Gene 17307 (Tetrahymena)
17307
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 17307.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 17307.AA | Ciliate-C7 | 69-228 | 36 | 5.6e-78 | 249.68 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 69-228 Range on HMM: 1-164/164 Sequence Identity: 36% (61 aa) IRFAGRGSFGTTIIGEDQNQN-RFAFKLIFIRTKHGQINQDIRGKALKEANVMSK-MDHPNVVKFYNYYETQNYIIIQMEECK-GDLNQFMKS--YELLS .||.|.|..|......||..| |.|.| ...|.|.|.|.|||......|.|.... .|.|.||......|.|..|.....||. |.|||.... ...|. FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN IESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNVAKIADFGLAAYVMQGTSKIKYSVQG ..|.|||...|.||..|.|....|..|||.|||||| ...|...|||||....|.. |....... EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKS-KYQINQYM |
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| S_TKc | 17307.AA | S_TKc | 66-337 | 21 | 1.8e-37 | 131.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 66-337
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)
YKSIRFAGRGSFGTTIIGEDQN-QNRFAFKLIFIRTKHGQINQDIRGKALKEANVMSKMDHPNVVKFYNYYETQNYIIIQMEECKG---DLNQFMKSYEL
|. .| |.|.||. . . . . ..| | | ....| ....| .|||.||.| .... ... . || | | || ...|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
------LSIESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNVAKIADFGLAAYVMQGTSKIKYSVQGAQLFRAPELQDELCQNLIQQLKKENPS
.. .| ..| ....| |..| . |||| .|||.|. . ||.|||||. . ... | ..|||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----------------
LVLQSK-KSDCFSLGLIFYSCLG--TPLSKFIKILQDGPASIDTPVMIEGQQEFECINKMLQLLCEHHPNKRMKLSDVIQ------QFKFL
.| |.| |.| |.| .| .| . .. . . |... ... ... |.||. .. | . ..
--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Pkinase | 17307.AA | Pkinase | 66-273 | 27 | 5.2e-31 | 110.73 | Pfam | 1-203 (293) | Show / Hide |
Range on Protein: 66-273
Range on HMM: 1-203/293
Sequence Identity: 27% (62 aa)
YKSIRFAGRGSFGTTIIGEDQNQNR-FAFKLIFIRTKHGQINQ-DIRGKALKEANVMSKMDHPNVVKFYNYYETQNYIIIQMEECKG-----DLNQFMK-
|. .| |.||||. .. ... .. .| | | |... . .| ..| |. .| ...|||.|..| ..|. ..| . || | | || ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST
-SYELL--SIESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNVA----KIADFGLAA--YVMQGTSKIKYSVQGAQLFRAPELQDELCQNLIQQ
.. . | . ..| .| .|..| |..| . ||||..|||||. .. ||.|||||. . . ... | ..|||. |.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEV--------IR-
LKKENPSLVLQSKKSDCFSLGLIFY
. ..|.| .|.|.|.|
------GGQYYGPKVDMWSCGCILY
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| Kinase | 17307.AA | Ciliate-A2 | 73-215 | 32 | 2.2e-28 | 95.75 | In-house | 1-153 (272) | Show / Hide |
Range on Protein: 73-215 Range on HMM: 1-153/272 Sequence Identity: 32% (50 aa) GRGSFGTTIIGED---QNQNRFAFKLIFIRTKHGQ-INQDIRGKALKEANVMSKMDHPNVVKFYNYYETQNYIIIQMEEC-KGDLNQFMK----SYELLS |.|.||. |. |. .| .| | . | ...| |.| . .|| .... .|||.|| . . .| |||| | ...|... . . .. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIP IESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNV-AKIADFGLAAYV . |... . |...|.| | . |||||.| |||||. |. | |||||... DHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKY |
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| Kinase | 17307.AA | Ciliate-E2 | 66-276 | 20 | 7.5e-28 | 92.68 | In-house | 1-290 (365) | Show / Hide |
Range on Protein: 66-276 Range on HMM: 1-290/365 Sequence Identity: 20% (60 aa) YKSIRFAGRGSFGTTIIGED-QNQNRFA-------------------FKLIFIRTKHGQINQDIRGKA-LKEAN----------VMSKMDHPNVVKFYNY || |. |.|.||. ... ..|..|| .. . |. ||.| . . ..| | ......|||..|.| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YE--TQNYIIIQMEECKG-DLNQFMK-----------------SYELLSIESFIKYGQ---------EISQGIQYVHDQG-LVLRDLKLDNILIDKMNVA .. ..|.| . || |.| || ...| .| . | | .|. .| ....| | .. . ||.|..|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIADFGLAAYVMQGTSKIKYSVQGAQLFRAPELQDELCQNLIQQ------------LKKENPSLVLQS-------------KKSDCFSLGLIFYSCL ||.||||. .. . .. . |..... ... .. ..| . . .|.. .|.| .||| |.| .| KIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML |
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| Kinase | 17307.AA | CAMK | 73-237 | 19 | 4.4e-27 | 83.73 | In-house | 3-291 (425) | Show / Hide |
Range on Protein: 73-237 Range on HMM: 3-291/425 Sequence Identity: 19% (56 aa) GRGSFGTTIIGEDQNQNR-------------FAFKLIFIR--------------------TKHGQIN--QDIRGKALKEANVMSK-------MDHPNVVK ||||||. ... | .. .| | | . .||.. . . | . ..| ..|.| .||||..| GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK FYNYYE------------TQNY--------IIIQM---EECKG-----DLNQFMKSYEL---------------LSIESFIKYGQEISQGIQYVHDQGLV .| .|| | .. ... | | | | || .. .. . .. . .| . | ....| |... | LYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV LRDLKLDNILIDKM-----------------NVAKIADFGLAAYVMQGT----------------------SKIKYSVQGAQLFRA-PEL ||||..|||.|. | ||.|||.|.....| . . . | . | ||. HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV |
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| Kinase | 17307.AA | CAMKL | 115-237 | 27 | 2.1e-26 | 81.16 | In-house | 61-204 (297) | Show / Hide |
Range on Protein: 115-237 Range on HMM: 61-204/297 Sequence Identity: 27% (39 aa) KEANVMSKMD---HPNVVKFYNYYETQNY------IIIQMEECKGD---LNQFM--KSYEL--LSIESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILI .|.. |.... |||..|.| .||... | . || | | | .. . . .. . .| . | ...| |..| | ||.|..|||. REIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL D-KMN-VAKIADFGLAAYVM---QGTSKIKYSVQGAQLFRAPEL | ..| ..||.|||.... . |. . | . |||. DENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI |
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| Kinase | 17307.AA | ULK | 66-244 | 25 | 1e-24 | 83.24 | In-house | 1-231 (329) | Show / Hide |
Range on Protein: 66-244 Range on HMM: 1-231/329 Sequence Identity: 25% (59 aa) YKSIRFAGRGSFGTTIIGEDQNQN-----RFAFKLIFIRTKHGQIN----QDIRGKALKEANVMSKMD--------HPNVVKFYNYYETQ--NYIIIQME | .. | ||||. |...... .| | | . .. . | | . .| .| |.. |||.||.| ..||. |.| | || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECKG-DLNQFMKSYELLSIES----------FIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMN------------VAKIADFGLAAYVMQG--TSK | | || |..| . |. . |.. . | .| .. |... . ||.|..||||.. . |.||||||.| |. . . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ IKYSVQ------GAQLFRAPELQDEL--CQN . .. | |. ||.. .. ... MMMTCVNEKRLCGTPLYMAPQILQGQGEQKP |
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| Kinase | 17307.AA | ULK | 66-212 | 27 | 5.6e-24 | 82.02 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 66-212 Range on HMM: 1-185/324 Sequence Identity: 27% (52 aa) YKSIRFAGRGSFG-TTIIGEDQNQN--RFAFKLIFIR---TKHGQIN---QDIRGKALKEANVMSKMD---HPN--VVKFYNYYETQ--NYIIIQMEECK | .. | |||| . |.....| ... | . . . | . . .| ..| |.. ||| .||.| ..||. |.| | || | YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN G-DLNQFMKSYELLSIES----------FIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMN------------VAKIADFGLA | || |..| . |. |.. . | .| .. |... . ||.|..|||| . . |.||||||.| GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 17307.AA | STE | 66-215 | 22 | 1.1e-23 | 80.57 | In-house | 1-197 (359) | Show / Hide |
Range on Protein: 66-215
Range on HMM: 1-197/359
Sequence Identity: 22% (45 aa)
YKSIRFAGRGSFGTTIIGEDQN----------------QNRFAFKLIFIRTK-----------HGQINQDIRGKALKEANVMSKMD--HPNVVKFYNYYE
.. |.. |.|.|||. . . . ....| | . .... ..|.... . ||| ..|.|.. |||.||.| .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
TQ-------NYIIIQMEECK-GDLNQFMK-SYELLSI------------ESFI-KYGQEISQG-IQYVHDQGLVLRDLKLDNILIDKMNVAKIADFGLAA
... | || . | | ...| |. . || | .. ..| .| .| |... . ||.| .|||. .|..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
YV
.
QL
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| Kinase | 17307.AA | Ciliate-E2-Unclassified | 66-276 | 21 | 1.4e-22 | 75.12 | In-house | 1-264 (352) | Show / Hide |
Range on Protein: 66-276
Range on HMM: 1-264/352
Sequence Identity: 21% (60 aa)
YKSIRFAGRGSFGTTIIGEDQNQNRFA-----------FKLIFIRTKHGQINQD-IRGKALKEANVMS-----------KMDHPNVVKFYNYYETQNYII
|| |. |.|.||. .. .|. .. .| |..|. .|.. .. . .|. .... ..||..||.. . .....|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY
IQMEECKG-DLNQFMKSY-----------------ELLSIESFI-----KYGQEISQGIQYVHDQG-LVLRDLKLDNILIDKMN---VAKIADFGLAAYV
| || |.| || |..|.. . .. . . .| .| ||..| | .. . ||.|..|||.|. . ||.|||.. .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
M-----QGT----------SKIKYSVQGAQLFR----APELQDELCQNLIQQLKKENPSLVLQSKKSDCFSLGLIFYSCL
. | ... ... | . |||. |... . | .|.|..||| |.| .|
QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV---LQGQNYDHSKA---------YKCDIWSLGVILYEML
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| Kinase | 17307.AA | CMGC | 66-237 | 16 | 7.1e-22 | 67.85 | In-house | 1-296 (513) | Show / Hide |
Range on Protein: 66-237 Range on HMM: 1-296/513 Sequence Identity: 16% (48 aa) YKSIRFAGRGSFGTTIIGED---------------QNQNRFAFKLIFIRTKHGQINQDIRG--------KALKEANVMSKM-----------------DH |. |. |.|..|. . | ..... | | |. . . .. .|| | . .. .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKS--TIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHH PNVVKFYNYYETQN-----------------YIIIQMEECKGDLNQFMKSYE---------LLSIES------------FIKYG------QEISQGIQ-- .|.|| |... . | .. . .| . || |..|.. || .. . | .|. NNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK YVHDQG--LVLRDLKLDNILIDKMNVA--------------------KIADFGLAAYVMQG--------------------TSKIKYSVQGAQLFRAPEL | | .. . |||| ||||.. . ||.||||| .. . ... .. ||||. YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI |
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| Kinase | 17307.AA | Pkinase_Tyr | 114-212 | 29 | 2.9e-14 | 48.92 | Pfam | 51-158 (270) | Show / Hide |
Range on Protein: 114-212 Range on HMM: 51-158/270 Sequence Identity: 29% (32 aa) LKEANVMSKM-DHPNVVKFYNYYE-TQNY--IIIQMEECKG-DLNQFMKSY----ELLSIESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNVA ..||..|... .|||.|..| . |.| || ... || . .. . |... ... ..|..| .| ...... ||| |.|... ||. MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV KIADFGLA ||.||||| KICDFGLA |
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| Kinase | 17307.AA | TyrKc | 66-334 | 15 | 1.2e-10 | -50.41 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 66-334
Range on HMM: 1-280/280
Sequence Identity: 15% (54 aa)
YKSIRFAGRGSFGTTIIGEDQNQNRFAFKLIFI-RTKHGQINQDIRGKALKEANVMSKM--DHPNVVKFYNYYETQ-------NYIIIQMEECK-GDLNQ
. .. |.| ||. |. . |.. | ..||..|.| .|||.|..| . .| . | || .. |||..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
FMKSYEL-LSIESFIKYGQEISQGIQYVHDQGLVLRDLKLDNILIDKMNVAKIADFGLAAYVMQG----TSKIKYSVQ---GAQ------------LFRA
. .... |. . .... |..| .| |..... ||| |.|... ...||.||||. .. . || |... |. ..
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG
--------------------------PE------LQDELCQNLIQQLKKENPSL----VLQSKKSDCFSLGLIFYSCLGTPLSKFIKILQDGPASIDTPV
|. .|. ... | . |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------------
MIEGQQEFECINKMLQLL---CEHHPNKRMKLSDVIQQF
.| .| |. ... |..| |.....|
-----F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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