Gene 22427 (Tetrahymena)

22427

Species: Tetrahymena
Alias: 18.m00453, 3701.m00210, TTHERM_00220990, PreTt22427, 505, 22427
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: Ciliate-C1

Sequence

Name Sequence Type Origin Length Description Download
22427.AA Protein None 466 None Fasta, JSON
22427.kin_dom Protein Kinase Domain None 275 None Fasta, JSON
22427.NA RNA None 1401 None Fasta, JSON

Protein domain

Protein domains of 22427.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22427.AA Ciliate-C1 11-285 45 2.9e-259 683.08 In-house 1-328 (328) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-328/328
Sequence Identity: 45% (150 aa)

YILGKTLGAGYHAKVKLASF-NGQ-QVAAKIFKS-------------------THSLASNMKTLKHEIGVMQKLN-HPNLVNLVEVIPNGTYTKKNGQTY
....||.|.||..||..... |.| ..|.|.||.                   ||...|.|.....||...|.|. |||.||.|..|....|.|||||||
MKIMKTIGHGYTCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKDSSSPRENTHHSESCMQDHNNEIKHLQELKNHPNIVNMVQIIREIQYDKKNGQTY

EALGIILEYCAGGELFEYVANSGR-FSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNLKVADFGFA----------TLMEGKDGNGLLKT
....|..|||..||||.|.|..|. |.||.||.||||||....|.|.|||.||||||||.|.|..||||.||||||          ||...|||......
CFMCIVFEYCSNGELFDYIAHKGPLFNEELARYYFHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFLNSASSQNTLSKQKDGEKMNHN

-------------------CLGTESYMAPEIHAKLPYNGSSVDLFAAAIILFIMYAGTPPFSK-ADPKDPYYKLMCTNRHDTFWQAHLKNKGSENFFSQS
                   |.|||.|||||.|.|..|.||.||.||...|||.|..|.|||.| |.|.||||...|.||....||.|.||.|..||||..
TSSTECSDASSDESHWLYVCMGTEGYMAPELHEKQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYWQCHQKNYGQHNFFSNE

FMDLINSLLAHDSVQRPSLAEVKSHPWY
||||||..||.....|..|.|.|.||||
FMDLINQMLAYNPQKRITLQEIKCHPWY
Kinase 22427.AA CAMK 16-285 24 3.5e-98 316.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-285
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

TLGAGYHAKVKLASF--NG------------QQVAAKIFKSTHSL--------------------------ASNMKTLKHEIGVMQK-------LNHPNL
||| |  .||||.    ..            |.||.|| . .                             ....| ...|| .|.|       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLVEVIPNGTYTKKNGQTYEA---------------LGIIL---EYCAGGEL----FEYVANS---------------GRFSEEVARAYFHQLIDALEY
..| ||. ...|.| |     .               . ...   ||| ||||    |.|.                  |||.|. || ||.|...|..|
IKLYEVYEDPHYFK-N-----TNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY

LHNNNIAHRDLKPENLLFDSQ-----------------FNLKVADFGFATLMEGKDGNG---------------------LLKTCLGTESYMA-PEIHAK
.|..||.||||||||.|.|.                  .|.|..|||||. ......|                      ..||. || .||| ||.  .
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

-------------LPYNGSSVDLFAAAIILFIMYAGTPPFSKADPKDPY---------YKLMCTNRHDTFWQAHLKNKG-----------------SENF
              || | ..|  .. .||.||  |.|||   . .. .         |.|.   .   ..  . . ..                 .. |
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-F

FSQSFMDLINSLLAHDSVQRPSLAEVKSHPWY
.||. .|||...|  |  .|........|||.
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22427.AA CAMKL 11-285 32 7.2e-85 270.76 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-297/297
Sequence Identity: 32% (102 aa)

YILGKTLGAGYHAKVKLASF---NGQQVAAKIFK--STHSLASNMKT-----------LKHEIGVMQKLN---HPNLVNLVEVIPNGTYTKKNGQTYEAL
|..||||| |  .|||||     .|..|| || .   .     ..|            .. ||  |..||   ||| . | ||| . ..   . .| . .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH---DIET-KKI

GIILEYCAGGE--LFEYVANS----GRFSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQF--NLKVADFGFATLMEGK-DGNG-LLKTCLGT
 ...||| |||  ||.|. .     ||..|. || || |...|..|.|...|.|||.||||.|.|..   |.|..||||..... . .|.| .|||. |.
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

ESYMAPEIHAK--LPYNGSSVDLFAAAIILFIMYAGTPPFSKADPKDPYYKLMCTNRHDTFWQAHLKNKGSENFF------SQSFMDLINSLLAHDSVQR
 .|||||| ..   ||.|  ||  .. .||. |  |. ||  .. .         .  | .   ..|...   ..      | .  ||| ..| ..  .|
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K-------QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR

PSLAEVKSHPWY
|.. ....|||.
PTIHQIMNHPWM
Kinase 22427.AA S_TKc 11-285 29 2e-82 281.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-231/231
Sequence Identity: 29% (86 aa)

YILGKTLGAGYHAKVKLASFNG--QQVAAKIFKSTHSLASNMKTLKHEIGVMQKLNHPNLVNLVEVIPNGTYTKKNGQTYEALGIILEYCAG--GELFEY
| .....| |  .||...  ..  ..|| || |         .... || ...| .|||.|.| .|. .           . | ...||| |  |.||.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDY

VANSGR------FSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNLKVADFGFATLMEGKDGNGLLKTCLGTESYMAPEIHAKLPYNGSSV
  . ||      |.| .|| |..|...||||.|...| ||||||||.|.|.  ..|..|||.|...         .|. ||  |||||.    .|.. ..
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKC

DLFAAAIILFIMYAGTPPFSKADPKDPYYKLMCTNRHDTFWQAHLKNKGSENFFSQSFMDLINSLLAHDSVQRPSLAEVKS-------HPWY
|  .  .||..|..| |||.     .  .|...                     |... |.|. .|  |  .||.  |.         ||| 
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22427.AA AGC 11-285 21 1.6e-75 193.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-395/395
Sequence Identity: 21% (90 aa)

YILGKTLGAGYHAKVKLASFN--------GQQVAAKIFKSTH--------SLASNMKT--------LKHEIGVMQKLN----------HPNLVNLVEVIP
. . |..| |   || |.  .        |.. | |. |  |         .. .|          .. |  ...|.|          ||..|.      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVK------

NGTYTKKNGQTYEA--LGIILEYCA---------GG-ELFEYVA---NSGRFSEEVARAYFHQ-------LIDALEYLHN-NNIAHRD-LKPENLLFDSQ
     .   |. .   | ...||.          || ||| .     ..|||.||.|| |. .       .. ||||||. ..| ||| |||||.|.|..
---ILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED

FNLKVADFGFATLMEGKD------------------------------------------------GNGLLKTCLG--TESYMAPEIHAKLPYNGSSVDL
 ..| .|||... . ...                                                .. . .|  |  |  ||||||       | ..| 
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDW

FA--AAIILFIMYAGTPPFSKADPKDPYYKLMCTNRHDTFWQAHLKN---KGSENF-------------FSQSFMDLINSLLAHDSVQRPS---------
 .    .... | .| |||.  .| .   .  ..|....| .    .   .  . |             ||.  .|||. ||  |  .|.          
WSFGLGCLMYEMLTGYPPFYGDNPQE-NRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDK

-LAEVKSHPWY
   |.|.||| 
GAEEIKNHPWF
Kinase 22427.AA Pkinase 11-285 29 1.4e-71 248.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YILGKTLGAGYHAKVKLASFNGQQ--VAAKIFKSTHSLASNMKTLKH--EIGVMQKLNHPNLVNLVEVIPNGTYTKKNGQTYEALGIILEYCAGG----E
| .|...|.|  ..|...   | .  || ||.|  |   .  .|. .  || .|..||||| | | ..  .      ..  |    ...||| ||    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIY----MVMEYCEGGLYVMD

LFEYVA--NSGRF--SEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNL----KVADFGFATLMEGKDGNGLLKTCLGTESYMAPEIHAKLP
||.|.   ..|.|  ||.... |. |.. .|||.|...| ||||||||.|.|.. ..    |..|||.| ...    |. ..|  ||  |||||.. . .
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

YNGSSVDLFAAAIILFIMYAGTPPFSKA------DPKDPYYKLMCTNRHDTFWQAHLKN----------KGSENFFSQSFMDLINSLLAHDSVQRPSLAE
| |..|| ... .||..|. | |||. .      |..  ... |..  |  ... . .           .      |... |.|...|. |  .||. ..
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQ

VKSHPWY
.. ||| 
ILQHPWF
Kinase 22427.AA AMPK 11-219 38 2e-64 190.2 In-house 1-200 (254) Show / Hide 
Range on Protein: 11-219
Range on HMM: 1-200/254
Sequence Identity: 38% (82 aa)

YILGKTLGAGYHAKVKLASFN--GQQVAAKIF-KSTHSLASNMKTLKHEIGVMQKLNHPNLVNLVEVIPNGTYTKKNGQTYEALGIILEYCAGGELFEYV
||.|||.| |   |||..     |..|| ||  |      . .. .. ||  .....||... | |||           | . . ...|| .|||||.|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVI---------IETPTDIFMVMEYVSGGELFDYI

ANSGRFSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNLKVADFGFATLMEGKDGNGLLKTCLGTESYMAPEIHAKLPYNGSSVDLFAAAI
.  || .|. |. .| | | ..||.|...|.||||||||||.| . |.|..|||   .|  |||  .|||. |   | |||. .  .|.|  ||.    .
VKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMM--KDG-EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGV

ILFIMYAGTPPF
||. |  |. ||
ILYAMLCGYLPF
Kinase 22427.AA Ciliate-E9 11-285 30 9.6e-63 199.4 In-house 1-298 (298) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-298/298
Sequence Identity: 30% (91 aa)

YILGKTLGAGYHAKVKLA--SFNGQQVAAKIFKSTHSLA-SNMKTLKHEIGVMQKLN-HPNLVNLVEVIPNGTYTKKNGQTYEALGIILEYCAGGELFEY
|....  . |    ||||     .  .| ||.|       . .| .. |.   . .  |.... |  .  |. |.|  ||    . |. ||   |.||. 
YRVHRNIAQGTQGQVKLAIDMQTRKKYAIKIMKHQQMNDEMFFKYFQREMNILNQVQPHRYIIQLQDICYNINYMKCHGQKFTINYIVMEYANNGCLFDL

V-ANSGRFSEEVARAYFHQLIDALEYLHNNN-IAHRDLKPENLLFDSQFNLKVADFGFATLMEGKD-----GNGLLKT--CLGTESYMAP----EIHAKL
.    . |.|.||. || ||||. ||.|.   | ||||||||.| |  .|.|. |||.    .  |     || . .     ||  |  |    .     
ISMHTEKFNENVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGMS-AQCRNDKTQVIGNLQCQPKENHGTNQYNPPNNQQQQYQGI

PYNGSSVDLFAAAIILFIMYAGTPPFSKADPKDP--------YYK--LMCTNRHDTFWQAHLKNKGSENFFSQSFMDLINSLLAHDSVQRPSLAEVKSHP
 |||  .|.| |..|||.|  .. ||    . .         ||    .|      ||     |   .   .|.|.|..|. |  |   |.|..|...||
KYNGQKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIYN---YRPEEQEFIDMMNWMLQQDPQNRISIQEIRMHP

WY
| 
WM
Kinase 22427.AA RAD53 11-220 29 3.1e-60 177.89 In-house 1-242 (305) Show / Hide 
Range on Protein: 11-220
Range on HMM: 1-242/305
Sequence Identity: 29% (75 aa)

YILGKTLGAGYHAKVKLAS--FNGQQVAAKIFKS---T---HSLASNMKTLKHEIGVMQKLNHPNLVNLVEVIPNGTYTKKNGQTYEALGIILEYCAGGE
|...|.||.|  ..||||    ..|.|| ||..    .    . ...|...  |. ...|||||. ... ... .           . . ..||.  |||
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTP---------QKYYYMVLELMTGGE

LFEYVANSGR----FSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQF------------------NLKVADFGFATLMEGKDGNG-LLKTCL
||. .. ..|    |.|  ...|| |..||. |||.|.|.|||||||| |...|                    .|..||| .  .    |.| ..||  
LFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFV----GEGSFMKTMC

GTESYMAPEIHAKL------PYN--------GSSVDLFAAAIILFIMYAGTPPFS
|| .| |||. ..        ..        ...||.  .  ||.|. .|.||||
GTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFS
Kinase 22427.AA MARK 11-219 40 7.9e-60 194.31 In-house 1-206 (262) Show / Hide 
Range on Protein: 11-219
Range on HMM: 1-206/262
Sequence Identity: 40% (88 aa)

YILGKTLGAGYHAKVKLAS--FNGQQVAAKIFKSTHSLA-SNMKTLKHEIGVMQKLNHPNLVNLVEVIPNGTY--TKKNGQTYEALGIILEYCAGGELFE
| ..||.| | .||||||     |..|| || . .      .|| .. || .|.||.||| . | .||       |...      . .|.||. ||||..
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVI----EQDTEQH-----QIYLIMEYASGGELYD

YVANS--GRFSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQF--NLKVADFGFATLM-EGKDGNGLLKTCLGTESYMAPEIHAKLPYNGSSV
|. .   || .|| ||..|.|.. |..|.|..||.|||.||||.| |..   | | .||||..   .|.     |.|. || .||||||  | ||.|  |
YIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK----LNTFCGTPPYMAPEIFLKKPYDGPKV

DLFAAAIILFIMYAGTPPF
|  .  ..|..|  |. ||
DIWSLGVVLYFMVCGYFPF
Kinase 22427.AA Ciliate-E2 11-285 20 4.1e-59 201.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-365/365
Sequence Identity: 20% (83 aa)

YILGKTLGAGYHAKVKLA--SFNGQQVAAKIFKSTHSLASN--------------------MKTLKHEIGVMQ----------------KLNHPNLVNLV
|.. | .| | ...|...    ...|.| ||.. . .  ..                     . .| || .|.                .|||||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

EVIPNGTYTKKNGQ--TYEALGIILEYCAGGELFEYVANS-----------GRFSEEVARAYFHQLID---------------ALEYLHNNN-IAHRDLK
|.           |  . . . ...||| ||.||.|  |.           ..|.|. .. .. |...               ||||||..| | |||.|
ECF----------QEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PENLLFDSQFNLKVADFGFAT-------------LMEGKDGNG-----------------LLKTCLGTESYMAPEIHAKLPYNG--------SSVDLFAA
|||.||     .|..|||...             ... .   .                 . .|..||  ||||||. . .|..         ..|....
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

AIILFIMYAGTPPFSKADPKDPYYKLMCTNRHDTFWQAHLKNKGSENFF---------------------SQSFMDLINS----LLAHDSVQRPS-LAEV
 .||..|  | |||                          . ..  .|.                     ||. .|||.     .|  |  .|..   ..
GVILYEMLFGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

KSHPWY
. ||| 
LNHPWF
Kinase 22427.AA ULK 11-285 26 4.3e-52 179.39 In-house 1-329 (329) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-329/329
Sequence Identity: 26% (91 aa)

YILGKTLGAGYHAKVKLAS---FN---GQQVAAKIFKSTHSLASN--------MKTLKHEIGVMQKLN--------HPNLVNLVEVIPNGTYTKKNGQTY
|.| . || |  .||  .     .   ...||.|.  .     .|        .. || || .|.||.        ||| | | ..           .| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF----------ETS

EA--LGIILEYCAGGELFEYVA----------NSGRFSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFN------------LKVADFGFAT
    . ||.||| || |..|            . .|.||. |. .|.|.. .. .|| .|| |||.||.| | .  .             ||.|||||| 
NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

LME-GKDGNGLLKTCL------GTESYMAPEIHA----KLPYNGSSVDLFAAAIILFIMYAGTPPFSKADPKDPYYKLMCTNRHDT--------FWQAHL
 .. ... . ...||.      ||  ||||.|      . ||. . .|..   .|.. |  | |||..  . | | . .  .. ..          .   
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQF

KNKGSENFFSQSFMDLINSLLAHDSVQRPSLAEVKSHPWY
...|... .|. . |||  .|  |  .| |  |. .||| 
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 22427.AA TyrKc 11-285 20 6.9e-13 -14.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YILGKTLGAGYHAKVKLASFNGQQVAAKIFKSTHSLASNMKTLKHEIGVMQKL--NHPNLVNLVEVIPNGTYTKKNGQTY---EALGIILEYCAGGELFE
  |||.|| |   .| ..  . .||| |  |. .     .. . .|. .| ||  .|||.|.|. |.     |.. .. .   | | |..||...| | .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVC-----TQQGRN-FMYIEPLMIVMEYMPHGDLKD

YVANSGR-FSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNLKVADFGFATLMEGKDGN---GLLKTCL---GTES-----YMAPEIH---
|  .... .. .    . .|  .  |||| .|. ||||   | | ....  |..||| .   . .| .   .  ..     |. .      ||||     
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

---------------------AKLPYNG------SSVDLFAAAIILFIMYAGTP--PFSKADPKDPYYKLMCTNRHDTFWQAHLKNKGSENFFSQSFMDL
                      . || |      |  ....     . |       | |                             .    ..   ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------F-VCCPDEMYQI

INSLLAHDSVQRPSLAEVKSHPWY
. .  ..|  .||. .|.  |   
MKQCWHEDPEDRPTFSEI--HECF
Kinase 22427.AA Pkinase_Tyr 11-161 24 4.4e-12 41.53 Pfam 1-156 (270) Show / Hide 
Range on Protein: 11-161
Range on HMM: 1-156/270
Sequence Identity: 24% (41 aa)

YILGKTLGAGYHAKVKLASFN------GQQVAAKIFKSTHSLAS-NMKTLKHEIGVMQKL-NHPNLVNLVEVIPNGTYTKKNGQTYEA--LGIILEYCAG
 ..||.||.|   .|...  .      ...|| |. | ...     .. . .|. .| .| .|||.|.|. |.             |   . |..||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---------DQGEPNQIYIVMEYMPH

GELFEYVAN----SGRFSEEVARAYFHQLIDALEYLHNNNIAHRDLKPENLLFDSQFNLKVADFG
| | .|  .     .... .    . .|  ...|||...|. ||||   | | ....  |..|||
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 22427.AA AMPK 253-285 33 7.6e-08 19.44 In-house 222-254 (254) Show / Hide 
Range on Protein: 253-285
Range on HMM: 222-254/254
Sequence Identity: 33% (11 aa)

FFSQSFMDLINSLLAHDSVQRPSLAEVKSHPWY
|.|..  |||...|  | ..| .  ... |||.
FLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 22427.AA MARK 260-285 38 8.6e-08 21.74 In-house 237-262 (262) Show / Hide 
Range on Protein: 260-285
Range on HMM: 237-262/262
Sequence Identity: 38% (10 aa)

DLINSLLAHDSVQRPSLAEVKSHPWY
.||..|| ..  .||.. |. .||| 
NLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 22427.AA RAD53 260-285 38 0.000859 6.6 In-house 280-305 (305) Show / Hide 
Range on Protein: 260-285
Range on HMM: 280-305/305
Sequence Identity: 38% (10 aa)

DLINSLLAHDSVQRPSLAEVKSHPWY
|||...|  |   |.. .|. .||| 
DLIKWMLCVDPEKRYTIDEALNHPWM