23447

Species: Tetrahymena
Alias: TTHERM_01371780, 1060, PreTt23447, 23447, 352.m00006
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
23447.AA Protein None 1222 None Fasta, JSON
23447.kin_dom Protein Kinase Domain None 130 None Fasta, JSON
23447.NA RNA None 3669 None Fasta, JSON

Protein domain

Protein domains of 23447.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23447.AA Ciliate-E1 559-729 20 2.2e-25 79.8 In-house 1-202 (202) Show / Hide
Range on Protein: 559-729
Range on HMM: 1-202/202
Sequence Identity: 20% (42 aa)

IKKGGEADIFTN-------QNIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIV-NHTKYIIHVMQKCQMSLYDEIL-----------
|..|.....|         ...| |.|.... ..  ....|.  ......  . ....  .|. |     . .| ....|..||.|..            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

--SKKVFSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQ-----QIDFIDPFCGYQMYTPGFKPK------NRERNLPFYH
   .. |. ..... |  ... || |.|. |.|.|||| |||. ...||...||| |.     |.. .. ..  ..| |  . .      |.. .  .  
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS

DIY
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DIY

Kinase 23447.AA Ciliate-B2 553-694 29 9.5e-16 33.42 In-house 1-151 (197) Show / Hide
Range on Protein: 553-694
Range on HMM: 1-151/197
Sequence Identity: 29% (45 aa)

FKLGHHIKKGGEADIFTNQ---------NIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIVNHTKYIIHVMQKCQMSLYDEIL----
. |.  | |||.  |.            ..|.|.     | | .  ..| . |  . |.||  . .  .|.  .| |  .. .|.||. || .|.     
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHE-IKIMKMFEYNINVVKYIDHIQ--INETIDVL-IMEKCECSLKQELQKIQK

SKKVFSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGAS
 .| |  . ... |   .  || .| . | | |||| |||.   .|| ..||| |
QQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS

Kinase 23447.AA Ciliate-C6 629-698 37 5.1e-12 38.89 In-house 117-188 (306) Show / Hide
Range on Protein: 629-698
Range on HMM: 117-188/306
Sequence Identity: 37% (27 aa)

KCQMSLYDEILSKKVFSLKEILRFISTAFHLLIVLRQ-KYIYHSDIKPGNILKIDD-NNYQLSDFGASQQID
| .....     .. |. .||. | .    .|  ..    | | |||| ||| .|| ||| |||||..||..
KQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLF

Kinase 23447.AA S_TKc 553-797 16 4.8e-08 -58.96 SMART 1-231 (231) Show / Hide
Range on Protein: 553-797
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

FKLGHHIKKGGEA------DIFTNQNIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIVNHTKYIIHVMQKCQM---SLYDEILSKKV
.... .| ||. .      .. |..  | |.||     .  ..| ..|.    .  || ..  . .        ...  ||  |     .|.| | ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQQIDFIDPFCG---------YQMYTPGFKPKNRERNLPFYH--
      |.  .. ...   .  |  . .. | | |.|| ||| .|. .  ..||| . |.   . |||                          .. .  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL-LDE-HIKICDFGLARQL---TTFCGTPWYMAPEVL----------------GYGKCK

-DIYSFGKTIQKLLM-----KLENQSKISKCLNEFIDEEICKDDEISIKVDCFEFPRKFIN--TLMRFTNDEVIE-------IELY
 |..|.| ..  .|         .. .. | .                  .. .| ||  .     | |  |. .        .  
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 23447.AA Ciliate-A1 626-699 24 4.9e-07 19.92 In-house 79-153 (301) Show / Hide
Range on Protein: 626-699
Range on HMM: 79-153/301
Sequence Identity: 24% (18 aa)

VMQKCQMSLYDEILSKKV-FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQQIDF
.| .||  .  .    .   .  ||  . .  .  .. .  . | |.|.||.|||  .|. . . |.| |.|  .
IMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQ

Kinase 23447.AA DYRK2 631-679 37 1.2e-05 14.0 In-house 84-134 (318) Show / Hide
Range on Protein: 631-679
Range on HMM: 84-134/318
Sequence Identity: 37% (19 aa)

QMSLYDEILSKKV--FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNIL
.|.||. |  ..   |||... ||.    . |  |..  | | | || |||
SMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL

Kinase 23447.AA LKB 668-703 38 1.7e-05 12.37 In-house 125-160 (265) Show / Hide
Range on Protein: 668-703
Range on HMM: 125-160/265
Sequence Identity: 38% (14 aa)

IYHSDIKPGNILKIDDNNYQLSDFGASQQIDFIDPF
. | ||||||.|   ||   ..|||   |..   ..
VVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRD

Kinase 23447.AA RAN 668-692 62 2.2e-05 13.89 In-house 170-195 (324) Show / Hide
Range on Protein: 668-692
Range on HMM: 170-195/324
Sequence Identity: 62% (17 aa)

IYHSDIKPGNILKID--DNNYQLSDFG
||| |||| ||| ||  | |  | |.|
IYHCDIKPENIL-IDGIDWNIYLCDWG

Kinase 23447.AA FRAY 670-694 56 2.7e-05 12.05 In-house 130-154 (277) Show / Hide
Range on Protein: 670-694
Range on HMM: 130-154/277
Sequence Identity: 56% (14 aa)

HSDIKPGNILKIDDNNYQLSDFGAS
| ||| ||||  .| . |..||| |
HRDIKAGNILIGEDGTIQIADFGVS

Kinase 23447.AA PHK 668-697 50 4.4e-05 12.98 In-house 130-159 (273) Show / Hide
Range on Protein: 668-697
Range on HMM: 130-159/273
Sequence Identity: 50% (15 aa)

IYHSDIKPGNILKIDDNNYQLSDFGASQQI
| | | || ||| .|. |  .|||| . |.
IVHRDLKPENILCDDNMNIKISDFGFACQL

Kinase 23447.AA C8 663-697 43 4.6e-05 13.64 In-house 139-177 (226) Show / Hide
Range on Protein: 663-697
Range on HMM: 139-177/226
Sequence Identity: 43% (17 aa)

LRQKYIYHSDIKPGNILKIDDNNYQ----LSDFGASQQI
. .| | | |||| |.|   |.||     |.||| . |.
IHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQV