Gene 4078 (Tetrahymena)
4078
Group:
Other
Family:
Ciliate-A5
Sequence
Protein domains of 4078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4078.AA | Ciliate-A5 | 28-292 | 33 | 4.4e-100 | 338.81 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 28-292 Range on HMM: 1-275/275 Sequence Identity: 33% (93 aa) RYGTMKLWINNATQQKYAEISKTLNDESVLEKRVEELNFRKELDHPSIVKLVSFNSQKKDEFCSSFYKLGLFYEYFSNNLRTEISERQKVR--AAYKEGE .||.||.|.|...|..|....|...||............|..|.||.||||..|...||.||||.|||....|||..|||..|...|.... ..|.|.| FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE LWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEIF-----IHVQPLSSYSQLLNNSLEEY--YISPQLFRCLKEFN----ASPVFDANKSD |||..|.|..|..||...|..||||||.|...|..|||||. . .. .||| |.. | |.||... .. . |. . ||| LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSD IYSIGMTVLEAATLENVSRVCYDQQNYVVKTDEVNKLLNQVRA-QYSLSLYSFLQKLLTEDEVLRPSVEGLFDELNQQY ....||. || .|.. .. . || . . |.| |. . || ....|. ..| .| ||. | .. |. VFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPD----FHQIYQYL |
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| Kinase | 4078.AA | Ciliate-E4 | 67-167 | 31 | 1.7e-26 | 85.28 | In-house | 50-150 (150) | Show / Hide |
Range on Protein: 67-167 Range on HMM: 50-150/150 Sequence Identity: 31% (32 aa) RKELDHPSIVKLVSFNSQKKDEFCSSFYKLGLFYEYFSNNLRTEISERQKVRAAYKEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLG |..| |. |... . .| | ||||.|.| .|.|| .| ..| ... | |.| .. . | ||| ..|. |||..| |. .. ||. RQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIA E D |
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| S_TKc | 4078.AA | S_TKc | 24-293 | 14 | 6.4e-10 | -31.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-293 Range on HMM: 1-231/231 Sequence Identity: 14% (42 aa) FNDER------YGTMKLWINNATQQKYAEISKTLNDESVLEKRVEELNFRKELDHPSIVKLVSFNSQKKDEFCSSFYKLGLFYEYFSN---NLRTEISER . | .|. .. ... |....| | .. |. |.. |. .|| |||| . .| .. || .. .|.. | .| YEILRKIGKGAFGKVYKCRHKKTGRIVA--IKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKR QKVRAA--YKEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGE----IFIHVQPLSSYSQLLNNSLEE----YYISPQLFRCLKEFNA .. . . | . .... ... . |. |... | |. | |. .. ..|.. .. .|..| .. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL-------- SPVFDANKSDIYSIGMTVLEAATLENVSRVCYDQQNYVVKTDEVNKLLNQVRAQYSLSLYSFLQKLLTEDEVLRPSVEGLFD----ELNQQYV .. |.|..|.| .. | .. . . .......... | .. .|..|.|. | ||.. .. . ... --GYGKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4078.AA | Ciliate-B2 | 107-219 | 23 | 8.1e-07 | 11.95 | In-house | 87-197 (197) | Show / Hide |
Range on Protein: 107-219 Range on HMM: 87-197/197 Sequence Identity: 23% (26 aa) LRTEISERQKVRAAYKEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEIFIHVQPLSSYSQLLNNSLEEYYISPQLFRCLKEFNASP |. |. || . ... | . |.. ....|. | ||.| |. .. .|. .. . | .| .. .| || | .. .. LKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK-DNQQIKIKGFTKKYASPEQMECDHNQTFVT VFDANKSDIYSIG | .|||||.| NIDF-QSDIYSMG |
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| Kinase | 4078.AA | Ciliate-E1 | 101-216 | 17 | 4e-06 | 16.52 | In-house | 77-202 (202) | Show / Hide |
Range on Protein: 101-216 Range on HMM: 77-202/202 Sequence Identity: 17% (22 aa) EYFSNNLRTEIS---------ERQKVRAAYKEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEIFIHV--QPLSSYSQLLNNSLEEY |. . .| ... . |. ... .. .. |. . .|...|. |.|| | |..|. .|. .. . | . . ... .. .. | ECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYY YISPQLFRCLKEFNASPVFDANKSDIY | ..|.. . . . ||||| YPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 4078.AA | NEK6 | 133-168 | 47 | 5e-06 | 15.47 | In-house | 112-147 (252) | Show / Hide |
Range on Protein: 133-168 Range on HMM: 112-147/252 Sequence Identity: 47% (17 aa) LLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEI | . . || | | ||.| || || .| ||||.. LCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDL |
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| Kinase | 4078.AA | SLK | 122-229 | 25 | 8e-06 | 15.53 | In-house | 95-199 (259) | Show / Hide |
Range on Protein: 122-229 Range on HMM: 95-199/259 Sequence Identity: 25% (27 aa) KEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEIFIHVQPLSSYSQLLNNSLEEYYISPQLFRCLKEFNASPVFDANKSDIYSIGMT .| . |. ... . .| |..| | |.. |...| .|.|.| . . . . . |.. | . | | | .| |.||.|.|.| TEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMC-ETFKDQP-YDY-KADIWSLGIT VLEAATLE ..| | .| LIEMAQME |
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| Kinase | 4078.AA | Ciliate-E2b | 139-165 | 37 | 5.5e-05 | 11.28 | In-house | 117-143 (272) | Show / Hide |
Range on Protein: 139-165 Range on HMM: 117-143/272 Sequence Identity: 37% (10 aa) YLKSKNVNHGDIRPYNVIITPEGQVKL || ..|. ..|| | |.... .|..|| YLHNQNIIYRDIKPENIMVDHKGYMKL |
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| Kinase | 4078.AA | Ciliate-C3 | 133-168 | 30 | 6.5e-05 | 13.97 | In-house | 105-140 (140) | Show / Hide |
Range on Protein: 133-168 Range on HMM: 105-140/140 Sequence Identity: 30% (11 aa) LLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEI .| . || |. ||||.. |..| ....|. . ILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 4078.AA | MSN | 122-226 | 28 | 0.000189 | 10.34 | In-house | 102-203 (265) | Show / Hide |
Range on Protein: 122-226 Range on HMM: 102-203/265 Sequence Identity: 28% (30 aa) KEGELWYLLDTLLNVVYYLKSKNVNHGDIRPYNVIITPEGQVKLGEIFIHVQPLSSYSQLLNNSL-EEYYISPQLFRCLKEFNASPVFDANKSDIYSIGM || . |. .| ...| .. | | ||. ||..| . .||| . . | |. | . |.. | | . .|. .| ..||..|.|. KEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQ-LDRTVGRRNTFIGTPYWMAPEVIACDENPDAT--YD-YRSDLWSVGI TVLEAA | .| | TAIEMA |
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| Kinase | 4078.AA | WEE | 212-227 | 50 | 0.000238 | 10.58 | In-house | 216-231 (297) | Show / Hide |
Range on Protein: 212-227 Range on HMM: 216-231/297 Sequence Identity: 50% (8 aa) KSDIYSIGMTVLEAAT |.||.|.|.|..|.|. KADIFSLGITIYELAC |
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| Zf-C3HC4 | 4078.AA | zf-C3HC4 | 1257-1297 | 33 | 4.8e-14 | 41.67 | Pfam | 1-48 (48) | Show / Hide |
Range on Protein: 1257-1297 Range on HMM: 1-48/48 Sequence Identity: 33% (16 aa) CSICLCEFEDEEKISFLACFHR-----FHNECIHKWFE--TKSTCPLC | ||.||..|.... .. | || |. .|| .|.. .. .||.| CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCIKRWWNHSGNTQCPIC |
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| RING | 4078.AA | RING | 1257-1297 | 31 | 4.4e-07 | 30.78 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 1257-1297 Range on HMM: 1-23/23 Sequence Identity: 31% (13 aa) CSICLCEFEDEEKISFLACFHRFHNECIHKWFETKSTCPLC |.|||. . .| | | |. || ||.| CPICLE-------PVVLPCGH-FCY-CI---------CPIC |
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