ||| | |.. . | . .             ..|| . .| |.   ||||||.||..          
YRIGKTLGKGSFGKVKLATHIRTT------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-

MYIHFVMEYCPGGD--LFEYVANK----GPLEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIKIIDFGLSRQFNSN----DKKHM
..|. |||||.||.  ||.|. ..    |...| || .. . . |||...||..|||||.||||||......    |||||||.| ..  .    ..| .
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLK

SVVGTPLYVAPEIIGE--KNYE-KECDNWSLGVIMYILLSGREPFYAKSLK------EVYDKIRNQRYDFNDSCWENITKQAKDLISKLLTVDPKKRFTC
   |.| | ||||.    | |. .. | ||.|||.| .. |. || . ...        | . .. .  ...  |  .  ...|||.|.|.|.|.||.|.
TFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

EQALKHQWF
.| ..| |.
HQIMNHPWM
Kinase 19206.AA RSK 39-300 30 6.5e-89 301.7 In-house 1-278 (278) Show / Hide 
Range on Protein: 39-300
Range on HMM: 1-278/278
Sequence Identity: 30% (87 aa)

ISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDK---IYMLQRELEVLKTLD-HPNIIKFYETYHDKMYIHFVMEYCPGGDLFEYVANKGP
...||.|..|.| |    .  ...  ....| | . |  .. .   .    .| ..|..   ||.|.. ....... ... .||||.||.||.   ... 
LKVLGQGGYGKVFLC---RKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKH

---LEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIKIIDFGLSRQF-NSNDKKHMSVVGTPLYVAPEIIG---EKN-YEKECDNW
   . | ||...| .. .|| |.|.. |.||||||||||..... ..  ||..|||...|| ... .. |. ..|  |.|||..     .. . | || |
FGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

SLGVIMYILLSGREPFYA---KSLKEVYDKIRNQRYDFNDSCWENITKQAKDLISKLLTVDPKKRFT-----CEQALKHQWF
||||.|| .|.|. ||..   .. ||. ..|.. .....   |..... |||||.|.|..||.|| .      |. ..|.||
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19206.AA MARK 36-300 39 1.6e-88 289.43 In-house 1-262 (262) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-262/262
Sequence Identity: 39% (109 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKD--KIYMLQRELEVLKTLDHPNIIKFYETYH--DKMY-IHFVMEYCPGGDLFEYVA
||.. ..|.||.. ||||.      ... .. .|||.. | .  |  .. ...||.|..| ||||||||....    ..   |...|||..||.|..|. 
YKMLKTIGHGSYAKVKLAC------HKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIK

NK--GPLEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTS-WDIKIIDFGLSRQFNSNDKKHMSVVGTPLYVAPEIIGEKNYE-KECDNW
..  |.|.| || .| . . |||   |||||||||.||||||    |.    .|||||||.|.... ...|  .  ||| | ||||.  | |. .. | |
AHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI---DENGNHNIKIIDFGFSICIP-PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIW

SLGVIMYILLSGREPFYAKS--LKEVYDKIRNQRYDFNDSCWENITKQAKDLISKLLTVDPKKRFTCEQALKHQWF
||||..|....|. || ...  .|| | ||.. .||. .     . |....||..||||.|..| |.|. .|| |.
SLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 19206.AA Ciliate-E2-Unclassified 36-300 28 1.2e-87 297.46 In-house 1-352 (352) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-352/352
Sequence Identity: 28% (102 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKIYMLQR--------ELEVLK----------------TLDHPNIIKFYETYHDKM
|||| |.|.|.||.|...  ..      .|...|.|.. | ..... ....         |.. .|                 ..||.|.|....  || 
YKIIKQIGQGGFGKVYKCQHKK------QKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ

YIHFVMEYCPGGDLFEYVANKGP-----------------LEEFEAA-----QIMKKLFSAVAHIHSKN-IVHRDLKPENILFTSKDKTSWDIKIIDFGL
.| .|||||.||||..|  ...                  ..|..|.     .... . ..  ..|.|| |.|||.|||||||... |    |||||||.
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGI

SRQFNSN---------------DKKHMSVVGTPLYV----APEIIGEKNYE----KECDNWSLGVIMYILLSGREPFYAKSLKE----------------
|.. ..|               ...  ...||| |     |||.....||.    ..|| ||||||.| .| |. |||... ..                
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

VYDKIRNQRYDFNDSCW----ENITKQAKDLIS----KLLTVDPKKRFTCEQALKHQWF
.|..| .. ..|. . |     .. ..|||.|.    |.| ..|.|| | ||.|.|.||
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19206.AA TyrKc 36-300 24 3.9e-17 54.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-300
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDKIYMLQRELEVLKTL--DHPNIIKFYETYHDK-------MYIHFVMEYCPGGDLF
 . . .|| | || | ..|..            |.|.. .|     . .. ||..... |  .||||...|    ..         .  ||||.|.||| 
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

EYVANKGP-LEEFEAAQIMKKLFSAVAHIHSKNIVHRDLKPENILFTSKDKTSWDIKIIDFGLSRQFNSN-------DKKHMSV-VGTP--L---YVAPE
.|  ...| |   .  ...    .  ...||||..||||   |.| ...      .|| ||||||   .        | ....   |.   |     |||
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

IIGEKNYEKECDNWSLGVIMY-ILLSGREPFYA-----KSLKEVYDKIRNQRYDFNDSCWEN--------ITKQAKDLISKLLTVDPKKRFTCEQALKHQ
 | .. .  . | || || |. |.  | .| .      .| .||. .... ..     . .|         ..   .....    ||..| | ..   |.
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

WF
 |
CF
Kinase 19206.AA Pkinase_Tyr 36-164 29 4e-17 58.62 Pfam 1-137 (270) Show / Hide 
Range on Protein: 36-164
Range on HMM: 1-137/270
Sequence Identity: 29% (41 aa)

YKIISQLGKGSFGSVKLATYRQGQNDRREKKLFAIKTILKDRVKDK---IYMLQRELEVLKTL-DHPNIIKFYETYH-DKMY--IHFVMEYCPGGDLFEY
 ... .||.|.||.|...|..    .  .|   |.|.. |.   ..   . .. ||....|.| .||||...|     ..    |  ||||.|.||| .|
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

VAN----KGPLEEFEAAQIMKKLFSAVAHIHSKNIVHRDL
  .    |.||   .  |.     .. .. .|||..||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 19206.AA Pkinase_Tyr 226-269 31 3.87831 1.09 Pfam 198-245 (270) Show / Hide 
Range on Protein: 226-269
Range on HMM: 198-245/270
Sequence Identity: 31% (15 aa)

WSLGVIMYILLS-GREP-FYAKSLKEVYDKI--RNQRYDFNDSCWENI
|| || |. ... |..| ..  |  |||..|  ...| .  . |.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEI
EFh 19206.AA EFh 351-379 44 2.4e-09 38.31 SMART 1-29 (29) Show / Hide 
Range on Protein: 351-379
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

EIESAFKMLDKDGNGELSFYELLDALKSQ
|.. .|.|.||||.|...| |..|..|| 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19206.AA efhand 351-379 37 4.1e-08 34.12 Pfam 1-29 (29) Show / Hide 
Range on Protein: 351-379
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIESAFKMLDKDGNGELSFYELLDALKSQ
|.. .||..||||.|...| |.....|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 19206.AA efhand 428-456 31 0.001234 17.72 Pfam 1-29 (29) Show / Hide 
Range on Protein: 428-456
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KMWNLFKYFDVNNTGYITKESLKEVISRE
.. ..|| ||... |||..| ..|.... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19206.AA EFh 428-456 27 0.011648 12.09 SMART 1-29 (29) Show / Hide 
Range on Protein: 428-456
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

KMWNLFKYFDVNNTGYITKESLKEVISRE
..  .|. ||... |||..| .|..... 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19206.AA efhand 464-492 44 2e-06 28.22 Pfam 1-29 (29) Show / Hide 
Range on Protein: 464-492
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

DLEQMIGEIDQNKDGMIDFNDFKKMMEKD
.|..|. |.|...|| |||..|..||.| 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19206.AA EFh 464-492 37 5e-06 27.28 SMART 1-29 (29) Show / Hide 
Range on Protein: 464-492
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

DLEQMIGEIDQNKDGMIDFNDFKKMMEKD
....|. ..|...|| |||..||.|| . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL