Gene 20856 (Tetrahymena)

20856

Species: Tetrahymena
Alias: 519, 3700.m00249, PreTt20856, 20856, TTHERM_00151980, 12.m00530
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-B1

Sequence

Name Sequence Type Origin Length Description Download
20856.AA Protein None 1094 None Fasta, JSON
20856.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
20856.NA RNA None 3285 None Fasta, JSON

Protein domain

Protein domains of 20856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20856.AA Ciliate-B1 22-262 39 1.3e-144 486.77 In-house 1-290 (290) Show / Hide 
Range on Protein: 22-262
Range on HMM: 1-290/290
Sequence Identity: 39% (115 aa)

YRVKGVLGHGAISEVLIG-----SICNEE---------DPFNE--QDVAIK-EKDIVHKLSTQR-----------DDHIVNIIEVIETNDTYYIVMEYCE
|....|.|.||||.|..|     ..|..|         ...|.  |..... |..|...|....           .|||.||..||.....|||.|||||
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

NGSLLDQIYLEIPNRL-KVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEK---------DGQYILKIGDYGLGKNEEIYMMHSCIGTINYMAPEMI
.|.|...|| ...|.. ..|..|..|..|||..||.|.|.|||||||||.||.|         ...||.||.|.|..|....|||.||.|||||||||..
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAPEIL

R-KQEYDFTVDIWALGCIMHELITGEQLFA--DFTIAEISNQIRSMEE--YRCIEG-NFGNLISR-----CLQPIASNRIKVNDLYIELY
. .|.||..||||..||||.|.||.||||.  ..|..|..||||....  |.|... |....|..     ||||...|||........|.
NFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 20856.AA S_TKc 22-262 25 8.7e-51 175.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-262
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

YRVKGVLGHGAISEVLIGSICNEEDPFNEQDVAIK--------EKDIVHKLSTQRDDHIVNIIEVIETNDTYYIVMEYCEN--GSLLDQIYLEIP-----
|..  ..|.|| ..|  .   .       . ||||        | .| .|    . ..||....|... | .|.|||||..  |.|.| |    .     
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIKEHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-NRLKVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQYILKIGDYGLGKNEEIYMMHSCIGTINYMAPEMIRKQEYDF-TVDIWALGCIMHEL
     ..  .  |. ... ..| ||| |||||||||.. |      .||.| || .       ....|| .|||||..    |..  .|.|..|||. |.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGEQLFADFTIAEISNQIRSMEEYRCIEGNFGNLISRCLQPIASNRIKVNDLYI--------ELY
..|. .|   ..... ..|.           . ..|..|||   ..|. . ..          .  
LCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20856.AA Ciliate-E2 22-257 17 1.2e-47 161.65 In-house 1-359 (365) Show / Hide 
Range on Protein: 22-257
Range on HMM: 1-359/365
Sequence Identity: 17% (65 aa)

YRVKGVLGHGAISEVLIG--SICNEEDP----------------FNEQDVAIKEK-----DIVHKLSTQR------------------DDH--IVNIIEV
| .  ..| |. . |  .     ...                  .. . .|.| .      .. .   .                   ..|  |....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TNDTYYIVMEYCENGSLLD------QIYLEIPN-----RLKVVVNFSTQLTK---------------GITFLHAHG-IAHRDLKPENIFIHEKDGQ
 .  .....|.|||||. |.|.|      .  .....      .| . ....|...               .. .||  . | |||.|||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

YILKIGDYGLGK-----NEEIY----------------------------MMHSCIGTINYMAPEMIRKQE---------YDFTVDIWALGCIMHELITG
  .|| | || |     |....                            | ....|| .|||||......         ||. .|||.||.|..|...|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

EQLFADFTIAEISN---QIRSME-------------EYRCIEGNFGNLISR----CLQPIASNRIK-VNDL
.  |    . .| .   .... |             ..  .. .  .||..    .||   ..||   ...
KPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 20856.AA Pkinase 70-211 37 8.8e-47 166.5 Pfam 60-212 (293) Show / Hide 
Range on Protein: 70-211
Range on HMM: 60-212/293
Sequence Identity: 37% (58 aa)

DHIVNIIEVIETNDTYYIVMEYCENG----SLLDQIY--LEIPN--RLKVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQY--ILKIGDYGL
..|| .... |..| .|.||||||.|    .| | |    . .     ... .. .|. .|. ..|..|| |||||||||.|. ..|.   ..||.| ||
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGL

GK---NEEIYMMHSCIGTINYMAPEMIR-KQEYDFTVDIWALGCIMHELITGEQLF
 |   .     |..  ||..||||| ||  |.|.  ||.|..|||..|...|. .|
AKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase 20856.AA CAMK 56-256 17 3.1e-44 140.0 In-house 80-418 (425) Show / Hide 
Range on Protein: 56-256
Range on HMM: 80-418/425
Sequence Identity: 17% (60 aa)

KEKDIVHKLSTQR----DDHIVNIIEVIE------------TNDT--------YYIVM---EYCENG----SLLDQIYLE------------IPNR----
.| .|  ||.  .      .|....||.|            | ..        .|.||   |||..|     |.| |               . .|    
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFT

LKVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFI-HEKDGQ-------------YILKIGDYGLGKNEEI-------------------------YMMH
 . .  .  |.  .. ..| |.|.||||||||| . . .|..             . .|| | |. .  .                           .|.
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK

SCIGTINYMA-PEMIRK--------------QEYDFTVDIWALGCIMHELITGEQLFADF-------------TIAEISNQIRSMEEYRCIEG-------
 . ||  ||| ||....              . |.. .|.|..|.|.  . .|.  | .              .. |.  .|.. . .   .        
TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN

-------------------NFGNLISRCLQPIASNRIKVND
                      .||...||.  ..|... .
YGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase 20856.AA ULK 55-208 30 2.6e-43 149.09 In-house 58-253 (329) Show / Hide 
Range on Protein: 55-208
Range on HMM: 58-253/329
Sequence Identity: 30% (59 aa)

IKEKDIVHKLSTQ-RDDH----IVNIIEVIETN--DTYYIVMEYCENGSLLDQIYLEIPNRLKV----------VVNFSTQLTKGITFLHAHGIAHRDLK
..| .| .||  . |  .    ||  ... ||   . .||.||||. | | . |    .  ...          ...|  |.  |  .|| |.| |||.|
KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIK

PENIFIHEKDGQ---------YILKIGDYGLGKNEEIY-----MMHSCI------GTINYMAPEMIR----KQEYD-FTVDIWALGCIMHELITGE
|.|| ||.....         ..|||.| |..|  .       ||..|       ||  ||||. .     ...|. ...||| ||||..|...|.
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase 20856.AA ULK 71-208 31 8.7e-43 148.46 In-house 76-249 (324) Show / Hide 
Range on Protein: 71-208
Range on HMM: 76-249/324
Sequence Identity: 31% (55 aa)

HIVNIIEVIETN--DTYYIVMEYCENGSLLDQIYLEIPNRLKV----------VVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQ---------
|||  ... ||   . .||.||||. | | . |    .  . .          ...|  |.  |  .|| |.| |||.||.|| ||.....         
HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPN

YILKIGDYGLGKN-----EEIYMMHSCI------GTINYMAPEMIR----KQEYD-FTVDIWALGCIMHELITGE
..|||.| |..|      .|  |...|       ||  ||||. .     ...|. . .||| ||||..|...|.
GVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase 20856.AA Ciliate-E2a 70-224 32 2.9e-41 119.23 In-house 59-229 (275) Show / Hide 
Range on Protein: 70-224
Range on HMM: 59-229/275
Sequence Identity: 32% (55 aa)

DHIVNIIEVIETNDTYYIVMEYCENGSLLDQIYLEIPNRLK--VVVNFSTQLT-KGITFLHAHGIAHRDLKPENIFIH--EKDG--QYILKIGDYGLGKN
..|  ..|| |....||.|||||| |.|.| |     .  .  ..  .  ||. .|.  .|  .| |||||||||..    |..  .  .|| | ||...
PNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATF

E--EIY-MMHSCIGTINYMA------PEMIRKQEYDFTVDIWALGCIMHELITGEQLFADFTIAEISNQIR
    ..  |..  ||  |.|      .| . .. ||  .|.| .|.|.. |..|...|   | .||  |..
IDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNK
Kinase 20856.AA TKL 28-261 16 4.5e-41 142.79 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-261
Range on HMM: 1-364/364
Sequence Identity: 16% (62 aa)

LGHGAISEVLIGSICNEEDPFN----EQDVAIKEKDIVH---------------------------------------KLSTQRDDHIVNIIE-VIETND
.| |. .||  |   ..          .|||.|   . .                                        .|  | ..|| ..  ... ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

T------------YYIVMEYCENGSLLDQIYLEIPNRLKVVVNFSTQLTKGITFLHAHG--------IAHRDLKPENIFIHEKD-----------GQYIL
.            ..||||||..||||...       . . .... .  .|. .||...        |.|||||..||...|.             .. .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDYGLGK-NEEIY--------------------MMHSCIGTINYMAPEMIRKQ----------------EYDFTVDIWALGCIMHELITGEQLFADFT
||.|.|| . ...                      . ....||...||||..|.|                ||.  .|... | .. |..|... ..|. 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

IA--------EISNQIRSMEEYR-------------CIEGN----FGNLISRCLQPIASNRIKVNDLYIEL
          |.   ... . .|             | . .    . .|. .| .. ...|   ...  .|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20856.AA Ciliate-E2-Unclassified 22-223 20 1.1e-40 138.89 In-house 1-298 (352) Show / Hide 
Range on Protein: 22-223
Range on HMM: 1-298/352
Sequence Identity: 20% (62 aa)

YRVKGVLGHGAISEVLIGSICNEEDPFNEQDVAIKEKDIVHKLSTQR---------------------------------DDHIVNIIEVIETNDTYYIV
|..  ..|.|. ..|      ..   .. .  ..| ...  |.  .                                  . .||. ... .. .. |||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCENGSLLDQIYLEIP-----------------NRLKVVV-----NFSTQLTKGITFLHAHG-IAHRDLKPENIFIHEKDGQYILKIGDYGL----GK
|||||.|.|.. |                         . ..     ..  |. .|. .||  . | |||.|||||..... . | .|| |.|.    ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

NEEIY-------------MMHSCIGTINYM----APEMIRKQEYD----FTVDIWALGCIMHELITGEQLFADFTIAE----------------ISNQI
|....             ||....||.|||    |||....|.||    . .|||.||.|..|...|.  | | .  .                . ..|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
Kinase 20856.AA STE 70-257 20 1.1e-37 130.67 In-house 90-351 (359) Show / Hide 
Range on Protein: 70-257
Range on HMM: 90-351/359
Sequence Identity: 20% (56 aa)

DHIVNIIEVIETN-------DTYYIVMEYCENGSLLDQIYL--EIPNR------------LKVVVNFSTQLTKG-ITFLHAHGIAHRDLKPENIFIHEKD
..||. .   . .       |. .|.|||...||| | |    .....             ...  .  |. ||   .|| |.| |||.|| ||..    
PNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----

GQYILKIGDYGLGK--NEEIY----------------MMHSCIGTINYMAPEMIRK------QEYDFTVDIWALGCIMHELITGEQLFADFTIAEISNQI
     |. | |. .  ....                 .  ...||  .||||.|..      ..||. .||| ||| . |..||.  ..|..  .   .|
----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMI

RSM--------------EEYRCIEG-----------------------NFGNLISRCLQPIASNRIKVNDL
  .              ..   ..                        .| . |..|||   ..| ....|
PFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase 20856.AA CAMKL 117-257 26 7e-27 82.69 In-house 134-291 (297) Show / Hide 
Range on Protein: 117-257
Range on HMM: 134-291/297
Sequence Identity: 26% (43 aa)

TQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQYILKIGDYGLGKNEE-I----Y-MMHSCIGTINYMAPEMIRK--QEYD-FTVDIWALGCIMHELITG
.|.  .. ..| |||.|||.||||| . |.. .  .|| | |..   . .      ... . |. .|||||.. .  ..|| . ||||..| |.  ...|
RQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCG

EQLFADFTIA-------EISNQIRSMEEYRC----IEGNFGNLISRCLQPIASNRIKVNDL
.  | | |..       .  ..|..  .| .    .     .||.. ||.  . |... ..
YLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI
Kinase 20856.AA TyrKc 22-261 19 1.8e-16 43.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-261
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YRVKGVLGHGAISEVLIGSICNEEDPFNEQDVAIK------EKDIVH---KLSTQ--RDDHIVNIIEVIETN-------DTYYIVMEYCENGSLLDQI-Y
 . . .||.||  ||  |           ..||.|      ..|. .    ..    . ..||... |. .        . ..|||||...|.|.| . .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LEIPNRLKVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQYILKIGDYGLGKNE----------EIYMMH---SCI--GTINYMAPEMIRKQE
 .    .|  ..|..|  .|  .|| ... ||||   |. ..|.    . ||.| || ..           . |..    ..     |  |||| |.. .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDFTVDIWALGCIMHELIT-GEQLFAD-----FTIAEISNQIRSMEEYRCIEG-----------NFGNLISRCLQPIASNRIKVNDLYIEL
. .  |.|. |  | |. | |.|   .      . .|. ..... .  .. .               .....| .  ...|   .... ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20856.AA Pkinase_Tyr 70-225 28 7.3e-13 44.19 Pfam 64-231 (270) Show / Hide 
Range on Protein: 70-225
Range on HMM: 64-231/270
Sequence Identity: 28% (49 aa)

DHIVNIIEVIE-TNDT--YYIVMEYCENGSLLDQIYL----EIPNRLKVVVNFSTQLTKGITFLHAHGIAHRDLKPENIFIHEKDGQYILKIGDYGLGK-
..||. . |.    .   .||||||...|.|||        . |  .|  .....|  ||  .|..... ||||   |. ..|   . . ||.| || . 
PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARD

--NEEIY--MMHSCIGTINYMAPEMIRKQEYDFTVDIWALGCIMHELIT-GEQL-FADFTIAEISNQI-RS
  |.. |  . ...   |  |||| |.  ..    |.|. |  | |..| |||  ... . .|. ..| ..
IYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase 20856.AA CAMKL 22-99 23 1.5e-12 36.2 In-house 1-112 (297) Show / Hide 
Range on Protein: 22-99
Range on HMM: 1-112/297
Sequence Identity: 23% (28 aa)

YRVKGVLGHGAISEVLIGSICNEEDPFNEQDVAIKEKD------------------------------IVHKLSTQR-DDHIVNIIEVIETNDT------
||.  .||.|. ..|  .  .       .. ||||  |                              |  .|.  .   .|. . ||||| ..      
YRIGKTLGKGSFGKVKLATHIRTT----GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKK

YYIVMEYCENGS--LLD
.|.|||||..|.  |.|
IYLVMEYCSGGEMDLFD