19995

Species: Tetrahymena
Alias: PreTt19995, 359.m00015, 715, 19995, TTHERM_01388160
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
19995.AA Protein None 511 None Fasta, JSON
19995.kin_dom Protein Kinase Domain None 175 None Fasta, JSON
19995.NA RNA None 1536 None Fasta, JSON

Protein domain

Protein domains of 19995.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19995.AA Ciliate-C7 45-216 74 1.5e-117 378.29 In-house 1-164 (164) Show / Hide
Range on Protein: 45-216
Range on HMM: 1-164/164
Sequence Identity: 74% (128 aa)

FRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQKGTLKEIIE
|||||||.||||||||. |..||||||||||||.|||......|.| |||.|||||..|||||.||..|.|.||.||||||||         |||..|||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG--------GTLNQIIE

RNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYV
|||||||||||||||||||..||||||||||.|||||||||||||||||||.||||||.|| ||.|..|||.
RNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM

Pkinase 19995.AA Pkinase 42-212 28 7.4e-26 92.51 Pfam 1-169 (293) Show / Hide
Range on Protein: 42-212
Range on HMM: 1-169/293
Sequence Identity: 28% (50 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQKGTLKE
|   | .|.|. | | .... ... ..|.| . .|.   .   ....   .|| |.| . ..|..| |.|.|  |. .|.|.  |.   |.|     |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM----DLFD

IIERNQNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVSDFGLADKL-TAKSGYST
.|.. .....   |  ...|.. | .||.|.||....  ||| .||||| ||.      ..||||| .. . ...  |
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT

Kinase 19995.AA AGC 45-201 24 3.3e-24 58.12 In-house 1-202 (395) Show / Hide
Range on Protein: 45-201
Range on HMM: 1-202/395
Sequence Identity: 24% (50 aa)

FRFL---GQGAQGLVLLAKNL------KNQMRYAIKGVQ----VRDPQGNLYDEAFNK--------VVQEIDILKQCRG---------SPYVVS-LLDSF
|.||   |.|. | | |..         ..  ||.| ..    . . . |  . . .         | .| .||..|..         .|..|. |  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DGKQF--MYLVLNECQDNFYCM---VQKG-TLKEIIERN-QNKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGNAVVSD
  |.    |.|.  ..   |.    .  |  |  ..    ...|..|  |  ||         |. .| |.|| ..    | || .|||.| .|.   .|
QDKDHTYLYFVMEYMPR--YVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD

FGLA
|||.
FGLC

Kinase 19995.AA Ciliate-E1 48-241 18 3.9e-21 65.82 In-house 1-202 (202) Show / Hide
Range on Protein: 48-241
Range on HMM: 1-202/202
Sequence Identity: 18% (39 aa)

LGQGAQGLVLLAKNLKNQ-MRYAIKGVQVRDPQGNLYDEAFNKVVQEID-ILKQCRGSPYVVSLLDSF--DGKQFMYLVLNECQDNFYCMVQ---KGTLK
.|.| ...|. ||. .|.   .|.| .....   |  .. |... .|.. |.|  ..  |.. ..| .  |  .........|.....   |   .   .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EY

EIIERNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYVQIKVFLNTKKKF------NQLNST
  . ..... ...   .. .... .|| ..|..| .  |.|..||||. .|| | .|||....|  .. .....  ... .  . ...      |. .  
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKI

NYKMGNF
|||   .
NYKSDIY

Kinase 19995.AA CAMK 47-201 18 7.1e-20 60.08 In-house 1-243 (425) Show / Hide
Range on Protein: 47-201
Range on HMM: 1-243/425
Sequence Identity: 18% (46 aa)

FLGQGAQGLVLLAKNLKNQ------------MRYAIKGVQV----------------RDPQGNLY------DEAFNKVVQEIDILKQCRG------SPYV
 ||.|. | | |... ...             ..||| .                  .| ...        ..   .| .||.|.|...|       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLLDSFDG-------------------KQFMYLVLNECQDNFYC-MVQKG----TLKEIIERNQN-------------KRLNEISAIKYAKDITEGLYY
..|.. ..                    ...||.|.        . ... |     | . | .. .             .|..|  | .| . | ... |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY

IHSKNCLVNDLKMDNILIDYN-----------------GNAVVSDFGLA
.||.|    ||| .|||.|.|                 .|  ..|||.|
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA

Kinase 19995.AA CAMKL 42-201 24 1.4e-19 59.05 In-house 1-176 (297) Show / Hide
Range on Protein: 42-201
Range on HMM: 1-176/297
Sequence Identity: 24% (45 aa)

YSDFRFLGQGAQGLVLLAKN-LKNQMRYAIKGVQVR----DPQGNLY------DEAFNKVVQEIDILKQCR--GSPYVVSLLDSFDGKQF------MYLV
|   . ||.|. | | ||.. . .. ..||| .  .    ||. .        .    .. .|| |.|. .  . | ...|.. .. ...      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LNECQDNFYCMVQKGT--LKEIIERNQNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVSDFGLA
.          .. |   | . |... ..|  . |  | .| . | ....|.||..    |.| .|||.|.||  |. ..|||..
ME--------YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS

Kinase 19995.AA Ciliate-E2-Unclassified 42-250 20 3.3e-19 63.28 In-house 1-239 (352) Show / Hide
Range on Protein: 42-250
Range on HMM: 1-239/352
Sequence Identity: 20% (51 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMRY-------AIKGVQVRDPQGNLYDEAFN-KVVQEID-------------ILKQCRGSPYVVSLLDSFDGKQFMY
|   . .|||..| | .... |..  |        |. . ..  . .  .. .. | ....              ||...  .|..| ... |  || .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHP-HPFIVKMFYCFQDKQNIY

LVLNECQDN--FYCMVQKGT----LKEIIERNQN-KRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVSDFGLADKL
.|.  |...  .... ....     ... ..... |.. |  |.     .|.. | .|| |.|.|| ..  |.| .|||.| ||   .  ..|||.. |.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

TAKSG-YSTNQYVQIKVFLNTKKKFNQLNSTNYKMGNFIFQ----APECYD
   .. . |||       . .|..... . .. ..|. ...    |||...
QQNNNCD-TNQ-------Q-QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ

Kinase 19995.AA Ciliate-E2 42-205 21 1.2e-18 60.68 In-house 1-207 (365) Show / Hide
Range on Protein: 42-205
Range on HMM: 1-207/365
Sequence Identity: 21% (47 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMRYAIK-------------GVQVRDPQGNLYDEA-FNKVVQEIDILKQCR---------------GSPYVVSLLDS
|   . .|||..| | ..|. |.| ..|||             .|..     . . .   . . |||.|... .                .|... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--GKQFMYLVLNECQDN--FYCMVQKGTL-KEIIERNQNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYNG
|    .. .|||.  || .  |... .. .  ...||  . |...|  .... | |..               .| |.|||| ..  |.| .|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NAVVSDFGLADKLT
   ..||||. |..
-IKIIDFGLSKKYD

Kinase 19995.AA S_TKc 42-356 18 8.1e-17 63.11 SMART 1-231 (231) Show / Hide
Range on Protein: 42-356
Range on HMM: 1-231/231
Sequence Identity: 18% (63 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQK--GTL
|   | .|.|| | | .... | . ..||| .              ... .||.|||.  . |..| |.|.|.  ...|.|.         ..    |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVME--------YCDGDLGDL

KEIIERNQNKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYVQIKVFLNTKKKFNQLNSTN
...|.... ..    ..|  | .|.. | ..| |.||.. .  ||| .|||.|   .  ..||||| .|                              .
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------T

YKMGNFIFQAPECYDPNDQ---------------IIGKVYYDEYKKLGVQVKQEPSNRVNTLIKLIKRYIIYSLVQGIDFNLVLNKHRPLNYDGEFQNFV
   |   . |||   . .                . |.  ..                .....|.|.                                 
TFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG---------------------------------

YHKNLQQLIDGLTQFVPRNRLPIKEALI---VLKGIICF
  . . ..|... |. |..|. . |||    . |    |
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 19995.AA ULK 42-201 23 3.3e-16 53.16 In-house 1-189 (329) Show / Hide
Range on Protein: 42-201
Range on HMM: 1-189/329
Sequence Identity: 23% (46 aa)

YSDFRFLGQGAQGLVLLAKNLKN----QMRYAIKGVQ----VRDPQ---GNLYDEAFNKVVQEIDILKQCR---GSPY----VVSLLDSFDGKQF--MYL
|.  . ||.|. | |  ..| |.    .  .|.| ..     ....   |   . . . . .||.|.|.     ....    .| |.| |  ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLNECQDNFYCMVQKGTLKEIIERNQN--------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VSDFGLA
..  |..        |.|...|..|..        |||.|  ||.. |.| .|. ..|..|.   |.| .||||. .                ..|||.|
IMEYCNG--------GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA





Kinase 19995.AA STE20 42-113 25 3.8e-14 48.38 In-house 1-73 (288) Show / Hide
Range on Protein: 42-113
Range on HMM: 1-73/288
Sequence Identity: 25% (20 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMR----YAIKGVQVRDP---QGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSF
| ... .|||. | | .| . ...      .||| . ....   |     . .. ...||.|.|||. .|..|. ..|.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSY

Kinase 19995.AA Ciliate-A2 139-201 34 1.9e-12 39.8 In-house 85-150 (272) Show / Hide
Range on Protein: 139-201
Range on HMM: 85-150/272
Sequence Identity: 34% (23 aa)

LKEIIE--RNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGN-AVVSDFGLA
| . |.   || | ...  ....|. | ... |.|.||  . ||.  ||||| ...  .. |||||
LQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA

Kinase 19995.AA STE20 137-205 30 8.3e-07 21.24 In-house 93-168 (288) Show / Hide
Range on Protein: 137-205
Range on HMM: 93-168/288
Sequence Identity: 30% (23 aa)

GTLKEIIER--NQNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLT
|.| .|...  . .|     ..||       ... .|| |.||...   |.| ||||.. .|..  .|||.. .||
GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLT

Kinase 19995.AA TyrKc 42-259 13 6e-06 -126.91 SMART 1-280 (280) Show / Hide
Range on Protein: 42-259
Range on HMM: 1-280/280
Sequence Identity: 13% (42 aa)

YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQC-RGSPYVVSLL-DSFDGK------QFMYLVLNECQDNFYCM
 .  . || || | | ...     .  |.| ..                 .|. |...     | .| |.    ...      . ...|.          
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--------Y

VQKGTLKEIIERNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAK-------SGYS------TN-------
. .| ||. . ....| |.    .... .| .|  |.|||||   ||   |.|.. |. . .|||||. ... .       . |.      ..       
MPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

---------------------------------QY-------VQIKVFLNTKKKFNQLNSTNY--------KMGNFIFQAPECYDPN-------DQIIGK
                                  |       .  .  ..  |. . .    .                  .| . .        .|. .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

V
 
F

Kinase 19995.AA Ciliate-A2 49-78 34 0.000114 12.47 In-house 1-32 (272) Show / Hide
Range on Protein: 49-78
Range on HMM: 1-32/272
Sequence Identity: 34% (11 aa)

GQGAQGLVLLAKNL--KNQMRYAIKGVQVRDP
|||. |.|....     |   |||| . . |.
GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDG