Gene 12559 (Tetrahymena)
12559
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 12559.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12559.AA | Ciliate-B2 | 387-469 | 38 | 2.5e-36 | 82.9 | In-house | 1-85 (197) | Show / Hide |
Range on Protein: 387-469 Range on HMM: 1-85/197 Sequence Identity: 38% (33 aa) YYLGKFIGEGGFGVVFDGK-IYQNNKIQEVIFKIQFT-DEQNMNESEEEYLIMKGFEKNINLINAIDYKKIDQNVSVILMEKCEY |||.|.|..||.|....| . . |...|||.| .. . .| ..|. ||| ||.||| . ||. .|.... |. |||||. YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCEC |
|||||||||
| Kinase | 12559.AA | Ciliate-B2 | 470-530 | 39 | 6.2e-33 | 74.73 | In-house | 130-197 (197) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 130-197/197 Sequence Identity: 39% (27 aa) IKPSNILINRYGIYVITDFGTSTKNKNDQPIQVKGYTESFAPKEVIKNE-------EVNYQSDVYSLG |||.|||. ..| || .||| | |..| |..|| | ..|..| ... ....|||.||.| IKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
|||||||||
| Kinase | 12559.AA | Ciliate-E1 | 470-527 | 45 | 1.2e-23 | 74.07 | In-house | 135-202 (202) | Show / Hide |
Range on Protein: 470-527 Range on HMM: 135-202/202 Sequence Identity: 45% (31 aa) IKPSNILINRYGIYVITDFGTST--KNKNDQPIQVKGYTESFAPKEVIK--------NEEVNYQSDVY |||.|||||..|.||..|||.| ||...| .|.||||....|.|... |...||.||.| IKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
|||||||||
| Kinase | 12559.AA | Ciliate-E1 | 393-469 | 37 | 2.5e-19 | 59.89 | In-house | 26-106 (202) | Show / Hide |
Range on Protein: 393-469 Range on HMM: 26-106/202 Sequence Identity: 37% (31 aa) IGEGGFGVVFDGKIYQNN--KIQEVIFKIQF--TDEQNMNESEEEYLIMKGFEKNINLINAIDYKKIDQN-VSVILMEKCEY ||.|.|..||..|...|| .....|....| ..... .|..|.|.||| |.|....|. |||.||||| ...|..|.|.. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCC |
|||||||||
| Kinase | 12559.AA | Ciliate-E2 | 470-530 | 19 | 6.3e-11 | 33.72 | In-house | 187-283 (365) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 187-283/365 Sequence Identity: 19% (20 aa) IKPSNILINRYGIYVITDFGTSTKNKND----------QPIQVKG-----------------------YTESFAPKEVIKNEEVN---------YQSDVY |||.|||. |.|||.|.|...| . .. . .| . . |...... . |..|.. IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW SLG ||| SLG |
|||||||||
| Kinase | 12559.AA | Ciliate-E3 | 470-537 | 28 | 2.8e-09 | 25.38 | In-house | 129-202 (202) | Show / Hide |
Range on Protein: 470-537 Range on HMM: 129-202/202 Sequence Identity: 28% (21 aa) IKPSNILINRYG---IYVITDFGTSTKNKNDQ-PIQVK--GYTESFAPKEVIKNEEVNYQSDVYSLGKTLETVF |||.|||. | | ||| | . ... .. . | | .|..|. .. . || ||.| . . IKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
|||||||||
| Kinase | 12559.AA | S_TKc | 387-584 | 16 | 4.6e-08 | -58.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 387-584
Range on HMM: 1-231/231
Sequence Identity: 16% (43 aa)
YYLGKFIGEGGFGVVFDGKIYQNNKIQEVIFKIQFTDEQNMNESEEEYLIMKGFEKNINLINAIDYKKIDQNVSVILMEKCEY-----------------
| ... ||.|.||.|. | . .. ..| || . . | |.| . |... .|. . . || |.
YEILRKIGKGAFGKVY--KCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
-------------------------------IKPSNILINRYGIYVITDFGTSTKNKNDQPIQVKGYTESFAPKEVIKNEEVNY-QSDVYSLGKTL----
.||.|||... |.||| ... | . . ||. .. .|..|.| .|
RFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML
--ETVFKDYEKLQNINQKEKTMLQKFKQILTDSALREQVFERKTCLELHK--------AFY
.. | .| . .| . . .|. . . |. .| |. |. . .
CGYPPFP---QMQMMFKKIG--SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 12559.AA | AGC | 469-497 | 44 | 6.3e-08 | 15.03 | In-house | 180-208 (395) | Show / Hide |
Range on Protein: 469-497 Range on HMM: 180-208/395 Sequence Identity: 44% (13 aa) YIKPSNILINRYGIYVITDFGTSTKNKND |.|| |||... | .|||| .....|| YLKPENILLDEDGHIKLTDFGLCKEGMND |
|||||||||
| Kinase | 12559.AA | C8 | 470-533 | 26 | 7.8e-07 | 19.88 | In-house | 149-226 (226) | Show / Hide |
Range on Protein: 470-533 Range on HMM: 149-226/226 Sequence Identity: 26% (21 aa) IKPSNILINRYGIYV----ITDFGTSTKNKNDQP-IQVKGY----TESFAPKEVIKN-----EEVNYQSDVYSLGKTL |||.|.|. . |. . ||| ... . .. || | . | . |..| . . |||..|.| | IKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
| Kinase | 12559.AA | Ciliate-E2-Unclassified | 470-530 | 26 | 1e-06 | 18.86 | In-house | 170-257 (352) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 170-257/352 Sequence Identity: 26% (23 aa) IKPSNILINRYG---IYVITDFGTSTKNKND------------QPIQVKGYTESFAPK--------EVIKNEEVN----YQSDVYSLG |||.|||.. | |.||| | |.... ...| . .| . | ||..... . |..|..||| IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG |
|||||||||
| Kinase | 12559.AA | ULK | 387-436 | 21 | 2e-06 | 18.97 | In-house | 1-54 (329) | Show / Hide |
Range on Protein: 387-436 Range on HMM: 1-54/329 Sequence Identity: 21% (12 aa) YYLGKFIGEGGFGVVFDGKIYQNN---KIQEVIFKIQ---FTDEQNMNESEEEYLI |.| . .|.| ||.|. |. ... ... .. .|. . ..|..| . .|.. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE-G-QYMW |
|||||||||
| Kinase | 12559.AA | TKL | 470-530 | 18 | 2e-06 | 19.43 | In-house | 166-276 (364) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 166-276/364 Sequence Identity: 18% (21 aa) IKPSNILINRYGI--------------YVITDFGTST-----KNKNDQPIQVK---------------GYTESFAPKEVIKNE----------------E .|..|||... . |.|||.|. .|.||. .. . | . . ||.... | LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFE VNYQSDVYSLG . ..|||| | YSEKCDVYSFG |
|||||||||
| Kinase | 12559.AA | CAMKK | 470-493 | 48 | 5e-06 | 14.7 | In-house | 222-248 (396) | Show / Hide |
Range on Protein: 470-493 Range on HMM: 222-248/396 Sequence Identity: 48% (13 aa) IKPSNILINRYG---IYVITDFGTSTK |||.||||. | .|.|||.|.. IKPQNILIDEEGCGEHVKIADFGVSHI |
|||||||||
| Kinase | 12559.AA | STE | 470-530 | 22 | 1.4e-05 | 15.83 | In-house | 178-255 (359) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 178-255/359 Sequence Identity: 22% (19 aa) IKPSNILINRYGIYVITDFGTSTKNKND------------------QPIQVKGYTESFAPKEVIKNEEVN------YQSDVYSLG |||.|||. ..|||.... .. . . | || |||.... . ...|..||| IKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAP-EVIQQNGQGRDKGYDTKCDIWSLG |
|||||||||
| Kinase | 12559.AA | Pkinase | 470-530 | 27 | 0.000165 | 17.02 | Pfam | 134-199 (293) | Show / Hide |
Range on Protein: 470-530 Range on HMM: 134-199/293 Sequence Identity: 27% (19 aa) IKPSNILINRYGIY----VITDFGTSTK--NKNDQPIQVKGYTESFAPKEVIK-NEEVNYQSDVYSLG .||.||||.. | |.||| . . . |.. .. | ... |||. ... . .|..|.| LKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG |
|||||||||
| Kinase | 12559.AA | TyrKc | 387-583 | 15 | 0.000175 | -150.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 387-583
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)
YYLGKFIGEGGFGVVFDGKIYQNNKIQEVIFKIQFTDEQNMNESEEEYLIMKGF-EKNINLINAIDYKKIDQ------NVSVILMEKCEY-------IKP
||| .||| ||.|. |. . ..| | | . . .| ||. . .. |... . . .. |.|| ... |.
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
S-----------------------------------NILINRYGIYVITDFGTSTKNKND------QPIQVKGY--TESF------APKEVIKNEEVNYQ
|.|... .. |.||| | . ..| . .| . . . |.|. . . .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK
SDV----------YSLGKTLETV-----FKDYEKLQNINQK-----EKT--------MLQKFKQILTDSALREQVFERKTCLELHKAF
||| ...|.. ...| .... | . . .. | . . .|. .| | |.|. |
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
|
|||||||||
| Kinase | 12559.AA | Ciliate-E2 | 387-469 | 19 | 0.000368 | 10.16 | In-house | 1-118 (365) | Show / Hide |
Range on Protein: 387-469 Range on HMM: 1-118/365 Sequence Identity: 19% (23 aa) YYLGKFIGEGGFGVVFDGKIYQNNK------IQEVI---------FKIQFTDEQNMNESEEEYLIM-KGFEKNIN-------------------LINAID | . | ||.|.||.|. .| ....| |. . .||.. .|.... |.. . . . || .|. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE YKK-IDQNVSVILMEKCEY . . .|.| . || |.. CFQEKDDNNIYLVMEYCQG |
|||||||||
| Kinase | 12559.AA | Ciliate-E2-Unclassified | 387-469 | 24 | 0.006244 | 6.03 | In-house | 1-105 (352) | Show / Hide |
Range on Protein: 387-469 Range on HMM: 1-105/352 Sequence Identity: 24% (26 aa) YYLGKFIGEGGFGVVFDGKIYQNN---------KIQEVIFKIQ-FTDEQNMNESEEEYLIMKGFEKN---------------INLINAIDYKKIDQNVSV | ..| ||.||||.|. . ... |||.. |.. . | . ||| .|. ..| . . ..... ..... .||. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI-Y ILMEKCEY | ||.||. IVMEYCEG |
|||||||||
| Kinase | 12559.AA | ULK | 470-489 | 37 | 0.008822 | 5.64 | In-house | 156-187 (329) | Show / Hide |
Range on Protein: 470-489 Range on HMM: 156-187/329 Sequence Identity: 37% (12 aa) IKPSNILINRY------------GIYVITDFG |||.||||. |.. |.||| IKPQNILIHNGQPKTDSKKVHPNGVLKIADFG |
|||||||||
| Kinase | 12559.AA | Ciliate-E3 | 387-426 | 27 | 0.012465 | 4.37 | In-house | 1-38 (202) | Show / Hide |
Range on Protein: 387-426 Range on HMM: 1-38/202 Sequence Identity: 27% (11 aa) YYLGKFIGEGGFGVVFDGKIYQNNKIQEVIFKIQFTDEQN | . .| |.||.|. | . . |.| | .....|. YTVQQILGCGQFGRVY--KAFDFQNNQDVAIKAIICQNQQ |
|||||||||
| Kinase | 12559.AA | TKL | 393-405 | 69 | 0.012856 | 5.26 | In-house | 1-13 (364) | Show / Hide |
Range on Protein: 393-405 Range on HMM: 1-13/364 Sequence Identity: 69% (9 aa) IGEGGFGVVFDGK ||.||||.|. || IGSGGFGEVYKGK |
|||||||||
| Kinase | 12559.AA | STE | 387-416 | 16 | 0.029909 | 3.9 | In-house | 1-42 (359) | Show / Hide |
Range on Protein: 387-416 Range on HMM: 1-42/359 Sequence Identity: 16% (7 aa) YYLGKFIGEGGFGVVFDGKIY------QNNKI------QEVI . . ..||.|.||.|. .. ..... .|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIM |
|||||||||
| Kinase | 12559.AA | CAMKK | 387-401 | 60 | 0.033084 | 2.3 | In-house | 1-15 (396) | Show / Hide |
Range on Protein: 387-401 Range on HMM: 1-15/396 Sequence Identity: 60% (9 aa) YYLGKFIGEGGFGVV | |.| ||.| ||.| YELMKEIGQGQFGKV |
|||||||||
| Kinase | 12559.AA | Pkinase | 387-405 | 42 | 0.088713 | 7.37 | Pfam | 1-19 (293) | Show / Hide |
Range on Protein: 387-405 Range on HMM: 1-19/293 Sequence Identity: 42% (8 aa) YYLGKFIGEGGFGVVFDGK | .|. ||.|.||.|. .. YHIGRKIGSGSFGCVYKCH |
|||||||||
| Kinase | 12559.AA | ULK | 513-530 | 21 | 0.203031 | 0.82 | In-house | 221-243 (329) | Show / Hide |
Range on Protein: 513-530 Range on HMM: 221-243/329 Sequence Identity: 21% (5 aa) EVIK----NEEVN-YQSDVYSLG .... ... . | .|..||| QILQGQGEQKPYYDYKCDIWSLG |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 673-706 | 20 | 11.006065 | 2.97 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 673-706 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) ILIYNSIADFYYEQCQFHMEKKYLQKSLELCNQL ... ... ||.| .. ..|..|.|.| . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 753-786 | 26 | 9.415288 | 3.21 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 753-786 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) SIYLNTLSWCYSSLNDHKQAFKVSEESLKMRLNL ... | .|| ..|...| . |..|| | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 836-859 | 37 | 0.007428 | 14.19 | Pfam | 1-24 (34) | Show / Hide |
Range on Protein: 836-859 Range on HMM: 1-24/34 Sequence Identity: 37% (9 aa) ARSLHCVGQCYLNMGDLEQAKKYL |. ... ||||...||...|..|. AEAWYNLGQCYYKQGDYDEAIEYY |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 878-911 | 17 | 13.641018 | 2.64 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 878-911 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) AVSLASIATYHQQSGEFIKSIFFYKKYFQMMRNL | . .. . . |.. . | .|.| . | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 920-953 | 17 | 0.068776 | 10.77 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 920-953 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) YNFLYNIAQSLFLNRQFQQSISILQDFLKIFSKD .||..|... ...... | .. ||.. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 12559.AA | TPR_2 | 958-991 | 17 | 41.189673 | 0.94 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 958-991 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) SKAHIIIGLCQLNIGQFLKSLESAINSISVNKNV .|. .|.| .. |.. . .| ... . | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||