Gene 22786 (Tetrahymena)
22786
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 22786.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22786.AA | Ciliate-B2 | 534-723 | 33 | 1.6e-64 | 150.61 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 534-723 Range on HMM: 1-197/197 Sequence Identity: 33% (67 aa) YKITKYLTSGGQADILIGTYLDDTNQEKEYVLRIVSSDQDTY-DYIREEFELVNKFQKASNIIKYYDSIYLEDIYTGVFIVEKCSGSLTDTLRSKRNNNV | ..||. .||. | | . . .. ...| ||. . | .| . . |.. |..|| |.| . |.| ||| || . | YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETID-VLIMEKCECSLKQELQKIQKQQK NFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYIYSDFGCSSKFL-DGLAENKGFTMKYCAPEQLIEE------YFTNYKADIYQLG .|..| .....|.|. ||...|.||||| ||||.|||. ..|||.|.||| || . . |||| || |||... .....||| .| CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 22786.AA | Ciliate-E1 | 540-720 | 30 | 6.9e-53 | 170.27 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 540-720 Range on HMM: 1-202/202 Sequence Identity: 30% (61 aa) LTSGGQADILIGTYLDD--TNQEKEYVLRIVS-SDQDTYDYIREEFELVNKFQKASNIIKYYDSIYLEDIYTGVFIVEKCSGSLTDTLR---------SK . .|........ . . . .. .... .... .|.|.|.... . |.| .||...| |.....|. ..|.|.|. ||.|.|. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC RNNNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYIYSDFGCSSKFLDGLAENK---GFTMKYCAPEQL-------IEEYFTNYKA ..|. .||.|.. .|.|.|..|| |...|||.|.||||.|||||..|||.|.|||.|... ... |.| .|. |||. .... ||| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIY ||| DIY |
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| Kinase | 22786.AA | STE | 578-720 | 24 | 6e-17 | 56.47 | In-house | 75-252 (359) | Show / Hide |
Range on Protein: 578-720 Range on HMM: 75-252/359 Sequence Identity: 24% (45 aa) IREEFELVNKFQK-ASNIIKYYDSIYLED----I-YTGVFIVEKCS-GSLTDTLRSK----RNNNVN------FTEQEIFKIVFDLVQG-LVEMRSYNIL | .| .. .|... ||.|||.. . |. . . | .. |||.| ...| ...| | | |..| .|......| | | .| ILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII HQDIKPDNILINRKGNYIYSDFGCSSKFLDGLA------------ENKGF------TMKYCAPEQLIEEYFT-----NYKADIY | ||||.|||. .|||..... | .| ... | . ||| . . . ..|.||. HRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW |
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| Kinase | 22786.AA | WEE | 616-726 | 28 | 4.4e-16 | 50.51 | In-house | 87-226 (297) | Show / Hide |
Range on Protein: 616-726 Range on HMM: 87-226/297 Sequence Identity: 28% (41 aa) CSGS---LTDTLRSKRNNNVNFTEQEIFKIVFDLVQGLVEMRSY-NILHQDIKPDNILINRKG--------------------NYIYSDFGCSSKFLDGL | |. | . . . |.| ..|..| .| |..||| . |. ...| ||||.||.|..|. .. ||| ... CNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS-- AENKGFTM------KYCAPEQLIE--EYFTNYKADIYQLGRTI .|. .. .|.||| | . .| ..|||||. || || -NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITI |
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| Kinase | 22786.AA | Ciliate-E2-Unclassified | 534-723 | 18 | 1e-15 | 51.04 | In-house | 1-257 (352) | Show / Hide |
Range on Protein: 534-723
Range on HMM: 1-257/352
Sequence Identity: 18% (48 aa)
YKITKYLTSGGQADILIGTYLDDT--------NQEKEYVLRIVSSDQDTYDYIREEFELVN-------------KFQKASNIIKYYDSIYLEDIYTGVFI
||| | . .||.... .. .. ..| ... . . . . .| . . .. ....... . .| . ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
VEKC-SGSLTDTLRS------------KRNNN-VNFTEQEIF-----KIVFDLVQGLVEMRSYN-ILHQDIKPDNILINRKG---NYIYSDFGCSSKFL-
|.| |.| . ... ..... ||||.. .. ..||| . . | |.| ||||.|||.. .| . .||| |.|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------------DGLAENKGFTMKYC----APEQLIEEYFTN---YKADIYQLG
. .. . | | ||| | .. . ||.||. ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
|
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| Kinase | 22786.AA | S_TKc | 534-778 | 19 | 6.3e-14 | 27.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 534-778 Range on HMM: 1-231/231 Sequence Identity: 19% (50 aa) YKITKYLTSGGQADILIGTYLDDTNQEKEYVLRIVSSDQDTYDYIREEFELVNKFQKASNIIKYYDSIYLEDIYTGVFIVEKCSG---SLTDTLRSKRNN |.| . . .|. . .. . ... . |.. . || | .. | . ||.|.||... .. | |.| .| | ..... . YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH NVN--FTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYIYSDFGCSSKFLDGLAENKGFTMKYCAPEQLIEEYFTNY-KADIYQLGRTIQ . |.| .. ... ....| . | .|.| |.||.|||... . .||| . .. | |.||| | .. |.|.. .| .. GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY QVLELYEKFRGVQTKFIK-----DLNNIIFCNMLQDQQDNRKECVDILI----LLSDSIV | | |. . . .| .. . . ...|| ..| . ..| .. . EMLCGYPPFP-QMQMMFKKIGSPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 22786.AA | CAMK | 539-719 | 16 | 9.3e-14 | 40.0 | In-house | 1-317 (425) | Show / Hide |
Range on Protein: 539-719
Range on HMM: 1-317/425
Sequence Identity: 16% (51 aa)
YLTSGGQADILIGTYLDDTNQE---------KEYVLRIVSSD-----------------------------QDTYDYIREEFELVNKFQK------ASNI
| .|. . .. .|..| ... |.. . . . . .| | |. .| |. ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
IKYYDSIYLED-------------IYTG----VFIV----EKCSG-----SLTDTLRSKRNNNVN-----------FTEQEIFKIVFDLVQGLVEMRSYN
|| |. . .. .. ...| | ||| | | ....... .. |||.| ... ..... . | |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
ILHQDIKPDNILINRK-----------------GNYIYSDFGCSSKFLDG-------------------------LAENKGFTMKYCA-PEQLIE-----
| | |.||.|||.. . .| .||| . || .| . . | |.| || |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------EYFTNYKADI
. ..|.|.
MQNATDEEKPYYGPKCDM
|
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| Kinase | 22786.AA | C8 | 534-726 | 20 | 1.5e-13 | 43.45 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 534-726 Range on HMM: 1-226/226 Sequence Identity: 20% (46 aa) YKITKYLTSGGQADILIGTYLDDTNQEKEYVLRIVSSDQD----TYDYIREEFELVNKFQKASNIIKYYDSIYLEDIYT-----G-----------VFIV . .|| .|. . . . .. .....| || . . .. | |.|. .|| ... || |.. . |. FNNFQYLSFGAYG-MVLKAK--NVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVM E--KCSGSLTDTLRSKRNNNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYI----YSDFGCSSKFLDGLA--ENKGF----TMKY | | | . .||... |.... ..| .. |. . . ||.|.||||.|.|. ..||. .||| .|. . . | . |..| EMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAY CAPEQLIE----EYFTNYKADIYQLGRTI |||.. . . . . |....| FAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 22786.AA | Ciliate-E5 | 581-687 | 32 | 2.7e-13 | 39.41 | In-house | 46-153 (271) | Show / Hide |
Range on Protein: 581-687 Range on HMM: 46-153/271 Sequence Identity: 32% (35 aa) EFELVNKFQKASNIIKYYDSIYLE--DIYTGVFIVEKCSGSLTDTLRSKRNNNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYIY ||.. .|. .||| |. . . .. | |.| |. |.... . . .|.|..| .||.|| . . ||.| |||| ||| . | EFNILKQFN-SPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQKHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKY SDFGCSSKF .|.| | || IDMGISRKF |
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| Kinase | 22786.AA | Ciliate-E3 | 633-730 | 31 | 4.7e-13 | 37.34 | In-house | 99-202 (202) | Show / Hide |
Range on Protein: 633-730 Range on HMM: 99-202/202 Sequence Identity: 31% (33 aa) NFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGN---YIYSDFGCSSKFLDGL----AENKGFTMKYCAPEQLIEEYFTNYKADIYQLGRT | |...| .|. ..||. . . || | ||||||||. | .||| | . . . |.| | ||||... . . |.| .| NKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISK-ESDYYSVGAV IQQVL . |. FCQLC |
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| Kinase | 22786.AA | ULK | 618-720 | 23 | 5.5e-13 | 42.46 | In-house | 102-236 (324) | Show / Hide |
Range on Protein: 618-720 Range on HMM: 102-236/324 Sequence Identity: 23% (32 aa) GSLTDTLRSKRN-----NNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYI------------YSDFGCSSKFLDG--LAENKGFT | | . . ... .. ...|||. .. ....|. |... || | ||||.||||. . . .||| .|..| ..... | GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF-AKHVDNNNMEQQMCQT MK----------YCAPEQLI----EEYFTNYKADIY .. | ||. | .. ...||.||. CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIW |
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| Kinase | 22786.AA | Pkinase | 534-720 | 21 | 4.2e-10 | 36.81 | Pfam | 1-196 (293) | Show / Hide |
Range on Protein: 534-720 Range on HMM: 1-196/293 Sequence Identity: 21% (45 aa) YKITKYLTSGGQADILIGTYLDDTNQEKEYVLRIVSSDQDTYDYIRE-----EFELVNKFQKASNIIKYYDSIY-LEDIYTGVFIVEKCSG-----SLTD |.| . . ||. . ... .. .... |.. . . . .. | .. ... . ||...||. . .|| .. | | | .| | YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY---MVMEYCEGGLYVMDLFD TLR-SKRNNNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNY----IYSDFGCSSKF-LDGLAENKGF--TMKYCAPEQLIEEYFTN .. ..... |.|.|. ... ...|| . | .|.| |.||.||||...|. .|||.. .| . ...| | |.||| . . YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG YKADIY .|.|.. PKVDMW |
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| Kinase | 22786.AA | TyrKc | 534-770 | 14 | 0.00012 | -147.51 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 534-770 Range on HMM: 1-280/280 Sequence Identity: 14% (43 aa) YKITKYLTSGGQADILIGTYLDDTNQEKEYVL--RIVSSDQDTYDYIREEFELVNKF-QKASNIIKYYDSIYL--------EDIYTGVFIVEKCSGSLTD . | | .| . ||. . | . .. ...| .. |. . ||.. | . | .. . ... |.| | ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKD TLRSKRNNNVNFTEQEIFKIVFDLVQGLVEMRSYNILHQDIKPDNILINRKGNYIYSDFGCSSKFLDG---------LAE----NKG--FTMKYCAPEQL ||..|.. .. .. .. .. .| | |. | |. |.|..... |||| | . |. .. . . .||| . YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI IEEYFTNY---------------KADIYQLG-----RTIQQVLELYEKFRGVQTKFI----------KDLNNIIFCNMLQDQQDNR---KECVDIL . || . | . |.|.|. .. . ... . | . . ..| .|..... NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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| TPR | 22786.AA | TPR | 1046-1079 | 26 | 0.000231 | 21.74 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1046-1079 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) ERQWANLGLSFYNMKQYKKALVFFQEDIKQQSSE . | |||...|.|..|..|. ..|. .. . . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 22786.AA | TPR_1 | 1046-1071 | 34 | 0.000939 | 17.09 | Pfam | 1-26 (34) | Show / Hide |
Range on Protein: 1046-1071 Range on HMM: 1-26/34 Sequence Identity: 34% (9 aa) ERQWANLGLSFYNMKQYKKALVFFQE . | |||. .|.|..|..|. ..|. AEAWYNLGNCYYKMGNYDEAIECYQK |
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| TPR_2 | 22786.AA | TPR_2 | 1046-1079 | 23 | 0.019974 | 12.67 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 1046-1079 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ERQWANLGLSFYNMKQYKKALVFFQEDIKQQSSE . | |||.. |....|..|. .... .| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 22786.AA | TPR_2 | 1088-1121 | 14 | 0.004866 | 14.84 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 1088-1121 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) AYSKFKIACCYFELGQFESAEKEFLELEEFFEKQ |. . ...||...|... |.. . .. . ... AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 22786.AA | TPR | 1088-1121 | 17 | 0.096498 | 9.51 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1088-1121 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) AYSKFKIACCYFELGQFESAEKEFLELEEFFEKQ | . .. ||. .|... |.. . . | .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 22786.AA | TPR_1 | 1088-1109 | 22 | 0.806082 | 6.85 | Pfam | 1-22 (34) | Show / Hide |
Range on Protein: 1088-1109 Range on HMM: 1-22/34 Sequence Identity: 22% (5 aa) AYSKFKIACCYFELGQFESAEK | . .. ||...|... |.. AEAWYNLGNCYYKMGNYDEAIE |
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| TPR_2 | 22786.AA | TPR_2 | 1136-1157 | 31 | 68.793703 | 0.15 | Pfam | 13-34 (34) | Show / Hide |
Range on Protein: 1136-1157 Range on HMM: 13-34/34 Sequence Identity: 31% (7 aa) NKGQFKQSIIYHSKALQELENL ..|.... | | |||. .| KQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 22786.AA | TPR_2 | 1309-1336 | 32 | 0.016219 | 12.99 | Pfam | 1-28 (34) | Show / Hide |
Range on Protein: 1309-1336 Range on HMM: 1-28/34 Sequence Identity: 32% (9 aa) ITILNYQAQVLFESAQYDQAIIFYEKSL ......|.... .||.|| .|||.| AEAWYNLGQCYYKQGDYDEAIEYYEKAL |
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| TPR | 22786.AA | TPR | 1309-1342 | 23 | 0.120572 | 8.66 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1309-1342 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ITILNYQAQVLFESAQYDQAIIFYEKSLPTMINI . ... ...... .||.|| .|.|.| | AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 22786.AA | TPR_1 | 1309-1336 | 25 | 0.442261 | 7.76 | Pfam | 1-28 (34) | Show / Hide |
Range on Protein: 1309-1336 Range on HMM: 1-28/34 Sequence Identity: 25% (7 aa) ITILNYQAQVLFESAQYDQAIIFYEKSL ... ...... .||.|| .|.| | AEAWYNLGNCYYKMGNYDEAIECYQKAL |
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| TPR_2 | 22786.AA | TPR_2 | 1351-1384 | 32 | 0.002102 | 16.13 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 1351-1384 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) AIVQSGLGMAYHQIRQFQVAINYYNSALKTMKDL | . ||..| . .... ||.||. ||| . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 22786.AA | TPR_1 | 1351-1384 | 26 | 0.007908 | 13.86 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 1351-1384 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AIVQSGLGMAYHQIRQFQVAINYYNSALKTMKDL | . . ||..|.. ... || .|. ||. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 22786.AA | TPR | 1351-1384 | 26 | 0.017098 | 15.53 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1351-1384 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AIVQSGLGMAYHQIRQFQVAINYYNSALKTMKDL | . . ||..|.. ... ||..|. ||. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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