Gene 2011 (Tetrahymena)
2011
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 2011.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2011.AA | Ciliate-C5 | 92-360 | 87 | 6.9e-192 | 637.29 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 92-360 Range on HMM: 1-260/260 Sequence Identity: 87% (235 aa) IYLTSYISQGGNGCVFEAKYNEEIVAVKCSKPKFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSFFDKKKPLPLNQIVG |||||||||||.||||||||||||||||||||.||||.||||||||||||||||||||||||.||||||||||.|||||..|||||||.||.||||||.| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDNGFFNIKYDIYGLGIILLEL |||||||||||||||||||||.||||||||||||||||. |.|.||||||||||||||||||||||||.||||||||||||||||||||||| FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLC---------DYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLEL TLGKFLEDKDCTFIRNGQLPNYICKNALFQDINQIIVQMLEVMPQNRIDSFELTKQLNKLRIKLESEFI ||||||||.||||||||.|||||.||||.|||||||..|||.||||||||||||||||.||.||||.|| TLGKFLEDEDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 2011.AA | Ciliate-E1 | 98-282 | 23 | 4e-24 | 75.64 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 98-282 Range on HMM: 1-202/202 Sequence Identity: 23% (51 aa) ISQGGNGCVFEAKYNEE--------IVAVKC--SKPKFEKIQEEEK-IMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQ---------SF |..|. . ||.||... |. ... .. .|.....|.. ||| .| |... |. . .. ...| ...|.| . .| .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC FDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKT-YDLKGFTRKYAAPELT------- ... . |.. ..|. .. ..|.|.||.||||.|||...|... . ||| || .| .. .. ||.| .|. || QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH DDNGFFNIKYDIY ..| |.|.||| NKNQKINYKSDIY |
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| Kinase | 2011.AA | S_TKc | 92-355 | 20 | 1.8e-15 | 49.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 92-355 Range on HMM: 1-231/231 Sequence Identity: 20% (56 aa) IYLTSYISQGGNGCVFEAKYNE--EIVAVKCSKPKFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSC---NLREIMQSFFDKKKP--L . | .|. |.|. .. .. .|||.|. | |.|. | .|.| . |.. | .. | . ...| . . .|...... .... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDNGFFNI-KYDIY | .. .. |. | . ... || |.|||||| |. ..| .||| .. . . |. | |||. .. | |.. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWW GLGIILLELTLGKFLEDKDCTFIRNGQLPNYICKNALFQDINQIIVQMLEVMPQNRIDSFELTK--QLNKLRIKL .|.|| |. |. . . |. . | .. ..| ..|.. |..|. |. . .. |. . SCGCILYEMLCGYPPFP---------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 2011.AA | CMGC | 92-223 | 15 | 1.3e-14 | 43.49 | In-house | 1-220 (513) | Show / Hide |
Range on Protein: 92-223
Range on HMM: 1-220/513
Sequence Identity: 15% (34 aa)
IYLTSYISQGGNGCVFEAKY----------------NEEIVAVKCSKPKFEKIQ---------------EEEKIMKLLK----------------DTPYV
..| .| | |.... ..||||.| | .|...| | ||.| |. . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
FKSIEEFLNKK---------------KSKYYQISKKYSCNLREIMQSFFDK------------------------KKPLPLNQIVGFAIQMSTVFE--KI
| .. | |. . | . ..| ..... .. .| ... .| .. |. . . .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC
QQNN--LIHSDIKPENILYDSQ
... || |.|||||| ...
HSHWGNIIHRDLKPENILINHN
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| Kinase | 2011.AA | C8 | 96-288 | 22 | 9.9e-13 | 40.61 | In-house | 5-226 (226) | Show / Hide |
Range on Protein: 96-288
Range on HMM: 5-226/226
Sequence Identity: 22% (52 aa)
SYISQGGNGCVFEAKYNEE--IVAVKCSKPKFE-KIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKK----YS-----------CNLRE-----
|.|.|. | | .|| .. .. | | . . .||..|.||| .. .| ||. . . |... .| . .. | | . |
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE
-----IMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGF----TRK
. . . .|..... .. |||| . |.. | .| ||||.|.| . .|.. |. ||| . .. . . | . | .
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------DFGFASQVSKNKSHIQSKKMNTCGTWA
YAAPELTDD----NGFFNIKYDIYGLGIIL
| ||| . . ...|. |.. .|..|
YFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 2011.AA | Pkinase | 100-297 | 25 | 1.2e-11 | 42.32 | Pfam | 9-211 (293) | Show / Hide |
Range on Protein: 100-297 Range on HMM: 9-211/293 Sequence Identity: 25% (55 aa) QGGNGCVFEAKYNEE--IVAVKCSKPKFEKIQE--------EEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSF----FDKKKPL- .|. |||.... . |||||. | . || .. | .||| | . |.. . .. | . |...| . . | | | ...... SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY -PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKS--FKDGSKTYDLKGFTRKYAAPELTDDNGFFNIKYD . ... .. |. | . ... || |.||||||.|.. . .| .||| .| .| .... | |. |.|||. .. | | FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------CVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVD IYGLGIILLELTLGKFL ....|.|| |. .|... MWSCGCILYEMLCGRPP |
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| Kinase | 2011.AA | Ciliate-B2 | 93-285 | 27 | 3e-11 | 22.6 | In-house | 2-197 (197) | Show / Hide |
Range on Protein: 93-285 Range on HMM: 2-197/197 Sequence Identity: 27% (58 aa) YLTSYISQGGNGCVFEAKYNEEI------VAVKCSKP----KFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSFFDKKK ||. || .|| | ..| | .. .|.| | ||.| ||||.. .| | |. . ... . | | | |.. .| ..| YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK PLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDN------GFFN . . .. |. .. .| .| ||||.||| .... | . ||| | | | |||| ||| || .. . CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN---------YVY-CDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNID IKYDIYGLG . ||| .| FQSDIYSMG |
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| Kinase | 2011.AA | Ciliate-E3 | 205-292 | 34 | 1e-10 | 29.94 | In-house | 121-202 (202) | Show / Hide |
Range on Protein: 205-292 Range on HMM: 121-202/202 Sequence Identity: 34% (31 aa) QNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGS---KTYDLKGFTRKYAAPELTDDNGFFNIKYDIYGLGIILLELT . |.|||||||.||| |. . . .| .||| || . |.. |.| |||||. .|.. . |.| .| ....| EKNIIHSDIKPDNILVDKNNNQLII-KI------CDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 2011.AA | Ciliate-E2 | 92-351 | 18 | 4.9e-10 | 30.63 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 92-351
Range on HMM: 1-365/365
Sequence Identity: 18% (70 aa)
IYLTSYISQGGNGCVFEA-------------------------KYNEEIVAVKCSKPK-FEKIQEEEKIMKLLK---------------DTPYVFKSIEE
. . | ||. |.|... |.. |.|.|. |.. | | |..||. .. . |.. | .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FLNKKKSKYYQISKKYSC-NLREIMQ---SFFDKK----KPLPLNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .|.....| . .. .|..... ..... |.. ...| . | .| | . ..| || ||||||||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
FNLSQILIYNLK-GDFGDSKSFKDGSK--------TYDLKGF------------------------TRKYAAPELTDDNGF--------FNIKYDIYGLG
.| ||| || ..| .. . . | | ||| . . | ||. ||
----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
IILLELTLGKF---LEDKDCTFIRNGQLPNYICKNALFQDIN------------QIIVQ----MLEVMPQNRIDSFELTKQLNKL
.|| |. ||. . |.| . . . .. .. . | .. ..| . ||.. |..||...| .. .
VILYEMLFGKPPFQQQIKQCKIDFPCPEWQKD-TQ-CIQ-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 2011.AA | Ciliate-E2-Unclassified | 92-351 | 19 | 1.9e-09 | 28.93 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 92-351
Range on HMM: 1-352/352
Sequence Identity: 19% (72 aa)
IYLTSYISQGGNGCVFEAKYNEE-------------IVAVKCSKPKFEKIQEEEKIMKLLK------------------DTPYVFKSIEEFLNKKKSKYY
. | |||.|.|.... ... |...| . | | |.|.|. .| . |.. | ...| ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY
QISKKY-SCNLREIMQSFFD-------------KKKPLPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEKCFNLSQILIYNLKGD
. . .|....... ..| .. .|.. .. | .|.. ..| || ||||||||.|.. | | |
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------NYYIKIID
FGDSKSFKD---------------GSKTYDLKGFTRKYA----APELTDDNGFFN---IKYDIYGLGIILLELTLGKFL-EDKDCT--------FIRN--
|| || .. .. .. . | | |||. . .. . .| ||..||.|| |. |.. .|..|. .| |
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNA
---GQLPNYICKNALFQDIN-----------------QIIVQMLEVMPQNRIDSFELTKQLNKL
.. | . || |. . ... .||.. | .|| .|| .. .
YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF
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| Kinase | 2011.AA | TKL | 169-295 | 16 | 2.9e-08 | 25.89 | In-house | 124-286 (364) | Show / Hide |
Range on Protein: 169-295
Range on HMM: 124-286/364
Sequence Identity: 16% (30 aa)
NLREIMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNN--------LIHSDIKPENILYDSQEK--------CFNLSQILIYNLKGDFGDSKSFK----
.|..... ..|.. .|.... . ..| .|| |.|..||| |. . . . | .||| |....
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI----CDFGLSRFMSQSGN
---------------DGSKTYDLKGFTRKYAAPELTDDNGFFNIKY---------------DIYGLGIILLELTLGK
...|| .. | . |||. ....... |. |.| ||.| |. ..
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC
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| Kinase | 2011.AA | CAMK | 205-288 | 21 | 4.7e-08 | 21.28 | In-house | 197-324 (425) | Show / Hide |
Range on Protein: 205-288
Range on HMM: 197-324/425
Sequence Identity: 21% (28 aa)
QNNLIHSDIKPENILYDSQEK---------CFNLSQILIYNLK-GDFGDSKSFKDG-----------------------SKTYDLKGFTRKYAA-PELTD
..| .| |.||||||.|. .. | . .|.| ||| .. |..| . . | |.| ||.
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN
D-------------NGFFNIKYDIYGLGIIL
. . | |. .|.||
GKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
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| Kinase | 2011.AA | TyrKc | 92-348 | 17 | 2.1e-07 | -103.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 92-348
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)
IYLTSYISQGGNGCVFEAKYNEEIVAVKCSK--PKFEKIQEEEKIMKLL-KDTPYVFK----SIEE------------------------FLNKKKSKYY
| | . | | |...... . ||||. | | . .| .||. | .. | . . ... .| |.. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
QISKKYSCNLREIMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKSFKDG------SKT
|.. . . |..| . | . ..|.|| |. |.|.... | .||| |. .|. ...
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDY
YDLKG--FTR-----KYAAPELTDDNGFFNIKYDIYGLGIILLEL-TLGKFLEDKD----------CTFIRNG---QLPNYICKNAL-----FQDINQII
|. |. .. . ||| . | |..| |.. |. . |. |.|. . ....| | ... . ... ||.
YRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIM
VQMLEVMPQNRIDSFELTKQL
| . | .| |. ...
KQCWHEDPEDRPTFSEIHECF
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| Kinase | 2011.AA | TKL | 98-139 | 19 | 1.3e-05 | 16.17 | In-house | 1-81 (364) | Show / Hide |
Range on Protein: 98-139 Range on HMM: 1-81/364 Sequence Identity: 19% (16 aa) ISQGGNGCVFEAKYNE----------EIVAVKCSKPKF-----------------------------EKIQEEEKIMKLLK | .|| |.|. .|.. . |||| | . .. .||| || ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR |
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| Kinase | 2011.AA | CAMK | 97-160 | 12 | 0.009928 | 3.82 | In-house | 1-133 (425) | Show / Hide |
Range on Protein: 97-160 Range on HMM: 1-133/425 Sequence Identity: 12% (16 aa) YISQGGNGCVFEAKYNEEI--------------VAVKC--------------------------------SKPKFEKIQEEEKIMKLLK------DTPYV . .|. | |.... . ||.| . . .... | .|||.|. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI FKSIEEFLNKK-----------------KSKYY | .| . ... ....| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMY |
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