Gene 19947 (Tetrahymena)

19947

Species: Tetrahymena
Alias: 115, 68.m00236, 3830.m00598, 19947, PreTt19947, TTHERM_00533900
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
19947.AA Protein None 949 None Fasta, JSON
19947.kin_dom Protein Kinase Domain None 182 None Fasta, JSON
19947.NA RNA None 2850 None Fasta, JSON

Protein domain

Protein domains of 19947.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19947.AA Ciliate-B2 444-565 29 3e-29 65.85 In-house 77-197 (197) Show / Hide 
Range on Protein: 444-565
Range on HMM: 77-197/197
Sequence Identity: 29% (36 aa)

VVVQELFSYTLEQEIQMLRQKNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNYKLANLGFSKLNQKYQEYKIYYLAFSQNYISPEI
| . | . . |.||.| . .. . |  . ..|.| ||  ||.|..    .| ||||.|. ..  |||.. . | | . .  .. .|.   | . | ||| 
VLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPEQ

SYKI-EKDQSIKITHKTDIYSLC
  .. ..  . .|  . ||||. 
MECDHNQTFVTNIDFQSDIYSMG
Kinase 19947.AA Ciliate-E1 424-562 30 1.7e-25 80.13 In-house 53-202 (202) Show / Hide 
Range on Protein: 424-562
Range on HMM: 53-202/202
Sequence Identity: 30% (45 aa)

QKNYVNQIYNVHYITSIKCCVVVQELFSYTLEQEIQ---------MLRQKNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNYKLAN
.. |. ||... .| ... |. ..|. ...|....|         ...|.. .|...|..|||.||  || ..||...||.||||.|.... .|||... 
KECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCD

LGFSKLNQKYQEYKIYYLAFSQNYISPEISYKIEK--DQSIKITHKTDIY
.| ||. .. |.. . |  . ..| .||  . .|   ... ||..|.|||
FGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 19947.AA C8 437-568 31 5.6e-15 48.53 In-house 88-226 (226) Show / Hide 
Range on Protein: 437-568
Range on HMM: 88-226/226
Sequence Identity: 31% (44 aa)

ITSIKCCVVVQ-ELFSYTLEQEIQMLRQKNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNY----KLANLGFSKLNQKYQE-YKIY
.|  | | | . ||    |.|  . .|.|.  || |.  .| ||.  |.  ||. . .| ||||.|    ||.||    ||. .||.   .| .. . . 
QTEEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSK

YL--AFSQNYISPEISYKIEKDQSIKITHKTDIYSLCLVI
       . |. ||| .| ...|  . . . |..|. || 
KMNTCGTWAYFAPEIEKK-QDNQYKQYRIQSDLFSVGLVL
Kinase 19947.AA Ciliate-C8 419-568 22 1.1e-12 42.05 In-house 44-238 (238) Show / Hide 
Range on Protein: 419-568
Range on HMM: 44-238/238
Sequence Identity: 22% (44 aa)

IFEKCQKNYVNQIYNVHYIT----SIK-----------------CCVVVQELFSYT--LEQEIQMLRQKNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHC
|  .||  .| | |.  |..    . .                   |. .|. . .  |.| .. .|.|.  .| ..  .| ||   ..  .|.   .| 
IMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHR

DIKPENVVKTLDGNY----KLAN------LGFSKLNQKYQE-YKIYYLAFSQNY-----------ISPEISYKIEKDQSIKITHKTDIYSLCLVI
||||.|    .| .|    ||..      .||.   .| .. | .     .. |           . ||. .|....||   . | |.||. || 
DIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
S_TKc 19947.AA S_TKc 381-642 16 1.7e-12 6.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 381-642
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

YCSLQQI------------NTG------LKISRETLQKAEQIHREWEVVYGSNKKNIFEKCQKNYVNQIYNVHYITSIKCCVVVQELFSY---TLEQEIQ
|  |..|            ...      .|| .      |.| || ..             .  .. ..| | .    ..  .| |. .    .| . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK

MLRQ--KNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNYKLANLGFSKLNQKYQEYKIYYLAFSQNYISPEISYKIEKDQSIKITH
  .   .. .|.  . . .. |.| .|  .|... ||.|.||||.  .   . |..  |....         . .  . .|..||.          . ..
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGK

-KTDIYSLCLVILEVLN----FNLSKFNALNILLNDFQQSSTFSNSSIEECQKSFEFDDVYDLFCKKCFNQDPHKRCDSYEILL-----NLLPLL
 | |..|.  .. | |     |    .  .....                       ... | | .||.. || ||    |.|      .. | .
CKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19947.AA CMGC 446-527 14 2.9e-12 35.67 In-house 133-285 (513) Show / Hide 
Range on Protein: 446-527
Range on HMM: 133-285/513
Sequence Identity: 14% (22 aa)

VQELFSYTLEQEIQMLR------QKNEW------------------FSIEQMCQIIIQLCIGLT--QIHQQK--LIHCDIKPENVVKTLDGNY-------
| |.  ..| | |.. .      ....                   |.| .   .. |.. ||    .|...   ||.|.||||.  . .. .       
VFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWK

-------------KLANLGFSK-LNQK------------------------YQEY
             |..  |... ...                         | .|
SEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY
Kinase 19947.AA Ciliate-E1 563-639 16 1.2e-10 31.35 In-house 127-202 (202) Show / Hide 
Range on Protein: 563-639
Range on HMM: 127-202/202
Sequence Identity: 16% (13 aa)

SLCLVILEVLNFNLSKFNALNILLNDFQQSSTFSNSSIEECQKSFEFDDVYDLFCKKCFNQDPHKRCDSYEILLNLL
.... ..    .|. . |  | ...||..|... |.....||.. . . .|   ...|..| .|.... ... ... 
QYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY
Kinase 19947.AA MSK 464-543 30 3.9e-09 27.04 In-house 94-176 (277) Show / Hide 
Range on Protein: 464-543
Range on HMM: 94-176/277
Sequence Identity: 30% (25 aa)

KNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLD---GNYKLANLGFSKLNQKYQEYKIYYLAFSQNYISPEI
| | |. .   .|. .| . . ..|| . || |.||||.  . .   |  ||   ||..|. . .|.. .   |.  | .||.
KREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEM
Kinase 19947.AA Ciliate-A1 465-570 26 4.3e-09 27.04 In-house 95-220 (301) Show / Hide 
Range on Protein: 465-570
Range on HMM: 95-220/301
Sequence Identity: 26% (33 aa)

NEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNYKLANLGFSK-LNQKY----------------QEYKIYYLAFSQNYISPEI---S
|.. . |.   |  |.  |.  || .  .| |.||.|..   |  .|.. || || | |.                 . |.      .  | |||     
NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMH

YKIEKDQSIKITHKTDIYSLCLVILE
|.  .    ||  . |.||| ..|..
YRDQMFIENKIYKQSDMYSLGCIICF
Kinase 19947.AA WEE 475-516 25 8.4e-09 25.73 In-house 115-177 (297) Show / Hide 
Range on Protein: 475-516
Range on HMM: 115-177/297
Sequence Identity: 25% (16 aa)

QIIIQLCIGLTQIHQQ-KLIHCDIKPENVVKTLDG--------------------NYKLANLG
||. ..| ||  ||..  ..| ||||||.  . ..                    ..|.. .|
QILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG
Kinase 19947.AA TKL 470-572 14 3.3e-08 25.66 In-house 131-283 (364) Show / Hide 
Range on Protein: 470-572
Range on HMM: 131-283/364
Sequence Identity: 14% (22 aa)

IEQMCQIIIQLCIGLTQIHQQK--------LIHCDIKPENVVKTLDGN--------------YKLANLGFSKLNQKY-----------------QEYKIY
..|.|..... . |.   |...        .||.|.|..|.    ...               |.. .|.|. ...                  .  |  
WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTT

YLAF-SQNYISPEISYKIEKDQS----------IKITHKTDIYSLCLVILEVL
.    . .. .||.  . .....           . . |.|.||  .|. |.|
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
Kinase 19947.AA Ciliate-E8 488-518 36 3.4e-08 21.72 In-house 106-138 (138) Show / Hide 
Range on Protein: 488-518
Range on HMM: 106-138/138
Sequence Identity: 36% (12 aa)

HQQKLIHCDIKPENVVKTL--DGNYKLANLGFS
|.   ||||.| .|..  .  | . |.   |||
HNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS
Kinase 19947.AA Pkinase 460-576 20 6e-06 22.08 Pfam 94-210 (293) Show / Hide 
Range on Protein: 460-576
Range on HMM: 94-210/293
Sequence Identity: 20% (26 aa)

MLR-QKNEWF--SIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNY----KLANLGFSKL--NQKYQEYKIYYLAFSQNYISPEISYKIEKD
... ... .|  | .. . .. |.. ||  .|... ||.|.||||.    .|.     |..  |..|.  . ... .. .  . . .|..||.   |   
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEV---IR--

QSIKITHKTDIYSLCLVILEVLNFNL
 . ....| |..|. ... |.|. ..
GGQYYGPKVDMWSCGCILYEMLCGRP
TyrKc 19947.AA TyrKc 361-638 15 8.2e-05 -144.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 361-638
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

FQLNQ---RQSFLILVSAIYNISYCSLQQINTGLKISRETLQKAEQIHREWEVVYGS--NKKNIFEKCQKNYVNQIYNVHYIT-----SIKCCVVVQELF
 .|..   .  | . . ....        |.   |  .|     | ..|| ..      . .||          ..| |         .|.   .| |. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIV---------RLYGVCTQQGRNFMYIEPLMIVMEYM

SY-TLEQEIQMLRQKNEWFSIEQMCQIIIQLCIGLTQIHQQKLIHCDIKPENVVKTLDGNYKLANLGFSKLNQKY-------QEYKIYY--LA---FSQN
..  | . ..  | |   .. ...... .| . |   .|....|| |.   |.  . ..  | .  | |.    .       . |.      .   .   
PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YISPEISYKIEKDQSIKITHKTDIYSLCLVILEVLNF------N-----LSKFNALNILLNDFQQSSTFSN---SSIEECQKSFEFDDVYDLFCKKCFNQ
  .||        .  | |.|.|..|   .. |.. .      .     .| . ... . . .      ..   |.          |..|.   |.| . 
WMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQ-IMKQCWHE

DPHKRCDSYEILLNL
||..|.   ||   .
DPEDRPTFSEIHECF
Kinase 19947.AA Pkinase 616-638 36 2.890845 2.02 Pfam 269-293 (293) Show / Hide 
Range on Protein: 616-638
Range on HMM: 269-293/293
Sequence Identity: 36% (9 aa)

FCKKCFNQDPHKRCDSYEILLN--L
|.|.|...||.||.   .||    .
FIKWCLCKDPKKRPTAEQILQHPWF