Gene 2142 (Tetrahymena)
2142
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 2142.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2142.AA | Ciliate-B2 | 8-198 | 35 | 3.7e-74 | 173.8 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 8-198 Range on HMM: 1-197/197 Sequence Identity: 35% (71 aa) YYIKRYLTSGGQSDIFQGYHQSDGGKIEDRVFKIIKS-DSTDYQDQMNEYNLLKSISYPINIIQFYDLIYIDSESVCIIIIEQCEKSLEEELRQMLQNNC ||. |. .||. |..|| .. .| .||| . .| .. .|.. .|. | ||.... | | | .|.. ..|.| || ||..|| .. . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQI-NETIDVLIMEKCECSLKQELQKIQKQQK LFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGNYVYTDFGISGKLK-GSEVEIKGYTLYFSPPEQLTQQ------SISNYKGELYAILG |.. . |. |.||||||..| ||.| ||||||||.. |||||.||||| | . ..||| | .. .|||. . . ... | .| CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYS-MG |
|||||||||
| Kinase | 2142.AA | Ciliate-E1 | 14-194 | 38 | 7.9e-56 | 179.93 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 14-194 Range on HMM: 1-202/202 Sequence Identity: 38% (78 aa) LTSGGQSDIFQGYHQSDG-GKIEDRVFKIIKS-DSTDYQDQMNEYN-LLKSISYPINIIQFYDLIYIDSESVCIIIIEQCEKSLEEELR---------QM . .|..|..|... |.. .... ..... .. ..||. .||. ..| . ..|||..| |.||. .||||.| |..||...|. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC LQNNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGNYVYTDFGISGKLK---GSEVEIKGYTLYFSPPEQL-------TQQSISNYKG ||.. ||. .. || |.||||||||...||||.||||||||.. |||||.||||| .|| ... .|||| |..||||. .. . ||| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS ELY ..| DIY |
|||||||||
| Kinase | 2142.AA | STE | 40-164 | 22 | 1.1e-12 | 41.24 | In-house | 45-200 (359) | Show / Hide |
Range on Protein: 40-164 Range on HMM: 45-200/359 Sequence Identity: 22% (36 aa) KIIKSDS------------------TDYQDQMNEYNLLKSISY-PINIIQFYDLIYIDS-----ESVCIIIIEQCE-KSLEEELR------QMLQNNC-- |... .. .. |. ..| ...| . ||...|. . .. .. . |. | .. ||.. .. ..|..| KQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH --LFTQAHFAQILFDLIDG-LIELRAHNIIHQDIKPQNILKTMLGNYVYTDFGISGKLKGS | | |..... | | | |.||| ||||.||| .|||..|.| | QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDS |
|||||||||
| Kinase | 2142.AA | CAMKK-Unclassified | 112-182 | 30 | 1.3e-12 | 37.07 | In-house | 196-278 (392) | Show / Hide |
Range on Protein: 112-182 Range on HMM: 196-278/392 Sequence Identity: 30% (26 aa) HFAQ------ILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGN-----YVYTDFGISGKLKGSEVE-IKGY--TLYFSPPEQLT .|.| | .. | . ||| |||||||| . .| . .||||| ...... . .|. |..| .||... NFNQACSYIIIYINEFDKIDHFQ--DIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWS |
|||||||||
| Kinase | 2142.AA | CAMKK | 112-191 | 25 | 2.3e-12 | 35.11 | In-house | 193-293 (396) | Show / Hide |
Range on Protein: 112-191 Range on HMM: 193-293/396 Sequence Identity: 25% (26 aa) H-FAQ------ILFDLIDGLIELRAHNIIHQDIKPQNILKTMLG---NYVYTDFGISGKLKGSEVEIKGY-------------TLYFSPPEQLTQ-QSIS | ... | .. . . ||| |||||||| . | . . .|||.| ...|.. .... | .| .||... . . HNYQKACSYIIIYINEFI-IDHFQ--DIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKE NYKG || | NYNG |
|||||||||
| Kinase | 2142.AA | CMGC | 8-143 | 14 | 7.5e-12 | 34.28 | In-house | 1-216 (513) | Show / Hide |
Range on Protein: 8-143 Range on HMM: 1-216/513 Sequence Identity: 14% (31 aa) YYIKRYLTSGGQSDIFQGYHQSDGGKI-----------EDRVFKIIKSDSTDYQDQM-------------NEYNLLKSIS----------------YPIN | | ... .| . ...... ..|. | |.||.. . .. | .|| .. . | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIQFYDLIYIDSES---------------VCIIIIEQCEKSLEEELRQMLQ-----NNCLFTQAH------------FAQIL------FDLIDGLI--EL |.. || .| . . .. | ....| . .... . .. ... | .. . .. || . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC RAHN--IIHQDIKPQNIL |. ||| |.||.||| HSHWGNIIHRDLKPENIL |
|||||||||
| Kinase | 2142.AA | S_TKc | 8-247 | 18 | 1.3e-11 | -6.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-247 Range on HMM: 1-231/231 Sequence Identity: 18% (50 aa) YYIKRYLTSGGQSDIFQGYHQSDGGKIEDRVFKIIKSDSTDYQDQMNEYNLLKSISYPINIIQFYDLIYIDSESVCIIIIEQCEK---SLEEELRQMLQ- | | | . .|. . ....| ..| . |||| .. ..| ..||. ||...|| .. . .. | |. .| . .... YEILRKIGKGAFGKVYKCRHKKTGRIV---AIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH -NNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGNYVYTDFGISGKLKGSEVEIKGYTLYFSPPEQLTQQSISNYKG----------- ... |. | . .. ....| . |.||| |.||.||| . . .|||.. .| |... .|| | | . GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI --ELYA---ILGNTQAALEFQIKSLEMNKFLYKNAHPSIYICLS-NIGKRYSEQGEYL-------KALK |... ..... .|. . | | || . ||.. LYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 2142.AA | Ciliate-E3 | 67-188 | 30 | 3.1e-11 | 31.6 | In-house | 63-187 (202) | Show / Hide |
Range on Protein: 67-188
Range on HMM: 63-187/202
Sequence Identity: 30% (40 aa)
NIIQFYDLIYIDSESVCIIIIEQCEK-SLEEELRQMLQNNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGN---YVYTDFGISGKLK
|. . .| .| . . |. | |.. .| . ..| . || .| .| |.|.. . |||| ||||.||| | ||| | .|.
NVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK-----TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLR
GSE--VEIK--GYTLYFSPPEQLTQQSISN
. | | ....|||. ||.||.
KNKGHTHTQYQGWTPFYAAPEQNDQQQISK
|
|||||||||
| Kinase | 2142.AA | C8 | 87-197 | 22 | 9.7e-11 | 33.61 | In-house | 99-226 (226) | Show / Hide |
Range on Protein: 87-197 Range on HMM: 99-226/226 Sequence Identity: 22% (29 aa) IEQCEKSLEEELRQMLQNNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGNYV----YTDFGISGKLKGSE--VEIKGY----TLYFS .| ||. |.. .. ... |.. .| .|||. . .||.|.||||.|.| . .||. |||.. ... .. ..| . |. .. MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYF PPEQLTQ----QSISNYKGELYA---IL ||.... ... . |. .| APEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
| Kinase | 2142.AA | Ciliate-A1 | 40-164 | 27 | 1.9e-10 | 31.74 | In-house | 31-154 (301) | Show / Hide |
Range on Protein: 40-164 Range on HMM: 31-154/301 Sequence Identity: 27% (35 aa) KIIK-SDSTDYQDQMNEYNLLKSISYPINIIQFYDLIYIDS-ESVCIIIIEQCEKSLEEELRQMLQNNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDI |||. .. |.. ..|| ..| | . .| . | | . . || | |.. . | . .| |. .| |.. . |||.| |. KIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGN---LFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDL KPQNILKTMLGNYVYTDFGISGKLKGS |||||| . |.|.| | .. KPQNILIHFDDKWKICDLGMSKQLEQN |
|||||||||
| Kinase | 2142.AA | MSN | 8-161 | 24 | 9.3e-10 | 28.15 | In-house | 1-154 (265) | Show / Hide |
Range on Protein: 8-161 Range on HMM: 1-154/265 Sequence Identity: 24% (39 aa) YYIKRYLTSGGQSDIFQGYHQSDGGKIEDRVFKIIKSDSTDYQDQMNEYNLLKSISYPINIIQFYDLIYIDS----ESVCIIIIEQCEKSLEEELRQMLQ . . . . | ...| |. | . .| .. . . .. | |.|| |. ||. .| | . ...| | .| .| . FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE---DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTK NNCLFTQAHFAQILFDLIDGLIELRAHNIIHQDIKPQNILKTMLGNYVYTDFGISGKL .. | | | ... || | .| .|| ||| ||.| | . |||.| .| GQSL-KEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQL |
|||||||||
| Kinase | 2142.AA | TPR_2 | 226-259 | 29 | 0.033399 | 11.88 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 226-259 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) YICLSNIGKRYSEQGEYLKALKYQNQSLKMRQAL .. |.|. | .||.| .|..| ...|| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| Kinase | 2142.AA | TPR | 226-259 | 20 | 0.121205 | 8.64 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 226-259 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YICLSNIGKRYSEQGEYLKALKYQNQSLKMRQAL . ...|.| | .|.| .|... ...|.. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| Kinase | 2142.AA | TPR_1 | 226-259 | 20 | 1.862965 | 5.58 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 226-259 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YICLSNIGKRYSEQGEYLKALKYQNQSLKMRQAL . ..|.| | ..|.| .|... .. |... AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| Kinase | 2142.AA | TPR_2 | 184-217 | 20 | 31.556762 | 1.35 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 184-217 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) QSISNYKGELYAILGNTQAALEFQIKSLEMNKFL . .. |..|. .|. . |.|. |.|. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| Kinase | 2142.AA | TPR_1 | 188-217 | 33 | 35.265407 | 1.12 | Pfam | 5-34 (34) | Show / Hide |
Range on Protein: 188-217 Range on HMM: 5-34/34 Sequence Identity: 33% (10 aa) NYKGELYAILGNTQAALEFQIKSLEMNKFL . .| .| .|| ..|.|. | ||.| YNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 268-301 | 17 | 4.313097 | 4.41 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 268-301 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) ANCLNIIGGLHAKLNQPKIALQFQLDALNMYKEI | ... .| ...|..... |... || . . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | 2142.AA | TPR | 310-343 | 23 | 0.661976 | 2.16 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 310-343 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AACLNNVGKRYDEIGENTIALNYLTQALVMSRLL | ...| | | |. |......|| . . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 310-343 | 26 | 1.975579 | 5.61 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 310-343 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AACLNNVGKRYDEIGENTIALNYLTQALVMSRLL |....| |. | . |. |..|. .|| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | 2142.AA | TPR_1 | 310-337 | 28 | 52.697525 | 0.51 | Pfam | 1-28 (34) | Show / Hide |
Range on Protein: 310-337 Range on HMM: 1-28/34 Sequence Identity: 28% (8 aa) AACLNNVGKRYDEIGENTIALNYLTQAL | ..| | | . |. |. .. .|| AEAWYNLGNCYYKMGNYDEAIECYQKAL |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 352-385 | 38 | 0.000171 | 19.99 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 352-385 Range on HMM: 1-34/34 Sequence Identity: 38% (13 aa) ATSLHNLGQLYSKIGQPQKALQYQLEALKVKEGI | ..||||.| | |....|..| .||| .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | 2142.AA | TPR_1 | 352-385 | 29 | 0.000431 | 18.27 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 352-385 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ATSLHNLGQLYSKIGQPQKALQYQLEALKVKEGI | . |||..| | |....|... .||.. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||
| TPR | 2142.AA | TPR | 352-385 | 29 | 0.001797 | 18.78 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 352-385 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ATSLHNLGQLYSKIGQPQKALQYQLEALKVKEGI | . |||..| | |. ..|... .||.. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 394-427 | 20 | 2.385861 | 5.32 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 394-427 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) SQTLHNIGQRYAELNRPQIGLSYQLKSLEIRKQF ..|.|| |....... . | |.|.. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 436-469 | 20 | 0.044472 | 11.44 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 436-469 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) AQSLDSVGERYAELKDYQKALTFQKESLEMRKAL | . |. |....||..|. . ...|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | 2142.AA | TPR | 436-469 | 23 | 0.762554 | 1.62 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 436-469 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AQSLDSVGERYAELKDYQKALTFQKESLEMRKAL |. . |. | ..||..|. . ...||. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_1 | 2142.AA | TPR_1 | 449-462 | 35 | 20.954711 | 1.91 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 449-462 Range on HMM: 21-34/34 Sequence Identity: 35% (5 aa) LKDYQKALTFQKES ...||||| . . IECYQKALELNPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 478-511 | 23 | 0.129292 | 9.8 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 478-511 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ASSLENVGERYAQLDQKQVALTHQLQALKMYKKL | . | |. |... . . |. . .||| . . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 520-553 | 23 | 49.085123 | 0.67 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 520-553 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ACCMNSVGKRYDEIGDLENALKYQLLSLEMKQRI | . . |. | . ||.. |..| .|. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 2142.AA | TPR_2 | 562-595 | 26 | 0.002605 | 15.8 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 562-595 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AQSLNNVGERYARIGNIQQAIKYQLQSLQMYESL | ..| |. |.. |. ..||.| ..|. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | 2142.AA | TPR | 562-595 | 23 | 0.09958 | 9.39 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 562-595 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AQSLNNVGERYARIGNIQQAIKYQLQSLQMYESL |. ..| |. | . |....||.. ..|.. .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_1 | 2142.AA | TPR_1 | 562-595 | 26 | 0.878257 | 6.72 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 562-595 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AQSLNNVGERYARIGNIQQAIKYQLQSLQMYESL |. ..| | | . || ..||.. . |.. .. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||