Gene 12644 (Tetrahymena)
12644
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 12644.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12644.AA | Ciliate-C7 | 13-184 | 64 | 8.9e-108 | 346.51 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 13-184 Range on HMM: 1-164/164 Sequence Identity: 64% (111 aa) FRFLGQGLQGLVMLAKDSKSNIRYAIKGVQVRDDKGKVYDEVQNLVKNEIDILQNCRGSPYVVSLLGSFEGKLFTYLVLSECQENFQFMIQKGTLTEIIT ||||||| ||||.||||.|.|.|||||||||||..|.......| |..||.||..|..|||||.|| .|||. |.||||.|||. |||..|| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG--------GTLNQIIE KSQNKRLNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGNAVVSDFGLAAKLTVKSEYSEDEYV ..|||||||||||||||||..|.||||||....|||||.||||||||||||.|||||..|| ||.|. ..|. RNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
|||||||||
| Kinase | 12644.AA | AGC | 13-172 | 24 | 2.7e-27 | 66.27 | In-house | 1-205 (395) | Show / Hide |
Range on Protein: 13-172 Range on HMM: 1-205/395 Sequence Identity: 24% (50 aa) FRFL---GQGLQGLVMLAKDS------KSNIRYAIKGVQ----VRDDKGKVYDEVQNL--------VKNEIDILQNCRG---------SPYVVS-LLGSF |.|| |.| | |.|... .. ||.| .. . ..| . . ... |..| .||..|.. .|..|. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGKLF--TYLVLSECQENFQFMI----QKG-TLTEIITKS-QNKRLNEISAIKYAKD-------ITEGIYYIHS-KGYLAND-LKMENILIDYNGNAVVS . | |.|. ... .. | | .. . ...|..| | || |. .. |.|| .|. | || ||||.| .|. . QDKDHTYLYFVMEYMPR---YVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT DFGLAAKL ||||. .. DFGLCKEG |
|||||||||
| Pkinase | 12644.AA | Pkinase | 10-177 | 26 | 1.1e-23 | 84.77 | Pfam | 1-167 (293) | Show / Hide |
Range on Protein: 10-177
Range on HMM: 1-167/293
Sequence Identity: 26% (48 aa)
YSDFRFLGQGLQGLVMLAKDSKSNIRYAIKGVQVRDDKGKVYDEVQNLVKNEIDILQNCRGSPYVVSLLGSFEGKLFTYLVLSECQE-----NFQFMIQK
| | .|.| | | .... ......|.| . .|..| .. . .| .|| |.... ..|..| |...|| | |.|. |. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST
GTLTEIITKSQNKRL--NEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGNA----VVSDFGLAAKL-TVKSE
...... | ...|.. | .|..|.||.| . ||| |||||| ||. ..|||||... . ...
---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS
|
|||||||||
| Kinase | 12644.AA | CAMK | 15-200 | 18 | 4.6e-21 | 63.97 | In-house | 1-279 (425) | Show / Hide |
Range on Protein: 15-200
Range on HMM: 1-279/425
Sequence Identity: 18% (52 aa)
FLGQGLQGLVMLAKDSKSN------------IRYAIKGVQV----------------RDDKGKVY------DEVQNLVKNEIDILQNCRG------SPYV
||.| | | |... ... ..||| . .|. .. .. . |..||.|.....| | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSLLGSFEG-------------------KLFTYLVL---SECQEN------FQFMIQKGTLTEII----TKSQNKRLNEISAIKYAKDITEGIYYIHSKG
..|. .| . . |.|. |. |.. ...| .| ...|..| | .| . | ... |.||..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN
YLANDLKMENILIDYN-----------------GNAVVSDFGLAAKLTVKSEYSEDEYVKQTNIFAHN-------NMKFNQF
||| ||||.|.| .| ..|||.|.|.. .... .. .|. . . || . |.. |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTF
|
|||||||||
| Kinase | 12644.AA | CAMKL | 10-173 | 25 | 4.2e-18 | 54.24 | In-house | 1-180 (297) | Show / Hide |
Range on Protein: 10-173 Range on HMM: 1-180/297 Sequence Identity: 25% (49 aa) YSDFRFLGQGLQGLVMLAKD-SKSNIRYAIKGVQVRDDKGKVYDEVQNL-------------VKNEIDILQNCR--GSPYVVSLLGSFEGKLF------T | . ||.| | | ||.. . ....||| . || | .. ... .. || |.. . . | ...|. .| . . YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKII----DKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI YLVLSECQENFQFMIQKGT--LTEIITKSQNKR--LNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNG--NAVVSDFGLAAKLT |||. .. | | . | | ..| . | | .| . | ....|.||.| |.| ||||.|.|| |. ..|||.... . YLVME--------YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYR |
|||||||||
| Kinase | 12644.AA | Ciliate-E2 | 10-219 | 19 | 1.5e-16 | 53.33 | In-house | 1-260 (365) | Show / Hide |
Range on Protein: 10-219
Range on HMM: 1-260/365
Sequence Identity: 19% (55 aa)
YSDFRFLGQGLQGLVMLAKDSKSNIRYAIK-------------GVQVRDDKGKVYDEVQ-NLVKNEIDILQ--NCRG--------------SPYVVSLLG
| . .||| .| | ..|. | . ..||| .|.. |.. . | . .|.||.|.. || . .|... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE
SFE--GKLFTYLVLSECQEN--FQFMIQKGTL-TEIITKSQNKRLNEISAIKYAKDITE---------------GIYYIHSKG-YLANDLKMENILIDYN
.|. . |||. || . |...... . ...|.| . |...| .... | |.. .. |.|||. . |.| ||||.
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
GNAVVSDFGLAAKLTVK-------------SEYSEDEYVKQTNIFAHNNMKFNQFNSKNF---------KMGNFYYQAPECYG
..||||. |.. . . . |... ..... . |. .|.||| ..
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD--------------QIIQQNMFNTICGTPGYMAPEILN
|
|||||||||
| Kinase | 12644.AA | STE | 10-173 | 18 | 1.7e-16 | 54.83 | In-house | 1-198 (359) | Show / Hide |
Range on Protein: 10-173 Range on HMM: 1-198/359 Sequence Identity: 18% (38 aa) YSDFRFLGQGLQGLVMLAKDSK---------------SNIRYAIKGVQVRDDKGKVYD------------EVQNLVKNEIDILQNCRG-SPYVVSLLGSF . . ...|.| | | .|.. | .. ..||| . ..... |. . | .. ...||.|...|. .|..| .|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY EGKL-------FTYLVLSECQ-ENFQFMIQ-KGTLTEIITKSQ--NKRLNEISAIKYAKDITEG-IYYIHSKGYLANDLKMENILIDYNGNAVVSDFGLA . . .... . . .|. |. . .... ..|..| ......| .| ||.||... |.| |||. . .|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC AKLT ..|| GQLT |
|||||||||
| S_TKc | 12644.AA | S_TKc | 10-299 | 19 | 4.7e-16 | 58.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-299 Range on HMM: 1-231/231 Sequence Identity: 19% (62 aa) YSDFRFLGQGLQGLVMLAKDSKSNIRYAIKGVQVRDDKGKVYDEVQNLVKNEIDILQNCRGSPYVVSLLGSFEGKLFTYLVLSECQENFQFMIQKGTLTE | | .|.| | |..... |.. ..||| . . ...||.||.. . |..| |...|. . |.|. | . |.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDL------GDLFD IITKSQNKR----LNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGNAVVSDFGLAAKLTVKSEYSEDEYVKQTNIFAHNNMKFNQFNSKNF .| | . .. ..| | .|.. | ... |.||.| . ||| ||||.| . ..|||||..| . YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------TT KMGNFYYQAPECYGPNDN----------------IGKVYYDEYKKQDVQVQQLPSIRGIDLKLIFSKHQPLDYKEFQNFGYHKQLQYLINELTQFVPRKR | .| ||| . . |. .. |. .. .. ... .|. . |. |.|| FCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKR LPIFEALI---------VL . . ||| . PTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 12644.AA | IRE | 82-179 | 28 | 7.4e-15 | 47.55 | In-house | 63-180 (292) | Show / Hide |
Range on Protein: 82-179 Range on HMM: 63-180/292 Sequence Identity: 28% (34 aa) EGKLFTYLVLSECQENFQFMIQKGTLTEIIT-----KSQNKRLN--------EISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDY--------NGN |.. | || |. ||.. | .... . ..| . .||..| .| .. .|....|. . || . .||| .||||.. |. EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR AVVSDFGLAAKLTVKSEYS .. ||||| | |.. || FMISDFGL-CKMLVEGRYS |
|||||||||
| Kinase | 12644.AA | Ciliate-E2-Unclassified | 10-219 | 20 | 2.2e-14 | 46.32 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 10-219 Range on HMM: 1-239/352 Sequence Identity: 20% (50 aa) YSDFRFLGQGLQGLVMLAKDSKSNIRYAIKGVQVRDDKG-KVYDEVQNLVKNEIDILQNCR------------------GSPYVVSLLGSFEGKLFTYLV | . .||| .| | .....| . ||.| . .. | . ... .||.....| .|..| .. |. | |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LSECQEN--FQFMIQKGT----LTEIITKSQN-KRLNEISAI-----KYAKDITEGIYYIHSKG-YLANDLKMENILIDYNG---NAVVSDFGLAAKLTV . |. . .|.. .... .. . .. |.. | |. .|.. | .|. |.|.|. . |.| ||||.| || . ..|||.. |. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSEYSEDEYVKQTNIFAHNNMKFNQFNSKNFKMGNFYYQ----APECYG ... .. ..|...... . ..|. .|. |||... NNNCD-TNQQ--------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
|||||||||
| Kinase | 12644.AA | Ciliate-A2 | 107-171 | 35 | 1e-12 | 40.76 | In-house | 85-152 (272) | Show / Hide |
Range on Protein: 107-171 Range on HMM: 85-152/272 Sequence Identity: 35% (24 aa) LTEIIT--KSQNKRLNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGN-AVVSDFGLAAK | . | ..| | ... ....|. | ..| |.|.| | ||. .||||| ... .. |||||.| LQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKK |
|||||||||
| Kinase | 12644.AA | STE20 | 10-81 | 22 | 1.4e-11 | 38.84 | In-house | 1-73 (288) | Show / Hide |
Range on Protein: 10-81 Range on HMM: 1-73/288 Sequence Identity: 22% (18 aa) YSDFRFLGQGLQGLVMLAKDSKSNIR----YAIKGVQVRDD---KGKVYDEVQNLVKNEIDILQNCRGSPYVVSLLGSF | ... .||| | | .| . ... .||| . .... . . ......||.|...|. .|..|. .||. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSY |
|||||||||
| Kinase | 12644.AA | STE20 | 105-173 | 30 | 2e-07 | 23.48 | In-house | 93-168 (288) | Show / Hide |
Range on Protein: 105-173 Range on HMM: 93-168/288 Sequence Identity: 30% (23 aa) GTLTEIITK--SQNK-----RLNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGNAVVSDFGLAAKLT |.||.|... . .| ..|| ... .| |.||... |.| |||.. .|.. .|||..|.|| GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLT |
|||||||||
| Kinase | 12644.AA | Ciliate-A2 | 17-68 | 29 | 4e-06 | 17.56 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 17-68 Range on HMM: 1-55/272 Sequence Identity: 29% (16 aa) GQGLQGLVMLAKD--SKSNIRYAIKGVQVRDDKGK-VYDEVQNLVKNEIDILQNC ||| |.|..... . | |||| . . | ... . . | |...|.|| GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
|||||||||
| Kinase | 12644.AA | TyrKc | 10-299 | 17 | 4.4e-05 | -140.52 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-299 Range on HMM: 1-280/280 Sequence Identity: 17% (57 aa) YSDFRFLGQGLQGLVMLAKDSKSNIRYAIKGVQVRDDKGKVYDEVQNLVKNEIDILQNC-RGSPYVVSLLGSFEGK-------LFTYLVLSECQENFQFM . . || | | |.... . | |.| .. . .|. |. . | .| |.| . ..| . .| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV-------MEYM IQKGTLTEIITKSQNKRLNEISAIKYAKDITEGIYYIHSKGYLANDLKMENILIDYNGNAVVSDFGLAAKLTVK---SEYSEDEYVKQTNIFAHNNMKFN | | . . |...| |. .... .| .| |.|||.. || |.|.. |. . .|||||. ... . |.| |.|.. PH-GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKE----------- QFNSKNFKM-GNFYYQAPECYGPNDNI--------------------GKVYYDE-----YKKQDVQVQQLPSIRGIDLKLI---FSKHQPLDYKEFQNFG .|. |. |||| |... |. | . . |.| .... . . . | | . ---HKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDYPMS---------F--VC YHKQLQYLINELTQFVPRKRLPIFEALIVL .. . .. . .. | .| | . CPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||