Gene 10886 (Tetrahymena)
10886
Sequence
Protein domains of 10886.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10886.AA | C8 | 159-285 | 29 | 1e-29 | 100.35 | In-house | 1-151 (226) | Show / Hide |
Range on Protein: 159-285
Range on HMM: 1-151/226
Sequence Identity: 29% (45 aa)
YESFQFIGSGTFSMVYSARKIKNNQNIALRIQEVKDQVYFNNYISIYKQIQMPLVIELYDVYYID--IEIHKFAIFELELVD-----------CDLMQ--
..||.. .| ..|| .|...|.|..|.| .|..... .| .|| |...||.|...|| |... . ... ||.| . |..|.
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME
---------LLEGQEQYGQLNDENKMSIAKQLIDAINYLHNFNIINRDIKP
.| ... .|...|.| || |.|| .||.| .||. |||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKP
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| Kinase | 10886.AA | Ciliate-E1 | 165-354 | 25 | 5.3e-29 | 91.69 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 165-354 Range on HMM: 1-202/202 Sequence Identity: 25% (52 aa) IGSGTFSMVYSARKIKNN-QNIALRIQEVK---DQVYFNNYISIYKQIQMPLVIELYDVYYIDIEIHKFAIFELELVDCDLMQLLEGQE----------- ||.| ||.|. |....|| ...|. |.... .|..|...| |..|.. . | | ...||. .............| ..|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --QYGQLNDENKMSIAKQLIDAINYLHNFNIINRDIKPIIPYPIIRLKNGSDVYNTNQLVGTMLFSAPENMVEPYDRFVYSKEVNKNITPNQNLNDYLIY ...|.....||.|..||||....||..||| |||| | |. ..| ||. .. . . ..... . |. . .|. .|. |. .. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIK---PQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQEHNKNQKI SKKSDIF ..||||. NYKSDIY |
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| Kinase | 10886.AA | Ciliate-C8 | 168-285 | 28 | 9.2e-29 | 100.29 | In-house | 1-147 (238) | Show / Hide |
Range on Protein: 168-285 Range on HMM: 1-147/238 Sequence Identity: 28% (42 aa) GTFSMVYSA------RKIK-NNQNIALRIQEVKDQVYFNNYISIYKQIQMPLVIELYDVYYID--IEIHK-----------------FAIFELELVD--C | |.|| .| ||.. .. ... || ... .|..| .. |||.|...|| .|.. .. . | .|.|. . | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC DLMQLLEG-QEQYGQLNDENKMSIAKQLIDAINYLHNFNIINRDIKP .| |... ... ...... |. || | || .|||| |||. ||||| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKP |
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| Kinase | 10886.AA | C2 | 168-285 | 27 | 4.8e-22 | 72.19 | In-house | 1-150 (245) | Show / Hide |
Range on Protein: 168-285 Range on HMM: 1-150/245 Sequence Identity: 27% (41 aa) GTFSMVYSARKIKNNQNIALRIQEVKD-----QVYFNNYISIYKQIQ-MPLVIELYDVYYIDIE---I------------HK----------FAIFELEL | |..| | | |. .|| |||... . ..| .|.| ||..|..|. .| . . . .. | .|.| GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF VDCDLMQLLEGQEQYG-QLNDENKMSIAKQLIDAINYLHNFNIINRDIKP ...| | .. . . ..... || .| | .|.||||| |.|. ||||| CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKP |
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| Kinase | 10886.AA | CMGC | 159-285 | 17 | 1.2e-14 | 43.62 | In-house | 1-212 (513) | Show / Hide |
Range on Protein: 159-285 Range on HMM: 1-212/513 Sequence Identity: 17% (37 aa) YESFQFIGSGTFSMVYSARKIKNNQN--------------IALRIQE---VKDQVY-------FN----NYISIYKQIQ-----------------MPLV || . ||.||...||..| ..||. .|. . ..| |. |.| |... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI IELYDVYYIDIEIHKFA-------------IFELELVDCDLMQLLEGQEQ-YGQ-----LNDEN------------KMSIA------KQLIDAIN--YLH . |||..| . . .. . . |..|.|| |... . . | |.. . .. .|.. ... |.| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH NFN--IINRDIKP . || ||.|| SHWGNIIHRDLKP |
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| Kinase | 10886.AA | Pkinase | 159-285 | 21 | 1.6e-13 | 48.87 | Pfam | 1-136 (293) | Show / Hide |
Range on Protein: 159-285 Range on HMM: 1-136/293 Sequence Identity: 21% (30 aa) YESFQFIGSGTFSMVYSARKIKNNQNIALRIQEVKDQVYFNNY-------ISIYKQIQMPLVIELYDVYYIDIEIHKFAIFELELVDC-----DLMQLLE |. . ||||.|. || ........ |. | ..... .. |.| | .. | ...|||... .. . .|.... ||. ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS GQEQYGQL--NDENKMSIAKQLIDAINYLHNFNIINRDIKP . ...| . .. ....|.. ...|.|. .|| ||.|| T-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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| Kinase | 10886.AA | S_TKc | 159-430 | 17 | 9.1e-13 | 10.31 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 159-430
Range on HMM: 1-231/231
Sequence Identity: 17% (54 aa)
YESFQFIGSGTFSMVYSARKIKNNQNIALRIQEVKDQVYFNNYISIYKQIQMPLVIELYDVYYIDIEIHKFAIFELELVDC---DLMQLLEGQEQYGQ--
|| . ||.|.|. || .|..| .. |. | . . |.| |. . | .. ||||.. .. . .|..| ||..... . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-LNDENKMSIAKQLIDAINYLHNFNIINRDIKP------------------IIPYPIIRLKNGSDVYNTNQLVGTMLFSAPENMVEPYDRFVYSKEVNKN
.. ....|...|..|.|. .|| ||.|| .. . ..|| . ||| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL----------------TTFCGTPWYMAPEVL----------------
ITPNQNLNDYLIYSK-KSDIFSLGATL-CMLDNFKSYNSEEFGKYLTMIKSYFQQPFEKFQINRQSQIYQFIEQFCQYEIDQRIPLFCIVD----QNPND
|.| |.|. |.| .| || . . . . .|. .. .||.. .|.. ..|. . .
-----------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP
FL
..
WF
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| Kinase | 10886.AA | Ciliate-E2 | 159-285 | 18 | 3.5e-10 | 31.13 | In-house | 1-189 (365) | Show / Hide |
Range on Protein: 159-285 Range on HMM: 1-189/365 Sequence Identity: 18% (35 aa) YESFQFIGSGTFSMVYSARKIKNNQN-----------------------IALRIQEVKDQVYFNNYISIYKQIQ----------------MPLVIELYDV |. . ||.|.|. || ....|.... .|. |.. .. .... |.|...|. | .|..|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YYIDIEIHKFAIFELELVDCDLMQLLE------GQE---QYGQLNDENKMSIAKQLID---------------AINYLHNFN-IINRDIKP .. . . . ..|. . ||..... ..| . ...... | ||... |..|||. | || ||||| FQEKDDNNIYLVMEY-CQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP |
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| Kinase | 10886.AA | CDK | 235-285 | 25 | 3.8e-08 | 21.99 | In-house | 98-136 (284) | Show / Hide |
Range on Protein: 235-285 Range on HMM: 98-136/284 Sequence Identity: 25% (13 aa) ELVDCDLMQLLEGQEQYGQLNDENKMSIAKQLIDAINYLHNFNIINRDIKP | .| ||..... .. .||.....|.| .|. ||.|| EYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKP |
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| Kinase | 10886.AA | Ciliate-A9 | 159-189 | 30 | 8.9e-08 | 13.68 | In-house | 1-33 (392) | Show / Hide |
Range on Protein: 159-189 Range on HMM: 1-33/392 Sequence Identity: 30% (10 aa) YESFQFIGSGTFSMVYSARKIK--NNQNIALRI .| ||.|.| |. .|.|. ..| | . FEPIKIIGEGAFGCVIQCRDIQQEDKQEYAVKV |
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| Kinase | 10886.AA | Ciliate-E2a | 256-285 | 35 | 1e-07 | 18.8 | In-house | 100-130 (275) | Show / Hide |
Range on Protein: 256-285 Range on HMM: 100-130/275 Sequence Identity: 35% (11 aa) DENKMSIAKQLI-DAINYLHNFNIINRDIKP ... ..| .||. ....|.|. ||. ||.|| IQEICDIMQQLLWQGLHYMHQRNIMHRDLKP |
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| Kinase | 10886.AA | CAMK1 | 159-187 | 31 | 3.4e-07 | 16.91 | In-house | 1-32 (276) | Show / Hide |
Range on Protein: 159-187 Range on HMM: 1-32/276 Sequence Identity: 31% (10 aa) YESFQFIGSGTFSMVYSARKIKN---NQNIAL || . ||.|.|| || . .... ....|. YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAI |
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| Kinase | 10886.AA | Ciliate-E2a | 159-220 | 33 | 1e-05 | 12.92 | In-house | 1-68 (275) | Show / Hide |
Range on Protein: 159-220 Range on HMM: 1-68/275 Sequence Identity: 33% (23 aa) YESFQFIGSGTFSMVYSARKIKNNQN------IALRIQEVKDQVYFNNYISIYKQIQMPLVIELYDVY |. ||.|.| || |........ | |. |.. || | |.|..|. | .| ||.|| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVY |
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| Kinase | 10886.AA | CDK | 159-187 | 38 | 1.4e-05 | 13.62 | In-house | 1-34 (284) | Show / Hide |
Range on Protein: 159-187 Range on HMM: 1-34/284 Sequence Identity: 38% (13 aa) YESFQFIGSGTFSMVYSARKIKNN-----QNIAL || . || ||. || || ... | .|| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVAL |
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| Kinase | 10886.AA | Ciliate-A9 | 262-285 | 45 | 2.1e-05 | 7.86 | In-house | 130-153 (392) | Show / Hide |
Range on Protein: 262-285 Range on HMM: 130-153/392 Sequence Identity: 45% (11 aa) IAKQLIDAINYLHNFNIINRDIKP | | .. |. |.| ||. ||.|| IMKCIMSAVMYMHQKNICHRDLKP |
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| Kinase | 10886.AA | CAMK1 | 264-285 | 45 | 2.9e-05 | 11.2 | In-house | 115-136 (276) | Show / Hide |
Range on Protein: 264-285 Range on HMM: 115-136/276 Sequence Identity: 45% (10 aa) KQLIDAINYLHNFNIINRDIKP ||...|..|.| .| ||.|| KQILSAVEYMHSKGIVHRDLKP |
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| Kinase | 10886.AA | C8 | 338-360 | 39 | 0.000116 | 12.23 | In-house | 204-226 (226) | Show / Hide |
Range on Protein: 338-360 Range on HMM: 204-226/226 Sequence Identity: 39% (9 aa) NQNLNDYLIYSKKSDIFSLGATL ... |.| .|...||.||.| | KKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 10886.AA | Ciliate-C8 | 346-360 | 60 | 0.000815 | 9.95 | In-house | 224-238 (238) | Show / Hide |
Range on Protein: 346-360 Range on HMM: 224-238/238 Sequence Identity: 60% (9 aa) IYSKKSDIFSLGATL |.|||||..|.| | IFSKKSDSYSVGLVL |
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| Kinase | 10886.AA | C2 | 346-373 | 44 | 0.003411 | 6.9 | In-house | 217-245 (245) | Show / Hide |
Range on Protein: 346-373 Range on HMM: 217-245/245 Sequence Identity: 44% (13 aa) IYSKKSDIFS-LGATLCMLDNFKSYNSEE || |.||.|| .| | ||| . |. .. IYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | 10886.AA | Ciliate-E2a | 347-360 | 35 | 0.015024 | 3.35 | In-house | 193-206 (275) | Show / Hide |
Range on Protein: 347-360 Range on HMM: 193-206/275 Sequence Identity: 35% (5 aa) YSKKSDIFSLGATL |..| |..|.|. . YDTKCDMWSCGVIF |
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| Kinase | 10886.AA | Ciliate-E2 | 347-360 | 57 | 0.017832 | 4.29 | In-house | 273-286 (365) | Show / Hide |
Range on Protein: 347-360 Range on HMM: 273-286/365 Sequence Identity: 57% (8 aa) YSKKSDIFSLGATL |..|.||.||| .| YDYKCDIWSLGVIL |
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