Gene 14173 (Tetrahymena)
14173
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 14173.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14173.AA | Ciliate-C7 | 78-233 | 77 | 1.9e-115 | 371.47 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-233 Range on HMM: 1-164/164 Sequence Identity: 77% (127 aa) FRFLGQGVQGLVLLAKDTKTNVRYAIKGVQVRDPHGNLDQDLNNRVKQEVEILTKCSDSPYVVSLIDQFEGQQFTYLVLTECQ--------ERNQNKRLN ||||||| ||||||||| |||.|||||||||||..||.|||.||.|.||..|| .|.||||||.|..|||||||.||||.||| ||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAFNQYM ||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..|||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 14173.AA | Pkinase | 75-218 | 27 | 3.1e-24 | 86.79 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 75-218 Range on HMM: 1-159/293 Sequence Identity: 27% (45 aa) YSDFRFLGQGVQGLVLLAKDTKTNVRYAIKGVQVRDPHGNLDQDLNNRVKQEVEILTKCSDSPYVVSLIDQFEGQQFTYLVLTECQE-----RNQ----- | | .|.| | | .... .|. ..|.| . .|. . . || . .. .|..|. .. ..|..| |.| || . |.|. |. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST --NKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLA .... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 14173.AA | CAMK | 80-242 | 16 | 1.9e-23 | 71.78 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 80-242 Range on HMM: 1-290/425 Sequence Identity: 16% (48 aa) FLGQGVQGLVLLAKDTKTN------------VRYAIKGVQV----------------RDPHGNLD------QDLNNRVKQEVEILTKCS------DSPYV ||.| | | |.....|. ...||| . .| .. . . .|..|.||. |.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLIDQFEG-------------------QQFTYLVL--------T----ECQERNQNK----------------RLNEISAIKYANDIAQGLYYIHSKSC ..|.. .| ... |.|. .. .. . . |..| | .| |.... |.||. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAFNQYMGNFLYQA-PE ||| .|||.|.. .| ..|||.| .. .. | .. . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 14173.AA | Ciliate-E2-Unclassified | 75-245 | 18 | 9.3e-20 | 65.22 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 75-245 Range on HMM: 1-239/352 Sequence Identity: 18% (45 aa) YSDFRFLGQGVQGLVLLAKDTKTNVRYAIKGVQ-VRDPHGNLDQDLNNRVKQEVEILTKC------------------SDSPYVVSLIDQFEGQQFTYLV | . .||| .| | .... |.. ||.| ... . .. . . . ..| ... . ...|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-----------------------QERNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADNLIN . | . ..|.|.. | |. .|. | ||| |.|.| .. |.| .|||.| | . ..|||.. .... MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSGYAFNQY---------------MGNFLYQ----APECFD ... .. .|. |. |||... NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 14173.AA | Ciliate-E2 | 75-244 | 18 | 7.5e-19 | 61.33 | In-house | 1-259 (365) | Show / Hide |
Range on Protein: 75-244 Range on HMM: 1-259/365 Sequence Identity: 18% (48 aa) YSDFRFLGQGVQGLVLLAKDTKTNVRYAIK-------------GVQ-VRDPHGNLDQDLNNRVKQEVEILT---------------KCSDSPYVVSLIDQ | . .||| .| | ..|. |.. ..||| .|. .. .. . .||| |. . ..|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFTYLVLTECQERN------------------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN |. .. |||. || . . |...| .... |.| .| |.||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNLINKSGY------------------------------AFNQYMGNFLYQAPECF ..||||. .. ... . ||.. |. |.||| . IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL |
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| Kinase | 14173.AA | CAMKL | 75-244 | 24 | 9.8e-18 | 53.03 | In-house | 1-205 (297) | Show / Hide |
Range on Protein: 75-244 Range on HMM: 1-205/297 Sequence Identity: 24% (50 aa) YSDFRFLGQGVQGLVLLAKDTKT-NVRYAIKGVQVR----DPHGNLD------QDLNNRVKQEVEILTKCS--DSPYVVSLIDQFEGQQF------TYLV | . ||.| | | ||....| ....||| . . ||. . .. |...|..|. . . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQERN----------QNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAFNQYMGNFLY . |. . ..| . | | .| | ...|.||. |.| .|||.|..| |. ..|||.. . ...| .. | | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY QAPECF .||| | MAPEIF |
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| Kinase | 14173.AA | Ciliate-E1 | 81-243 | 21 | 2.6e-17 | 53.22 | In-house | 1-181 (202) | Show / Hide |
Range on Protein: 81-243
Range on HMM: 1-181/202
Sequence Identity: 21% (39 aa)
LGQGVQGLVLLAKDTKTN-VRYAIKGVQVRDPHGNLDQDLNNRVKQEVE-ILTKCSDSPYVVSLIDQFEGQQF-TYLVLTEC-----QERNQ--------
.|.| ...|. || ..| .|.| ..... | .|. .. ...| |. |.. .||... .| ... ..|| .. .|
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW
------NKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAFNQYMGNFLYQAPEC
.. ... .. . .. .|| ..|.. . |.|..||||. || | .|||....|.|.. . .. |. ||.
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ
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| Kinase | 14173.AA | ULK | 75-218 | 22 | 5.4e-16 | 52.4 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-218 Range on HMM: 1-189/329 Sequence Identity: 22% (43 aa) YSDFRFLGQGVQGLVLLAKDTKT----NVRYAIKGVQ----VRDPH---GNLDQDLNNRVKQEVEILTKCSD---SPY----VVSLIDQFEGQQF--TYL |. . ||.| | | ... || |. .|.| .. .... | | . . .|.|..|. | . ... .| |.| || ... .|. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VLTECQER------NQNKRLNEIS----------AIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA .. |. ..||.|.| ||.. .|..|. ..|.. . |.| .||||. . ..|||.| IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 14173.AA | S_TKc | 75-331 | 19 | 6.6e-16 | 56.33 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-331
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)
YSDFRFLGQGVQGLVLLAKDTKTNVRYAIKGVQVRDPHGNLDQDLNNRVKQEVEILTKCSDSPYVVSLIDQFEGQQFTYLVLTECQE--------RNQNK
| | .|.| | | .....||. ..||| . .....|..|| | . |..| |.| |. .. |.|. | ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
R------LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAFNQYMGNFLYQAPECFDPADP-----------
| ..| | .|. |...| |.||. . ||| .|||.| . ..||||| | . . | | ||| . . ..
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI
----FIGKV-YHDEYLKLGVTVRQEPSNRGIDFKLASNKHKQLNYDGEFNNFVYHKQLKYIIEGLTNFIPKNRMPIKEALI-----ILKGII
. |. .. .. .. .. ...| .|... .. |..|. . ||| . .
LYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 14173.AA | ULK | 75-218 | 23 | 1.3e-15 | 51.91 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-218 Range on HMM: 1-185/324 Sequence Identity: 23% (44 aa) YSDFRFLGQGVQG-LVLLAKDTKT---NVRYAIKGVQ--------VRDPHGNLDQDLNNRVKQEVEILTKCS--DSPY--VVSLIDQFEGQ--QFTYLVL |. . ||.| | | ... || |. .|.| .. ... | | . . |.|..|. | .|. .| |.| || . ..|... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQER------NQNKRLNEIS----------AIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA |. ..||.|.| ||.. .|..|. ..|.. . |.| .|||| . ..|||.| EYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 14173.AA | SAK | 75-221 | 29 | 4.6e-14 | 44.02 | In-house | 1-150 (254) | Show / Hide |
Range on Protein: 75-221 Range on HMM: 1-150/254 Sequence Identity: 29% (45 aa) YSDFRFLGQGVQGLVLLAKDTKTNVRYAIKGVQVRDPHGNLDQDLNNRVKQEVEILTKCSDSPYVVSLIDQFEGQQFTYLVLTECQE-------RNQNKR | ||.| | || .| ||| . | . .||..|||| .. | .. | || . . |||| |. ... . YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMI---DKKLMQKTGMVQRVRNEVEIHCQLKH-PSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRP LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNL | | .. ..| |. |.|| . || . |||. . . ||||| | FTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQL |
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| Kinase | 14173.AA | Ciliate-A2 | 163-218 | 35 | 1.3e-09 | 29.82 | In-house | 94-150 (272) | Show / Hide |
Range on Protein: 163-218 Range on HMM: 94-150/272 Sequence Identity: 35% (20 aa) NQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGN-AVVSDFGLA || | ... ....|. | ... |.|.| . ||. ||||| ... .. ||||| NQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA |
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| Kinase | 14173.AA | TyrKc | 75-327 | 16 | 4e-06 | -123.58 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-327
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)
YSDFRFLGQGVQGLVLLAKDTKTNVRYAIKGVQVRDPHGNLDQDLNNRVKQEVEILTKC-SDSPYVVSLIDQFEGQ-------QFTYLVLT-----ECQE
. . || | | | ... . . |.| .. .| .|..| . | .| |. | . ..|. ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
RNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAFNQY--MGNFL----YQAPECF---
. ...| |. .... .||.| |.||| | || |.|.. . . .|||||. .. .. . | . |... ||||.
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG
--------------------DPADPFIG-----KVYHD--EYLKLGVTVRQEPS----NRGIDFKLASNKHKQLNYDGEFNNFVYHKQLKYIIEGLTNFI
. . | | . . ||.| | .| |. | .. . |.. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F--VCCPDEMYQIMKQCWHED
PKNRMPIKEALIIL
|..| .| ..
PEDRPTFSEIHECF
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| Kinase | 14173.AA | Ciliate-A2 | 82-134 | 28 | 1.1e-05 | 16.06 | In-house | 1-56 (272) | Show / Hide |
Range on Protein: 82-134 Range on HMM: 1-56/272 Sequence Identity: 28% (16 aa) GQGVQGLVLLAKD--TKTNVRYAIKGVQVRDPHGN-LDQDLNNRVKQEVEILTKCS ||| |.|..... . | |||| . . |... .| . | | ..| .|. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN |
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