Gene 20457 (Tetrahymena)

20457

Species: Tetrahymena
Alias: 3682.m00048, 20457, PreTt20457, 141.m00114, TTHERM_00823890, 648
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
20457.AA Protein None 789 None Fasta, JSON
20457.kin_dom Protein Kinase Domain None 269 None Fasta, JSON
20457.NA RNA None 2370 None Fasta, JSON

Protein domain

Protein domains of 20457.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20457.AA Ciliate-B1 19-286 32 3e-67 229.71 In-house 1-290 (290) Show / Hide 
Range on Protein: 19-286
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

YKLTQQLGNGSISVVFKAE---RQEDSKIFAVKYVSSFTFEG-QRKNKYQQNELEISKKIMEIK-----------SKNLIEIYEVIQEDSEDSYIIMEFC
|.. ...|.|.|| ||...    |.  ...||| ... |  .    ||| |.||||.... ..              .   ||.|||....  |||||.|
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQ-YYIIMEYC

DMCDLFSFSLTFWINWQ--TAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSH-------KNDETKKIEYNIKIGDFGLSKEGDI--FTSTVGTPNYM
.  ||... . .  | .   ...|  ||| ||. ||  .|.|||||||||...         | ..     | .||.|||.|| ...  . |.|||.|||
EQGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQN----HYIFKITDFGISKMQQEYMMQSCVGTINYM

GPETYQ-EGDKTKETDIWAFGAILFELIEKKQYFS--SHSAAMIYNQIKNFQAYDKQRLTKIEDSDILERVNN-LIQKCLNVKPQNRIQSEELVLEIQ
 ||        .|. |||.|| |..|.| ..|.|     ... . |||.||| .| |.   .. ..|.  . .  . .||.. | ||| .  .. .. 
APEILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQC---HFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 20457.AA S_TKc 19-289 25 1.5e-59 205.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-289
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

YKLTQQLGNGSISVVFKAERQEDSKIFAVKYVSSFTFEGQRKNKYQQNELEISKKIMEIKSKNLIEIYEVIQEDSEDSYIIMEFCDM--CDLFSFSLTFW
|.. ...| |. ..|.|.   .. .|.|.| ..          .  ..|..| ||    . .|.. .|.|.|.  .. |..||.||    |||..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

-------INWQTAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGLSKEGDIFTSTVGTPNYMGPETYQEGDKTK-ETDI
       ..  .|  . |||.|... .|. .| |||||||||....           .|||.||||...    |. .|||.|| ||       .| . |.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDW

WAFGAILFELIEKKQYFSSHSAAMIYNQIKNFQAYDKQRLTKIEDSDILERVNNLIQKCLNVKPQNRIQSEELVLEI-----QSIL
|..| ||.|..  .  |.    .|....|.                   . . ..|.|||.. |..|.   |.  .         .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20457.AA Ciliate-E2 19-281 21 5e-49 166.42 In-house 1-359 (365) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-359/365
Sequence Identity: 21% (82 aa)

YKLTQQLGNGSISVVFKAERQEDSKIFAVK-------------YVSSFTFEGQRKNKYQQNELEISKKIM-----------------EIKSKNLIEIYEV
||. ...|.|. ..|.|... .. | || |             .| .. ..  ...|.| ....  ..||                 .....|.|..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IQE-DSEDSYIIMEFCDMCDLFSFSLTFWIN------------WQTAIEFGYQIAC---------------GINDLHRFN-ITHRDLKPENIFVSSHKND
 || | .  |..||.|.  |||..   ....            .. .... .||.                ... ||  | | |||.|||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

ETKKIEYNIKIGDFGLSK-----------------------------------EGDIFTSTVGTPNYMGPETYQEGD---------KTKETDIWAFGAIL
        ||| ||||||                                     ..| ...|||.|| || .. ..          ... |||..| ||
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

FELIEKKQYFSSHSAAMIYNQIKNFQAY-DKQRLTKIEDSDILERVN------------NLIQK----CLNVKPQNRIQ-SEEL
.|.. .|  |        ..|||. .   ...  .|  . .| . ..            .||.|    .|...|..||.  |..
YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 20457.AA Pkinase 19-285 23 7.5e-49 173.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-285
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

YKLTQQLGNGSISVVFKAERQEDSKIFAVKYVSSFTFEGQRKNKYQQN--ELEISKKIMEIKSKNLIEIYEVIQEDSEDSYIIMEFCDMC----DLFSFS
|.. ...| || ..|.|. .. ..||.||| ..    |   |...  .  |..| |..    ..| ...|.. .. . . |..||.|..     |||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF-DY

LT----FWI--NWQTAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGLSK----EGDIFTSTVGTPNYMGPETYQ-EGD
..     ..   ..... . |||..|.. .|. .| |||||||||..... . ..      .||.||||.|     .  .|. .|||.|| ||  .   .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

KTKETDIWAFGAILFELIEKKQYFSSH------SAAMIYNQIKNFQAYDKQRLTKIEDSDIL-----------------ERVNNLIQKCLNVKPQNRIQS
 ... |.|..| ||.|.. ..  |..|      .   ....|.  .     .    ....|                  |    .| .||...|. |.  
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPL----HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

EELVLE--I
|...    .
EQILQHPWF
Kinase 20457.AA ULK 19-276 25 1e-46 161.55 In-house 1-313 (324) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-313/324
Sequence Identity: 25% (79 aa)

YKLTQQLGNGSIS-VVFKA--ERQED-SKIFAVKYVSSFTFEGQRKN-------KYQQNELEISKKIMEIKSKN--LIEIYEVIQEDSE-DSYIIMEFCD
| | ..|| ||   .|.|.  .....  ...|.| .. . .  . ..       . ..|| .| ||. |.|..|   .. |.. ... .   |||||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

MCDLFSFSLT----------FWINWQTAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSHK---NDETK--KIEYNIKIGDFGLSKE-G------DIF
  ||...  .            .. | ||.| .||. |  .||  || |||.||.|| .. ..   ... |  . .. .||.|||..|         ...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK-KVHP-NGVLKIADFGFAKHVDNNNMEQQMC

TSTV------GTPNYMGPETYQ----EGDKT-KETDIWAFGAILFELIEKKQYFSSHSAAMIYN-QIKNFQA-------YDKQRLTKI---EDSDILERV
...|      ||| || |.  |    . . . ...||| .| |..|..  | .|.|  .   |. ..|  .          .| . .    .|  | . .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

NNLIQKCLNVKPQNRI
 .||...| ...  ||
KDLIRRMLQYDEKDRI
Kinase 20457.AA Ciliate-E2-Unclassified 19-281 22 8.1e-43 146.36 In-house 1-346 (352) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-346/352
Sequence Identity: 22% (79 aa)

YKLTQQLGNGSISVVFKAERQEDSKIFAVKYVSSFTFEGQRKNKYQQNELEISKKIMEIK------------------SKNLIEIYEVIQE-DSEDSYII
||. .|.|.|. ..|.|... .. ...| || ...    |.. .... |.  ..|.|..|                  ..... .... .. | .  ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEFCDMCDLFSFSLTFW------------------INWQTAI-----EFGYQIACGINDLHRFN-ITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGL
||.|.  ||. .   ..                  .  | |.      . .|| .|.. ||. | | |||.|||||.... ..       |.||| |||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGI

SK-------------------EGDIFTSTVGTPNYM----GPETYQEGDKT----KETDIWAFGAILFELIEKKQYFSSHSAAM----------------
||                     .......||||||     || .|.        .. |||..| ||.|..  .  |.. .                   
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

IYNQIKNFQAYDKQRLT----KIEDSDILERVNNLIQKCLNVKPQNRIQSEEL
.|..||. . . .        |. .    . .|.|.||.|...| .||. |..
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
Kinase 20457.AA ULK 19-276 24 2e-42 145.93 In-house 1-318 (329) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-318/329
Sequence Identity: 24% (79 aa)

YKLTQQLGNGSISVVFKAERQED----SKIFAVKYVSSFTFEGQRKNKY-------QQNELEISKKIMEI-KSKN----LIEIYEVIQEDSE-DSYIIME
| | ..|| ||  .|.|.. ...     ...|.| ......  . .. .        .|| .| ||.    ..||     .. |.. ... .   |||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCDMCDLFSFSLT-----------FWINWQTAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSHK---NDETK--KIEYNIKIGDFGLSKE---G---
.|.  ||...  .             .. | ||.| .||. |  .||  || |||.||.|| .. ..   ... |  . .. .||.|||..|    .   
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK-KVHP-NGVLKIADFGFAKHVDNDNME

-DIFTSTV------GTPNYMGPETYQ----EGDKT-KETDIWAFGAILFELIEKKQYFSSHSAAMIY-NQIKNFQAY--------DKQRLTKI---EDSD
 ......|      ||| || |.  |    . . . ...||| .| |..|..  | .|..  .   | ..|..   .        .|| |      .|  
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

ILERVNNLIQKCLNVKPQNRI
| . . .||...| ...  ||
ISPECKDLIRRMLQYDEKDRI
Kinase 20457.AA CAMK 24-280 17 4e-40 126.49 In-house 1-418 (425) Show / Hide 
Range on Protein: 24-280
Range on HMM: 1-418/425
Sequence Identity: 17% (75 aa)

QLGNGSISVVFKAERQEDS------------KIFAVKYVSSFTFEG------------------------QRKNKYQ-QNELEISKKIME----IKSKNL
.|| || ..|..... ..             . .|.| ..     .                        . |.. . ..|.|| ||. .    .. .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IEIYEVIQE-----------DSED--------SYIIM---EFCDMC----DLFSFSLTF--------------W--INWQTAIEFGYQIACGINDLHRFN
| .|||..              ..         |..|   |.|.      |||..                  .  .. . |  .  ||..... .|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ITHRDLKPENIFVSSHKNDETKKIE---------YNIKIGDFGLSKE---------------------------GDIFTSTVGTPNYMG-PETYQ-----
| ||||||||| ......|. . .|         .|||| |||....                           |. ..  .||| ||  ||  .     
IVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------EGDKTKETDIWAFGAILFELIEKKQYFSSH-------------SAAMIYNQIKNFQAY-DKQRLTKIE-------DSDILER--------V
         .   ....|.|. | ||. .   .  | .              .   .. .|.. . . .   ...|        ..|| .         .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

NNLIQKCLNVKPQNRIQSEE
 .||.|.|.| |..|.  |.
KDLIRKMLQVDPEKRMTIEQ
Kinase 20457.AA TKL 25-285 18 2.1e-39 137.21 In-house 1-364 (364) Show / Hide 
Range on Protein: 25-285
Range on HMM: 1-364/364
Sequence Identity: 18% (67 aa)

LGNGSISVVFKAERQEDS--------KIFAVKYVSSFTFEGQRKNK---------------------YQQNELEISKKIMEIKSKNLIEIYEVIQEDSED
.| |. ..|.|.. .  .        |  |||  .|       ||                      ... | |  . .  ..  |.. .. . .. . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------SYIIMEFCDMCDLFSFSLTFWINWQTAIEFGYQIACGINDLHRFN--------ITHRDLKPENIFVSSHKNDE-----TKKIEYNIKI
             .|.||.|.  .|... .     |.  . . ..||.|.| ||  |        | |||||..||.| .. ..        ......||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

GDFGLSKEGD-----------------------IFTSTVGTPNYMGPETYQEGDKTKET----------------DIWAFGAILFELIEKKQYFS-SHSA
.|||||.. .                          . .|||..| ||  .. ....|                 |...|| .|.|..  .. ..  .. 
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

AMIYN---QIKNFQAYDKQRLTKIE-----------DSDILERVNNLIQKCLNVKPQNRIQSEELVLEI
 || .   ..   ...||..   |             .|..... .|.|.| . .|..|   .|.. ..
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20457.AA AGC 19-287 16 9e-38 93.99 In-house 1-391 (395) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-391/395
Sequence Identity: 16% (67 aa)

YKLTQQLGNGSISVVFKAERQE-----DS-KIFAVKYVSSFT-FEGQRKNKYQQNELEIS----------KKIME-IK----------SKNLIE-IYEVI
...   .| || . |. ... .     |. |..|.| ..  .     .||. ...  | .          ..|.| ..          . ...   .   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QEDSED-SYIIMEFCD--------MCDLFSFSLTF------WINWQTAIEFGYQ-------IACGINDLHR-FNITHRD-LKPENIFVSSHKNDETKKIE
| .. .  |..||..         . .. .|.  .        . ..|  .  .       |....  ||.  .| ||| ||||||   ..         
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---------

YNIKIGDFGLSKEGDI------------------------------------------------------FTSTVG--TPNYMGPETYQEGDKTKETDIW
 .||. ||||.|||                                                         .. .|  ||.|| ||       .|. |.|
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

A--FGAILFELIEKKQYFSSHS----------AAMIYNQIKNFQ--AYDKQRLTKI------EDSDILERVNNLIQKCLNVKPQNRIQSEEL------VL
.  .|....|..  .  |....           . ....|.| .    .|...         ||. . .   .||.|.|.. | .|. . .       . 
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

EIQS
||..
EIKN
Kinase 20457.AA STE 19-281 17 2.4e-28 97.26 In-house 1-351 (359) Show / Hide 
Range on Protein: 19-281
Range on HMM: 1-351/359
Sequence Identity: 17% (63 aa)

YKLTQQLGNGSISVVFKAERQE---------------DSKIFAVKYVS------------SFTFEGQRKNKYQQNELEISKKI---MEIK--SKNLIEIY
... ...|.|.  .|.|| . .                 .|.|.| ..            .   |   .|| .... .| | |   .. .  ..| .. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-E--LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY

EVIQEDS------EDSYIIMEFCDM---CDLFS------FSLT------FWINWQTAIEFGYQIACG-INDLHRFNITHRDLKPENIFVSSHKNDETKKI
     ..      .. .|.||..|     |.        ..|.      .... .  . . .||  |  . ||. .| |||.|| ||..           
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------

EYNIKIGDFGLSKEGDI-------------------FT-STVGTPNYMGPETYQE------GDKTKETDIWAFGAILFELIEKKQYFSS-HSAAMIYNQI
   .|. |||...  .                     . . |||| .| ||  |       .. .   ||| .|  . |... |  ..  |   .... .
---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP

KNFQAY-----------DKQRLTKIED---------------SDILERVNNLIQKCLNVKPQNRIQSEEL
.|. ..           .  .|    .               .   .  .. |.|||.  |..|  ...|
FNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase 20457.AA CAMKL 128-216 36 2.2e-24 74.58 In-house 135-227 (297) Show / Hide 
Range on Protein: 128-216
Range on HMM: 135-227/297
Sequence Identity: 36% (36 aa)

QIACGINDLHRFNITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGLS---KE-----GDIFTSTVGTPNYMGPETYQE---GDKTKETDIWAFGAILF
|| ...| .|. .| |||.||||| .....|        |||| |||.|   ..     |. ..   |.|.|| || .|        ...|||. | ||.
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILY
Kinase 20457.AA TyrKc 19-285 19 2.4e-14 9.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-285
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

YKLTQQLGNGSISVVFKAERQEDSKIFAVKYVSSFTFEGQRKNKYQQNELEI---SKKIMEI--KSKNLIEIYEVIQEDS------EDSYIIMEFCDMCD
 .| ..||.|   .|.|..        ||| . . .            . ..    .  ...  . .|.. .| |. ...      |  .|.||...  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LFSFSLTFW--INWQTAIEFGYQIACGINDLHRFNITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGLSKEG----------DIFTSTV--GTP----
| ..       ..... ..| .||||| . ||. |. ||||   |. |.. .          .||.|||||...          |  ...   |.     
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

-NYMGPETYQEGDKTKETDIWAFGAILFELIEK-KQYFSS-----HSAAMIYNQIKNFQAYDKQRLTKIED-------SDILERVNNLIQKCLNVKPQNR
   | ||. ..|  | ..|.|.||  ..|.    .|  .       |.. .....|.       |. . ..           |  . ....| . .| .|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-----GYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDR

IQSEELVLEI
   .|.. ..
PTFSEIHECF
Kinase 20457.AA CAMKL 19-111 23 8e-06 14.45 In-house 1-113 (297) Show / Hide 
Range on Protein: 19-111
Range on HMM: 1-113/297
Sequence Identity: 23% (27 aa)

YKLTQQLGNGSISVVFKAER-QEDSKIFAVKYVS--SFTFEGQRKNK------YQQN----ELEISKKIMEIK-SKNLIEIYEVIQ------EDSEDSYI
|.. ..|| || ..|  |.  .   .  |.| .     . . . |..       .      | .| |..  |   .| | .||||.      |  .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIET-KKIYL

IMEFCDMCD--LFSF
.|| |.  .  || .
VMEYCSGGEMDLFDY
Kinase 20457.AA Pkinase_Tyr 123-177 32 0.000196 15.64 Pfam 114-159 (270) Show / Hide 
Range on Protein: 123-177
Range on HMM: 114-159/270
Sequence Identity: 32% (18 aa)

IEFGYQIACGINDLHRFNITHRDLKPENIFVSSHKNDETKKIEYNIKIGDFGLSK
... .|||.| . |.. |. ||||   |. |..         .  .||.||||..
LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---------NNVVKICDFGLAR