Gene 24111 (Tetrahymena)

24111

Species: Tetrahymena
Alias: TTHERM_00589960, 24111, 3726.m00044, 81.m00168, PreTt24111, 349
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
24111.AA Protein None 477 None Fasta, JSON
24111.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
24111.NA RNA None 1434 None Fasta, JSON

Protein domain

Protein domains of 24111.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24111.AA CDPK 28-294 57 4e-206 637.88 In-house 1-271 (271) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-271/271
Sequence Identity: 57% (160 aa)

AASKKTLGQGTYGSVIKVKLK-NSNQQR-AIKIIPKSRVKNPQ---RFLNEINIMRNLDHPNIIKLYETFEDARNVYLVME--LCDGGELFDRIIAKGHY
   ||.||.|..|.| |||.| ..||.| |.|||||||||...   .|.|||.|...||||||||.||...| .|.|.|||  .| ||||||.||.|||.
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDS----PIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLEGKYDE
||.||. ...||..|||.||||.|.||||||||.|...|.|||    .|||||.|.|..|. | .||       |.  ||.|.||||||.||||..||.|
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI-------EDKKMSQRCGTPYYIAPEVLQKKYNE

GCDIWSLGVILFILLSGVPPFYGPNDSAILEMVKSRKFSFDIPEFNNVSESAKDLIRKCLTT-PDKRFTASQILQHPWM
 |||||.||||.|||.|.||||| ||. |.|.||  |.||..||....|..|||||||.|.. |.||..|.|.|||||.
KCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 24111.AA CAMK1 31-294 45 3.9e-151 442.62 In-house 4-276 (276) Show / Hide 
Range on Protein: 31-294
Range on HMM: 4-276/276
Sequence Identity: 45% (129 aa)

KKTLGQGTYGSVIKVKLKNS---NQQRAIKIIP-KSRVKNP-----QRFLNEINIMRN---LDHPNIIKLYETFEDARNVYLVMELCDGGELFDRIIAKG
.|..| |. . | ... |..   ..| |||.|  |. .|.      ....|||.||..   .|||||||.|| .|. . .||||||. ||||||||. ||
GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKG

HYTEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDSPIK--VIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLEGK---
.|||..|| .  ||..||...||.||.|||||||| |. .|..||.||  ..||||| || ..|              |.|. |||.|. |||||.|   
NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN------------LMKTACGTPGYVAPEVLECKKDK

-YDEGCDIWSLGVILFILLSGVPPFYGPN-DSAILEMVKSRKFSFDIPEFNNVSES-AKDLIRKCLTT-PDKRFTASQILQHPWM
 ||  ||.|| |||..||| | ||||. | |. ..|..|. .. |. |...|.|.. |||.|.. |.  | ||.|..|.|.||| 
PYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 24111.AA CAMK 33-294 32 2.7e-137 445.31 In-house 1-425 (425) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-425/425
Sequence Identity: 32% (137 aa)

TLGQGTYGSVIKVKLKNSN------------QQRAIKIIPKSRVK----------------------------NPQRFLNEINIMRN-------LDHPNI
|||.|..| | ... ||..            |. |||||.|...|                            . .....||.||..       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYETFEDARN-------------------VYLVM---ELCDGGEL----FDRIIAKGH---------------YTEQEARITFTQIVQAVNHCHSNGI
|||||..||...                   .|.||   |.|.||||    ||.|...|.               .||.|||  | ||..||..|||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPENFLLLNKSDDSP--------------IKVIDFGLSYIFQENEL------KIGGGPITGE-------KLSMSTRAGTPYYIS-PEVLEGK---
.|||||||| || ...|||.              ||.||||.. .|...|       . ||  .  .          |.|. |||.|.. ||||.||   
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YDEGCDIWSLGVILFILLSGVPPFYGP-------------NDSAILEMVKSRKFSFDIPEFNN------------VSES--------A
            |.. ||.||.||||.|.|.| |||||.             ||. ..|.... |..|. |.| .            .|..        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLIRKCLTT-PDKRFTASQILQHPWM
||||||.|.. |.||.|..|.|.||||
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24111.AA Ciliate-E2a 26-294 42 8.3e-122 360.31 In-house 1-275 (275) Show / Hide 
Range on Protein: 26-294
Range on HMM: 1-275/275
Sequence Identity: 42% (121 aa)

YQAASKKTLGQGTYGSVIKVKLKNSNQQ-RAIKIIPKSRVKN--PQRFLNEINIMRNLDHPNIIKLYETFEDARNVYLVMELCDGGELFDRIIAKGHYTE
| .  .| .|.|..||| ....|. ..| ...|.| | ...    . | |||||||.|||||||||||..|| .| |||||.|.||||.|.|. .. ..|
YKF--IKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFE

Q--EARITFTQIV-QAVNHCHSNGICHRDLKPENFLLL--NKSDD--SPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYIS------PEV
   |..    |.  |.....|...| ||||||||.|.   .|...  | ||.|||||.  .. .           ||  | .. |||.|.       .||
EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD-----------EKKYMFQKCGTPGYVAPEVLNNKEV

LEGK-YDEGCDIWSLGVILFILLSGVPPFYGPNDSAILEMVKSRKFSFDIPE-FNNVSESAKDLIRKCLTT-PDKRFTASQILQHPWM
|..| ||. ||.||.|||..|||.| |||.| . . ||...|  |..|..|| ....| ..|||..| |   | ||.|| |.|.|||.
LKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 24111.AA S_TKc 28-294 36 1.5e-109 371.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-231/231
Sequence Identity: 36% (104 aa)

AASKKTLGQGTYGSVIKVKLKNSNQQRAIKIIPKSRVKNPQRFLNEINIMRNLDHPNIIKLYETFEDARNVYLVMELCDG--GELFDRIIAKGH------
    ...|.|..|.| |.. |..... |||||.       .....||.|... .||||.|||..|.|  ..|.|||.|||  |.|||.|  .|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

YTEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDSPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLEGKYDE-GC
..| .||  . ||..|...|||.||.|||||||| || .      ||..||||. ..                   .|  |||.|..||||  .|.   |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL--GYGKCKC

DIWSLGVILFILLSGVPPFYGPNDSAILEMVKSRKFSFDIPEFNNVSESAKDLIRKCLT-TPDKRFTASQILQ-------HPWM
|.||.|.||...|.| |||.  .. .......              |..|||.|||||.  |.|| || ..||       |||.
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24111.AA CAMKL 32-294 39 2.8e-105 336.95 In-house 5-297 (297) Show / Hide 
Range on Protein: 32-294
Range on HMM: 5-297/297
Sequence Identity: 39% (120 aa)

KTLGQGTYGSVIKVKL-KNSNQQRAIKIIPKSRVK-NPQRFLN--------------EINIMRNLD---HPNIIKLYETFEDARN------VYLVMELCD
||||.|..| |   .  .. ... ||||| |.. . .|.   |              ||.||. |.   |||||||||..|. ..      .|||||.|.
KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCS

GGE--LFDRIIAKGH----YTEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDSPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAG
|||  |||.|...||     .| |||  |.||| |||.|||.||.|||.|||| || .. .   ||.||||.| .....        | |.   ..|. |
GGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPC--------IFGPGQKLKTFCG

TPYYISPEVLEG--K-YD-EGCDIWSLGVILFILLSGVPPFYGPND------SAILEMVKSRKFSFDIPEFNNVSESAKDLIRKCLTT-PDKRFTASQIL
.| | .||...|  | ||    ||||.||||. .. |  || ....         ... | ..  . .| .. || ...||||| |.. |.||.|. ||.
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

QHPWM
.||||
NHPWM
Kinase 24111.AA Pkinase 28-294 35 5.69999999999e-101 346.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-293/293
Sequence Identity: 35% (108 aa)

AASKKTLGQGTYGSVIKVKLKNSNQQRAIKIIPKSRVKN--PQRFLN--EINIMRNLDHPNIIKLYETFEDARNVYLVMELCDGG----ELFDRII--AK
   ....|.|..|.| | . |..... |.|||.|.. |   .|. ..  || ||..|.||||..||..||| ...|.|||.|.||    .|||.|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHY--TEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDD-SPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLE--G
| .  .|.|..  ..||......|||.||.||||||||.|. |. .  ...|..||||.  |.           .  .  |.|..|||.|..|||.    
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWYMAPEVIRGGQ

KYDEGCDIWSLGVILFILLSGVPPFYGP------NDSAILEMVKSRKFSFDIPEFNNVS-----------------ESAKDLIRKCLTT-PDKRFTASQI
.|.  .|.||.|.||...|.| |||.|       .. ............||.|. ...|                 |..||.|..||.  | || || ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LQHPWM
|||||.
LQHPWF
Kinase 24111.AA RAD53 31-294 33 8.8e-96 285.77 In-house 4-305 (305) Show / Hide 
Range on Protein: 31-294
Range on HMM: 4-305/305
Sequence Identity: 33% (107 aa)

KKTLGQGTYGSVIKVKLKNSNQQRAIKIIPK-------SRV-KNPQRFLNEINIMRNLDHPNIIKLYETFEDA-RNVYLVMELCDGGELFDRIIAKGH--
 |.||.| .|.| ... |.  |. ||||| |       ... |.. .. ||..|...| ||.||..|. |... ...|.|.|| .|||||..|.. .   
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQ

--YTEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDS---------------PIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTP
  ..| ... .| |.. ||.  |.|||||||||||| |. .....                 ||. ||||| . .| ..             | |  |||
MGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSF-------------MKTMCGTP

YYISPEVLEGK----------------YDEGCDIWSLGVILFILLSGVPPFYGPND-----SAILEMVKS-RKFSFDIPEFNNVSESAKDLIRKCLTT-P
 |  |||. .|                |   .|.||.|.||.|.|.| |||  . .       . | .|.  |..|. |.   .||.|||||.. |.  |
QYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDP

DKRFTASQILQHPWM
.||.|. ..|.||||
EKRYTIDEALNHPWM
Kinase 24111.AA Ciliate-E2 28-294 30 9.5e-95 321.08 In-house 1-365 (365) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-365/365
Sequence Identity: 30% (118 aa)

AASKKTLGQGTYGSVIKVKLKNSNQQR------------------AIKIIPKSRV--KNPQRFLNEINIMR----------------NLDHPNIIKLYET
    | .|||..||| |.| .. ..|                   .|||. . ..  .. . ...||.|||                .|.||||||.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DARNVYLVMELCDGGELFDRII------------AKGHYTEQEARITFTQIVQ---------------AVNHCHSNG-ICHRDLKPENFLLLNKSD
|.  |  |.|||||.|.||.|||.|.            . . .||.|..  ..||.|               |....||.. |.|||.|||| |.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

DSPIKVIDFGLSYIFQEN-----------ELKIGGGPITGEKLSM---------STRAGTPYYISPEVLEGK----------YDEGCDIWSLGVILFILL
   ||.|||||| .....           ...  .. ...    |          | .|||.| .||.|.||          ||. ||||||||||...|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGVPPFYGPNDSAILEMVKSRKFSFDIPE--------------FNNVSESAKDLIRK----CL-TTPDKRFT-ASQILQHPWM
.| |||        ..  |  |..|. ||              ....|...||||.|    .|   |.||.| ..|||.|||.
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24111.AA CAMK-Unique 28-294 25 2.4e-90 298.42 In-house 1-363 (363) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-363/363
Sequence Identity: 25% (95 aa)

AASKKTLGQGTYGSVIKVKLKNSNQQRAIKIIPKSRVKNPQRFL--------------------NEINIMRNLDHPNIIKLYET----FEDAR-------
    . .|.|..| |.... .     .|.|.. | ...|  . .                    .|..|.. .|||||||||..    |.|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NVYLVMELCDGGELFDRIIA--------------------KGHYTE--QEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSD-----
        . |.|||.|.||.||| |..                    .||..|   ...  ......||.. ||..| |||||.|| .. .  .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------DSPIKVIDFGLSYIFQENELK-IGGGPITGEKLSMSTRAGTPYYISP--------------EVLE-GKYDEGC----DIWSLGVILFILLSG
        .. ||..||||.  ...|.   .           |.|. |||.|..|              ||..  .||. |    ||||||||....|.|
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHM-----------MQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCG

VPPFYGPNDS--------AILEMVKSRKF-SFDIPEFNN---VSESAKDLIRKCLTTP-DKRFTASQILQHPWM
 |||.....          |.|  .. .. .|| . ..    .|..|||.. .|.|.  |.| .|...|.|.| 
CPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 24111.AA RSK 31-294 35 1.3e-89 303.98 In-house 1-278 (278) Show / Hide 
Range on Protein: 31-294
Range on HMM: 1-278/278
Sequence Identity: 35% (103 aa)

KKTLGQGTYGSVIKVKLK---NSNQQRAIKIIPKSRVKNPQR----FLNEINIMRNLD-HPNIIKLYETFEDARNVYLVMELCDGGELFDRIIAKGH---
 | |||| ||.|  .. .   ...|. | |.. |. ... |.     . |.||.     ||.|..|...|..   .||.||.| |||||...  ..|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YTEQEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDD-SPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLE----GK-
 .| ||.. . .|| || | |. || |||||||| |. ..| .   ||..|||.. .|              ..  . |  .|  |. ||.|     .. 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-----------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGG

YDEGCDIWSLGVILFILLSGVPPFYG---PNDSAILEMVKSRKFSFDIPEFNNVSESAKDLIRKCLT-TPDKRFT-----ASQILQHPWM
.|. ||.|||||... .|.| |||.|    | . |.. ... |||...|. ...|. |||||||.|.  | || .     |..|.||||.
HDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 24111.AA MARK 31-294 39 2.8e-84 275.39 In-house 4-262 (262) Show / Hide 
Range on Protein: 31-294
Range on HMM: 4-262/262
Sequence Identity: 39% (109 aa)

KKTLGQGTYGSVIKVKLKNSNQQRAIKIIPKSRVKNPQR---FLNEINIMRNLDHPNIIKLYETFE--DARN-VYLVMELCDGGELFDRIIAK--GHYTE
.||.|.|.|. | ..  |..... ||||..| .   ||    .  ||.||. |||||||||....|  . .. .||.||.. ||||.|.|.|.  |. .|
LKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHE

QEARITFTQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDSPIKVIDFGLSYIFQENELKIGGGPITGEKLSMSTRAGTPYYISPEVLEGK-YD-EGCDI
 |||  |.||| ||| |||..|.|||.|||| .|. .     || ||||.| .......              .|  ||| | .||....| ||    ||
EEARRIFRQIVSAVNYCHSKNIVHRDIKPEN-ILIDENGNHNIKIIDFGFSICIPPGQK-------------LNTFCGTPPYMAPEIFLKKPYDGPKVDI

WSLGVILFILLSGVPPFYGPN--DSAILEMVKSRKFSFDIPEFNNVSESAKDLIRKCLTT-PDKRFTASQILQHPWM
|||||.|.....|  || | .  .  . . . . |..  || .  || ....||.. ||. |..| |...|..||||
WSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD--IPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 24111.AA TyrKc 28-294 24 2e-15 26.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-294
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

AASKKTLGQGTYGSVIKVKLKNSNQQRAIKIIPKSRVKNPQRFLNEINIMRNL--DHPNIIKLYETFEDA-------RNVYLVMELCDGGELFDRIIAKG
   .|.|| | .| | | ..|   .| |.| . ..     . |..|..||..|  .||||..||    .          ...|||....| | |.. ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

HYTEQEARITF-TQIVQAVNHCHSNGICHRDLKPENFLLLNKSDDSPIKVIDFGLSYIFQENELKIGGGPITGEKLSM----STRA-GTPYYISPEVL-E
.    .  . | .|| .  .. ||... ||||   | |. ..     .|. |||||  . ... . |     ..  ..    ....       .||.. .
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLS-RDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECINY

GKYDEGCDIWSLGVILF-ILLSGVPPFYG-----PNDSAILEMVKSRKFSFDIPE-----FNNVSESAKDLIRKCLTT-PDKRFTASQILQHPWM
||. .  |.|| || .. |.  | .| .|      ... ..| ||...     |.     |   ..   .....|    |..| | |.|  |  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 24111.AA Pkinase_Tyr 32-110 31 8.3e-14 47.39 Pfam 5-94 (270) Show / Hide 
Range on Protein: 32-110
Range on HMM: 5-94/270
Sequence Identity: 31% (28 aa)

KTLGQGTYGSVIKVKLK----NSNQQRAIKII-PKSRVKN--PQRFLNEINIMRNL-DHPNIIKLYETFE-DARN--VYLVMELCDGGEL
|.||.| .|.| | ..|    | ... |.|.. ...  ..   . |..|..||..| .||||..||     . .   .|.|||.. .| |
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Efhand 24111.AA efhand 339-367 41 2e-06 27.79 Pfam 1-29 (29) Show / Hide 
Range on Protein: 339-367
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

ELGKLFKQLDKNNDGVLTIEEITAGLNKL
|| ..||..||..|| ...||  ... ||
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 24111.AA EFh 339-367 31 0.000147 22.39 SMART 1-29 (29) Show / Hide 
Range on Protein: 339-367
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELGKLFKQLDKNNDGVLTIEEITAGLNKL
|. ..|. .||..|| .. ||  ... .|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 24111.AA EFh 374-402 27 2e-06 28.47 SMART 1-29 (29) Show / Hide 
Range on Protein: 374-402
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

EIESIISSMDTDGSGTINYTEFIAASMDK
|.. ... .|.||.|.|.. ||... . .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 24111.AA efhand 374-402 27 6e-06 26.16 Pfam 1-29 (29) Show / Hide 
Range on Protein: 374-402
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

EIESIISSMDTDGSGTINYTEFIAASMDK
|.. ... .|.||.|.|.. ||... ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 24111.AA EFh 410-438 34 3.3e-07 31.17 SMART 1-29 (29) Show / Hide 
Range on Protein: 410-438
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

KLLHAFRMLDLDGSGKISKDELKSVLGTD
..  .|||.| ||.|.|...|.| .. . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 24111.AA efhand 410-438 27 7.6e-07 29.47 Pfam 1-29 (29) Show / Hide 
Range on Protein: 410-438
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

KLLHAFRMLDLDGSGKISKDELKSVLGTD
.|  .|...| ||.|.|...|..... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 24111.AA EFh 448-476 41 1.8e-09 38.71 SMART 1-29 (29) Show / Hide 
Range on Protein: 448-476
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

YWENMIKEADKNGDGEIDYSEFVEMMNKT
 .. |....||.|||.||. ||..|| . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 24111.AA efhand 448-476 55 2.9e-09 38.35 Pfam 1-29 (29) Show / Hide 
Range on Protein: 448-476
Range on HMM: 1-29/29
Sequence Identity: 55% (16 aa)

YWENMIKEADKNGDGEIDYSEFVEMMNKT
 ...|.||.||.|||.||. ||.||| |.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL