Gene 2721 (Tetrahymena)
2721
Group:
Other
Family:
Ciliate-A7
Sequence
Protein domains of 2721.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2721.AA | Ciliate-A7 | 627-929 | 40 | 6.7e-167 | 560.76 | In-house | 1-360 (360) | Show / Hide |
Range on Protein: 627-929 Range on HMM: 1-360/360 Sequence Identity: 40% (146 aa) RQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSN--------HHQIECRELRNEFRFLKKMDHPRIIS------LSNNSEFIRDRNYCGLLLPQAE |...|..||||.|||.|.||....|..|.|...|.|.| ||..||..|.||..||||||||.||. ..|..||...||.|..|..||| RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE CNLMQ-FAKTQRHGKVSLA------------QMRIAFRQIAEAIHYLHEN-YISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQTLRK |.|.| |.....|...... |||..|||||.|.||||.. .|.||||||.|.|.|..|...........|..........|.|..||| CDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLR- QVKIEDLKKNWKQRCKQYVAPELIKLLNG------KRPRT----PSD------EKACDVFALGVSFFIIIFYQLPF-CGSALKTDQR-YKHFFKGQNEKF |..|||..||||.|||||.|||.|..||. ..... ..| ||.|||||.|||||.|.|.|.|| |... ..|.. |||.|.....|| QQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKF WS--QFKSMLTKFQ----------QQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL |. |...|...|| .|........|||.||.|.|.|..|..|.|.|.|||. WQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF |
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| Kinase | 2721.AA | Ciliate-C1 | 736-929 | 30 | 4.5e-37 | 93.43 | In-house | 135-328 (328) | Show / Hide |
Range on Protein: 736-929 Range on HMM: 135-328/328 Sequence Identity: 30% (65 aa) FRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQ-TLRKQVKIEDLKKN---------------WKQRC---KQY |.| .| |.|.| | | |.|| | . .. |.|||||| | || || || ||. .| . .| | | | FHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFL--------NSASSQNTLSKQKDGEKMNHNTSSTECSDASSDESHWLYVCMGTEGY VAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTK ||||. . . . .. | ||.|| |... .|| |. .|. |. | .. ..| . . | |.| . .|..|| |. |...| | MAPELHE-------KQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYW----QCHQKNYGQHNFFSNEFMDLINQMLAYNPQK RLTIEQVLEHPWL |.|..... |||. RITLQEIKCHPWY |
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| Kinase | 2721.AA | Ciliate-E2 | 736-929 | 19 | 1.4e-32 | 109.14 | In-house | 151-365 (365) | Show / Hide |
Range on Protein: 736-929 Range on HMM: 151-365/365 Sequence Identity: 19% (52 aa) FRQIAE---------------AIHYLHENY-ISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNS--------FKRNSRFSQTLRKQVKIEDLKKNWKQ ..||.. |..|||.. | | ||||.| .. |..|||.. .. ..| . ...| | . ... MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-------- RCKQ---------------YVAPELIKLLN------GKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTK | |.||| .. . .|. ..||...||| ... .| ..|| . . ---QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG-----YDYKCDIWSLGVILYEMLFGKPPF-----------------------------QQQ FQQQENSYP----------------------EELKDLFNK----VLEPEPTKRLT-IEQVLEHPWL .|.. ..| .| |||..| |. .| ||.| .||.|.|||. IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| S_TKc | 2721.AA | S_TKc | 625-929 | 19 | 1.5e-29 | 105.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 625-929
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)
QYRQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSNHHQIECRELRNEFRFLKKMDHPRIISLSNNSEFIRDRNYCGLLLPQAEC---NLMQFAKT
|.||. . .| . .. .|.. .||.. . .|.| . ||| .|| |. | ....| .. . . .. .|... |
YEILRKIGKGAFGKVYKCRHKKTGRIV--AIKIIK-----------EHIRREIQILKK-HHPNIVKL---YDVFQD-DHLYMVMEYCDGDLGDLFDYIKK
QRHGK----VSLAQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQTLRKQVKIEDLKKNWKQRC--KQ
..... . . | ..||..|. |.|.. | | |.||.| .. . |..|||.| | . |
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------------TTFCGTPW
YVAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPT
|.|||.. . . ..||. ..|. ... . . ||. ..|. . . ..|.||. .| |. .|.
YMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPE
KRLTIEQVLE-------HPWL
||.|. ..|. |||.
KRPTA-EALQDEWDIKCHPWF
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| Kinase | 2721.AA | CAMK | 630-929 | 18 | 4.1e-29 | 90.38 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 630-929
Range on HMM: 1-425/425
Sequence Identity: 18% (82 aa)
LIGRSSNSKIFELKDS-ST-DEN--------IGQVVKIVPHK-MSNHH-----------------------QIECRELRNEFRFLKK-------MDHPRI
.|| | .| .. .. .| .|. .||.. | ..... . ....|.| . .|| .||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ISLSN-----------NSEF-IRD------RNYCGLLL------PQAEC--NLMQFAKTQRH-------------GKVSLAQMRIAFRQIAEAIHYLHEN
|.| |. . . .... . . . | | .. . ... |... .. | ||||..|.||.|..
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH
YISHNDIKPDNMFVFSE-----------------NDYKLADFGFAIDLPKPNS------FKRNSRFSQTLRKQVKIEDLKKNWKQRC--KQYVA-PELIK
| | |.||.| . . |. |..|||||. ... .. .| .. . . |. ... . | .| |.| ||...
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN---QWTTPTEGQKMKTFCGTPEYMAAPEVLN
LLNGKRPR------TPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQ----FKSMLTKFQQQENSYP--------------
.. | . ..||. ..|| .| .|| |. . . | . . .. | .. . ..|
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-------E----WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE
--------------EELKDLFNKVLEPEPTKRLTIEQVLEHPWL
.| ||| .| |...|.||.||||.|.|||.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 2721.AA | Ciliate-E2-Unclassified | 628-929 | 18 | 1.7e-21 | 71.37 | In-house | 4-352 (352) | Show / Hide |
Range on Protein: 628-929 Range on HMM: 4-352/352 Sequence Identity: 18% (68 aa) QRLIGRSSNSKIFELKDSSTD---------ENIGQVVKIVPHK---MSNHHQIECRELRNEFR--------FLKKMDHPRIISLSNNSEFIRDRNYCGLL .. ||. ...|.......... .. . .|.. .| | . ....... . .| |. ..|| |. . . .|.... . IKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIV---KMFYCFQDKQNIYIV LPQAE-CNLMQFAKTQRH---------------GKVSLAQMR-----IAFRQIAEAIHYLHENY-ISHNDIKPDNMFVFSEN---DYKLADFGFAIDLPK . ..| .|.|. | . . ... |.. |.|| ... |||.. | | ||||.| .. ... |..|||... . . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ PNSFKRNS-RFSQTLRKQVKIEDLKKNWKQR-CKQYV----APELIKL-LNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKG .| .. .. . . .| . .. | . .| |||... .... ..||...||| .. ..| ..|| . . .| .. . NNNCD-TNQQ------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI- Q---NEKFWSQFKSMLTKFQQQEN-----SYPEELKDLFN----KVLEPEPTKRLTIEQVLEHPWL . .. . ...| ..|. ... ..| ||. | | |. | ||.|.||.|.|||. NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 2721.AA | CAMKK-Unclassified | 837-929 | 30 | 2.3e-18 | 56.15 | In-house | 312-392 (392) | Show / Hide |
Range on Protein: 837-929 Range on HMM: 312-392/392 Sequence Identity: 30% (29 aa) KACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKH-FFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL | .|. .|||.|...... ||| . |..| .| . . .| .|... . ..|.|||..| .. |.||.||.|.|.|||. KKADIWSLGVTFYCMVYHSLPFWH---KNLQELFHQMICQKEINFPPQYHPHC----------SHEFKDLIQKMCDKNPKKRITIDQMLVHPWF |
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| Kinase | 2721.AA | Aur | 899-929 | 41 | 6.4e-17 | 40.68 | In-house | 227-257 (257) | Show / Hide |
Range on Protein: 899-929 Range on HMM: 227-257/257 Sequence Identity: 41% (13 aa) PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL ..|.||| .|.|. .| .|.|..|...||| SKEAKDLISKILQHDPKQRMTLDQIMNHPWI |
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| Kinase | 2721.AA | Pkinase | 669-777 | 24 | 3.2e-15 | 54.89 | Pfam | 41-159 (293) | Show / Hide |
Range on Protein: 669-777 Range on HMM: 41-159/293 Sequence Identity: 24% (30 aa) ECRELRN--EFRFLKKMDHPRIISLSNNSEFIRDRNYCGLLLPQAEC-----NLMQFAKTQRHGKV--SLAQMRIAFRQIAEAIHYLHENYISHNDIKPD .....|. | . .|...|| |. | .. .|.... . .. .|. |. . .|.|||.. | . . ..||.... |.|.. | | |.||. KDQTHRRLSEIQIMKRLNHPNIVRL---YDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE NMFVFSENDY----KLADFGFA | .. .... |..|||.| NILIDNNGHIDACVKICDFGLA |
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| Kinase | 2721.AA | CAMKK | 733-858 | 24 | 2.4e-14 | 41.5 | In-house | 179-326 (396) | Show / Hide |
Range on Protein: 733-858 Range on HMM: 179-326/396 Sequence Identity: 24% (39 aa) RIAFRQIAEAIHYLH-ENY-------------------ISHNDIKPDNMFVFSEN---DYKLADFGFAIDLPKPNSFKRNSRFSQTLRKQVKIEDLKKNW . ||... .. ||| .. | | ||||.| . .|. |.|||| .. ... .... |. | ... .| WKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNC-ES--------CFQRELNK KQRCKQYVAPELIKLLNGK--------RPRTPSDEKACDVFALGVSFFIIIFYQLPF . . . ||||. |.| | | . ||.|. ||||......|...|| TAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPF |
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| Kinase | 2721.AA | Pkinase | 816-929 | 22 | 3.6e-14 | 51.19 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 816-929 Range on HMM: 177-293/293 Sequence Identity: 22% (29 aa) YVAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGS---ALKTDQRYKHFFKGQ--NEKFWSQFKSML--------TKFQQQENSYPEEL |.|||.|. . . ...|....|. ... .. ..||.|. ||..... ... .. |.. |. . .. .||. YMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF-HWTF-HNWSEEC KDLFNKVLEPEPTKRLTIEQVLEHPWL ||. .. |.. |.||.|.||.|.|||. KDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 2721.AA | Ciliate-E9 | 837-929 | 25 | 6.1e-14 | 40.58 | In-house | 204-298 (298) | Show / Hide |
Range on Protein: 837-929 Range on HMM: 204-298/298 Sequence Identity: 25% (27 aa) KACDVFALGVSFFIIIFYQLPFCGSALKTD-------QRYK--HFFKGQNEKFWSQFKSMLTKFQQQENSYP--EELKDLFNKVLEPEPTKRLTIEQVLE .. |.| .|. |.... | || . | | | |. . || ||.. | | | .|. | |. .| .| .|... QKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIY---------NYRPEEQEFIDMMNWMLQQDPQNRISIQEIRM HPWL |||. HPWM |
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| Kinase | 2721.AA | CAMKL | 655-777 | 25 | 2.2e-13 | 38.95 | In-house | 30-176 (297) | Show / Hide |
Range on Protein: 655-777 Range on HMM: 30-176/297 Sequence Identity: 25% (38 aa) VKIVP-HKMSNHHQIECR----------ELRNEFRFLKKMD---HPRIISLSNNSEFIRDRNY------CGLLLPQAECN---LMQFAKTQRH--GKVSL .||. |..| ..... .| | . .|... || ||.| | | .... . | . .. |... . ..| |. . IKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL---YEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPE AQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSEND--YKLADFGFA . | |||| .|..|.|.. | | ||||.| . . .. |..||||. HEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 2721.AA | CAMKK | 899-929 | 54 | 5.7e-13 | 37.07 | In-house | 366-396 (396) | Show / Hide |
Range on Protein: 899-929 Range on HMM: 366-396/396 Sequence Identity: 54% (17 aa) PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL .|.||||... || .||||.||.|...|||. SEDLKDLIKRMLEKNPTKRITIPQIKVHPWV |
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| Kinase | 2721.AA | Ciliate-E9 | 736-780 | 34 | 6.5e-12 | 33.99 | In-house | 117-162 (298) | Show / Hide |
Range on Protein: 736-780 Range on HMM: 117-162/298 Sequence Identity: 34% (16 aa) FRQIAEAIHYLHENY-ISHNDIKPDNMFVFSENDYKLADFGFAIDL |.|. ..| |.| |.| |.||.|| . . |. |||. . . FKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGMSAQC |
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| Kinase | 2721.AA | Aur | 736-778 | 36 | 7.5e-12 | 27.04 | In-house | 107-150 (257) | Show / Hide |
Range on Protein: 736-778 Range on HMM: 107-150/257 Sequence Identity: 36% (16 aa) FRQIAEAIHYLHENYISHNDIKPDNMFVF-SENDYKLADFGFAI ..||..|..|.|.. | | |||| | . .... |..||| .. MYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSV |
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| Kinase | 2721.AA | CAMKL | 899-929 | 41 | 1.1e-11 | 33.41 | In-house | 268-297 (297) | Show / Hide |
Range on Protein: 899-929 Range on HMM: 268-297/297 Sequence Identity: 41% (13 aa) PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL . ...|| | |.. |.|| ||.|...|||. S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 2721.AA | CAMKK-Unclassified | 726-775 | 25 | 6.2e-09 | 24.91 | In-house | 174-249 (392) | Show / Hide |
Range on Protein: 726-775 Range on HMM: 174-249/392 Sequence Identity: 25% (19 aa) KVSLAQMRIAFRQIAEAIHYLHENY---------------------ISHNDIKPDNMFVFSEND-----YKLADFG | .. . .. |||.. .. |.| . | | ||||.| .| |.|||| KMHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFG |
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| TyrKc | 2721.AA | TyrKc | 611-929 | 11 | 7.9e-05 | -144.52 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 611-929
Range on HMM: 1-280/280
Sequence Identity: 11% (43 aa)
IDEKNFVPNSAFLKQYRQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSNHHQIECRELRNEFRFLKKM--DHPRIISL-----SN--NSEFIRDR
| . . || . |. ... | || ... .....| | ..| .|| |. | . | |. .
ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIE
NYCGLLLPQAECNLMQFAKTQRHGKVSLAQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKP-------NSFKR----NS
.. .. . .| .. . |. ...... |||. |||.. . | |. | | ... | .||| . |. . ..
PLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG
R------------------------------------FSQTLRKQ-----VKIEDLKKNWKQR----CKQYVAPELIKLLNGKRPRTPSDEKACDVFALG
. . |. .. ... .. ||. . ... . .
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----------------------
VSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
| |.|. .. . . .| .| | ... | .
---------------------------------------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 2721.AA | Ciliate-E2 | 625-689 | 15 | 0.009391 | 5.26 | In-house | 1-95 (365) | Show / Hide |
Range on Protein: 625-689 Range on HMM: 1-95/365 Sequence Identity: 15% (15 aa) QYRQRLIGRSSNSKIFELKDSSTDENI----------------GQVVKIVPHKMSNHHQIECREL-RNEFR-------------FLKKMDHPRII ...||. . ..... |. ...... .. .||. |. .. ||| . ...| |....|| || YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII |
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