Gene 4498 (Tetrahymena)
4498
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 4498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4498.AA | Ciliate-C7 | 74-249 | 75 | 5.1e-121 | 389.55 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 74-249 Range on HMM: 1-164/164 Sequence Identity: 75% (133 aa) FRFLGQGVQGLVVLAKDSKTNMRYAIKGVQVRDLHGNIDEDLKNRVKQEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLNECQVYNTKLNTINKQKGTLT ||||||| ||||.||||.||||||||||||||| .||||.|..|.|.|||.|||.|.||||||.|..|||||||.|||||||| |||. FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG------------GTLN QIFERNQNKRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAINQYV || |||||||||||||||||.|||.||||||||.|.|||||||||||||.|||||.||||||||..||.|.||||. QIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 4498.AA | Pkinase | 71-234 | 26 | 2.5e-23 | 83.56 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 71-234 Range on HMM: 1-159/293 Sequence Identity: 26% (48 aa) YSDFRFLGQGVQGLVVLAKDSKTNMRYAIKGVQVRDLHGNIDEDLKNRVKQEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLNECQVYNT----KLN--- | | .|.| | | .... .|. ..|.| . .|. . . |. . .. .||.|.|.. ..|..| |.| || . |.|. |. .. | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCE--GGLYVMDLFDYI -TINKQKGTLTQIFERNQNKRL--NEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLA | ..... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| ST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 4498.AA | CAMK | 76-234 | 17 | 5.1e-20 | 60.53 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 76-234 Range on HMM: 1-243/425 Sequence Identity: 17% (46 aa) FLGQGVQGLVVLAKDSKTN------------MRYAIKGVQVRDLHGNI----------------------DEDLKNRVKQEIEILKKCR------DSPYV ||.| | | |... .|. ..||| . . | .. .. . .|..||||.||.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLIDQFEG-------------------QQFSYLVLNECQVYNTKLNTINKQKGTLTQIFERNQNK-----------------------------RLNEI ..|.. .| ... |.|. | | .. |..| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME---------------------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTER SAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYH-----------------GNAVVSDFGLA | .| |.... |.||. ||| .|||.|.. .| ..|||.| EARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 4498.AA | S_TKc | 71-396 | 18 | 6.3e-15 | 41.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 71-396
Range on HMM: 1-231/231
Sequence Identity: 18% (65 aa)
YSDFRFLGQGVQGLVVLAKDSKTNMRYAIKGVQVRDLHGNIDEDLKNRVKQEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLNECQVYNTKLNTINKQK-
| | .|.| | | .... ||. ..||| . .....||.|||| . |..| |.| |. .. |.|. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCD------------GD
-GTLTQIFERNQNKR----LNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAINQYVCTHIFFIILKRYSNN
|.| .. .... .. ..| | .|. |...| |.||. . ||| .|||.| . ..||||| |
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------
SIQKLKMGNFLYQAPECFNPADQFIGKVYHDEYLKLGVNVKQEPSNRSEACSLGIKYKA---------ILGYYFLSKKYIFIQGINLNLASNKHKQLNYD
. | | ||| . .| .. | .|. . | .... .| .
---TTFCGTPWYMAPEVL-------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----
DEFKNFVYHKQLKQIIEGLTNFVPRNRMSIKEALI-----ILKGII
...|..|... .. |..|... ||| . .
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 4498.AA | Ciliate-E2-Unclassified | 71-282 | 19 | 7.4e-15 | 47.99 | In-house | 1-238 (352) | Show / Hide |
Range on Protein: 71-282 Range on HMM: 1-238/352 Sequence Identity: 19% (48 aa) YSDFRFLGQGVQGLVVLAKDSKTNMRYAIKGVQ-VRDLHGNIDEDLKNRVKQEIEILKKCR------------------DSPYVVSLIDQFEGQQFSYLV | . .||| .| | .....|.. ||.| ... . .. . . . ..|...... ..|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNECQVYNTKLNTINKQKGT---LTQIFERNQN-KRLNEISAI-----KYANDIAEGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADNLI . |. ... .. |.|.|. .|..... |.. | |. .|. | .|| |.|.| .. |.| .|||.| | . ..|||.. ... MEYCE-GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ NKSGYAINQYVCTHIFFIILKRYSNNSIQKL--KMGNFLYQ----APECF . ... .. . ...... |.. ..|. |. |||.. QNNNCD-TNQ---------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL |
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| Kinase | 4498.AA | Ciliate-E2 | 71-283 | 18 | 9.9e-14 | 43.49 | In-house | 1-260 (365) | Show / Hide |
Range on Protein: 71-283
Range on HMM: 1-260/365
Sequence Identity: 18% (51 aa)
YSDFRFLGQGVQGLVVLAKDSKTNMRYAIK-------------GVQ-VRDLHGNIDEDLKNRVKQEIEILKKCR---------------DSPYVVSLIDQ
| . .||| .| | ..|. |.. ..||| .|. .. .. .. .|||| |... . ..|... ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FE--GQQFSYLVLNECQVYNTKLNTINKQKGTLTQIFERNQNKRLNEISAIKYANDIAE---------------GLYYIHSKS-CLVNDLKMDNILIDYH
|. .. |||. || ... . |...| ....| . |...| .... |.. .| |.||| .. |.| .|||.
FQEKDDNNIYLVMEYCQ-GGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
GNAVVSDFGLADNLINK---------SGYAINQYVCTHIFFIILKRYSNNSIQKLKM-----------GNFLYQAPECFN
..||||. .. .. .. .. . |.. . ... . |. |.||| .|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-----------QIIQQNMFNTICGTPGYMAPEILN
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| Kinase | 4498.AA | STE-Unique | 169-239 | 30 | 2.9e-11 | 35.68 | In-house | 378-462 (616) | Show / Hide |
Range on Protein: 169-239 Range on HMM: 378-462/616 Sequence Identity: 30% (26 aa) KGTLTQIFERNQN-------KRLNEISAIKYANDIAEGLYYIHSKS--CLVNDLKMDNILIDYHG-----NAVVSDFGLADNLIN .||| || .|. . . | .|.|. |.||| |.||. . ||| .||... | .....|||.| ... HGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQP |
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| Kinase | 4498.AA | STE | 71-140 | 19 | 1.4e-10 | 33.66 | In-house | 1-97 (359) | Show / Hide |
Range on Protein: 71-140 Range on HMM: 1-97/359 Sequence Identity: 19% (19 aa) YSDFRFLGQGVQGLVVLAKDSK---------------TNMRYAIKGVQVRDL-----------HGNIDEDLKNRVKQEIEILKKCRD-SPYVVSLID . . ...|.| | |..|.. | |. ..||| . ... |.... ......||.|.|||.. .|..| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG |
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| Kinase | 4498.AA | Ciliate-A2 | 179-234 | 35 | 7.1e-10 | 30.76 | In-house | 94-150 (272) | Show / Hide |
Range on Protein: 179-234 Range on HMM: 94-150/272 Sequence Identity: 35% (20 aa) NQNKRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGN-AVVSDFGLA || | ... ....|. | ... |.|.| . ||. ||||| ... .. ||||| NQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA |
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| Kinase | 4498.AA | CAMKL | 71-152 | 23 | 1e-09 | 27.04 | In-house | 1-100 (297) | Show / Hide |
Range on Protein: 71-152 Range on HMM: 1-100/297 Sequence Identity: 23% (24 aa) YSDFRFLGQGVQGLVVLAKD-SKTNMRYAIKGVQ--VRDLHGNID--------EDLKNRVKQEIEILKKCR--DSPYVVSLIDQFEGQQF------SYLV | . ||.| | | ||.. . |. ..||| . . ... |. . |...||.|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV L . M |
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| Kinase | 4498.AA | ULK | 71-152 | 25 | 1.3e-09 | 30.33 | In-house | 1-96 (324) | Show / Hide |
Range on Protein: 71-152 Range on HMM: 1-96/324 Sequence Identity: 25% (24 aa) YSDFRFLGQGVQG-LVVLAKDSKT---NMRYAIKGVQVRDLHGNID----EDLKNRVKQEIEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL |. . ||.| | | ... || | .|.| .. . . . ... |.||.|.|| .|. .| |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM |
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| Kinase | 4498.AA | ULK | 170-234 | 27 | 3.3e-09 | 28.37 | In-house | 105-189 (329) | Show / Hide |
Range on Protein: 170-234 Range on HMM: 105-189/329 Sequence Identity: 27% (23 aa) GTLTQIFERNQN--------KRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA |.| |. ..|.. |||.| ||.. .|..|. ..|.. . |.| .||||. . ..|||.| GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 4498.AA | CAMKL | 182-234 | 34 | 1.7e-08 | 23.11 | In-house | 122-176 (297) | Show / Hide |
Range on Protein: 182-234 Range on HMM: 122-176/297 Sequence Identity: 34% (19 aa) KRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLA .|. | | .| | ....|.||. |.| .|||.|..| |. ..|||.. GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 4498.AA | ULK | 71-152 | 23 | 7.4e-08 | 23.6 | In-house | 1-99 (329) | Show / Hide |
Range on Protein: 71-152 Range on HMM: 1-99/329 Sequence Identity: 23% (24 aa) YSDFRFLGQGVQGLVVLAKDSKT----NMRYAIKGVQ----VRDLH---GNIDEDLKNRVKQEIEILKKCRD---SPY----VVSLIDQFEGQQF--SYL |. . ||.| | | ... || | .|.| .. .... | . ... .|.||.|.|| . ... .| |.| || ... |. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VL .. IM |
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| Kinase | 4498.AA | ULK | 168-234 | 26 | 1.1e-07 | 23.36 | In-house | 100-185 (324) | Show / Hide |
Range on Protein: 168-234 Range on HMM: 100-185/324 Sequence Identity: 26% (23 aa) QKGTLTQIFERNQN-------KRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA . |.| |. ..|.. |||.| ||.. .|..|. ..|.. . |.| .|||| . ..|||.| NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 4498.AA | Ciliate-A2 | 78-129 | 30 | 2.5e-07 | 21.8 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 78-129 Range on HMM: 1-55/272 Sequence Identity: 30% (17 aa) GQGVQGLVVLAKD--SKTNMRYAIKGVQVRDLHGN-IDEDLKNRVKQEIEILKKC ||| |.|..... . | |||| . . | .. |.. . | |...||.| GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
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| Kinase | 4498.AA | STE-Unique | 72-139 | 26 | 7.2e-07 | 19.82 | In-house | 1-67 (616) | Show / Hide |
Range on Protein: 72-139 Range on HMM: 1-67/616 Sequence Identity: 26% (18 aa) SDFRFLGQGVQGLVVLAKDSKTNMRYAIKGVQVRDLHGNIDEDLKNRVKQEIEILKKCRDSPYVVSLI . ..|.| | |..... |.. |.||| . .. . | | | ||||.|... ....| .. NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY |
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| Kinase | 4498.AA | TyrKc | 71-298 | 15 | 1.7e-05 | -133.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 71-298 Range on HMM: 1-280/280 Sequence Identity: 15% (51 aa) YSDFRFLGQGVQGLVVLAKDSKTNMRYAIKGVQVRDLHGNIDEDLKNRVKQEIEILKKC-RDSPYVVSLI----DQFE-----GQQF------------S . . || | | |.... . . |.| .. . .|..|..| . | .| |. .|.. .. . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YLVLNECQVYNTKLNTINKQKGTLTQIFERNQNKRLNEISAIKYANDIAEGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNL----------- || .. . |. .... .||.| |.||| | || |.|.. . . .|||||. .. YLRKHRPK---------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKD INK-----SGY-----------AINQYVCTH-------------IFFIILKRYSN-----NS----IQKLKMGNFLYQAPE--------CFNPADQFIGK . .| .|| ...|. || . |.. | |...| |. . | |. | | . . YYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ VYHD------------EYL | |.. CWHEDPEDRPTFSEIHECF |
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| Kinase | 4498.AA | STE | 170-239 | 26 | 5.1e-05 | 13.8 | In-house | 122-199 (359) | Show / Hide |
Range on Protein: 170-239 Range on HMM: 122-199/359 Sequence Identity: 26% (22 aa) GTLTQIFE------RNQN------KRLNEISAIKYANDIAEG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLIN |.|..| . ...| .|..| .... .| .| |||.||. |.| .|||. . .|||.. .|.. GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTD |
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