Gene 26388 (Tetrahymena)
26388
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 26388.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26388.AA | Ciliate-C7 | 130-297 | 72 | 1e-110 | 356.06 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 130-297 Range on HMM: 1-164/164 Sequence Identity: 72% (128 aa) FRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKCRDSPYVVSLIDQFEGQQFSYLVLTECQ--------ERNQNKRLN ||||||| |||||||||.||||||||||||||| ||.|.|.||.|.||..|| .|.||||||.|..|||||||.||||.||| ||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSDFGLADNLINKSDYSINQYM ||||||||.||||||||||||.|..||||||||||||.|||||| ||||||||..||.|.||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVC------------DFGLADNLTQKSKYQINQYM |
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| Pkinase | 26388.AA | Pkinase | 127-265 | 25 | 1.8e-19 | 69.93 | Pfam | 1-154 (293) | Show / Hide |
Range on Protein: 127-265 Range on HMM: 1-154/293 Sequence Identity: 25% (40 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKCRDSPYVVSLIDQFEGQQFSYLVLTECQE-----RNQ----- | | .|.| | | .... .|. ..|.| . .|. . |. . .. .|..|. .. ..|..| |.| || . |.|. |. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST --NKRL--NEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGNA----VVC .... | ...|. |..||.|.||.... ||| .||||| .|. .| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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| Kinase | 26388.AA | CAMK | 132-319 | 16 | 2.9e-18 | 54.77 | In-house | 1-315 (425) | Show / Hide |
Range on Protein: 132-319
Range on HMM: 1-315/425
Sequence Identity: 16% (53 aa)
FLGQGVQGLVLLAKDSKTN------------MRYAIKGVQVRDLYGN----------LDKD------------LNNRVKQEVEILTKCR------DSPYV
||.| | | |... .|. ..||| . . | .. .|| .|..|.||. |.. | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSLIDQFEG-------------------QQFSYLVL--------T----ECQERNQNK----------------RLNEISAIKYANDIAQGLYYIHSKSC
..|.. .| ... |.|. .. .. . . |..| | .| |.... |.||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
LLNDLKMDNILIDYHG-------NAVVCKLIFNNKLVQF----SDFGLADNLINKSDYS----------------------INQYMGNFLYQA-PECFDP
||| .|||.|... . || . .. .|||.| .. .... . . | | | || .
VHRDLKPENILLDDNNDDSDPVEHD---E-IF-D-WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG
A------------EPYIGVSV
.||.| ..
KGHCNMQNATDEEKPYYGPKC
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| Kinase | 26388.AA | Ciliate-E2-Unclassified | 127-309 | 19 | 3.8e-15 | 48.99 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 127-309 Range on HMM: 1-239/352 Sequence Identity: 19% (49 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKCRD-------------------SPYVVSLIDQFEGQQFSYLV | . .||| .| | .....|.. ||.| . | . . .. . .. ... .|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-----------------------QERNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSD . | . ..|.|.. | |. .|. | ||| |.|.| .. |.| .|||.| |. | . .| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------NYYIKIID FGLADNLI----------NKSDYSINQYM----GNFLYQ----APECFD ||.. ... .| .. ..| | |. |. |||... FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 26388.AA | Ciliate-E1 | 133-307 | 18 | 5.2e-13 | 39.08 | In-house | 1-181 (202) | Show / Hide |
Range on Protein: 133-307
Range on HMM: 1-181/202
Sequence Identity: 18% (37 aa)
LGQGVQGLVLLAKDSKTN-MRYAIKGVQVRDLYGNLDKDLNNRVKQEVE-ILTKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQER-----N--------
.|.| ...|. || ..| .|.| ..... | ... .. ...| |. . |.. .||... .| ........|... .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW
-----QNKRLNEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSDFGLADNLINKSDYSINQYMGNFLYQAPEC
... ... .. . .. .|| ..|.. . |.|..||||. || | | |||....|.|........ |. ||.
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC------------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQ
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| Kinase | 26388.AA | S_TKc | 127-353 | 19 | 2.2e-12 | 4.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 127-353 Range on HMM: 1-231/231 Sequence Identity: 19% (53 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKCRDSPYVVSLIDQFEGQQFSYLVLTECQE--------RNQNK | | .|.| | | .... ||. ..||| . .....|..|| | . |..| |.| |. .. |.|. | ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG R------LNEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSDFGLADNLINKSDYSINQYMGNFLYQAPECFDPAE | ..| | .|. |...| |.||. . ||| .|||.| . .||||| | . . | | ||| . RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---- PYIG------------------------VSVRQEPSKKVNILFKFLLQKLINT-----IPINSNRV-------KHVL .| . . . . . .| ...|. . . . . GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 26388.AA | Ciliate-E2 | 127-308 | 16 | 2.7e-12 | 38.49 | In-house | 1-259 (365) | Show / Hide |
Range on Protein: 127-308
Range on HMM: 1-259/365
Sequence Identity: 16% (45 aa)
YSDFRFLGQGVQGLVLLAKDSKT-----------------------NMRYAIKGVQVRD-LYGNLDKDLNNRVK------QEVEILTKCRDSPYVVSLID
| . .||| .| | ..|. |. .. ||.| .. .. . . ........ .| .|| . ..|... ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE
QFE--GQQFSYLVLTECQERN------------------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLLNDLKMDNILIDYHG
|. .. |||. || . . |...| .... |.| .| |.||| .. |.| .|||.
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----
NAVVCKLIFNNKLVQFSDFGLADNLINKSDYSI------------------------------NQYMGNFLYQAPECF
. .||||. .. ..... . |.. |. |.||| .
-------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL
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| Kinase | 26388.AA | SAK | 127-256 | 27 | 1.1e-11 | 35.81 | In-house | 1-133 (254) | Show / Hide |
Range on Protein: 127-256 Range on HMM: 1-133/254 Sequence Identity: 27% (38 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKCRDSPYVVSLIDQFEGQQFSYLVLTECQE-------RNQNKR | ||.| | || .| . ||| . . ... . .||..|||| .. . | .. | || . . |||| |. ... . YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKT---GMVQRVRNEVEIHCQLKH-PSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRP LNEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILI | | .. ..| |. |.|| . || . |||. FTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILL |
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| Kinase | 26388.AA | AGC | 130-261 | 23 | 9.5e-11 | 22.5 | In-house | 1-193 (395) | Show / Hide |
Range on Protein: 130-261 Range on HMM: 1-193/395 Sequence Identity: 23% (45 aa) FRFL---GQGVQGLVLLAKDS------KTNMRYAIKGVQVRD---LYG--NLDKDLNNR-------VKQEVEILTKCRD---------SPYVVS-LIDQF |.|| |.| | | |... |. ||.| .. .. . ... .. |..| .||.||. .|..|. | | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGQQF--SYLVLT---------------ECQERNQN--K--RLNEISAIKYAND-------IAQGLYYIHS-KSCLLND-LKMDNILIDYHGN . .. |.|. | ..|. | |..| | || |. .| |.|| . | || .|||.| .|. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
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| Kinase | 26388.AA | ULK | 127-282 | 23 | 3.4e-10 | 32.45 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 127-282
Range on HMM: 1-185/324
Sequence Identity: 23% (44 aa)
YSDFRFLGQGVQG-LVLLAKDSKT---NMRYAIKGVQVR-DLYGNLD---KDLNNRVKQEVEILTKCR--DSPY--VVSLIDQFEGQ--QFSYLVLTECQ
|. . ||.| | | ... || | .|.| .. ... . . . |.|..|. | .|. .| |.| || . . |... |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
ER------NQNKRLNEIS----------AIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHG---NAVVCKLIFNNKLVQFSDFGLA
..||.|.| ||.. .|..|. ..|.. . |.| .|||| . . |... | . .|||.|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK--KVHP-NGVLKIADFGFA
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| Kinase | 26388.AA | Ciliate-A2 | 215-265 | 32 | 2.8e-07 | 21.62 | In-house | 94-145 (272) | Show / Hide |
Range on Protein: 215-265 Range on HMM: 94-145/272 Sequence Identity: 32% (17 aa) NQNKRLNEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGN-AVVC || | ... ....|. | ... |.|.| | ||. ||||| ... ..| NQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLC |
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| Kinase | 26388.AA | STE | 127-196 | 17 | 3e-06 | 18.06 | In-house | 1-97 (359) | Show / Hide |
Range on Protein: 127-196 Range on HMM: 1-97/359 Sequence Identity: 17% (17 aa) YSDFRFLGQGVQGLVLLAKDSK---------------TNMRYAIKGVQVRDL-----------YGNLDKDLNNRVKQEVEILTKCRD-SPYVVSLID . . ...|.| | | .|.. | |. ..||| . ... . | ... .....|..|. ||.. .|..| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG |
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| Kinase | 26388.AA | TyrKc | 127-353 | 14 | 9e-06 | -129.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 127-353
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)
YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDLYGNLDKDLNNRVKQEVEILTKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE------CQE
. . || | | | ... . . |.| .. .| .|..| . | .| |. |. .....| ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
RNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSDFGLADNLINK-------SDYSIN---QYM--GN
. ...| |. .... .||.| |.||| | || |.|.. . | |||||. .. .. . |. .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP
FLYQAPECF-----------------------DPAEPYIGVSVRQEPSKKVNILFKFLLQKLINTIPIN------------------------------S
||||. . ..|| |. . .. ..... | .| |
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF
NRVKHVL
. ... .
SEIHECF
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| Kinase | 26388.AA | STE | 217-306 | 22 | 1.3e-05 | 15.98 | In-house | 145-232 (359) | Show / Hide |
Range on Protein: 217-306 Range on HMM: 145-232/359 Sequence Identity: 22% (24 aa) NKRLNEISAIKYANDIAQG-LYYIHSKSCLLNDLKMDNILIDYHGNAVVCKLIFNNKLVQFSDFGLADNLIN---------------KSDYSINQYMGNF ..|..| .... .| .| |||.||. |.| .|||. | .|||.. .|.. .. | | QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP LYQAPE . ||| -WMAPE |
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| Kinase | 26388.AA | Ciliate-A2 | 134-162 | 35 | 0.000328 | 10.86 | In-house | 1-31 (272) | Show / Hide |
Range on Protein: 134-162 Range on HMM: 1-31/272 Sequence Identity: 35% (11 aa) GQGVQGLVLLAKD--SKTNMRYAIKGVQVRD ||| |.|..... . | |||| . . | GQGCFGCVIFVEHMDNHNNEKYAIKIQSIID |
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