Gene 22015 (Tetrahymena)

22015

Species: Tetrahymena
Alias: PreTt22015, 213.m00065, TTHERM_01052920, 816, 22015
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
22015.AA Protein None 541 None Fasta, JSON
22015.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
22015.NA RNA None 1626 None Fasta, JSON

Protein domain

Protein domains of 22015.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22015.AA CDPK 55-308 50 1.5e-183 567.58 In-house 1-271 (271) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-271/271
Sequence Identity: 50% (137 aa)

YIIHNQIGQGHFGVVKKVVHK-ITNEER-AVKIIQKSQEKAQKY---SLNEIELLRSLDHPHILKIYEFYEDKNNFYVVLE--LLKGGELFDKISEGNML
|.|....|.||||.|.||.|| .||.|| |.|||.||. | ...    .||||.|..||||.|.||||||.|..|.|.|.|  ...||||||.| | ...
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

KEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDN---FNIKVIDWGGAMRFEQD-----ELYYDFFGTKLYMSPEQYQQKYNYKCDLWSIG
.||.|..||||||||..|.||.|..||||||||||.. ...|.   .|||||||| ...|.|.     . .....|| .|..||..|.|||.|||.||.|
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILFILISGESP-FGDSPQTIQKNILAMKYKFNQESWHSVSQECMDLIRKLLCS-QDKRLTAQQALNHPWF
|||.||..|. | .|.. | |....  .||.|... |...|.|..|||||.||  ..||..|||||.||||
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 22015.AA CAMK 60-308 27 7.89999999999e-118 381.43 In-house 1-425 (425) Show / Hide 
Range on Protein: 60-308
Range on HMM: 1-425/425
Sequence Identity: 27% (117 aa)

QIGQGHFGVVKKVVHKITN------------EERAVKIIQKS----------------------------QEKAQKYSLNEIELLRS-------LDHPHI
..|.| ||.||...|| |.            .. |.||| |.                            ..| .|  ..|||....       ||||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKIYEFYED-------------------KNNFYVVL---ELLKGGEL----FDKISEGNM---------------LKEKQAQEIMRQILSAIIYAHSQNV
.|.||.|||                   ....| |.   |.  ||||    ||.| |                  ..|..|. ..|||.||. | ||.|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDLKPENILLEVDSSDN-------------FNIKVIDWGGAMRFEQ------------------------DELYYDFFGTKLYMS-PEQYQQK-----
.|||||||||||  ...|.             .|||.||.| | .|..                        ......|.||  ||. ||  ..|     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNYKCDLWSIGVILFILISGESPFGDS--------------PQTIQKNILAMKYKFNQES------------WHSVSQE--------CMD
          |..||| ||.||||.|. .|..|| ..              .. . ..|.. || |  .             |...|.|        |.|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRKLLC-SQDKRLTAQQALNHPWF
||||.|.   .||.|..|.|||||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22015.AA Ciliate-E2a 55-308 40 1.6e-113 335.54 In-house 1-275 (275) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-275/275
Sequence Identity: 40% (111 aa)

YIIHNQIGQGHFGVVKKVVHKITNEE-RAVKIIQKSQEKA--QKYSLNEIELLRSLDHPHILKIYEFYEDKNNFYVVLELLKGGELFDKISEGN-MLKE-
| ....||.| ||.|... ||.|... ...|.|.| ...   ..|  ||| ..|.||||.|.|.||.|||.||.| |.|...||||.|||..   . .| 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

KQAQEIMRQILS-AIIYAHSQNVMHRDLKPENILLE--VDSS-DNFNIKVIDWGGAMRF--EQDELYYDFFGTKLYMS------PEQ-YQQKYNYKCDLW
... .||.|.|. .. | |..|.|||||||||||..    .| .|..||.||.| | ..   . .  .   ||  |.       .|   ...| .|||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SIGVILFILISGESPFGD-SPQTIQKNILAMKYKFNQES-WHSVSQECMDLIRKLLCSQ-DKRLTAQQALNHPWF
|.|||..||..|..||   . . | ... . |. ||.   |  .|.||.||..|.|  .  ||.|||||||||||
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 22015.AA CAMK1 55-308 39 1.4e-99 290.17 In-house 1-276 (276) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-276/276
Sequence Identity: 39% (109 aa)

YIIHNQIGQGHFGVVKKVVHKIT---NEERAVKIIQ-KS--QEKAQ---KYSLNEIELLRS---LDHPHILKIYEFYEDKNNFYVVLELLKGGELFDKIS
|.....|| | |..|....|| |   ... |.|.|  |.  ..| .   .. .|||| ...   .|||.| |.||.||..| || |.||..||||||.| 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

EGNMLKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIK--VIDWGGAMRFEQDE-LYYDFFGTKLYMSPEQYQQK----YNYKCDL
|     ||.| .||.|||||. | ||....||||||||.|.. | .... ||  ..| | . .|..|| | .. .||  |. ||   .|    | ..||.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYY-DKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSIGVILFILISGESPF-GDS-PQTIQKNILAMKYKFNQESWHSVSQE-CMDLIRKLLCSQ-DKRLTAQQALNHPWF
||||||..||  | .|| ...  ... . |.  .| |    |...| .   |.|...|.    ||.|..|.|||||.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 22015.AA S_TKc 55-308 36 2.3e-95 324.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQKSQEKAQKYSLNEIELLRSLDHPHILKIYEFYEDKNNFYVVLELLKG--GELFDKISEGNM------
| |...||.| ||.|.|..|| |... |.|||        .  ..||..|.. .||.| |.|....| ...|.|.|.. |  |.||| | . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIKVIDWGGAMRFEQDELYYDFFGTKLYMSPEQYQQKYNY-KCDLWSIGVILFIL
. | .|. .|.||..|. | ||....|||||||||||        .||..| | | ..      . | ||  ||.||    .|.. ||| ||.|.||...
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEM

ISGESPFGDSPQTIQKNILAMKYKFNQESWHSVSQECMDLIRKLLC-SQDKRLTAQQALN-------HPWF
..|. ||   .|.. |.|.              |.|. |.|||.|.   .||.|| .||.       ||||
LCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22015.AA Ciliate-E2 55-308 28 1.3e-92 313.98 In-house 1-365 (365) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-365/365
Sequence Identity: 28% (110 aa)

YIIHNQIGQGHFGVVKKVVHKITNE-----------------------ERAVKIIQKSQEKAQK---YSLNEIE----------LLRSLDHPHILKIYEF
|.....|||| ||.|.|. .. ...                       . |.||..|.| ...|   . ..||.          .|..|.||.|.|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--DKNNFYVVLELLKGGELFDKIS------------EGNMLKEKQAQEIMRQILS---------------AIIYAHSQN-VMHRDLKPENILLEVDSS
..  |.||.| |.|...||.||| |             . . ..||....||.|||.               |. | ||.| ..|||.||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

DNFNIKVIDWGGAMRFEQD--------------------------------ELYYDFFGTKLYMSPEQYQQK----------YNYKCDLWSIGVILFILI
    ||.||.| . .. .|                                .... . ||  ||.|| .. |          |.||||.||.||||....
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGESPFGDSPQTIQKNILAMKYKFNQE--------------SWHSVSQECMDLIRK-----LLCSQDKRLT-AQQALNHPWF
.|. ||       |..|.  |..|...              ||...||||.|||.|     | . ..||.| ..|.||||||
FGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22015.AA CAMKL 55-308 33 2.1e-87 278.98 In-house 1-297 (297) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-297/297
Sequence Identity: 33% (102 aa)

YIIHNQIGQGHFGVVKKVVH-KITNEERAVKIIQKSQEKAQKYSLN---------------EIELLRSLD---HPHILKIYEFYEDKNN------FYVVL
|.|  ..|.|.||.||  .| ..|.|. |.||| |.  .   ....               ||.....|.   ||.| |.|| .|....      .| |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELLKGGE--LFDKISEG----NMLKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIKVIDWGGAMRFE-Q----DELYYDFFGTKL
|.  |||  |||.| .       ..|..|. . |||.||. | ||... |||.|||||||  . .   |||.|| | .  .. .    ...   | |.  
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YMSPEQYQQ--K-YN-YKCDLWSIGVILFILISGESPFGDSP-------QTIQKNILAMKYKFNQESWHSVSQECMDLIRKLLCS-QDKRLTAQQALNHP
||.|| .|   | |. .| | ||.||||. .. |. || | .        .  .    |.  ..   | .|| .| |||||.|    .|| |..| .|||
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WF
|.
WM
Kinase 22015.AA Pkinase 55-308 34 1.8e-85 295.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-293/293
Sequence Identity: 34% (102 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQKSQEKA--QKYSLN--EIELLRSLDHPHILKIYEFYEDKNNFYVVLELLKGG----ELFDKIS--EG
| |. .||.| ||.|.| .|| |... ||||| |. ||   ... ..  ||.....|.||.|...|...|||.. |.|.|.. ||    .||| ||  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NML--KEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIKVIDWGGAMR--FEQDELYYDFFGTKLYMSPEQYQ--QKYNYKCDLWSI
. .   |.... .|.|||... | ||....||||||||||.  .   .  .|..|.| |       .. ...| ||  ||.||  .  |.| .|.| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILFILISGESPFGDS-------PQTIQKNILAMKYKFNQESWHSVS-----------------QECMDLIRKLLC-SQDKRLTAQQALNHPWF
|.||.....|. || ..       .. . ..|.  ...|. . |.|.|                 .|| |.|...||    ||.||.|.|.||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 22015.AA CAMK-Unique 55-308 24 3.3e-85 281.23 In-house 1-363 (363) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-363/363
Sequence Identity: 24% (90 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQK--SQEKAQKY------------------SLNEIELLRSLDHPHILKIYEF----YEDKN-------
|. |. ||.| ||.|...  . |  ..|.|...|   ..|.||                     .|.......|||.|.|.|..    ..|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NFYVVLELLKGGELFDKISE--------------------GNMLKE--KQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSD----
        ..| |.|.. ||.|||.| .                       . |   ... ||...|||. |.|||.. |||||.|||..     |    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------NFNIKVIDWGGAMRFEQDELYY---DFFGTKLYMSP--------------EQYQ-QKYNYKC----DLWSIGVILFILISGESPFGDSPQT-
        | .||..|.| .  ... . .     . || .||.|              |    |.| ..|    |.||.|||......|..||  ..   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

--------IQKNILAMKY-KFNQESWHS---VSQECMDLIRKLLCSQ-DKRLTAQQALNHPWF
        | ..|.. .| .|  . ||.   .|||  |.. ... .  |.|..| ..| |.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 22015.AA Ciliate-E2-Unclassified 55-308 28 2.9e-81 276.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 55-308
Range on HMM: 1-352/352
Sequence Identity: 28% (102 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQKSQEKAQKYS------------LNEIE-------------LLRSLDHPHILKIYEFYEDKNNFYVVL
|.|. ||||| ||.|.|..|| ...  | |.. |.|...||.             .|...             .|....||.|.| ..  .||.|.| |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELLKGGELFDKISE-----------------GNMLKEKQAQ-----EIMRQILSAIIYAHSQN-VMHRDLKPENILLEVDSSDNFNIKVIDWGGAMRFE-
|...||.|.. |..                 .... |.||.      ...|||... | |..| . |||.||||||.  . . |..||.||.| ... . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQ

---------------QDELYYDFFGTKLYM----SPEQYQQ-KYN----YKCDLWSIGVILFILISGESPFG--DSPQ---------------TIQKNIL
               .......| ||  ||    .|| .|. .|.    |||| || ||||. .. |. ||.  .. |                ...||.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

AMKYKFNQESW----HSVSQECMDLIR----KLLC-SQDKRLTAQQALNHPWF
. ...|. ..|    . .|.|. |.|.    |.|   ..||.|..|.||||||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22015.AA RSK 57-308 29 2.6e-69 236.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 57-308
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

IHNQ--IGQGHFGVVKKVVHKITNEERAVKIIQKSQEKA----QKYSLNEIELLRSLD-HPHILKIYEFYEDKNNFYVVLELLKGGELFDKIS-EGNM--
.     .|.| . ...|..|. |. . |.|...|.  ..    ... . |.. |     || | . .. ....  .| ..|...|||||.... |. .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIKVIDWGGAMRFEQD--ELYYDFFGTKLYMSPEQYQ----QK-YNYKCDLWSIG
. |. |...|..| .|. . |.| . ||||||||||.. .| ..  ||..| | .  |  |  .. . | .|  || ||       |. ..  ||.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILFILISGESPFGD----SPQTIQKNILAMKYKFNQESWHSVSQECMDLIRKLLCSQ-DKRLT-----AQQALNHPWF
|... . .| .||      ... | |.|.  |. .. . |...|||. |||||.|.    |||.     |.. ..||||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 22015.AA RAD53 55-199 33 1.9e-48 142.1 In-house 1-172 (305) Show / Hide 
Range on Protein: 55-199
Range on HMM: 1-172/305
Sequence Identity: 33% (57 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQK-------SQEKAQKYSL-NEIELLRSLDHPHILKIYEFYEDK-NNFYVVLELLKGGELFDKI-SEG
|..   .|.|.||.||... | | .  |.||| |       . . . . .. ||.| |. | || | .||......  ..| ||||  |||||.|| | .
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

NM---LKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDN--------------FNIKVIDWG
     ..| .. .. .|.. |. | |...  ||||||||||.. .. ..              | ||. | |
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFG
Kinase 22015.AA RAD53 229-308 38 3.3e-32 92.84 In-house 218-305 (305) Show / Hide 
Range on Protein: 229-308
Range on HMM: 218-305/305
Sequence Identity: 38% (34 aa)

YNYKCDLWSIGVILFILISGESPFGDS------PQTIQKNILA-MKYKFNQESWHSVSQECMDLIRKLLCSQ-DKRLTAQQALNHPWF
|. |.|.||.|.||.|. .|  ||.|.      . .. . |.   || |  ..|...|.|  |||...||   .||.|. .||||||.
YTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase 22015.AA TyrKc 55-290 21 5e-13 -12.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-290
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YIIHNQIGQGHFGVVKKVVHKITNEERAVKIIQKSQEKAQKYSLNEIELLRSL--DHPHILKIYEFYEDK-------NNFYVVLELLKGGELFDKISEGN
     ..| |.||.| | . |   .. ||| ....    ..  ..|......|  .||.|...|    ..          ..|.|. ..| | | . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

M-LKEKQAQEIMRQILSAIIYAHSQNVMHRDLKPENILLEVDSSDNFNIKVIDWGGAMRFEQDE-------LYYDF-F--GTK--L---YMSPEQYQQK-
  |. |.  ... || .   | ||.|. ||||   |.|.  .      .|. |  | .|.  |.        ||.     |.|  |    |.||  . . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDF-GLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNYKCDLWSIGVILF-ILISGESPFGD------SPQTIQKNILAMKYKFNQES--------------------WHSVSQE--CMDLIRKLL
.. | | || || .. |.  |..|  .      |.| . ... . ..    ..                    ||    .  ..  |....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 22015.AA Pkinase_Tyr 55-176 24 4.5e-08 27.97 Pfam 1-137 (270) Show / Hide 
Range on Protein: 55-176
Range on HMM: 1-137/270
Sequence Identity: 24% (34 aa)

YIIHNQIGQGHFGVVKKVVHK----ITNEERAVKII-QKSQEKA--QKYSLNEIELLRSL-DHPHILKIYEFYE-DKNN--FYVVLELLKGGELFDKISE
 ..  ..|.|.||.|.| . |     |. . |||.. ... ...  ..  ..|......| .||.|.. |     ..     |.|.|. ..| | |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----GNMLKEKQAQEIMRQILSAIIYAHSQNVMHRDL
    .. |. |.  .. .|| ..  | .|.|  ||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Efhand 22015.AA efhand 377-405 37 2e-06 27.76 Pfam 1-29 (29) Show / Hide 
Range on Protein: 377-405
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

YLREQFKQLDLNGDGILTKEELKTAYKQI
 |.| ||..| .||| ...||.....|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22015.AA EFh 377-405 34 2.8e-05 24.78 SMART 1-29 (29) Show / Hide 
Range on Protein: 377-405
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

YLREQFKQLDLNGDGILTKEELKTAYKQI
 ..| |. .| .||| ...||.|.. | .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22015.AA efhand 415-443 34 5e-06 26.47 Pfam 1-29 (29) Show / Hide 
Range on Protein: 415-443
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NLEEIFDQIDLDNNGVINFTEFISATMDK
 |.|.|...| |..| |.| ||... ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22015.AA EFh 415-443 31 6.5e-05 23.57 SMART 1-29 (29) Show / Hide 
Range on Protein: 415-443
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

NLEEIFDQIDLDNNGVINFTEFISATMDK
 ..|.|. .| |..| |.| ||. . . .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22015.AA efhand 451-479 31 5e-06 26.33 Pfam 1-29 (29) Show / Hide 
Range on Protein: 451-479
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLLQAFNYFDQDKNGYITQDELANIIGNS
.| ..|. ||.|..|||. .|. ... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22015.AA EFh 451-479 27 1.3e-05 25.86 SMART 1-29 (29) Show / Hide 
Range on Protein: 451-479
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

KLLQAFNYFDQDKNGYITQDELANIIGNS
.. ..|. ||.|..|||. .|.  .. . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 22015.AA efhand 497-525 37 3.2e-05 23.53 Pfam 1-29 (29) Show / Hide 
Range on Protein: 497-525
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

LWQLILEQSDKNQDGKIEFEEFEYMMNLY
 .. . .. ||..||.|.||||  ||   
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 22015.AA EFh 497-525 37 0.001194 19.37 SMART 1-29 (29) Show / Hide 
Range on Protein: 497-525
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

LWQLILEQSDKNQDGKIEFEEFEYMMNLY
 .. . .  ||. ||.|.||||  ||   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL