Gene 9437 (Tetrahymena)
9437
Group:
Other
Family:
Ciliate-B1
Sequence
Protein domains of 9437.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9437.AA | Ciliate-B1 | 54-227 | 45 | 2.6e-106 | 359.47 | In-house | 98-290 (290) | Show / Hide |
Range on Protein: 54-227 Range on HMM: 98-290/290 Sequence Identity: 45% (88 aa) YCEAGSLFNYILN-QKSMAQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFT---------KRNGNHVFKITDFGYSCIGQN-QLQSIIGTINYIAP |||.|.|.|||.| .......|....|.|||||.|.||...|.||||||..||.. |......|||||||.|...|. ..||..|||||.|| YCEQGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAP EILS-QQSYSKTVDIWALGLTMYEIAYRKQLFQ--QKTVQQTAQMILSFKCLDDHGHSQNDLFQVIKE-----CLNPDTEARIKIDQVVEILQ |||. .|.|.|.||||..|..||||....|||. ..|.|..|..|..|.|.|...|.||...|.|.. ||.||.|.||.|||....| EILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM |
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| Kinase | 9437.AA | TKL | 54-226 | 19 | 9.6e-38 | 131.71 | In-house | 119-364 (364) | Show / Hide |
Range on Protein: 54-226
Range on HMM: 119-364/364
Sequence Identity: 19% (50 aa)
YCEAGSLFNYILNQKSMAQIIQIQICLQIAKGLQWLHSQD--------IIHRDLKPDSILFTKRNGNH-----------VFKITDFGYSCIGQN------
||. |||..|.. ....|.||.|...|||.. |||||||.. || . . |. . ||.||| | ..
YCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND
----------------QLQSIIGTINYIAPEILSQQ----------------SYSKTVDIWALGLTMYEIAYRKQLFQ-QKTVQQTAQ----MILSFKCL
.. ...||... |||.| .| .||. .|... |. ..||. |.. .. .. .. .| .... |.
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD
-----------------DDHGHSQNDLFQVIKECLNPDTEARIKIDQVVEIL
. . .. . ...| ..| |.| ......|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
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| Kinase | 9437.AA | Pkinase | 54-226 | 26 | 7.2e-36 | 127.91 | Pfam | 81-293 (293) | Show / Hide |
Range on Protein: 54-226 Range on HMM: 81-293/293 Sequence Identity: 26% (57 aa) YCEAG----SLFNYIL--NQKSM--AQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNGNHV---FKITDFGYSC---IGQNQLQSIIGTINY ||| | .|| || ..... . ...||..||. .||. ||||||||. ||. | .|. .||.||| .. . |..... ||..| YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWY IAPEILS-QQSYSKTVDIWALGLTMYEIAYRKQLFQQK------TVQQTAQMILSFKCLDDHGHSQ--------------------NDLFQVIKECLNPD .|||.. .| |.. ||.|..|...|| . .. .|... . .| ..|.. . | . .. ..|| ||..| MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD TEARIKIDQVVEI--L . |. ..|... . PKKRPTAEQILQHPWF |
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| Kinase | 9437.AA | Ciliate-E2 | 54-222 | 25 | 8.7e-36 | 120.31 | In-house | 115-359 (365) | Show / Hide |
Range on Protein: 54-222
Range on HMM: 115-359/365
Sequence Identity: 25% (66 aa)
YCEAGSLFNYILNQ-KSMAQIIQ-------IQIC---LQIAK---------------GLQWLHSQD-IIHRDLKPDSILFTKRNGNHVFKITDFGYS---
||. |.|| || |. |. ..|. .|. ||.. .|. |||. |||||.||. ||| ||.|||.|
YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKY
-------------------------------CIGQNQLQSIIGTINYIAPEILSQQS---------YSKTVDIWALGLTMYEIAYRKQLFQQKTVQQTAQ
| ||. ..|.|| .| |||||. .. |.. .|||.|| ..|| . | | | .
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQI
MI--LSFKCLD-------------DHGHSQNDLFQVIKE----CLNPDTEARIK-IDQV
. ..| | . .. . .. . || .|. | | || ..|.
KQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
|
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| Kinase | 9437.AA | Ciliate-E2-Unclassified | 54-222 | 24 | 9.1e-34 | 114.51 | In-house | 102-346 (352) | Show / Hide |
Range on Protein: 54-222
Range on HMM: 102-346/352
Sequence Identity: 24% (60 aa)
YCEAGSLFNYILNQKS-------------------MAQII---QIQICLQIAKGLQWLHSQD-IIHRDLKPDSILFTKRNGNHVFKITDFGYS-------
||| |.|..|| ..|. |.. . ... || .||. ||.. |||||.||. |||.. ..| ||.||| |
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN
-----------CIGQNQLQSIIGTINYI----APEILSQQSYSKT----VDIWALGLTMYEIAYRKQLFQQKTVQQ----------------TAQMILSF
. |. .....||.||. |||.| .| |... .|||.|| .||. . . |.... | | |.
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK
KCLDDH-------GHSQNDLFQVIK----ECLNPDTEARIKIDQV
.. .. |... |. .|. . . || ..|.
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
|
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| Kinase | 9437.AA | ULK | 54-170 | 31 | 1.8e-32 | 110.7 | In-house | 101-253 (329) | Show / Hide |
Range on Protein: 54-170 Range on HMM: 101-253/329 Sequence Identity: 31% (48 aa) YCEAGSLFNYIL----------NQKSMAQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNG---------NHVFKITDFGYSCI-GQN----- ||. | |..|| ..| . . ||.. ||. |...||.. |||||.||. || .. .. | |.||.||| . . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ QLQSII------GTINYIAPEILS----QQSYS-KTVDIWALGLTMYEIAYRK .... || | ||.||. |. |. ...||| || .||. | | MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK |
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| Kinase | 9437.AA | ULK | 54-225 | 25 | 6e-32 | 110.68 | In-house | 98-321 (324) | Show / Hide |
Range on Protein: 54-225 Range on HMM: 98-321/324 Sequence Identity: 25% (57 aa) YCEAGSLFNYIL---------NQKSMAQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNG---------NHVFKITDFGYSCI------GQNQ ||. | |..|| ..| . . ||.. ||. |...||.. |||||.||. || .. .. | |.||.||| . . |.. YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM LQSII------GTINYIAPEILS----QQSYS-KTVDIWALGLTMYEIAYRKQLFQQKTVQQTA-------------QMILSFKCLDDH-----GHSQND .|.. || | ||.||. |. |. . .||| || .||. | | |. ... | . . .. . .. CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE LFQVIKECLNPDTEARIKIDQVVEI . . |. .| | . || .... .. CKDLIRRMLQYDEKDRISWEEIFNH |
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| S_TKc | 9437.AA | S_TKc | 14-230 | 21 | 4.5e-31 | 110.48 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-230 Range on HMM: 1-231/231 Sequence Identity: 21% (57 aa) YKVLGLISQGLSKQTYLVEGEKSKERFSMKVFREQNADSK------------------------------YCEA--GSLFNYILNQKS------MAQIIQ |..| .| .| . |.. |..... .|. . . . ||. |.|| || .... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA IQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNGNHVFKITDFGYSCIGQNQLQSIIGTINYIAPEILSQQSYSK-TVDIWALGLTMYEIAYRKQLFQ .. ||...|. .||. ||||||||. ||... . ||.||| ... ...|| .|.|||.| .|.| .|.|..| ..|| .... .|. RFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP QKTVQQTAQMILSFKCLDDHGHSQNDLFQVIKECLNPDTEARIKIDQVVE-----ILQRMY ..|.. ..|. .. . |. ||. | | |. . .. . . --QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 9437.AA | CAMK | 54-224 | 17 | 6e-30 | 93.11 | In-house | 141-421 (425) | Show / Hide |
Range on Protein: 54-224
Range on HMM: 141-421/425
Sequence Identity: 17% (49 aa)
YCEAG----SLFNYILNQKS---------------MAQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNGN--------------HVFKITDF
||. | ||.|| ... . .. ||. ... .||..|.||||||. ||....|.. . ||.||
YCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
GYSCIGQN--------------------------QLQSIIGTINYIA-PEILSQQS--------------YSKTVDIWALGLTMYEIAYRKQLFQQK---
| ... . .. || |.| ||.|.... |.. .|.|..| .| . |. .
GFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDN
----------TVQQTAQMILSFKCLDDHGH----------------SQN-------DLFQVIKECLNPDTEARIKIDQVVE
. ... ..|.. |. .. . |.. . . |. .|..| | |..|.|. .
EICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
|
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| Kinase | 9437.AA | RSK | 77-165 | 37 | 1.3e-29 | 104.7 | In-house | 108-204 (278) | Show / Hide |
Range on Protein: 77-165 Range on HMM: 108-204/278 Sequence Identity: 37% (37 aa) QICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNGN-HVFKITDFGYSCIGQNQ----LQSIIGTINYIAPEILS---QQS-YSKTVDIWALGLTMYE .. .|.. .. ||.|.||||||||. ||.. .. | |.|||| .... .. ... ..||.|.|||.| ||. ..| .|.| || ||| FYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYE |
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| Kinase | 9437.AA | STE | 54-167 | 27 | 5.6e-29 | 99.53 | In-house | 118-262 (359) | Show / Hide |
Range on Protein: 54-167
Range on HMM: 118-262/359
Sequence Identity: 27% (43 aa)
YCEAGSLFNYILNQKSMA--------------QIIQIQICLQIAKG-LQWLHSQDIIHRDLKPDSILFTKRNGNHVFKITDFGYSCIGQN----------
|...||| | . ... . . || || || |. |||. |||||.||. ||. |..||| . . ..
YMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNI
---------QLQSIIGTINYIAPEILSQ------QSYSKTVDIWALGLTMYEIA
. ....|| . |||...| . |. .||| ||.|. | |
IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
|
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| Kinase | 9437.AA | CAMK-Unique | 54-165 | 24 | 1.1e-28 | 91.61 | In-house | 116-285 (363) | Show / Hide |
Range on Protein: 54-165 Range on HMM: 116-285/363 Sequence Identity: 24% (41 aa) YCEAGSLFNYILN--------------------QKSMAQ--IIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNG-------------NHVFKIT ||..| || .|. | ... ..|..... . .|||||.|||||.. |.. .. |. |.. YCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLC DFGYSC-IGQNQLQ----SIIGTINYIAP--------------EILSQQSYSKTV----DIWALGLTMYE ||| .| . .|. ...||. |.|| |.. .| |. . |||.|| .||. DFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYY |
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| TyrKc | 9437.AA | TyrKc | 3-226 | 18 | 3.1e-11 | -40.94 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 3-226 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) QQIQNIIGKQEYKV--LGLISQGLSKQT----YLVEGEKSKERFS-----MKVF--REQN--------ADSK--------------YCEAGSLFNYILNQ . ..| .. . .| . .. | |. .| | |. . . .| ... |.. |.| .|. . ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH KS-MAQIIQIQICLQIAKGLQWLHSQDIIHRDLKPDSILFTKRNGNHVFKITDFGYSCIGQNQ--------LQSI----IGT----INYIAPEILSQQSY . ...|.|||.| . |||. .||||| .| .... . ||.||| | . . . | | ||| . . RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF SKTVDIWALGLTMYEIA-YRKQLFQQ-----KTVQQTAQMILSFKCLDDHGH--------SQNDLFQVIKECLNPDTEARIKIDQVVEIL . |.|. | .|.|| | .| .. |. . . . . .. . ...|..|.| . | | | ...|.. TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 9437.AA | Pkinase_Tyr | 54-99 | 36 | 5.5e-09 | 31.07 | Pfam | 88-137 (270) | Show / Hide |
Range on Protein: 54-99 Range on HMM: 88-137/270 Sequence Identity: 36% (18 aa) YCEAGSLFNYILN----QKSMAQIIQIQICLQIAKGLQWLHSQDIIHRDL |.. |.| .| . ... .|.|.|||||...|.|. .||||| YMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| Kinase | 9437.AA | Pkinase_Tyr | 141-166 | 34 | 0.197442 | 5.47 | Pfam | 182-207 (270) | Show / Hide |
Range on Protein: 141-166 Range on HMM: 182-207/270 Sequence Identity: 34% (9 aa) APEILSQQSYSKTVDIWALGLTMYEI ||| .. .. |.|. | .|.|| APECINYGKFTTKSDVWSFGVLMWEI |
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| Kinase | 9437.AA | Pkinase_Tyr | 200-226 | 25 | 1.86119 | 2.17 | Pfam | 244-270 (270) | Show / Hide |
Range on Protein: 200-226 Range on HMM: 244-270/270 Sequence Identity: 25% (7 aa) DLFQVIKECLNPDTEARIKIDQVVEIL .. ...|.| ..| | | ...|.| EIYDLMKQCWHYDPEDRPTFSEIHEQL |
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