Gene 29759 (Tetrahymena)
29759
Group:
Other
Family:
Ciliate-A5
Sequence
Protein domains of 29759.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 29759.AA | Ciliate-A5 | 30-289 | 45 | 3.9e-153 | 515.04 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 30-289 Range on HMM: 1-275/275 Sequence Identity: 45% (124 aa) AYGEVKIMKNELNQEILAVKQYSFQDRDRLDNFIKRTEKRKQLISPYIVELIDVEADKAEDFCSNFFKLSLVYQYHPENLFQLIEKRKKLR--KRFTEQE .||..||.||...||....||...||.||...|....|.|.||..|.||.|||....|.|.|||.|.|....|.||..||.|....||... ....||| FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE LFLLIDCVSSALLVFDSFELRHGDIRPQTILISQDNKFKLTDVK----FLT--QFSQYKRLLIGVSDTN--YLSPQLFYQMEHR----IANPEHNETISD |....||..|...........|||||||.|...||...||.|.. |.. ..|.||......|..| ||||...|||.|| |..||||...|| LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSD IFSLGLICLEMASMRSI-QGIYDPETFQIQEEKVEKIIYQMKEDKYSESLIELILRMLQIEENDRINPYQIQQYL .|.||.|||||..||.. |..||.||||||.....|...||||.||||..|..|..|||.|||.|....||.||| VFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 29759.AA | Ciliate-E4 | 21-169 | 23 | 8.8e-19 | 59.44 | In-house | 2-150 (150) | Show / Hide |
Range on Protein: 21-169 Range on HMM: 2-150/150 Sequence Identity: 23% (35 aa) HFVKQVENDAYGEVKIMKNELNQEILAVKQYSFQDRDRLDNFIKRTEKRKQLISPYIVELIDVEADKAEDFCSNFFKLSLVYQYHPENLFQLIEKRKKLR . | || . || .| . | || ... .|. | . |... | . ||| . .| ... | ..| | | .|. RKIESVKDIHYGDIQIMEHKIQKQIIVMKIRKFQNETKARQQQQQFRRRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQG KRFTEQELFLLIDCVSSALLVFDSFELRHGDIRPQTILISQDNKFKLTD .|.|.|.. . | .|. . . |||..|. |...| |. | QHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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| Kinase | 29759.AA | S_TKc | 20-289 | 19 | 1.6e-11 | -7.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 20-289 Range on HMM: 1-231/231 Sequence Identity: 19% (55 aa) LHFVKQVENDAYGEVKIMKNELNQEILAVKQYSFQDRDRLDNFIKRTEKRKQLISPYIVELIDVEADKAEDFCSNFFKLSLVYQYHPE---NLFQLIEKR ...... |.|.|. .. ..| |.|. . ... . |. .| |.|| |.|| | .| .| | . .||..|.|| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKR KK--LRKRFTEQELFLLIDCVSSALLVFDSFELRHGDIRPQTILISQDNKFKLTD---VKFLTQFSQYKRLLIGVSDTNYLSPQLFYQMEHRIANPEHNE .. ||..|.| . .. . .|| | | |. |. ||... |..| ..| . .|..| .. .. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----------GYGK TISDIFSLGLICLEMASMRSIQGIYDPETFQIQEEKVEKIIYQMKEDKYSESLIELILRMLQIEENDRINPYQIQQ---------YL .|. |.| | ||.. . |.... |.| |......| ..|| . ..|. .. | .. CKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 29759.AA | Ciliate-E1 | 26-217 | 16 | 3.7e-07 | 19.83 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 26-217 Range on HMM: 1-202/202 Sequence Identity: 16% (34 aa) VENDAYGEVKIMKNELNQ-EILAVKQYSFQDRDRLDNFIKRTEKRKQLISPYIVELIDVEADKAEDFCSNFFKLSLVYQYHPENLFQLIE---------K ..| .. |.. |.. |. . |.| .. . ..| . ... ... . .. | .. . . .| ... .. ... ..|.. .. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICI-IIFECCCCSLKDYLQNHNRLEYWQQ RKKLRKRFTEQELFLLIDCVSSALLVFDSFELRHGDIRPQTILISQDNKFKLTDVKFLT--QFSQYKRLLIGVSDTNYLSPQLFYQMEHRIANPEHNETI .. . ||.|.. .| .| . .. . |.|| || |||.........| . .|.. . |.|..|. |... ....|..| CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGY-THYYYPPEQYNCP-EQ-EHNKNQKI ---SDIF |||. NYKSDIY |
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| Kinase | 29759.AA | Ciliate-B2 | 113-169 | 31 | 2e-06 | 10.91 | In-house | 91-147 (197) | Show / Hide |
Range on Protein: 113-169 Range on HMM: 91-147/197 Sequence Identity: 31% (18 aa) IEKRKKLRKRFTEQELFLLIDCVSSALLVFDSFELRHGDIRPQTILISQDNKFKLTD ..| .| .| |..| |. .| .| | . . | ||.|| ||..| ......| LQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCD |
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| Kinase | 29759.AA | Ciliate-A1 | 214-292 | 23 | 5e-06 | 16.33 | In-house | 209-301 (301) | Show / Hide |
Range on Protein: 214-292 Range on HMM: 209-301/301 Sequence Identity: 23% (23 aa) SDIFSLGLICLEMAS----------MRSIQGIYDPETFQIQEEK----------VEKIIYQMKEDKYSESLIELILRMLQIEENDRINPYQIQQYLDPI ||..|||.| .. . ...| | ..|... . |||. . .| | || .|.| | | |. |. ..| . SDMYSLGCIICFLCYKEDSHPYVGTIVNIFGN------NMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCLYIF |
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| Kinase | 29759.AA | Ciliate-E2 | 108-287 | 19 | 7e-06 | 16.11 | In-house | 120-361 (365) | Show / Hide |
Range on Protein: 108-287
Range on HMM: 120-361/365
Sequence Identity: 19% (50 aa)
NLFQLIEKRKKLR-------KRFTEQELFLLIDCVSS---------------ALLVFDSFE-LRHGDIRPQTILISQDNKFKLTDVK---FLTQFSQYKR
.||..|...|| | |.|||.| .. . . || | | || |. ||. |..| ......|...
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRT
------LLIGVS------------------------DTNYLSPQLFY------QMEHRIANPEHNETISDIFSLGLICLEMASMRSIQGIYDPETFQIQE
... . .|..|. . | . .. . .||.||| | || . . .|.
HKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-----QKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQ
EKVEKIIYQMKE---------------DKYSESLIELILR----MLQIEENDRIN-PYQIQQ
| || .. .| .| |.. . || . ||| ... ||. . || .
IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
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| Kinase | 29759.AA | ULK | 236-281 | 30 | 3.2e-05 | 14.54 | In-house | 273-314 (324) | Show / Hide |
Range on Protein: 236-281 Range on HMM: 273-314/324 Sequence Identity: 30% (14 aa) YDPETFQIQEEKVEKIIYQMKEDKYSESLIELILRMLQIEENDRIN . ..|. ..... .. |..| |. ...|| ||||..|.|||. Q---QIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRIS |
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| Kinase | 29759.AA | Ciliate-C6 | 214-289 | 28 | 4.3e-05 | 14.01 | In-house | 234-306 (306) | Show / Hide |
Range on Protein: 214-289 Range on HMM: 234-306/306 Sequence Identity: 28% (22 aa) SDIFSLGLICLEMASMRSIQGIYDPETFQIQEEKVEKIIYQMKEDKYSESLIELILRMLQIEENDRINPYQIQQYL .||||||.| | | | .. | . .| |. . . |...|.| .| |. .|| . |. . . | CDIFSLGMILLYMLTLSDISQVNCDEFMKNQ--KIRIMKNMCKDISYKE-IIKLVSKMLETNPDHRPDMSILIQTI |
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| Kinase | 29759.AA | NRBP | 197-270 | 28 | 5.4e-05 | 13.14 | In-house | 170-242 (261) | Show / Hide |
Range on Protein: 197-270 Range on HMM: 170-242/261 Sequence Identity: 28% (21 aa) FYQMEHRIANPEHNETISDIFSLGLICLEMASMRSIQGIYDPETFQIQEEKVEKIIYQMKEDKYSESLIELILR |. |. | . .. | ||.| |. |||| . .|. . |. ...|| ... | . ||. .|. |. FFAPEYGILEVTDLTTAVDIYSFGMCALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSL-EDPMQRDFIRKCLQ |
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| Kinase | 29759.AA | Ciliate-E5 | 214-227 | 57 | 8.5e-05 | 11.32 | In-house | 258-271 (271) | Show / Hide |
Range on Protein: 214-227 Range on HMM: 258-271/271 Sequence Identity: 57% (8 aa) SDIFSLGLICLEMA |||.|||.. ||. SDIYSLGIVFLELT |
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| Kinase | 29759.AA | Pkinase | 214-289 | 16 | 0.00015 | 17.17 | Pfam | 193-293 (293) | Show / Hide |
Range on Protein: 214-289 Range on HMM: 193-293/293 Sequence Identity: 16% (17 aa) SDIFSLGLICLEMASMRSIQG--IYDPETFQIQEEKVEKIIY----QMKEDKYS-------------------ESLIELILRMLQIEENDRINPYQIQQY .|..|.|.|. ||.. | . . .... | .....| . . ..| |.....| ..|. ..|... || | VDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH --L . PWF |
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| Kinase | 29759.AA | Ciliate-A1 | 149-169 | 52 | 0.00024 | 10.63 | In-house | 124-144 (301) | Show / Hide |
Range on Protein: 149-169 Range on HMM: 124-144/301 Sequence Identity: 52% (11 aa) HGDIRPQTILISQDNKFKLTD | |. || ||| |.|.|. | HRDLKPQNILIHFDDKWKICD |
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| Kinase | 29759.AA | Ciliate-C6 | 149-169 | 50 | 0.000621 | 9.83 | In-house | 159-180 (306) | Show / Hide |
Range on Protein: 149-169 Range on HMM: 159-180/306 Sequence Identity: 50% (11 aa) HGDIRPQTILISQD-NKFKLTD | || |. ||| | |...|.| HRDIKPSNILIMDDENNYYLSD |
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| Kinase | 29759.AA | Ciliate-B2 | 214-220 | 71 | 0.005688 | 2.71 | In-house | 191-197 (197) | Show / Hide |
Range on Protein: 214-220 Range on HMM: 191-197/197 Sequence Identity: 71% (5 aa) SDIFSLG |||.|.| SDIYSMG |
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| Kinase | 29759.AA | Ciliate-E2 | 20-83 | 17 | 0.16656 | 0.91 | In-house | 1-100 (365) | Show / Hide |
Range on Protein: 20-83 Range on HMM: 1-100/365 Sequence Identity: 17% (17 aa) LHFVKQVENDAYGEVKIMKNELNQE-----------------------ILAVKQYSFQDRDRLDNFIK--R---------TEKR--KQLISPYIVELIDV |.|. . ..| |. .|. ..|. | |.|... .. . . |. | ||. .|| .|.|...... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC |
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| Kinase | 29759.AA | ULK | 42-127 | 20 | 0.259108 | 0.49 | In-house | 25-127 (324) | Show / Hide |
Range on Protein: 42-127 Range on HMM: 25-127/324 Sequence Identity: 20% (22 aa) N--QEILAVKQYS---FQDRDRLDN------FIKRTEKRKQLI----SPY--IVELIDVEADKAEDFCSNFF-KLSLVYQYHPE-NLFQLIEKRKKLR-- | ... |.|. . ... ... ..|. . . . .|. ||.|.|. .. . . ... | . .|.|.|.|.||| NTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSN-------HNNIYIIMEYCNGGDLEQYIKKNKKLPET ---KRFTEQE ||..||| EEKKRLSEQE |
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| Kinase | 29759.AA | Pkinase | 74-139 | 20 | 3.208265 | 1.86 | Pfam | 59-121 (293) | Show / Hide |
Range on Protein: 74-139 Range on HMM: 59-121/293 Sequence Identity: 20% (15 aa) SPYIVELIDVEADKAEDFCSNFFKLSLVYQYHPE-----NLFQLIE--KRKKLRKRFTEQELFLLIDCVSSAL .|.||.|.|. | .. .| |.. || .|. ..... |.|.|. . . ..| HPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGL |
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