Gene 7343 (Tetrahymena)
7343
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 7343.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| DUF221 | 7343.AA | DUF221 | 545-584 | 34 | 0.000181 | 14.13 | Pfam | 18-56 (338) | Show / Hide |
Range on Protein: 545-584 Range on HMM: 18-56/338 Sequence Identity: 34% (14 aa) VQHQMIYKDNKL-SVIQAPDPTDINWNNLHYSQNEKIKRRY .||... ... . ||.| || | ||. | |.. ||. LQHHHP-M-YHWTPTYIAPEPHDIIWENLSMSWWERWIRRF |
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| DUF221 | 7343.AA | DUF221 | 713-740 | 42 | 0.015338 | 8.18 | Pfam | 272-299 (338) | Show / Hide |
Range on Protein: 713-740 Range on HMM: 272-299/338 Sequence Identity: 42% (12 aa) YSPIVPMTIFWSLIGLILQYWVDKYNLI ||.| |. ...|...| |.|.||.|| YSVICPLILPFGAIYFCLGYFVYKYQLI |
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| Kinase | 7343.AA | Ciliate-A8 | 1240-1380 | 48 | 1.7e-87 | 297.0 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 1240-1380 Range on HMM: 1-151/151 Sequence Identity: 48% (73 aa) YKYQKLLGKNDFSYMIVAYSIKFGCLVSIKVIQMLNGVNRVNKKKIDEQMQTLQKIRNESYVLYIIESIQDEEHGLFAIVYQYCSC--------NLDTIL |||||.|.|.||||...||||...|.|.||.|...|..|..|.|......|..|||.||.|.|.|||.|||.|.|..|||...|.| ||..|| YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL N--LNKLELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYNNLFL . |||...||..|..|||||.|....|..|.|..|||.|||.|...|.|. ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 7343.AA | Ciliate-E1 | 1246-1424 | 21 | 1.3e-27 | 87.16 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 1246-1424 Range on HMM: 1-202/202 Sequence Identity: 21% (43 aa) LGKNDFSYMIVAYSIKFG-CLVSIKVIQMLNGVNRVNKKKIDEQMQTLQKIRNESYVLYIIESIQDEEHGLFAIVYQYCSCNLDTILN------------ .|...|| .. |.... . | .|.|.. | ... .. .. . ..|...| |...||. |.... ...|. ..|.|.| |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ --LNKLELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYNNLFLITDFGLNQ--TPQSFKSTQIFCCRDSENTQGLVI------QYNSNM-KNS |.. .|......||..|||.|. . |.| .||| |||.... . ....|||. . .. ...|... .. . . ..| .. ..| QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIF ||. DIY |
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| Kinase | 7343.AA | Ciliate-B2 | 1281-1385 | 27 | 8.3e-12 | 23.94 | In-house | 42-149 (197) | Show / Hide |
Range on Protein: 1281-1385 Range on HMM: 42-149/197 Sequence Identity: 27% (30 aa) NKKKIDEQMQTLQKIRNESYVLYIIESIQDEEHGLFAIVYQYCSCNLDTILN---LNK--LELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKY .|. |.. .. .. . .| .|..|| .| .. . | | | |. . . . . . | .||. ||| . . |.| ||| ||||... DKEEIQHEIKIMKMFEYNINVVKYIDHIQINET-IDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN NNLFLITDFG .| .. .||| GN-YVYCDFG |
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| Kinase | 7343.AA | S_TKc | 1240-1490 | 19 | 2.1e-11 | -9.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1240-1490
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)
YKYQKLLGKNDFSYMIVAYSIKFGCLVSIKVIQMLNGVNRVNKKKIDEQMQTLQKIRNESYVLYIIESIQDEEHGLFAIVYQYCSC---NLDTILNLNK-
|. ...|| |. .. .| | .| ||.| ..| .| |.| . .. .....|| . . .| ||. .| ... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR
------LELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYNNLFLITDFGL-NQTPQSFKSTQIFC----CRDSENTQGLVIQYNSNMK-NSDI
. .. ..||....| . .. | | .|| |||... |.|||| | .| | .. . . | .|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL--------------GYGKCKCDW
FNLGIILIEAFIQRRLTQNEKQDIINQPSLLQALPFLKNSKKFK-FVEQILCK------MIDQNND---DTKLLPYS
.|.||.| . . . . . | .... |. .| |....|.| . . | |. |.
WSCGCILYEMLCGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 7343.AA | Ciliate-E2-Unclassified | 1269-1386 | 17 | 2.9e-10 | 31.85 | In-house | 17-193 (352) | Show / Hide |
Range on Protein: 1269-1386
Range on HMM: 17-193/352
Sequence Identity: 17% (32 aa)
KVIQMLNG---------VNRVNKKKIDEQ----------MQTLQ--------KIRNE-------SYVLYIIESIQDEEHGLFAIVYQYC-SCNLDTILNL
|... .. .....|.|. .. |. .. || .. .... .. ||... . ||..|| .| ...
KCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYIVMEYCEGGDLWQYIKK
------------------NKLELEQVL-----AMAYQLLKGL-IILYENSITHNNIKPNNILFSKYNN--LFLITDFGL
.... .|.. ...|.|.|| . ..| | | .|||.||||.. .. |.|||.
RKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI
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| Kinase | 7343.AA | Ciliate-E3 | 1240-1386 | 29 | 4.4e-09 | 24.78 | In-house | 1-152 (202) | Show / Hide |
Range on Protein: 1240-1386 Range on HMM: 1-152/202 Sequence Identity: 29% (45 aa) YKYQKLLGKNDFSYMIVAYSIKFGCLVSIKVIQMLNGVN---RVNKKKIDEQMQTLQKIRNESYVLYIIESIQDEEHGLFAIVYQYCSC-NLDTILNLNK | |..||. |. |.. | ||.| | | . .| . | |.| | .|. . ... |.. . ||..||| .| . . . YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIK--Q LELEQ--VLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYNN--LFLITDFGL ... | .. .. |...|.|.. | | | ||| ||| .| || | |||. QNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGE |
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| Kinase | 7343.AA | Ciliate-E2 | 1240-1386 | 19 | 5.4e-09 | 27.0 | In-house | 1-202 (365) | Show / Hide |
Range on Protein: 1240-1386 Range on HMM: 1-202/365 Sequence Identity: 19% (40 aa) YKYQKLLGKNDFSYMIVAYSIKFGCLVSIK--------------VIQMLNGVNRVNKKKIDEQMQTLQKIR---------NE---------SYVLYIIES || .|..|. |. . .| .... || | ... .....|..| ...| .. .| || ... ..|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IQDEEHGLFAIVYQYCSC-NLDTILNLN------------KLELEQVLAMAYQLLK---------------GLIILYENS-ITHNNIKPNNILFSKYNNL |.. . .| ||. .| ... | .. ..... . .|.|. .| | .. | | .|||.|||| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FLITDFGL |.|||| IKIIDFGL |
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| Kinase | 7343.AA | ULK | 1318-1386 | 25 | 1.3e-08 | 26.31 | In-house | 97-188 (329) | Show / Hide |
Range on Protein: 1318-1386 Range on HMM: 97-188/329 Sequence Identity: 25% (23 aa) IVYQYCSC-NLDTILNLNK-----------LELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYN-----------NLFLITDFGL |.. || .|..... || |. .... .|.| |. |... | | ||| ||| .. . . . |.|||. IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF |
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| Kinase | 7343.AA | Ciliate-E4 | 1344-1375 | 34 | 8.5e-08 | 22.58 | In-house | 112-143 (150) | Show / Hide |
Range on Protein: 1344-1375 Range on HMM: 112-143/150 Sequence Identity: 34% (11 aa) MAYQLLKGLIILYENSITHNNIKPNNILFSKY .|... .. |. |||...|| ||.|. | IAFCCINAMYYLQQVNITHGDLKPSNIFFDQY |
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| Kinase | 7343.AA | CLK | 1336-1374 | 33 | 1.2e-07 | 18.29 | In-house | 111-149 (350) | Show / Hide |
Range on Protein: 1336-1374 Range on HMM: 111-149/350 Sequence Identity: 33% (13 aa) LELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSK ...... .|||||.. . | ....|| || ||.|.. YPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD |
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| Kinase | 7343.AA | DYRK2 | 1338-1371 | 41 | 4.3e-07 | 18.76 | In-house | 101-134 (318) | Show / Hide |
Range on Protein: 1338-1371 Range on HMM: 101-134/318 Sequence Identity: 41% (14 aa) LEQVLAMAYQLLKGLIILYENSITHNNIKPNNIL |. | ..|...|..| |..| | | || ||| LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL |
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| Kinase | 7343.AA | Pkinase | 1304-1386 | 22 | 1e-06 | 24.82 | Pfam | 65-158 (293) | Show / Hide |
Range on Protein: 1304-1386 Range on HMM: 65-158/293 Sequence Identity: 22% (22 aa) IIESIQDEEHGLFAIVYQYCSC-----NLDTILN---LNKL--ELEQVLAMAYQLLKGLIILYENSITHNNIKPNNILFSKYNNL---FLITDFGL .... .| .. .| || . | ... ... . ... ..||.|.|| .....| | .|| |||... ... . |.|||| LYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL |
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