Gene 22011 (Tetrahymena)

22011

Species: Tetrahymena
Alias: TTHERM_01052880, 818, 22011, PreTt22011, 213.m00061
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
22011.AA Protein None 505 None Fasta, JSON
22011.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
22011.NA RNA None 1518 None Fasta, JSON

Protein domain

Protein domains of 22011.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22011.AA CDPK 41-308 50 4.7e-181 559.79 In-house 1-271 (271) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-271/271
Sequence Identity: 50% (143 aa)

YIIKNKLGEGNVGVVRRVIEK-NTGDEK-AMKIIPKN-LQDKDQELQLTMEIDILKQLDHPSIIKMYEFYQDKKNFYIITE--IVKGGELFDKIVDINSF
|.||..||.|. |.||.|..| .|..|. |||||||. ..||.|. |. .||.|||||||| |||.||||||.||.||..|  ...||||||.|.. ..|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

NEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTATIFDE------KKQTKIVGTPYYIDFICIKQNIAPEVLRKSY
.|..||||..||.| |.|.|...|.||||||||.|.......... .| ||||||||...||       ||.....||||||         |||||.|.|
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWV-IYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYI---------APEVLQKKY

TEKSDIWTCGIILYIMLTGEPPFFGK-ENEIVQNIMDCKFSMDQDVWKVISVECKDLIKQMICP-EEKRLSAAQVQMHPWV
 ||.||| ||.||||.| |.|||.|| ..||.......|.|.... |. ||.|.||||..|.|. ..||.||.|...|||.
NEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 22011.AA Ciliate-E2a 41-308 39 5.9e-111 327.84 In-house 1-275 (275) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-275/275
Sequence Identity: 39% (112 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKD-QELQLTMEIDILKQLDHPSIIKMYEFYQDKKNFYIITEIVKGGELFDKIVDINSFNEI-
| ...|.|.|| |.|. .  |.||...|||.. | ..... .. ....||.|..||||| |||.||.|.|..|.|...| ..||||.|||.   .|.|  
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-DAAYIFNQIIS-VVQYIHEKKIMHRDLKPENVLLE-YDSTSQNPTKYSIKVIDWGTATIF--DEK-KQTKIVGTPYYIDFICIKQNIA------PEV-L
 ... |  |...  ..|.| ..||||||||||.|..  ...|.   .  ||.||.|.|| .  ||| .  ...|||.|.         |      .|| .
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSI--QNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYV---------APEVLNNKEVLK

RKSYTEKSDIWTCGIILYIMLTGEPPFFG-KENEIVQNIMDCKFSMDQDV-WKVISVECKDLIKQMICPE-EKRLSAAQVQMHPWV
.|.|..| |.| ||.|.||.|.|.||| | ..|||.|.. .||.. .. . |. .| |||||.|.|  .  .||..|.|   |||.
HKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 22011.AA CAMK 46-308 27 6.7e-108 348.86 In-house 1-425 (425) Show / Hide 
Range on Protein: 46-308
Range on HMM: 1-425/425
Sequence Identity: 27% (119 aa)

KLGEGNVGVVRRVIEKNTG------------DEKAMKIIPKNLQDKDQ--------------------------ELQLTMEIDILKQ-------LDHPSI
.||.|. |.|...|.|||.             . |.|||.|.  ...|                          . ..  ||.|.|.       |||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKMYEFYQD-------------------KKNFYIIT---EIVKGGEL----FDKIVDINS---------------FNEIDAAYIFNQIISVVQYIHEKKI
||.||.|.|                   .|..|...   | . ||||    ||.||.  .               |.| .|...| ||.| |.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDLKPENVLLEYDSTSQNP---------TKYSIKVIDWGTATIFDE-------------------------KKQTKIVGTPYYIDFICIKQNIAPEVL
.||||||||.|| .......|          .. ||.||.| |..||.                         .| .  .|||.|.         |||||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA--------APEVL

RKS---------------YTEKSDIWTCGIILYIMLTGEPPFFGK--------------ENEIVQNIMDCKFSMDQDV------------WKVISVE---
...               |..|.|.| ||.||||||.|.||| |.              ..|. ..|| .|.... .             |. || |   
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH

-----CKDLIKQMICP-EEKRLSAAQVQMHPWV
     |||||..| ..  |||....|.  |||.
FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22011.AA CAMK1 41-308 37 2.2e-103 301.38 In-house 1-276 (276) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-276/276
Sequence Identity: 37% (108 aa)

YIIKNKLGEGNVGVVRRVIEKNT---GDEKAMKIIP--KNLQDKDQE--LQLTMEIDILK---QLDHPSIIKMYEFYQDKKNFYIITEIVKGGELFDKIV
|......|.|  ..|.....|.|   |.. |.|.|   |... ||.    .| .||.|.|   ..||| |||.||.|.... ||...| |.||||||.||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

DINSFNEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYS-IK--VIDWGTATIFDEK--KQTKIVGTPYYIDFICIKQNIAPEVL
.  ...| ||. |  ||.| |.|.|.| |.|||||||| |..      ..  .| ||  ..| | ..|||..  . .. .|||.|         .|||||
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYY------DKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGY---------VAPEVL

R----KSYTEKSDIWTCGIILYIMLTGEPPFFGKE--NEIVQNIMDCKFSMDQDVWKVISVE-CKDLIKQMICPE-EKRLSAAQVQMHPWV
     | |  . |.| .|.|.||.|.| |||...   ||. . |. |.. .. . |  || .  ||.||.|.... .||....|.  |||.
ECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 22011.AA AGC 41-308 22 1.3e-86 223.22 In-house 1-395 (395) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-395/395
Sequence Identity: 22% (95 aa)

YIIKNKLGEGNVGVVRRVIEK------NTGDEKAMKIIPKNL---QDKD-QELQLTME------------IDILKQLD----------HPSIIK-MYEFY
. ..  .|.|  | |. | .|       ||.  |||.. |     ..|  .. .   |             .||....          || |.| ..  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKKN--FYIITEIVK---------GG-ELFDKIV---DINSFNEIDAAYIFNQ-------IISVVQYIHE-KKIMHRD-LKPENVLLEYDSTSQNPTKY
|||..   |.. | ..         || |||  .    .  .|.|  | ... .       |.. ..|.|. ..| ||| |||||.||  |         
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--------G

SIKVIDWGTATIFD---------------------------------------------------EKKQTK-IVG--TPYYIDFICIKQNIAPEVLRKSY
 ||  | | ....                                                    ....|. ..|  || |         .|||.|   |
HIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEY---------MAPEIL---Y

TEKSDIWT--CGIILYIMLTGEPPFFGK-----------ENEIVQNIMDCK-FSMDQDVW-----------KVISVECKDLIKQMIC-PEEKRLS-----
.   |.|.   |...| |||| |||.|.           ..|. |.||... |....  .           . .|.|.|||||...|   ||||      
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----AAQVQMHPWV
     | ... ||| 
FGDKGAEEIKNHPWF
Kinase 22011.AA S_TKc 41-308 33 2.2e-86 294.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-231/231
Sequence Identity: 33% (95 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKDQELQLTMEIDILKQLDHPSIIKMYEFYQDKKNFYIITEIVKG--GELFDKIVDINS----
| | .|.|.|  |.|.....|.|| . |.|||.          ..  ||.|||. .|| |.|.|...|| ...|...| . |  |.||| |.. ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FNEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTATIFDEKKQTKIVGTPYYIDFICIKQNIAPEVLRKSYTE-
  |.| .|.... ||.. ..|.|...|.||||||||.||             ||..| | |...     | ..|||.|         .|||||  .|.  
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWY---------MAPEVL--GYGKC

KSDIWTCGIILYIMLTGEPPFFGKENEIVQNIMDCKFSMDQDVWKVISVECKDLIKQMICPE-EKRLSAAQVQM-------HPWV
|.|.| ||.|||.||.|.|||   .... ..|.              | |.||.|... . . |||..| ..         |||.
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22011.AA Ciliate-E2 41-308 28 1.2e-85 290.88 In-house 1-365 (365) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-365/365
Sequence Identity: 28% (111 aa)

YIIKNKLGEGNVGVVRRVIEKNTGD-----------------------EKAMKIIPKN-LQDKDQELQLTMEID----------ILKQLDHPSIIKMYEF
|.. .|.|.|| |.|...  ....                        ..||||. || .. . ||... .||.          ||.||.|| ||||||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DKKNFYIITEIVKGGELFDKIV------------DINSFNEIDAAYIFNQIIS---------------VVQYIHEKK-IMHRDLKPENVLLEYDST
.|  |..|.|...| ..||.||| |             | ..|.|  ..||. ||..                ..|.|.|. |.|||.||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

SQNPTKYSIKVIDWGTATIFDEK-----------KQTKIV----GTPYYID----------FICIKQNIAPEVLR-KS---------YTEKSDIWTCGII
        ||.||.|.....|..           . .       .|| |.|          ...     |||.|. |.         |..|.||| .|.|
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

LYIMLTGEPPFFGKENEIVQNIMDCKFSMDQD--------------VWKVISVECKDLIKQ----MICPE-EKRLS-AAQVQMHPWV
||.||.|.|||        |.|..||.. ..                || .| |||||||.    |.. . |||.. . |.  ||| 
LYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22011.AA CAMK-Unique 41-308 24 1.2e-77 255.9 In-house 1-363 (363) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-363/363
Sequence Identity: 24% (92 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKDQELQ------------------LTMEIDILKQLDHPSIIKMYEF----YQDKK-------
|.  . .|.|| |.|.... . ||...|.|.. |  .  .  .|                  |. |..|.| .||| ||| |..    ..|.|       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NFYIITEIVKGGELFDKIVD--------------------INSFNE--IDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDST-----
        ..||..|.. ||.|||.|..                      .|.|   |.. |. .. |.| | |...| |||||.||... |        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

---SQNPTKYSIKVIDWGTATIFDEKKQT----KIVGTPYYIDFICIKQNIAP--------------EVLR-KSYTEKS----DIWTCGIILYIMLTGEP
   . .   . ||..|.| .. ....|      ...|||.|         .||              ||.    | ...    ||| .| |.|.||.|.|
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCY---------MAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCP

PFFGKENE---------IVQNIMDCKF-SMDQDVWKV---ISVECKDLIKQMICPE-EKRLSAAQVQMHPWV
|| .  ..         | ..|. ... . | ..| .   ||.| ||..|.    .  .|.||..   |.|.
PFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 22011.AA Pkinase 41-308 32 9.4e-76 262.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-293/293
Sequence Identity: 32% (100 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKDQELQLTM--EIDILKQLDHPSIIKMYEFYQDKKNFYIITEIVKGG----ELFDKIV--DI
| |. |.|.|. |.|.. ..|.||.. |.|||.|  ...... ...   || |.| |.|| |...|....||.. |...| . ||    .||| |   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NSF--NEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTAT---IFDEKKQTKIVGTPYYIDFICIKQNIAPEVLR-
..|   | ..  .. ||.. ..|.|...|.||||||||.|.   .. ....  ..|..|.| |    .      | ..|||.|         .||||.| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWY---------MAPEVIRG

-KSYTEKSDIWTCGIILYIMLTGEPPFFGK-------ENEIVQNIMDCKFSMDQDVWKVIS-----------------VECKDLIKQMICP-EEKRLSAA
 . |. |.|.| ||.|||.||.|.||| |.       .......||..... | . |  ||                  ||||.|| ..|.  .||..|.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

QVQMHPWV
|.  |||.
QILQHPWF
Kinase 22011.AA CAMKL 41-308 31 1.9e-74 236.94 In-house 1-297 (297) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-297/297
Sequence Identity: 31% (99 aa)

YIIKNKLGEGNVGVVRRVIE-KNTGDEKAMKIIPKNLQDKDQELQ-------------LTMEIDILKQLD---HPSIIKMYEFYQDKKN------FYIIT
|.|   ||.|. |.|.  .  ..|| . |.||| |.   .|.  .             .. || |.|.|.   || |||.|| ......      .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EIVKGGE--LFDKIVDI----NSFNEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTATIFD------EKKQTKIV
| . |||  |||.||       .. | .|  .| ||.| |.|.|...| |||.||||.|| ..  .       ||.|| | .....      ..| .   
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN------NIKIIDFGFSNMYRPCIFGPGQKLKTFC

GTPYYIDFICIKQNIAPEVLRK---SYT-EKSDIWTCGIILYIMLTGEPPFF-------GKENEIVQNIMDCKFSMDQDVWKVISVECKDLIKQMICP-E
|.| |          |||.. .   .|   | ||| ||.||| |..|. ||        ||.|      .. .     ..|. .| .|.|||..|  .  
GSPPY---------MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNP

EKRLSAAQVQMHPWV
||| .. |. .|||.
EKRPTIHQIMNHPWM
Kinase 22011.AA RSK 43-308 31 4.4e-72 245.79 In-house 1-278 (278) Show / Hide 
Range on Protein: 43-308
Range on HMM: 1-278/278
Sequence Identity: 31% (91 aa)

IKNK--LGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKDQE-LQLTM-EIDILKQLD-HPSIIKMYEFYQDKKNFYIITEIVKGGELFDKIVDINS---
.| .  .| | | ..|... ..|| . |||.. |.  .. |  .  || |..||.    || |.. .. .|... .|.|.| ..|||||...    .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTATIF--D-EKKQTKIVGTPYYIDFICIKQNIAPEVLR----K
| | .|.... .|.. |...|...| ||||||||.|.. .| ..     .||..| | . .|  | ...  . ..|  |         .|||.|.    .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEG----HIKLTDFGFCKQFRCDHNQWTMTFCYTIEY---------MAPEMLKRANQQ

S-YTEKSDIWTCGIILYIMLTGEPPFFG----KENEIVQNIMDCKFSMDQDVWKVISVECKDLIKQMIC-PEEKRLS-----AAQVQMHPWV
. ...  |.|. |...| |||| ||| |      .|| ..|. .|||.. . |. .| |.||||..| .  ..|||.     |.... ||| 
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 22011.AA Ciliate-E2-Unclassified 41-308 26 6.5e-66 225.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 41-308
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEK-AMKIIPKNLQDKDQELQL----------TMEID-------------ILKQLDHPSIIKMYEFYQDKKNFYII
|.|  ..|.|. |.|.....|... .. |||.. |. ..|..  .            ...              ||....|| |.||..  |||.|.||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEIVKGGELFDKIVDINS-----------------FNEIDAA-----YIFNQIISVVQYIHEKK-IMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTA
.| ..||.|.. | . ..                 | |  |.     ..| ||..  .|.|.|. | |||.||||.|.  .       .| ||.||.| .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----NYYIKIIDFGIS

T-----------------IFDEKKQTKIVGTPYYI-DFICIKQNIAPEVLRK-SYT----EKSDIWTCGIILYIMLTGEPPFFG-KENE-----------
                  |....... ..|||.|.          |||||..  |     .|.|||..|.||| ||.|..||.. ....           
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ------YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----IVQNIMDCKFSMDQDVW----KVISVECKDLIK----QMICPE-EKRLSAAQVQMHPWV
     . |||...... .   |    | .| |.||.|.    .|.    .||... |.  ||| 
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22011.AA TyrKc 41-314 20 1.7e-11 -36.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 41-314
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YIIKNKLGEGNVGVVRRVIEKNTGDEKAMKIIPKNLQDKDQELQLTMEIDILKQL--DHPSIIKMYEFYQDK-------KNFYIITEIVKGGELFDKIVD
   . |||||. |.|.. . |    . | | . ..      .  .  |. |...|  .|| |...|    ..       .  .|..| ...| | | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

INS-FNEIDAAYIFNQIISVVQYIHEKKIMHRDLKPENVLLEYDSTSQNPTKYSIKVIDWGTATIFDEK-KQTKIVGTPYYID--FICIK--QNI---AP
    ..  |  ..  || .  .|.|.|.. ||||   |.|.  .          .|. | | .   ... .|   . . ||      . |    |   ||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAP

EVLRKS-YTEKSDIWTCGIILY-IMLTGEPPFFG------KENEIVQNIMDCKFSMDQDV--WKV----ISVECKDLIKQMICP-EEKRLSAAQVQMHPW
|..... .|.|||.|  |. .. |.  |..|  |      .  |....... .  .  .     .     . |  ...||      |.| . ...     
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----

VQKHIAL
   |  .
---HECF
Kinase 22011.AA Pkinase_Tyr 41-125 29 8e-06 20.38 Pfam 1-94 (270) Show / Hide 
Range on Protein: 41-125
Range on HMM: 1-94/270
Sequence Identity: 29% (28 aa)

YIIKNKLGEGNVGVVRRVIEK----NTGDEKAMKIIPKNLQDKDQ--ELQLTMEIDILKQL-DHPSIIKMYEFYQ-DKKN--FYIITEIVKGGEL
 ..  |||||. |.|.. . |    ||. . | |.. |.  ...|     .  |. |.||| .|| |...|     ...    ||..| ...| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 22011.AA Pkinase_Tyr 221-258 39 2.705031 1.62 Pfam 182-222 (270) Show / Hide 
Range on Protein: 221-258
Range on HMM: 182-222/270
Sequence Identity: 39% (16 aa)

APEVLRKS-YTEKSDIWTCGIILYIMLT-GEPP-FFGKENE
|||... . .|.|||.|  |. .. ..| || | . |  ||
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE
Efhand 22011.AA efhand 363-391 24 7e-06 26.0 Pfam 1-29 (29) Show / Hide 
Range on Protein: 363-391
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

QFKSIFEKMDLNNDGQLTKDEIESGFKQF
..| .|...| ..||.....|  ...|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22011.AA EFh 363-391 27 5.5e-05 23.8 SMART 1-29 (29) Show / Hide 
Range on Protein: 363-391
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

QFKSIFEKMDLNNDGQLTKDEIESGFKQF
.|| .|...| ..||.....|   ..| .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22011.AA efhand 400-428 27 5.9e-07 29.86 Pfam 1-29 (29) Show / Hide 
Range on Protein: 400-428
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DIDKIFTNVDLDGNGKINYSEFITACIQH
.....|  .| ||.|.|.. ||.... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22011.AA EFh 400-428 27 2e-06 28.34 SMART 1-29 (29) Show / Hide 
Range on Protein: 400-428
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DIDKIFTNVDLDGNGKINYSEFITACIQH
.....|  .| ||.|.|.. ||....   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 22011.AA EFh 436-464 31 2e-06 28.85 SMART 1-29 (29) Show / Hide 
Range on Protein: 436-464
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLQKAFEVFDSDGNNYLTKDELMDIFDSK
.....|..|| ||. |....|..|.. |.
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22011.AA efhand 436-464 27 6e-06 26.28 Pfam 1-29 (29) Show / Hide 
Range on Protein: 436-464
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

KLQKAFEVFDSDGNNYLTKDELMDIFDSK
.|...|..|| ||. |....|..... ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 22011.AA efhand 473-501 44 3.5e-08 34.36 Pfam 1-29 (29) Show / Hide 
Range on Protein: 473-501
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

QIKQIYSQFDTNGDEQISFDEFKLMMKKY
..|.. ..||..|| .|.|.||. |||| 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22011.AA EFh 473-501 44 1.6e-05 25.6 SMART 1-29 (29) Show / Hide 
Range on Protein: 473-501
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

QIKQIYSQFDTNGDEQISFDEFKLMMKKY
..|.. . ||..|| .|.|.||| |||. 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL