2721

Species: Tetrahymena
Alias: PreTt02721, 273.m00026, TTHERM_01205310, 2721, 770
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
2721.AA Protein None 931 None Fasta, JSON
2721.kin_dom Protein Kinase Domain None 305 None Fasta, JSON
2721.NA RNA None 2796 None Fasta, JSON

Protein domain

Protein domains of 2721.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2721.AA Ciliate-A7 627-929 40 6.7e-167 560.76 In-house 1-360 (360) Show / Hide
Range on Protein: 627-929
Range on HMM: 1-360/360
Sequence Identity: 40% (146 aa)

RQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSN--------HHQIECRELRNEFRFLKKMDHPRIIS------LSNNSEFIRDRNYCGLLLPQAE
|...|..||||.|||.|.||....|..|.|...|.|.|        ||..||..|.||..||||||||.||.      ..|..||...||.|..|..|||
RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE

CNLMQ-FAKTQRHGKVSLA------------QMRIAFRQIAEAIHYLHEN-YISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQTLRK
|.|.| |.....|......            |||..|||||.|.||||.. .|.||||||.|.|.|..|...........|..........|.|..||| 
CDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLR-

QVKIEDLKKNWKQRCKQYVAPELIKLLNG------KRPRT----PSD------EKACDVFALGVSFFIIIFYQLPF-CGSALKTDQR-YKHFFKGQNEKF
|..|||..||||.|||||.|||.|..||.      .....    ..|      ||.|||||.|||||.|.|.|.|| |... ..|.. |||.|.....||
QQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKF

WS--QFKSMLTKFQ----------QQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
|.  |...|...||          .|........|||.||.|.|.|..|..|.|.|.|||.
WQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF

Kinase 2721.AA Ciliate-C1 736-929 30 4.5e-37 93.43 In-house 135-328 (328) Show / Hide
Range on Protein: 736-929
Range on HMM: 135-328/328
Sequence Identity: 30% (65 aa)

FRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQ-TLRKQVKIEDLKKN---------------WKQRC---KQY
|.|   .| |.|.| | | |.|| | .  ..   |.||||||  |        ||  || || ||. .| . .|               |   |     |
FHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFL--------NSASSQNTLSKQKDGEKMNHNTSSTECSDASSDESHWLYVCMGTEGY

VAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTK
 ||||.        . . . .. | ||.||  |...   .||   |. .|. |. |   .. ..|    . . |   |.| . .|..|| |. |...| |
MAPELHE-------KQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYW----QCHQKNYGQHNFFSNEFMDLINQMLAYNPQK

RLTIEQVLEHPWL
|.|..... |||.
RITLQEIKCHPWY

Kinase 2721.AA Ciliate-E2 736-929 19 1.4e-32 109.14 In-house 151-365 (365) Show / Hide
Range on Protein: 736-929
Range on HMM: 151-365/365
Sequence Identity: 19% (52 aa)

FRQIAE---------------AIHYLHENY-ISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNS--------FKRNSRFSQTLRKQVKIEDLKKNWKQ
..||..               |..|||..  | | ||||.| ..      |..|||.. .. ..|          .    ...| | . ...        
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD--------

RCKQ---------------YVAPELIKLLN------GKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTK
   |               |.||| ..  .      .|.       ..||...||| ... .| ..||                             . .
---QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG-----YDYKCDIWSLGVILYEMLFGKPPF-----------------------------QQQ

FQQQENSYP----------------------EELKDLFNK----VLEPEPTKRLT-IEQVLEHPWL
 .|.. ..|                      .| |||..|     |. .| ||.| .||.|.|||.
IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

S_TKc 2721.AA S_TKc 625-929 19 1.5e-29 105.45 SMART 1-231 (231) Show / Hide
Range on Protein: 625-929
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

QYRQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSNHHQIECRELRNEFRFLKKMDHPRIISLSNNSEFIRDRNYCGLLLPQAEC---NLMQFAKT
    |.||. . .| .  .. .|..     .||..           . .|.| . ||| .|| |. |    ....| ..  . .  ..    .|... | 
YEILRKIGKGAFGKVYKCRHKKTGRIV--AIKIIK-----------EHIRREIQILKK-HHPNIVKL---YDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

QRHGK----VSLAQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKPNSFKRNSRFSQTLRKQVKIEDLKKNWKQRC--KQ
.....     .  . |  ..||..|. |.|.. | | |.||.| .. .    |..|||.|  |                             .  |    
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------------TTFCGTPW

YVAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPT
|.|||..          . . ..||. ..|. ... .  . ||.     ..|.  .  .                        ..|.||. .| |. .|.
YMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPE

KRLTIEQVLE-------HPWL
||.|. ..|.       |||.
KRPTA-EALQDEWDIKCHPWF

Kinase 2721.AA CAMK 630-929 18 4.1e-29 90.38 In-house 1-425 (425) Show / Hide
Range on Protein: 630-929
Range on HMM: 1-425/425
Sequence Identity: 18% (82 aa)

LIGRSSNSKIFELKDS-ST-DEN--------IGQVVKIVPHK-MSNHH-----------------------QIECRELRNEFRFLKK-------MDHPRI
 .|| | .| .. ..  .| .|.            .||.. | .....                       .  ....|.| . .||       .||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISLSN-----------NSEF-IRD------RNYCGLLL------PQAEC--NLMQFAKTQRH-------------GKVSLAQMRIAFRQIAEAIHYLHEN
|.|             |. .   .      .... . .      .  |    | .. . ...             |... .. |  ||||..|.||.|..
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

YISHNDIKPDNMFVFSE-----------------NDYKLADFGFAIDLPKPNS------FKRNSRFSQTLRKQVKIEDLKKNWKQRC--KQYVA-PELIK
 | | |.||.|  . .                  |. |..|||||. ... ..      .| .. .  .   |. ...  .  | .|    |.| ||...
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN---QWTTPTEGQKMKTFCGTPEYMAAPEVLN

LLNGKRPR------TPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQ----FKSMLTKFQQQENSYP--------------
   ..          | . ..||. ..||  .|     .|| |.  . .           |    .     . .. | .. . ..|              
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-------E----WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE

--------------EELKDLFNKVLEPEPTKRLTIEQVLEHPWL
              .| ||| .| |...|.||.||||.|.|||.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 2721.AA Ciliate-E2-Unclassified 628-929 18 1.7e-21 71.37 In-house 4-352 (352) Show / Hide
Range on Protein: 628-929
Range on HMM: 4-352/352
Sequence Identity: 18% (68 aa)

QRLIGRSSNSKIFELKDSSTD---------ENIGQVVKIVPHK---MSNHHQIECRELRNEFR--------FLKKMDHPRIISLSNNSEFIRDRNYCGLL
.. ||. ...|..........          .. . .|.. .|   | . .......  . .|         |. ..|| |.   .  .  .|.... . 
IKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIV---KMFYCFQDKQNIYIV

LPQAE-CNLMQFAKTQRH---------------GKVSLAQMR-----IAFRQIAEAIHYLHENY-ISHNDIKPDNMFVFSEN---DYKLADFGFAIDLPK
. ..|  .|.|. | . .                ...  |..       |.|| ... |||..  | | ||||.| .. ...     |..|||... . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

PNSFKRNS-RFSQTLRKQVKIEDLKKNWKQR-CKQYV----APELIKL-LNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKHFFKG
.| .. .. .       . .| . .. | .    .|     |||...   ....       ..||...||| .. ..| ..|| .   . .| ..  .  
NNNCD-TNQQ------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-

Q---NEKFWSQFKSMLTKFQQQEN-----SYPEELKDLFN----KVLEPEPTKRLTIEQVLEHPWL
.   .. . ...|   ..|. ...       ..| ||. |    | |.  | ||.|.||.|.|||.
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 2721.AA CAMKK-Unclassified 837-929 30 2.3e-18 56.15 In-house 312-392 (392) Show / Hide
Range on Protein: 837-929
Range on HMM: 312-392/392
Sequence Identity: 30% (29 aa)

KACDVFALGVSFFIIIFYQLPFCGSALKTDQRYKH-FFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
| .|. .|||.|...... ||| .   |..|  .|   .  . .| .|... .          ..|.|||..| ..  |.||.||.|.|.|||.
KKADIWSLGVTFYCMVYHSLPFWH---KNLQELFHQMICQKEINFPPQYHPHC----------SHEFKDLIQKMCDKNPKKRITIDQMLVHPWF

Kinase 2721.AA Aur 899-929 41 6.4e-17 40.68 In-house 227-257 (257) Show / Hide
Range on Protein: 899-929
Range on HMM: 227-257/257
Sequence Identity: 41% (13 aa)

PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
..|.||| .|.|. .| .|.|..|...||| 
SKEAKDLISKILQHDPKQRMTLDQIMNHPWI

Kinase 2721.AA Pkinase 669-777 24 3.2e-15 54.89 Pfam 41-159 (293) Show / Hide
Range on Protein: 669-777
Range on HMM: 41-159/293
Sequence Identity: 24% (30 aa)

ECRELRN--EFRFLKKMDHPRIISLSNNSEFIRDRNYCGLLLPQAEC-----NLMQFAKTQRHGKV--SLAQMRIAFRQIAEAIHYLHENYISHNDIKPD
.....|.  | . .|...|| |. |    .. .|.... . .. .|.      |. . .|.|||..  |  . .  ..||.... |.|.. | | |.||.
KDQTHRRLSEIQIMKRLNHPNIVRL---YDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE

NMFVFSENDY----KLADFGFA
| .. ....     |..|||.|
NILIDNNGHIDACVKICDFGLA

Kinase 2721.AA CAMKK 733-858 24 2.4e-14 41.5 In-house 179-326 (396) Show / Hide
Range on Protein: 733-858
Range on HMM: 179-326/396
Sequence Identity: 24% (39 aa)

RIAFRQIAEAIHYLH-ENY-------------------ISHNDIKPDNMFVFSEN---DYKLADFGFAIDLPKPNSFKRNSRFSQTLRKQVKIEDLKKNW
.  ||... .. ||| ..                    | | ||||.|  . .|.     |.|||| .. ... .... |.  |         ... .| 
WKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNC-ES--------CFQRELNK

KQRCKQYVAPELIKLLNGK--------RPRTPSDEKACDVFALGVSFFIIIFYQLPF
 .  . . ||||.   |.|        | |   . ||.|. ||||......|...||
TAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPF

Kinase 2721.AA Pkinase 816-929 22 3.6e-14 51.19 Pfam 177-293 (293) Show / Hide
Range on Protein: 816-929
Range on HMM: 177-293/293
Sequence Identity: 22% (29 aa)

YVAPELIKLLNGKRPRTPSDEKACDVFALGVSFFIIIFYQLPFCGS---ALKTDQRYKHFFKGQ--NEKFWSQFKSML--------TKFQQQENSYPEEL
|.|||.|.         . . ...|....|. ... .. ..||.|.       ||..... ...  ..  |..  |.         . ..      .||.
YMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF-HWTF-HNWSEEC

KDLFNKVLEPEPTKRLTIEQVLEHPWL
||. .. |.. |.||.|.||.|.|||.
KDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 2721.AA Ciliate-E9 837-929 25 6.1e-14 40.58 In-house 204-298 (298) Show / Hide
Range on Protein: 837-929
Range on HMM: 204-298/298
Sequence Identity: 25% (27 aa)

KACDVFALGVSFFIIIFYQLPFCGSALKTD-------QRYK--HFFKGQNEKFWSQFKSMLTKFQQQENSYP--EELKDLFNKVLEPEPTKRLTIEQVLE
.. |.| .|.  |.... | ||  .    |       | |    |.    . || ||..         |  |   | .|. |  |. .| .| .|...  
QKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIY---------NYRPEEQEFIDMMNWMLQQDPQNRISIQEIRM

HPWL
|||.
HPWM

Kinase 2721.AA CAMKL 655-777 25 2.2e-13 38.95 In-house 30-176 (297) Show / Hide
Range on Protein: 655-777
Range on HMM: 30-176/297
Sequence Identity: 25% (38 aa)

VKIVP-HKMSNHHQIECR----------ELRNEFRFLKKMD---HPRIISLSNNSEFIRDRNY------CGLLLPQAECN---LMQFAKTQRH--GKVSL
.||.   |..|  .....           .| | . .|...   || ||.|    | | ....      . | .  ..     |... . ..|  |. . 
IKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL---YEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPE

AQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSEND--YKLADFGFA
 . |  |||| .|..|.|.. | | ||||.|  . . ..   |..||||.
HEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS

Kinase 2721.AA CAMKK 899-929 54 5.7e-13 37.07 In-house 366-396 (396) Show / Hide
Range on Protein: 899-929
Range on HMM: 366-396/396
Sequence Identity: 54% (17 aa)

PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
.|.||||... || .||||.||.|...|||.
SEDLKDLIKRMLEKNPTKRITIPQIKVHPWV

Kinase 2721.AA Ciliate-E9 736-780 34 6.5e-12 33.99 In-house 117-162 (298) Show / Hide
Range on Protein: 736-780
Range on HMM: 117-162/298
Sequence Identity: 34% (16 aa)

FRQIAEAIHYLHENY-ISHNDIKPDNMFVFSENDYKLADFGFAIDL
|.|. ..| |.|    |.| |.||.|| .    . |. |||. . .
FKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGMSAQC

Kinase 2721.AA Aur 736-778 36 7.5e-12 27.04 In-house 107-150 (257) Show / Hide
Range on Protein: 736-778
Range on HMM: 107-150/257
Sequence Identity: 36% (16 aa)

FRQIAEAIHYLHENYISHNDIKPDNMFVF-SENDYKLADFGFAI
..||..|..|.|.. | | |||| |  .  .... |..||| ..
MYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSV

Kinase 2721.AA CAMKL 899-929 41 1.1e-11 33.41 In-house 268-297 (297) Show / Hide
Range on Protein: 899-929
Range on HMM: 268-297/297
Sequence Identity: 41% (13 aa)

PEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
. ...||  | |.. |.|| ||.|...|||.
S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 2721.AA CAMKK-Unclassified 726-775 25 6.2e-09 24.91 In-house 174-249 (392) Show / Hide
Range on Protein: 726-775
Range on HMM: 174-249/392
Sequence Identity: 25% (19 aa)

KVSLAQMRIAFRQIAEAIHYLHENY---------------------ISHNDIKPDNMFVFSEND-----YKLADFG
| .. . .. |||.. .. |.| .                      | | ||||.|    .|        |.||||
KMHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFG

TyrKc 2721.AA TyrKc 611-929 11 7.9e-05 -144.52 SMART 1-280 (280) Show / Hide
Range on Protein: 611-929
Range on HMM: 1-280/280
Sequence Identity: 11% (43 aa)

IDEKNFVPNSAFLKQYRQRLIGRSSNSKIFELKDSSTDENIGQVVKIVPHKMSNHHQIECRELRNEFRFLKKM--DHPRIISL-----SN--NSEFIRDR
|  .    . || . |. ...                          |  || ...    .....| | ..|   .|| |. |     .   |  |. . 
ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIE

NYCGLLLPQAECNLMQFAKTQRHGKVSLAQMRIAFRQIAEAIHYLHENYISHNDIKPDNMFVFSENDYKLADFGFAIDLPKP-------NSFKR----NS
 .. ..   .  .| .. .  |.  ......     |||.   |||.. . | |.   |  | ...  | .||| . |.             .     ..
PLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R------------------------------------FSQTLRKQ-----VKIEDLKKNWKQR----CKQYVAPELIKLLNGKRPRTPSDEKACDVFALG
.                                    . |.         .. ... .. ||.    . ...  . .                       
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----------------------

VSFFIIIFYQLPFCGSALKTDQRYKHFFKGQNEKFWSQFKSMLTKFQQQENSYPEELKDLFNKVLEPEPTKRLTIEQVLEHPWL
                                             |       |.|. ..  .  . .| .| | ...  |  .
---------------------------------------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 2721.AA Ciliate-E2 625-689 15 0.009391 5.26 In-house 1-95 (365) Show / Hide
Range on Protein: 625-689
Range on HMM: 1-95/365
Sequence Identity: 15% (15 aa)

QYRQRLIGRSSNSKIFELKDSSTDENI----------------GQVVKIVPHKMSNHHQIECREL-RNEFR-------------FLKKMDHPRII
   ...||. . ..... |. ......                .. .||.  |. .. |||  .   ...|              |....|| ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII