Gene 13472 (Tetrahymena)
13472
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 13472.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13472.AA | Ciliate-A8 | 33-117 | 45 | 2.2e-28 | 95.34 | In-house | 1-85 (151) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 1-85/151 Sequence Identity: 45% (39 aa) YVYEKEISRGNFSLIVQARSIKNESCKVAIKILNY-EQNSKIDLEKLNKQADFLSSLKDEKYILQFIGTIQDLSYEITAIITEYCE |.|.| . | ||..||| || |. |.|||||..| .| || ....|. . .|.||||||.|..|||. .. .||.||.|. YKYQKVLEKGDFSYVVQAYSI-NHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCD |
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| Kinase | 13472.AA | Ciliate-E1 | 39-120 | 28 | 5.7e-19 | 58.7 | In-house | 1-84 (202) | Show / Hide |
Range on Protein: 39-120 Range on HMM: 1-84/202 Sequence Identity: 28% (24 aa) ISRGNFSLIVQARSIKNESCKVAIKILNYEQN-SKIDLEKLNKQAD-FLSSLKDEKYILQFIGTIQ-DLSYEITAIITEYCETYL |..| ||....|....| ..||.|| |...| .........|. . ... .| |.||.|.| .|. |..| ...|....|.... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLK |
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| Kinase | 13472.AA | S_TKc | 33-232 | 15 | 8.8e-11 | -18.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 33-232
Range on HMM: 1-231/231
Sequence Identity: 15% (43 aa)
YVYEKEISRGNFSLIVQARSIKNESCKVAIKILNYEQNSKIDLEKLNKQADFLSSLKDEKYILQFIGTIQDLSYEITAIITEYCET-------YLS----
| ..| .| |. ..| .| .|||||.. |.. . . |.. . ..| ......|| . ...|||.. |.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR
----------------------------------------------------FSKLIHCENDDQQQGNLNYQSPEVIDEKKPYTI-AADVFSIGVIILEA
..... . . | ..| .|||. .|. ..|. |.|.|. |
HGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM
LIQRKI---QTTEYFKLKSQNLVSAFPDLFSQQNHEFVTKILSKMVDPDPSKRSQPIDLLQ-----LLNKFK
| .. | . ||. .|. ...|. . ||.|| ..|| . .
LC-GYPPFPQMQMMFKKIG--------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 13472.AA | TKL | 134-228 | 15 | 3.3e-09 | 29.32 | In-house | 233-364 (364) | Show / Hide |
Range on Protein: 134-228 Range on HMM: 233-364/364 Sequence Identity: 15% (21 aa) QQGNLNYQSPEVIDEK---------------KPYTIAADVFSIGVIILEALIQRKIQTTEYFKLK--------------SQNLVSAFPDLFS-------- | |.... .|||.... ..|. ..||.| |... | | .. |.... ... . . . QCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK -QQNHEF---VTKILSKMVDPDPSKRSQPIDLLQLL .... . . |.. . |.||.|| ..|. | MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 13472.AA | Ciliate-E2-Unclassified | 136-226 | 18 | 4.2e-08 | 24.24 | In-house | 224-348 (352) | Show / Hide |
Range on Protein: 136-226 Range on HMM: 224-348/352 Sequence Identity: 18% (23 aa) GNLNYQ----SPEVIDEKKPYT---IAADVFSIGVIILEALIQRKIQT--T------------------EYFKLKSQNLVSAFP-------DLFSQQNHE |..||. .|||........ ...|..| |||. | | .. . .... . |. .. .. . |.. . GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKD FVTKILSKMVDPDPSKRSQPIDLLQ |....|.|| . .|.|| .. ..|. FINDLLQKMLKKNPNKRITFEQILN |
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| Kinase | 13472.AA | Ciliate-E2 | 132-226 | 18 | 8.3e-08 | 22.87 | In-house | 245-361 (365) | Show / Hide |
Range on Protein: 132-226
Range on HMM: 245-361/365
Sequence Identity: 18% (23 aa)
DQQQGNLNYQSPEVIDEKKP--------YTIAADVFSIGVIILEALIQRKIQTTEYFKLKSQNLVSAFPDLF--------------SQQNHEFVTKILSK
... |...|..||.. || |. ..|..|.|||. | | . . .. || . .. . . ...|
NTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK
----MVDPDPSKRSQ-PIDLLQ
| . ||.|| . . ..|.
FGKRMLQKDPEKRITGWEQILN
|
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| Kinase | 13472.AA | PEK | 140-228 | 21 | 2.4e-07 | 20.86 | In-house | 555-655 (655) | Show / Hide |
Range on Protein: 140-228 Range on HMM: 555-655/655 Sequence Identity: 21% (22 aa) YQSPEVIDEK----KPYTIAADVFSIGVIILEALIQRKIQTTEYFKLKSQNLVSA----FPDLFS----QQNHEFVTKILSKMVDPDPSKRSQPIDLLQ- | |||... . . |. .|..| |.|..| ... ..||.. . | .. . ||. |. .... .....|...||..| .. ..|| YMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYP--FFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQH -LL .. EFF |
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| Kinase | 13472.AA | CAMK | 38-117 | 12 | 2e-06 | 15.7 | In-house | 1-143 (425) | Show / Hide |
Range on Protein: 38-117 Range on HMM: 1-143/425 Sequence Identity: 12% (18 aa) EISRGNFSLIVQARSIKNES-----------CKVAIKILNYEQNSKI--------------------------DLEKLNKQADFLSSLK------DEKYI .. ||.|. .. ... ||||||.. .. .. |.... . . ...|. | . | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LQFIGTIQDLSY--------EITA----------IIT---EYCE .... ...| .| . ... |||. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCS |
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| Kinase | 13472.AA | CAMK1 | 140-164 | 55 | 2e-06 | 14.83 | In-house | 179-205 (276) | Show / Hide |
Range on Protein: 140-164 Range on HMM: 179-205/276 Sequence Identity: 55% (15 aa) YQSPEVIDEK--KPYTIAADVFSIGVI |. |||. | ||| | |..||||| YVAPEVLECKKDKPYDKACDMWSIGVI |
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| Kinase | 13472.AA | TyrKc | 33-228 | 13 | 4e-06 | -124.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 33-228 Range on HMM: 1-280/280 Sequence Identity: 13% (39 aa) YVYEKEISRGNFSLIVQARSIKNESCKVAIKILNYEQNSKIDLEKLNKQADFLSSL-KDEKYILQFIGTIQD-----LSYEITAIITEYCE-----TYLS . .|.. .|.| ..... . .||.| |. . .| . . | ...| .. . |....| . . .. | |..||.. || ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR FSK-------------------------------------LIHCEN-----------------------DDQQ-----QGN----LNYQSPEVIDEKKPY .. |.. .. | .|. . .||.|...| . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F TIAADVFSIGVII-----LEALIQRK-----IQTTEYFKLKSQNLVSAFPDL-----FSQQNHEFVTKILSKMVDPDPSKRSQPIDLLQLL |.. ||.| || . . . . .| ... | |. | .. . .| .. . ||..| .. ... TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 13472.AA | C8 | 128-165 | 23 | 1e-05 | 15.98 | In-house | 181-226 (226) | Show / Hide |
Range on Protein: 128-165 Range on HMM: 181-226/226 Sequence Identity: 23% (11 aa) CENDDQQQ----GNLNYQSPEVIDE----KKPYTIAADVFSIGVII .. . ... |.. | ||.. . | |.| |.||.|.. KSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 13472.AA | CAMK | 136-164 | 27 | 1.4e-05 | 13.14 | In-house | 281-323 (425) | Show / Hide |
Range on Protein: 136-164 Range on HMM: 281-323/425 Sequence Identity: 27% (12 aa) GNLNYQS-PEVIDE-------------KKPYTIAADVFSIGVI | . | . |||. |..|. ..|. |.||| GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI |
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| Kinase | 13472.AA | STE | 136-167 | 32 | 2e-05 | 15.24 | In-house | 225-260 (359) | Show / Hide |
Range on Protein: 136-167 Range on HMM: 225-260/359 Sequence Identity: 32% (12 aa) GNLNYQSPEVIDE-----KKPYTIAADVFSIGVIILE | . .||||. .|.|.. .|. |.| |.| GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE |
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| Kinase | 13472.AA | STE | 33-117 | 14 | 7.3e-05 | 13.25 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 1-120/359 Sequence Identity: 14% (17 aa) YVYEKEISRGNFSLIVQARSIKNE--------------SCKVAIKILNYEQNSKI---------------DLEKLNKQADFLSSLKD-EKYILQFIGTIQ . ..| .|.| ..|. .|| . .|||..|.|.... ..... | .... ... ..| ...|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF DLSYE-----ITAIITEYCE . . . |. ||.. KEGHNHKNDDELWICMEYMD |
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| Kinase | 13472.AA | Pkinase | 138-169 | 37 | 0.000854 | 14.5 | Pfam | 175-206 (293) | Show / Hide |
Range on Protein: 138-169 Range on HMM: 175-206/293 Sequence Identity: 37% (12 aa) LNYQSPEVIDEKKPYTIAADVFSIGVIILEAL ..| .|||| . ..|. ..|..|.|.|. | | PWYMAPEVIRGGQYYGPKVDMWSCGCILYEML |
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| Kinase | 13472.AA | Ciliate-E2 | 33-117 | 16 | 0.002108 | 7.52 | In-house | 1-117 (365) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 1-117/365 Sequence Identity: 16% (19 aa) YVYEKEISRGNFSLIVQARSIKNESC-----------------KVAIKILNYEQNSKIDLEKLNKQADFLS---------------SLKDEKYILQFIGT | | | .|||. . ... .|. ||.||| . ....| ..| ... . . .. . ..|.... . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IQDLSYEITAIITEYCE |. . . ...|||. FQEKDDNNIYLVMEYCQ |
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| Kinase | 13472.AA | Pkinase | 33-117 | 18 | 0.002153 | 13.08 | Pfam | 1-83 (293) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 1-83/293 Sequence Identity: 18% (16 aa) YVYEKEISRGNFSLIVQARSIKNESCKVAIKILNYEQNSKIDLEKLNK--QADFLSSLKDEKYILQFIGTIQDLSYEITAIITEYCE |. .. | .|.|. ... .... .||.||.... ... .. . . . . .| . ..|...... .| . .| ...|||| YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIY-MVMEYCE |
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| Kinase | 13472.AA | CAMK1 | 33-66 | 30 | 0.00216 | 5.65 | In-house | 1-36 (276) | Show / Hide |
Range on Protein: 33-66 Range on HMM: 1-36/276 Sequence Identity: 30% (11 aa) YVYEKEISRGNFSLIVQARSIKN--ESCKVAIKILN |. ||| || || ... ... ..|||... YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCID |
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| Kinase | 13472.AA | C8 | 37-74 | 15 | 0.004854 | 6.53 | In-house | 5-41 (226) | Show / Hide |
Range on Protein: 37-74 Range on HMM: 5-41/226 Sequence Identity: 15% (6 aa) KEISRGNFSLIVQARSIKNESCKVAIKILNYEQNSKID . .| |.......|. .| . ....|.. ......|. QYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQ |
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| Kinase | 13472.AA | TKL | 39-117 | 13 | 0.020634 | 4.51 | In-house | 1-121 (364) | Show / Hide |
Range on Protein: 39-117
Range on HMM: 1-121/364
Sequence Identity: 13% (16 aa)
ISRGNFSLIVQARSIKNESCK--------VAIKILNYEQNSKID------------------------LEKLNKQADFLSSLKDEKYILQFIGTIQDLSY
| .| |. . ... . . | ||.|... ..... . ... .. . | . |.||.| .. ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC
EI-----------TAIITEYCE
.|..|||.
GCVCMHPVGPWGQLCIVMEYCP
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| Kinase | 13472.AA | Ciliate-E1 | 129-159 | 10 | 0.067248 | 2.54 | In-house | 165-202 (202) | Show / Hide |
Range on Protein: 129-159 Range on HMM: 165-202/202 Sequence Identity: 10% (4 aa) ENDDQQQGNLNYQSPEVI-------DEKKPYTIAADVF .. .. . .|..||.. ........ |.. QQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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