Gene 10631 (Tetrahymena)
10631
Group:
Other
Family:
Ciliate-A5
Sequence
Protein domains of 10631.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10631.AA | Ciliate-A5 | 35-293 | 35 | 4.8e-125 | 421.72 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 35-293 Range on HMM: 1-275/275 Sequence Identity: 35% (97 aa) RFGDIQIYKEKGTDRYVFLKGHWCGDEENYNQFLRQCNRRIKINHPNVLKMIGFNQHSETQICGDFSKINCYYEYYSLNLEKELEKRFPEQ--KYFTEPE . | . |.| . |. | .|| .| . | ...|||..|.|.|..|.....|..|.|.||||||.. |||.|...|...| ....|.| FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE IWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNG--------IVNQSKNGYAKALFDGDTPYLSPLLMNAFANKE----KRPSHNHFKSD .||..|.....|.....|.|.||||||.|..|| .|||||.|.. |...|...|..........||||.......... .||.||..||| LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSD VYSLGMTMLECCSLFKA-LNFYDYSSCEIRYN-LIEDFLQKARLMYSGFLVNLIREMLNREEFQRPTFHEISAIL |..|||..||.|..... ...|||....|..| ||....|... .||....|.|..||..||..||.||.|...| VFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 10631.AA | Ciliate-E4 | 25-174 | 26 | 2.7e-29 | 94.74 | In-house | 1-150 (150) | Show / Hide |
Range on Protein: 25-174 Range on HMM: 1-150/150 Sequence Identity: 26% (40 aa) FTFVREKKDPRFGDIQIYKEKGTDRYVFLKGHWCGDEENYNQFLRQCNRRIKINHPNVLKMIGFNQHSETQICGDFSKINCYYEYYSLNLEKELEKRFPE . . || .||||| | . .| |. | . | ||.. ||.| . .. . .| | | .... .|| .|. .. . YRKIESVKDIHYGDIQIMEHKIQKQIIVMKIRKFQNETKARQQQQQFRRRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQ QKYFTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLAD . .|.| ||| . . .|| .. . |.|||..| |.... ||.|| GQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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| Kinase | 10631.AA | Ciliate-B2 | 114-225 | 28 | 4.4e-16 | 34.22 | In-house | 87-197 (197) | Show / Hide |
Range on Protein: 114-225 Range on HMM: 87-197/197 Sequence Identity: 28% (32 aa) LEKELEKRFPEQKYFTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGIVNQSKNGYAKALFDGDTPYLSPLLMNAFANKEKRPS |..||.| .|| |.. . .| ... | .. | | ||.| |.|.. |. .. | || |. | || |... | . . LKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHN-QTFVT HNHFKSDVYSLG |.||.||.| NIDFQSDIYSMG |
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| Kinase | 10631.AA | Ciliate-E1 | 108-222 | 19 | 5e-13 | 39.15 | In-house | 77-202 (202) | Show / Hide |
Range on Protein: 108-222 Range on HMM: 77-202/202 Sequence Identity: 19% (25 aa) EYYSLNLEKELE--------KRFP-EQKYFTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGIVN--QSKNGYAKALFDGDTPY |... .|...|. . . .|..||. .. ..| .. . . .....|.|.|| | |.| . |. ...| || .... . . . . | ECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYY LSPLLMNAFANKEKRPSHNHFKSDVY .| .| . ..... ..|||.| YPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 10631.AA | SLK | 125-230 | 30 | 9.3e-12 | 35.83 | In-house | 91-194 (259) | Show / Hide |
Range on Protein: 125-230 Range on HMM: 91-194/259 Sequence Identity: 30% (33 aa) QKYFTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGIVNQSKNGYAKALFDGDTPY-LSPLLMNAFANKEKRPSHNHFKSDVYS .. ||. | |. ...| . |||. | |.. |.|.|. |.|.||| |. . |. | ||| . | .. |.. .|.|..| EHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQ---PYDYKADIWS LGMTMLE ||.|..| LGITLIE |
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| Kinase | 10631.AA | S_TKc | 25-297 | 19 | 1e-11 | -5.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-297 Range on HMM: 1-231/231 Sequence Identity: 19% (56 aa) FTFVREKKDPRFGDIQIYKEKGTDRYVFLKGHWCGDEENYNQFLR--QCNRRIKINHPNVLKMIGFNQHSETQICGDFSKINCYYEYYSL---NLEKELE ....|. || ..|.|.|.| .| ....| |. .. .|||. |.... |. ... || . .| . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK KRFPEQKY--FTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGIVNQSKNGYAKALFDGDTPYLSPLLMNAFANKEKRPSHNHF || .. .. |.| ...... |..| . |..| | |. | |.||. ..|..| |. | | | |..| .. ..... KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----------GYGKC KSDVYSLGMTMLECCS---LFKALNFYDYSSCEIRYNLIEDFLQKARLMYSGFLVNLIREMLNREEFQRPTFHEISA-----ILTPYR |.|..|.| .. |... .| . ...| | . ..|| .|... .||| |. . . |. KCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 10631.AA | MEK4 | 151-230 | 40 | 3.8e-10 | 29.12 | In-house | 129-204 (275) | Show / Hide |
Range on Protein: 151-230 Range on HMM: 129-204/275 Sequence Identity: 40% (32 aa) KIYHGDIRPINVLLTVAGQVKLADNGIVNQSKNGYAKALFDGDTPYLSPLLMNAFANKEKRPSHNHFKSDVYSLGMTMLE || | |. | |.|| .| ||| | || | . .|| | ||. | . ..|... .||| ||| || | KIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDG----YDIRSDVWSLGITMYE |
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| Kinase | 10631.AA | STE | 66-230 | 22 | 7.7e-08 | 23.89 | In-house | 80-260 (359) | Show / Hide |
Range on Protein: 66-230 Range on HMM: 80-260/359 Sequence Identity: 22% (44 aa) QFLRQCNRRIKINHPNVLKMIGFNQHSETQICGDFSKINCYYEYYS-LNLEKELEKRFPEQK----------YFTEPEIWYLIDSIVNA-CSFFESNKIY .....|| . |||. | .| . . ... .... . || . |.. ..... .| .| |..| | . .|. . .. .|..| KIMKKCNH---M-HPNIVKYYGCYFKEGHN-HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII HGDIRPINVLLTVAGQVKLADNGIVNQSKNGYA----------------KALFDGDTPYLSP--LLMNAFANKEKRPSHNH-FKSDVYSLGMTMLE | || | |.|| |||.| |. | . .| | . ||. .| .. | . . .. . .|.|..||| |..| HRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIE |
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| Kinase | 10631.AA | WEE | 124-230 | 21 | 1.2e-07 | 21.84 | In-house | 104-228 (297) | Show / Hide |
Range on Protein: 124-230 Range on HMM: 104-228/297 Sequence Identity: 21% (28 aa) EQKYFTEPEIWYLIDSIVNACSFFESN-KIYHGDIRPINVLLTVAG--------------------QVKLADNGIVNQSK--NGYAKALFDGDTPYLSPL ......|..|| .. |... .. || . | || | |.... . |..| | |. . | .. || .|..| WNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPE LMNAFANKEKRPSHNHFKSDVYSLGMTMLE . . ....| ..|.|..|||.|..| ILQG----YYHYTH-LYKADIFSLGITIYE |
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| Kinase | 10631.AA | TK-Unique | 211-293 | 22 | 1.3e-07 | 22.41 | In-house | 207-294 (294) | Show / Hide |
Range on Protein: 211-293 Range on HMM: 207-294/294 Sequence Identity: 22% (20 aa) RPS--HNHF---KSDVYSLGMTMLECCSLFKALNFYDYSSCEIRYNLIEDFLQKARLMY-SGFLVNLIREMLNREEFQRPTFHEISAIL ... |... ||||.|.| .| |...| . ........|. .. . . .. . . | . ||... ...|. .||.| .| .| SLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | 10631.AA | LKB | 141-177 | 35 | 8.1e-07 | 16.33 | In-house | 114-150 (265) | Show / Hide |
Range on Protein: 141-177 Range on HMM: 114-150/265 Sequence Identity: 35% (13 aa) VNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGI . .| . | .. | || | | |||... .|. | |. CDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGV |
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| Kinase | 10631.AA | TyrKc | 25-293 | 16 | 1.6e-05 | -133.31 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-293
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)
FTFVREKKDPRFGDIQIYKEKGTDRYVFLKGHWCGDEENYNQFLRQCNRRIKI--NHPNVLKMIGFNQHSETQICGDF---SKINCYYEYYSL-NLEKEL
|. .. || . . | . | | . |.| . |. .|||.....| ... . | . || .. .| . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYL
EKRFPEQKYFTEPEIWYLIDSIVNACSFFESNKIYHGDIRPINVLLTVAGQVKLADNGIVNQSKNG--------YAKALF--DGD--TPY--LSPLLMNA
|. |. .. .. . | . ... .|... | |. |.|.. ..|| .| | ... | .. .|. |. ..| .
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--
FANKEKRPSHNHF--KSDVYSLGMTMLECCSLFKALNFYD----YSSCEIRYNLIEDFLQKARLM--------YSGFLVNLIREMLNREEFQRPTFHEIS
.. | ||||.| | .| | ... . . | |.. .. . . . . . ..... ... .|||| ||
--------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH
AIL
..
ECF
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| Kinase | 10631.AA | LKB | 268-289 | 40 | 0.012061 | 3.74 | In-house | 238-259 (265) | Show / Hide |
Range on Protein: 268-289 Range on HMM: 238-259/265 Sequence Identity: 40% (9 aa) LVNLIREMLNREEFQRPTFHEI |.|||. || . .|.. |.| LQNLIKGMLQYDHNKRFSCHQI |
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| Kinase | 10631.AA | TK-Unique | 145-174 | 37 | 0.028561 | 3.78 | In-house | 145-176 (294) | Show / Hide |
Range on Protein: 145-174 Range on HMM: 145-176/294 Sequence Identity: 37% (12 aa) SFFES--NKIYHGDIRPINVLLTVAGQVKLAD .. .| || |.|. ||||| ...|..| EYLASQRKKIVHRDLCARNVLLTEDKVCKICD |
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| Kinase | 10631.AA | SLK | 25-87 | 20 | 0.037524 | 2.92 | In-house | 1-63 (259) | Show / Hide |
Range on Protein: 25-87 Range on HMM: 1-63/259 Sequence Identity: 20% (13 aa) FTFVREKKDPRFGDIQIYKEKGTDRYVFLKGHWCGDEENYNQFLRQCNRRIKINHPNVLKMIG . . | | || .. ..| .... | |||. . .. . ...|||..|... WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYE |
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