2675

Species: Tetrahymena
Alias: 813, TTHERM_01075630, PreTt02675, 2675, 219.m00028
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
2675.AA Protein None 521 None Fasta, JSON
2675.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
2675.NA RNA None 1566 None Fasta, JSON

Protein domain

Protein domains of 2675.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2675.AA CDPK 77-333 57 1.9e-200 620.16 In-house 1-271 (271) Show / Hide
Range on Protein: 77-333
Range on HMM: 1-271/271
Sequence Identity: 57% (157 aa)

MILSPPLGKGAYGEVRKAIHK-ASGQLR-AIKIIKINEVSQEDK-QNLENEIDILRNLDHPNIIKIFEFYKDSNYYYIVSE--LCTGGELFDKIIEEKSF
......||||..|.|||..|| ...| | |.|||. ..|..... |.. |||.||..|||||||||.||| |...|||| |  .||||||||.|||...|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

DEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQ----TLKVIDFGTSRYYDPE-----NKLTQRLGTPYYIAPEVLKKEYNEKCDIWSCG
.|..|..|..|.|.||||||||.||||||||||.|.|.. ...    ..||||.|||...|..     .|..||.|||||||||||.| |||||||||||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILYILLCGYPPFASKVDSEILEKVKLGEYNFNKPEWRHVSQDAKNLINNMLQYNPQQRYSARQCLQDKWF
|||||||||||||  | |.||.|||| |.|.|..||| |.|..||.||..||.|.|..|.|| |.||..||
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase 2675.AA CAMK1 78-333 44 8.4e-156 456.43 In-house 2-276 (276) Show / Hide
Range on Protein: 78-333
Range on HMM: 2-276/276
Sequence Identity: 44% (123 aa)

ILSPPLGKGAYGEVRKAIHKAS---GQLRAIKIIK-INEVSQEDK---QNLENEIDILRN---LDHPNIIKIFEFYKDSNYYYIVSELCTGGELFDKIIE
..   .|.|| .||....|| .   |.  |||.|.    ....|    ..|||||.|...   .|||||||..|.| . |..|.| ||.|||||||.|.|
EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVE

EKSFDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQTLK--VIDFGTSRYYDPEN-KLTQRLGTPYYIAPEVLK----KEYNEKCDIWS
 ... | .|..|.||.|.||.|.||. ||||||||||||| .  .  ..|  ..||| |...|... ..... |||.|.|||||.    | |  .||.||
KGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWS

CGVILYILLCGYPPFASKV-DSEILEKVKLGEYNFNKPEWRHVSQD-AKNLINNMLQYNPQQRYSARQCLQDKWF
.|||.|||||||||| ..  |.|..||.| .||.| .|.| ..|   ||..|..||  .|..||.. |||...|.
IGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase 2675.AA Ciliate-E2a 83-333 44 1e-145 431.86 In-house 7-275 (275) Show / Hide
Range on Protein: 83-333
Range on HMM: 7-275/275
Sequence Identity: 44% (120 aa)

LGKGAYGEVRKAIHKASGQL-RAIKIIKINEVSQEDKQNLENEIDILRNLDHPNIIKIFEFYKDSNYYYIVSELCTGGELFDKIIEEKSFDEF--KACNI
.|||..| |..| ||  |.  ...|.|| .... ..|....|||.|.|.||||||||..|.|.| |.||.| |.| ||||.|||.. |.|.|.  ..| |
IGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDI

IKQVL-QAVNYCHSNKIVHRDLKPENLLYD-NDTPS---QTLKVIDFGTSRYY--DPENKLTQRLGTPYYIA------PEVLKKE-YNEKCDIWSCGVIL
..| | |...|.|...|.||||||||.|.. ... |   . .|.||||.....  | .... |. |||.|.|      .||||.. | .|||.||||||.
MQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIF

YILLCGYPPFASKVDSEILEKVKLGEYNFNKPE-WRHVSQDAKNLINNMLQYNPQQRYSARQCLQDKWF
||||||.|||  |  .|||...|  ...|| || |  .|...|.|.  ||...|..|..| |.|...||
YILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 2675.AA CAMK 82-333 29 2e-135 439.19 In-house 1-425 (425) Show / Hide
Range on Protein: 82-333
Range on HMM: 1-425/425
Sequence Identity: 29% (124 aa)

PLGKGAYGEVRKAIHKASG------------QLRAIKIIKINEVS--------------------------QEDKQNLENEIDILRN-------LDHPNI
 ||.|..|.|...||| ..            |  |||||. . ..                          ..|..|...||.|...       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKIFEFYKDSNY-------------------YYIVS---ELCTGGEL----FDKIIEEKS---------------FDEFKACNIIKQVLQAVNYCHSNKI
||..|.| |..|                   .|.|    |.|.||||    ||.|.| ..               |.|  |. ...|...||.||||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLYDNDTPSQ--------------TLKVIDFGTSRYYDPEN------------------------KLTQRLGTPYYIA-PEVLKKE-----
|||||||||.|.|.. ...              ..|.|||| ....|| .                        |.. . |||.|.| ||||...     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNEKCDIWSCGVILYILLCGYPPFASK-------------VDSEILEKVKLGEYNFNKPE------------WRHVSQD--------AKN
          |..|||.|||||||||.||||||| ..              |.|..||.. |.|.|  |.            | ..|..        .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINNMLQYNPQQRYSARQCLQDKWF
||..|||..|..|... |||...|.
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 2675.AA S_TKc 77-333 37 1.7e-111 377.66 SMART 1-231 (231) Show / Hide
Range on Protein: 77-333
Range on HMM: 1-231/231
Sequence Identity: 37% (103 aa)

MILSPPLGKGAYGEVRKAIHKASGQLRAIKIIKINEVSQEDKQNLENEIDILRNLDHPNIIKIFEFYKDSNYYYIVSELCTG--GELFDKIIEEKS----
  .  ..||||.|.|.|..|| .|.. ||||||         .....||.||.. .||||.|..... | ...|.| |.| |  |.||| | . ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQTLKVIDFGTSRYYDPENKLTQRLGTPYYIAPEVLKKEYNE-KCDIWSCGVILYI
  |.|  |. ...|...|..||||..|.||||||||.| |.     ..|..||| .| .      |   |||.|.|||||   |.  |||.||||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LLCGYPPFASKVDSEILEKVKLGEYNFNKPEWRHVSQDAKNLINNMLQYNPQQRYSARQCLQ-------DKWF
.|||||||    . ....|..              |..||..|...||..|..|..| ..||       . ||
MLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 2675.AA CAMKL 76-333 36 1.2e-108 347.82 In-house 1-297 (297) Show / Hide
Range on Protein: 76-333
Range on HMM: 1-297/297
Sequence Identity: 36% (111 aa)

YMILSPPLGKGAYGEVRKAIH-KASGQLRAIKIIKINEVS--------------QEDKQNLENEIDILRNLD---HPNIIKIFEFYKDSNY------YYI
| |.   ||||..|.|. |.| .  |.  |||||...  .              . |. ... || |.. |.   ||||||..| . ....      .|.
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VSELCTGGE--LFDKIIEE----KSFDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQTLKVIDFGTSRYYDP-----ENKLTQRLGTP
| |.| |||  |||.|...    ....|  |. . .|.. |||||||..|||||.||||.| |..  . ..|.|||| | .|.|     ..||. . |.|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

YYIAPEVLKK--E-YN-EKCDIWSCGVILYILLCGYPPFA------SKVDSEILEKVKLGEYNFNKPEWRHVSQDAKNLINNMLQYNPQQRYSARQCLQD
 | |||....  . |.  | |||||||||| ..||| ||        ..|   ... |  .  .. | | ||| |...||  ||| || .|... | ...
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

KWF
.|.
PWM

Kinase 2675.AA Pkinase 77-333 33 1e-102 352.36 Pfam 1-293 (293) Show / Hide
Range on Protein: 77-333
Range on HMM: 1-293/293
Sequence Identity: 33% (98 aa)

MILSPPLGKGAYGEVRKAIHKASGQLRAIKIIKINEVSQEDKQNLEN--EIDILRNLDHPNIIKIFEFYKDSNYYYIVSELCTGG----ELFDKII--EE
  .  ..|.|..|.|.|..|| .|.. |.||||  . . . .|.. .  || |...|.||||....... |....|.| |.| ||    .||| |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KSF--DEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYD-NDTPSQTLKVIDFGTSRY--YDPENKLTQRLGTPYYIAPEVLK--KEYNEKCDIWSC
..|  .|  ......|.|....||||..|.||||||||.|.| |.... ..|..||| ..   | .   .| . |||.|.||||..  ..|  |.|.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYILLCGYPPFASK------VDSEILEKVKLGEYNFNKPEWRHVS-----------------QDAKNLINNMLQYNPQQRYSARQCLQDKWF
|.|||..|||.||| ..       . ....... ... |. |.|. .|                 ...| .|...|...|..|..|.|.||..||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 2675.AA Ciliate-E2 77-333 27 1.8e-102 346.7 In-house 1-365 (365) Show / Hide
Range on Protein: 77-333
Range on HMM: 1-365/365
Sequence Identity: 27% (106 aa)

MILSPPLGKGAYGEVRKAIHKASGQLR------------------AIKIIKINEVSQEDKQNLENEIDILR----------------NLDHPNIIKIFEF
 ..   .|.|..| |.|. ..  ...                   .|||. .. ... .......||.|.|                .|.||||||..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--DSNYYYIVSELCTGGELFDKII------------EEKSFDEFKACNIIKQVLQ---------------AVNYCHSNK-IVHRDLKPENLLYDNDTP
..  | |..|.| |.| ||.||| |.            . |.|.|.....|.||.||               |..|.||.. |.|||.||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

SQTLKVIDFGTSRYYDPE----------NKLTQRL-----------------------GTPYYIAPEVLK----------KEYNEKCDIWSCGVILYILL
   .|.||||.|..||..          .....                         |||.| |||.|.          |.|..||||||.|||||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGYPPFASKVDSEILEKVKLGEYNFNKPE--------------WRHVSQDAKNLINN----MLQYNPQQRYS-ARQCLQDKWF
.|.|||        ... | ....|..||              | ..||..|.||..    |||..|..|.. . |.|. .||
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 2675.AA RAD53 78-333 35 3e-102 305.4 In-house 2-305 (305) Show / Hide
Range on Protein: 78-333
Range on HMM: 2-305/305
Sequence Identity: 35% (108 aa)

ILSPPLGKGAYGEVRKAIHKASGQLRAIKIIKI---N---EVSQEDKQNLENEIDILRNLDHPNIIKIFEFYKD-SNYYYIVSELCTGGELFDKIIEEKS
..|  ||.|..|.|..|. |  .|  |||||.    .     .. .. ...||. ||..| ||.||.|.... . . |||.| || ||||||.||.  | 
YMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKR

----FDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQ---------------TLKVIDFGTSRYYDPENKLTQRL-GTPYYIAPEVLKK
    ||| ..  . .| . ||.| |.| |.|||||||| |....   .                .|. ||| |.  . |  ... . ||| | ||||. .
CQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVG-EGSFMKTMCGTPQYVAPEVITS

----------------EYNEKCDIWSCGVILYILLCGYPPFA-SKVD----SEILEKVKL-GEYNFNKPEWRHVSQDAKNLINNMLQYNPQQRYSARQCL
                .|. |.|.|| |.||||.|||||||  .. .      . |..|  | |.| .|.|. .|. ||.||..||. .|  ||.. . |
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

QDKWF
.  |.
NHPWM

Kinase 2675.AA CAMK-Unique 77-333 26 4.5e-100 331.07 In-house 1-363 (363) Show / Hide
Range on Protein: 77-333
Range on HMM: 1-363/363
Sequence Identity: 26% (97 aa)

MILSPPLGKGAYGEVRKAIHKASGQLRAIKIIKINEVSQEDKQN------------------LENEIDILRNLDHPNIIKIFEF----YKDSN-------
 ..  ..|.|..|.|.... .. | ..|.|..|   .. . .                    |..|..|.. .|||||||....    . |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YYYIVSELCTGGELFDKIIE--------------------EKSFDE--FKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTP-----
        |.||| |.|.||.|||.|..                    . .| |    .|.|. ..|.||.| ||..|||||||.||... .  .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------SQTLKVIDFGTSRYYDPENKLT---QRLGTPYYIAP--------------EVLK-KEYNEKC----DIWSCGVILYILLCGYPPFASKVDS-
           .|..||| ...|.   . .    . |||.|.||              ||..   | ..|    ||||.|||.|..|||.|||.. ..  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------EILEKVKLGEY-NFNKPEWRH---VSQDAKNLINNMLQYNPQQRYSARQCLQDKWF
       ||.|. . |.| || .. |.    .|| ||... . ... | .| || . |.  |.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase 2675.AA RSK 78-333 32 1.2e-84 287.47 In-house 1-278 (278) Show / Hide
Range on Protein: 78-333
Range on HMM: 1-278/278
Sequence Identity: 32% (91 aa)

ILSP-PLGKGAYGEVRKAIHKASGQLRAIKIIKINEVSQEDK--QNLENEIDILRNLD-HPNIIKIFEFYKDSNYYYIVSELCTGGELFDKIIEEKS---
.    ..|.|..  .|| .|...||. | |..| ... | .|       |..||     ||.|.. .. ...  . |.. |.| |||||... .||.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPS-QTLKVIDFGTSRYYDPE-NKLTQR-LGTPYYIAPEVLK----KE-YNEKCDIWSCG
|.|  || .. ..  || . |. .|.|||||||| |||... .  ..|..||| ... ... |..|.   .|  |.|||.||    .. ... ||.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLCGYPPFAS---KVDSEILEKVKLGEYNFNKPEWRHVSQDAKNLINNMLQYNPQQRYS-----ARQCLQDKWF
|..| .| |.|||..   .  .||..... |..... |.|  .||.||.||. ||. .|..|..     | . .|..||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 2675.AA Ciliate-E2-Unclassified 76-333 30 6.2e-84 285.16 In-house 1-352 (352) Show / Hide
Range on Protein: 76-333
Range on HMM: 1-352/352
Sequence Identity: 30% (107 aa)

YMILSPPLGKGAYGEVRKAIHKASGQLRAIKIIK-INEVSQEDKQNL---------ENEID-------------ILRNLDHPNIIKIFEFYKDSNYYYIV
| |.   .|.|..|.|.|..||  .|. |.|..| |....|  ..|          .|..              ||.|..||.|.| |.  .| .. |||
YKIIK-QIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

SELCTGGELFDKIIEEKS-----------------FDEFKAC-----NIIKQVLQAVNYCHSNK-IVHRDLKPENLLYDNDTPSQTLKVIDFGTSRYYD-
 |.| ||.|.. | . |.                 |.|..|.     ....|.||. .|.|... |.|||.||||.|.||.     .|.|||| |..|. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------PENKLTQRLGTPYYI----APEVLKK-EYN----EKCDIWSCGVILYILLCGYPPFASKVDSE----------------ILEKVK
               ........ |||.|.    |||||.. .|.    .||||||.||||| .| ||.|| .. . .                .... |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

LGEYNFNKPEW----RHVSQDAKNLIN----NMLQYNPQQRYSARQCLQDKWF
 ....|.| .|     |.|. ||..||     ||..|| .|... | |.  ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 2675.AA TyrKc 77-332 22 3.5e-19 70.95 SMART 1-280 (280) Show / Hide
Range on Protein: 77-332
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

MILSPPLGKGAYGEVRKAIHKASGQLRAIKIIKINEVSQEDKQNLENEIDILRNL--DHPNIIKIFEFYKDS-------NYYYIVSELCTGGELFDKIIE
  |   || ||.|||.|.. |   .  |.| .| .      .. . .|. |...|  .||||....    ..         ..|| |.. .| | | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EKS-FDEFKACNIIKQVLQAVNYCHSNKIVHRDLKPENLLYDNDTPSQTLKVIDFGTSRYYDPE-----NKLTQRL----GTP-----YYIAPEVL-KKE
 .  .   . ...  |. .  .| ||....||||   | |....    | |. ||| ||. . .     .| . |     |.         |||.. ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNEKCDIWSCGVILY-ILLCGYPPFAS-----KVDSEILEKVKLGEYNFNKPE-----WRHVSQDAKNLINNMLQYNPQQRYSARQCLQDKW
...| |.|| || .. |.  | .|        . ..|..|.|| |..    |.       . ...  ...    ...| .| . ...  ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF

Kinase 2675.AA Pkinase_Tyr 77-200 24 8.8e-14 47.3 Pfam 1-137 (270) Show / Hide
Range on Protein: 77-200
Range on HMM: 1-137/270
Sequence Identity: 24% (34 aa)

MILSPPLGKGAYGEVRKAIHK----ASGQLRAIKIIKINEVSQED--KQNLENEIDILRNL-DHPNIIKIFEFYK-DSNY--YYIVSELCTGGELFDKII
 ..   ||.||.|||.|.. |      ..  |.|..|    ..|.  .. . .|. |...| .||||..       ..    .||| |.. .| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

E----EKSFDEFKACNIIKQVLQAVNYCHSNKIVHRDL
.    .....    ...  |. .. .| .|....||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase 2675.AA APH 195-229 26 0.000404 14.93 Pfam 172-207 (248) Show / Hide
Range on Protein: 195-229
Range on HMM: 172-207/248
Sequence Identity: 26% (10 aa)

IVHRDLKPENLLYDNDTPSQTLK---VIDFGTSRYYDP
..|.|..| |...|   ...  .   |||...... ||
WCHGDFHPGNVMWDP--RPDGGRVTGVIDWDDACWGDP

Kinase 2675.AA Pkinase_Tyr 244-288 26 4.443096 0.89 Pfam 182-230 (270) Show / Hide
Range on Protein: 244-288
Range on HMM: 182-230/270
Sequence Identity: 26% (13 aa)

APE-VLKKEYNEKCDIWSCGVILYILLC-GYPP-FASKVDSEILEKV-K
|||    .....| |.|| || .. ..  |  | ..   ..|..|.. .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE

Efhand 2675.AA efhand 383-411 37 5e-06 26.55 Pfam 1-29 (29) Show / Hide
Range on Protein: 383-411
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

QLLKTFKQLDTDGDGMLSQQELLNGYKKI
.| . ||..|.|||| .. .|.....||.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 2675.AA EFh 383-411 27 9e-06 26.45 SMART 1-29 (29) Show / Hide
Range on Protein: 383-411
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

QLLKTFKQLDTDGDGMLSQQELLNGYKKI
.. . |. .|.|||| .. .|.. . |..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 2675.AA efhand 420-444 36 2e-06 28.2 Pfam 1-25 (29) Show / Hide
Range on Protein: 420-444
Range on HMM: 1-25/29
Sequence Identity: 36% (9 aa)

EVKKIMDQVDKNKSGKIDYSEFVMA
|.|......||...|.||. ||. .
ELKEMFKEFDKDGDGYIDFEEFCEM

EFh 2675.AA EFh 420-448 31 3e-05 24.69 SMART 1-29 (29) Show / Hide
Range on Protein: 420-448
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

EVKKIMDQVDKNKSGKIDYSEFVMATCNR
|.|.... .||...|.||. ||...  . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 2675.AA efhand 456-484 31 6e-07 29.85 Pfam 1-29 (29) Show / Hide
Range on Protein: 456-484
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLQMAFKMFDKDNNGSLTVDEIRKLFNSH
.|. .||.||||..| ....| .... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 2675.AA EFh 456-484 31 3e-06 28.0 SMART 1-29 (29) Show / Hide
Range on Protein: 456-484
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLQMAFKMFDKDNNGSLTVDEIRKLFNSH
.....|.|||||..| .. .| .... | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

EFh 2675.AA EFh 490-518 44 7.2e-09 36.7 SMART 1-29 (29) Show / Hide
Range on Protein: 490-518
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

VIKDIIKEVDKNQDGQISFAEFRDMMLNL
 .|......||. ||.|.| ||.||| .|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 2675.AA efhand 490-518 48 8e-09 36.7 Pfam 1-29 (29) Show / Hide
Range on Protein: 490-518
Range on HMM: 1-29/29
Sequence Identity: 48% (14 aa)

VIKDIIKEVDKNQDGQISFAEFRDMMLNL
 .|...||.||..||.|.| ||..|| .|
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL