Gene 1114 (Tetrahymena)

1114

Species: Tetrahymena
Alias: 3731.m00085, 333, TTHERM_00670900, 1114, 100.m00175, PreTt01114
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: Ciliate-C1

Sequence

Name Sequence Type Origin Length Description Download
1114.AA Protein None 486 None Fasta, JSON
1114.kin_dom Protein Kinase Domain None 285 None Fasta, JSON
1114.NA RNA None 1461 None Fasta, JSON

Protein domain

Protein domains of 1114.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1114.AA Ciliate-C1 178-462 52 1.7e-272 718.18 In-house 1-328 (328) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

MKKLKQLGTGKTSDVFLYQNNQGQ-KLAVKQFK-----------------------SEIGKQIHDQEVSILCELD-HPNIISMVS------HTSDN----
||..|..|.|.|..||.......| ..||||||                       ||...|.|..|...|.||. ||||..||.      ....|    
MKIMKTIGHGYTCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKDSSSPRENTHHSESCMQDHNNEIKHLQELKNHPNIVNMVQIIREIQYDKKNGQTY

----IAFEFASSGDIFDYALSKP--FEPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENFQLKVGDFGLSSFLNSASSQNTLSKQVSSEEMSLN
    |.||..|.|..|||...|.  |..||||||..|||||..||||.||||||||.||..|||||.||..|||...||||||||||||||...|.|..|
CFMCIVFEYCSNGELFDYIAHKGPLFNEELARYYFHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFLNSASSQNTLSKQKDGEKMNHN

TSSTECSDASSDESHWLYESVGTETYMAPELINKQRYLGEQVDIFAFGVILFSLIHGFPPYQRIAHISDPFYRLLIEKKYAKYWTILEKKT--HIKCESS
||||||||||||||||||...|||.||||||..||||.|..|||||.|||||...||.||...|||.|||.||...|..|..||....|..  |......
TSSTECSDASSDESHWLYVCMGTEGYMAPELHEKQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYWQCHQKNYGQHNFFSNE

FIDLMNKLLEPNPQKRITLEEIKCHPWM
|.||.|..|..||||||||.|||||||.
FMDLINQMLAYNPQKRITLQEIKCHPWY
Kinase 1114.AA CAMK 183-462 20 1.6e-80 259.06 In-house 1-425 (425) Show / Hide 
Range on Protein: 183-462
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

QLGTGKTSDVFLYQNN-QG------------QKLAVKQFK------------------------------SEIGKQIHDQEVSILCE-------LDHPNI
.||.|  . |.| ..   .            || |.|  .                              ..  ..   .|..|.         ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISMVSHTS-----------------------DNIAF---EFASSG----DIFDYALSK----------------PFEPELARYYMIQLINVLDYIHQQNI
|..  .                           . .   |..| |    |.|||  ..                 |. . ||.|. |..  ..|.|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKLENLFLDEN-----------------FQLKVGDFGLSSFLNSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHW--------LYESVGTET
.|||||.||. ||.|                 ...|. |||.. .... ......|.. . | |  |        .      |        .....||  
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN--------Q------WTTPTEGQKMKTFCGTPE

YMA-PELINK-------------QRYLGEQVDIFAFGVILFSLIHGFPPYQRIAHISDP--------FYRLLIEKKYAKYWTILEKKTHIK---------
||| ||..|.             ..| |...|. . ||||. .  |.||..   . ...         |.|.   . .||. . .. ..|          
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

---------CESSFIDLMNKLLEPNPQKRITLEEIKCHPWM
         .  . .|| .|.|...|.||.|.|... ||||
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 1114.AA S_TKc 178-462 24 1.3e-67 231.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-231/231
Sequence Identity: 24% (75 aa)

MKKLKQLGTGKTSDVFLYQNNQ-GQKLAVKQFKSEIGKQIHDQEVSILCELDHPNIISMVSHTSD---NIAFEFASS--GDIFDYALSKP-------FEP
 ..|...| |  . |.. ...  |.. |.|. |     .   .|..|| . .||||. .  .  |    . .|...   || |||  ...       | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

ELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENFQLKVGDFGLSSFLNSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWLYESVGTETYMA
  ||.|| |... |.|.|...|.||||| ||..|||  ..|..||||. .|                                      .  .||  |||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------TTFCGTPWYMA

PELINKQRYLGEQVDIFAFGVILFSLIHGFPPYQRIAHISDPFYRLLIEKKYAKYWTILEKKTHIKCESSFIDLMNKLLEPNPQKRITLEEIKC------
||..    | .. .|. ..|.||. .. | ||..   ..   | ...                     ....|...|.|. .|.||.|  |.        
PEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPWM
 |||.
CHPWF
Kinase 1114.AA Pkinase 178-462 23 6.1e-61 213.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-293/293
Sequence Identity: 23% (76 aa)

MKKLKQLGTGKTSDVFLYQNNQGQK-LAVKQF-KSEIGKQIHDQ-----EVSILCELDHPNIISM--VSHTSDNIA--FEFASSG----DIFDYAL---S
 ......| |  . |.. ..   .|  |||.. |... .. . .     |..|. .|.||||. .  . ...|.|   .|..  |    | |||     .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPF--EPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENFQL----KVGDFGLSSFLNSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWL
..|  ... .. || |..  |.|.|...|.|||||.||...|.| ..    |..||||. ...                                 .. .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------------------------Y-NNS-M

YESVGTETYMAPELINKQRYLGEQVDIFAFGVILFSLIHGFPPYQ-R----IAHISDPFYRLLIEKKYAKYWTIL-------------EKKTHIKCESSF
.  .||  |||||.|....| |  ||....|.||. .. | ||.. .      |  .  ...  ....   |  .             ...  .. ....
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEEC

IDLMNKLLEPNPQKRITLEEIKCHPWM
.|.....|...|.||.| |.|..|||.
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1114.AA CAMKL 179-462 24 7.4e-60 189.63 In-house 2-297 (297) Show / Hide 
Range on Protein: 179-462
Range on HMM: 2-297/297
Sequence Identity: 24% (83 aa)

KKLKQLGTGKTSDVFLYQN-NQ-GQKLAVKQFK-SEIG-KQIHDQ---------------EVSILCELD---HPNIISMVSHTS----------DNIAFE
. .|.||.|  . | | ..    |.| |.|  . . |  ... ..               |..|.  |.   |||||..  .             ..  |
RIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME

FASSGD--IFDYALSKP-----FEPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENF--QLKVGDFGLSSF---LNSASSQNTLSKQVSSEEMS
 .|.|.   |||  ...     .... || |  |..  ..|.|...|.|||.|.||. ||||   ..|. |||.| .                       
YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-------------------

LNTSSTECSDASSDESHWLYESVGTETYMAPELINK--QRYLGEQVDIFAFGVILFSLIHGFPPYQ-----RIAHISDPFYRLLIEKKYAKYWTILEKKT
              . . | .. |.  |||||....  ..| | .||| . ||||. .. |  |       .          .  . .  .|| | .  .
-----------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNK----------QGKDNI-YLYWKIMCG-Y

H--IKCES-SFIDLMNKLLEPNPQKRITLEEIKCHPWM
.  | ..  . .||  |.|..|| ||.|...|. ||||
YPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 1114.AA Ciliate-E2 178-462 21 4.8e-57 194.36 In-house 1-365 (365) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-365/365
Sequence Identity: 21% (85 aa)

MKKLKQLGTGKTSDVFLYQN------------------------NQGQKLAVKQF--------KSEIG--KQIHD-----QEVSILCELDHPNIISMVSH
 |..|..|.|  ..|.. ..                        ..... |.|..        |.||   ..|..     .| .|| .|.||||| |. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

TS--DN----IAFEFASSGDIFDYA----LSKPFEPE--------LARYYMIQLIN---------------VLDYIHQQN-ICHRDLKLENLFLDENFQL
    |.    . .|... || |||     .....|.|         ..|.| |...                | |.|..| |.|||.|.||...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVGDFGLSSFLNSASSQNT-----LSKQVSSEEMSLNTSSTECSDASSDES----HWLYESVGTETYMAPELINKQRYLG--------EQVDIFAFGVIL
|. ||||| ...  . ..|       ..  . ..|  ..  .             .. .  .||  ||||| .|.. | .        ...||...||||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD--------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

FSLIHGFPPYQRIAHISDPFYRLLIEKKYAKYWTILEKK-------------THIKCESSFIDLMNK----LLEPNPQKRIT-LEEIKCHPWM
. .. | ||.              ....  . . . ...              . |.. . .||..|    .|. .|.||||  |.|. |||.
YEMLFGKPPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1114.AA Ciliate-E2-Unclassified 179-462 22 1.4e-47 163.13 In-house 2-352 (352) Show / Hide 
Range on Protein: 179-462
Range on HMM: 2-352/352
Sequence Identity: 22% (84 aa)

KKLKQLGTGKTSDVFLYQN-NQG-----------QKLAVKQFKS-----------EIGKQIHDQEVS-------ILCELDHPNIISMVSHTSDN----IA
|..||.|.|  ..|.. |. .|.           |. ..|| ..           .. |   .|. .       ||  ..||.|. |. .  |     | 
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-KYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

FEFASSGDIFDYALS------------------KPFEPELAR-----YYMIQLINVLDYIHQQN-ICHRDLKLENLFLDEN---FQLKVGDFGLSSFLNS
 |..  || ..|  .                  | |. . |.     .|. |... |.|.|..| |.|||.|.||...|.|   ...|. |||.|.....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

ASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHW----LYESVGTETYM----APELINKQRYLG---EQVDIFAFGVILFSLIHGFPPYQRIAHISDP
 . .   . |                      . |    ..  .||  ||    |||.. .| | .   ...||...||||. .. | .|..    ... 
NNNCD-TNQQ-------------------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQ

--------------FYRLLIEKKYAKYW-------TILEKKTHIKCESSFIDLMNKLLEPNPQKRITLEEIKCHPWM
              .|.  ..|.. . .        .. ..    ..    ||. |.|. || ||||.|.|..|||.
QLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 1114.AA AGC 178-398 19 8.4e-42 104.65 In-house 1-306 (395) Show / Hide 
Range on Protein: 178-398
Range on HMM: 1-306/395
Sequence Identity: 19% (63 aa)

MKKLKQLGTGKTSDVFLYQNNQ-------GQKLAVKQFKSEI--------GKQIHDQE------------VSILCELD----------HPNIIS-MVSHT
 . || .|.|  . |.| . .        |.  |.|  | .           .    |              || ...          ||.|.. . .  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

SDNIA--FEFASS-------------G-DIFDYAL----SKPFEPELARYYMIQ-------LINVLDYIHQ-QNICHRD-LKLENLFLDENFQLKVGDFG
 |.      |                | . | .      .. |. | ||.|. .       ..  |.|.|. ..| ||| ||.||. |||.  .|  |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSSFLN--------------SASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWLY--------------ESVG--TETYMAPELINKQRYLGEQVDI
|.  ..              ... .|.   | .| .|.  | .. |  .. ..    .                .|  |  ||||| .      | ..|.
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS-NMD--T-NK-CNPNNWQRNN-MSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDW

FA--FGVILFSLIHGFPPYQ
 .  .|.... .. | ||..
WSFGLGCLMYEMLTGYPPFY
Kinase 1114.AA ULK 178-462 18 1.6e-37 128.55 In-house 1-329 (329) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-329/329
Sequence Identity: 18% (67 aa)

MKKLKQLGTGKTSDVFLY--QNNQ---GQKLAVKQ-FKSEIGKQIHD-----------QEVSILCELD--------HPNIISMVSH--TSDN----IAFE
  . ..|| |    |.    ....   ..| |.|.  |... .. ..           .|. |. .|.        ||||. .     ||..    | .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FASSGDIFDYALSKP-----------FEPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENF------------QLKVGDFGLSSFLNSA-SSQN
.   || ..|   .            .. . |. ...|..| . ..|..|| |||.|..|  .....            .||..|||.. ....   .|.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TLSKQV-SSEEMSLNTSSTECSDASSDESHWLYESV---GTETYMAPELIN---KQRYLGEQ-VDIFAFGVILFSLIHGFPPY--QRIAHISDPFYRLLI
 .  .|                                 ||  ||||....   .|   ..  .||. .|.|.. .. | ||.  . .    . ... ||
MMMTCVNE---------------------------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLI

EKKYAKYWTILEKKTHIK-------CESSFIDLMNKLLEPNPQKRITLEEIKCHPWM
....  . .|  ... ..       . . ..||  ..|. .. .||. ||.  |||.
NNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1114.AA Ciliate-E2a 179-398 25 8e-37 105.94 In-house 2-217 (275) Show / Hide 
Range on Protein: 179-398
Range on HMM: 2-217/275
Sequence Identity: 25% (63 aa)

KKLKQLGTGKTSDVFL-YQNNQGQKLAVKQFKSEIGKQIH------DQEVSILCELDHPNIISMV----SHTSDNIAFEFASSGDIFDYALSKP-FEPE-
|..|..|.|.   |.|  . ..|.. |.| |.     |..       .|..|. .||||||| .     ....  . .|. ..|. .|.   .  |  | 
KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-LARYYMIQLI-NVLDYIHQQNICHRDLKLENLFLD-------ENFQLKVGDFGLSSFL--NSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWLY
  .. .| ||.   | |.||.|| |||||.||....       .|...|. ||||. |   .                                |   ..
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD--------------------------------EKKYMF

ESVGTETYMA------PELINKQRYLGEQVDIFAFGVILFSLIHGFPPYQ
  .||  |.|      .| .....| ....|..  |||.. |. | ||..
QKCGTPGYVAPEVLNNKEVLKHKQY-DTKCDMWSCGVIFYILLCGKPPFK
Kinase 1114.AA CMGC 178-395 14 5.1e-33 105.15 In-house 1-341 (513) Show / Hide 
Range on Protein: 178-395
Range on HMM: 1-341/513
Sequence Identity: 14% (53 aa)

MKKLKQLGTGKTSDVFLYQN---------------NQGQKLAVKQFKSEIGKQIHDQ--------------EVSILCEL-----------------DHPN
 ...|..| |  . |.  ..               . ... |.| .|..  .... .              |..|| .|                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IISMVSHTSD---------------------NIAFEFASSGDIFDYALS----------KPFEPEL------------ARYYM------IQLINVLD--Y
|...  .  .                     .. ||.    | ..|  .          .|...               .|.|       |... |.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHQQN--ICHRDLKLENLFLDEN--------------------FQLKVGDFGLSSFLNSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHW------
.|...  |.||||| ||. ...|                    ..||..||||. .... |.... ... |                             
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS-F--------------------KNVNKDD

-----LYESVGTETYMAPELINKQRYL---------GEQVDIFAFGVILFSLIHG--------FP
     ... | |  | |||..   ..          ....|. ..| |.. .. |         |
KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP
Kinase 1114.AA MARK 220-393 29 1.6e-31 100.44 In-house 49-202 (262) Show / Hide 
Range on Protein: 220-393
Range on HMM: 49-202/262
Sequence Identity: 29% (55 aa)

EVSILCELDHPNIISM---VS--HTSD--NIAFEFASSGDIFDYALSK---PFEPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENF--QLKVG
|..|.  |||||||..   .   ...   ..  | ||.|. .||  ..   . . |.|| .  |..  . | |..||.|||.|.||. .|||   . |  
EIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKII

DFGLSSFLNSASSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWLYESVGTETYMAPELINKQRYLGEQVDIFAFGVILFSLIHG
|||.|   .. .                                 | .  ||  |||||...|..| |  ||| . ||.|. ...|
DFGFSICIPPGQK--------------------------------LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCG
Kinase 1114.AA AGC 437-462 41 2.9e-13 29.14 In-house 360-395 (395) Show / Hide 
Range on Protein: 437-462
Range on HMM: 360-395/395
Sequence Identity: 41% (15 aa)

DLMNKLLEPNPQKRIT----------LEEIKCHPWM
||..|||...| ||..           |||| ||| 
DLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 1114.AA TyrKc 178-462 21 2.6e-12 -23.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 178-462
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

MKKLKQLGTGKTSDVFLYQNNQGQKLAVKQFKSEIGKQIHDQEVSILCEL--DHPNIISMVSHTSDN-----------IAFEFASSGDIFDYALSKP--F
 ...|.|| |    |.. . .  .. |||  |..  ..   .| .|.|.|  .||||. ..   ..            | .|... ||  ||  ..   .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

EPELARYYMIQLINVLDYIHQQNICHRDLKLENLFLDENFQLKVGDFGLSSFLNSA---SSQNTLSKQVSSEEMSLNTSSTECSDASSDESHWLYES---
 ..   ....|  .  .|.|..|. ||||   |  ..||.. |..||||| .. .                                  ||.  | .   
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------------------------ESKDYYRKKEH

VGTET-----YMAPELINKQRYLGEQVDIFAFGVIL---FSLIHGFPPYQRIAH--ISDPFYRLLIEKKYAKYWTILEKKTHIK------CESSFIDLMN
 |. |      |||| ||. ..  .. |...||| .   |..  | .||  ..   .|.   . .... |      ...  ..       | .   ..| 
KGGKTMLPIRWMAPECINYGKF-TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGY-----RMPQPPNDYPMSFVCCPDEMYQIMK

KLLEPNPQKRITLEEIKCHPWM
.  . .| .| | .||  |  .
QCWHEDPEDRPTFSEI--HECF
Kinase 1114.AA CMGC 402-462 20 6e-10 27.91 In-house 416-513 (513) Show / Hide 
Range on Protein: 402-462
Range on HMM: 416-513/513
Sequence Identity: 20% (20 aa)

HISDPFYRLLIEK------KYAKYWTILEKKTH-------------------------------IKCESSFIDLMNKLLEPNPQKRITLEEIKCHPWM
.. ..|.|. |..      .. | |. |... .                                .| . .|||..|.|. .|.|||| |..  ||. 
NHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 1114.AA MARK 437-462 53 1.3e-09 27.76 In-house 237-262 (262) Show / Hide 
Range on Protein: 437-462
Range on HMM: 237-262/262
Sequence Identity: 53% (14 aa)

DLMNKLLEPNPQKRITLEEIKCHPWM
.| ..|| .|| .|.|.|||  ||||
NLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 1114.AA Ciliate-E2a 436-462 51 4.9e-09 22.77 In-house 249-275 (275) Show / Hide 
Range on Protein: 436-462
Range on HMM: 249-275/275
Sequence Identity: 51% (14 aa)

IDLMNKLLEPNPQKRITLEEIKCHPWM
.||| |.||..|.|||| ...  |||.
KDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 1114.AA Pkinase_Tyr 278-312 40 0.001059 13.16 Pfam 124-158 (270) Show / Hide 
Range on Protein: 278-312
Range on HMM: 124-158/270
Sequence Identity: 40% (14 aa)

LDYIHQQNICHRDLKLENLFLDENFQLKVGDFGLS
..| ...|. ||||   |  ..||.. |..||||.
MEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 1114.AA Pkinase_Tyr 219-236 36 0.141501 5.96 Pfam 52-70 (270) Show / Hide 
Range on Protein: 219-236
Range on HMM: 52-70/270
Sequence Identity: 36% (7 aa)

QEVSILCEL-DHPNIISMV
.|..|...| .||||....
REAKIMKQLGHHPNIVRLY
Kinase 1114.AA Pkinase_Tyr 363-388 38 8.135911 0.0 Pfam 181-205 (270) Show / Hide 
Range on Protein: 363-388
Range on HMM: 181-205/270
Sequence Identity: 38% (10 aa)

MAPELINKQRYLGEQVDIFAFGVILF
|||| ||  .   .. |. .||| ..
MAPECINYGK-FTTKSDVWSFGVLMW