Gene 4856 (Tetrahymena)
4856
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 4856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4856.AA | Ciliate-E1 | 56-240 | 29 | 1.8e-53 | 172.17 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 56-240 Range on HMM: 1-202/202 Sequence Identity: 29% (60 aa) LQESRQTVILKAYSKKLK-QNVALKVSNYI----KGSLEHLKREYD-IIKGIKEASSIVKIYDFIYFEKYLISVLVMEYCEMSLYEEME---------LY . .. . ...||.... . ..||.|. |.. . ... ...||. | | .|. .|..|.|.|. ....|.....|.|..||..... .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC KQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGISKRLNSDSSNTNDISGLTFKYSSPEQYKH---YENQDQLLSCKT .| ...........||.|. .|...| |.||| ||||||||....|.|..||||||| |.. . .. ...| | .|..||||.. ..|..| ..|. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIF ||. DIY |
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| Kinase | 4856.AA | Ciliate-B2 | 54-243 | 32 | 7.6e-48 | 110.56 | In-house | 5-197 (197) | Show / Hide |
Range on Protein: 54-243 Range on HMM: 5-197/197 Sequence Identity: 32% (64 aa) EFLQESRQTVILKAY---SKKLKQNVALKVSNY-IKGSLEHLKREYDIIKGIKEASSIVKIYDFIYFEKYLISVLVMEYCEMSLYEEMELYKQLNKWYSQ ... . . .| . | | . .|..|.|. . | . |. |.| .||. |.| .. | ||.|| || || .|... .. | . . KYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINET-IDVLIMEKCECSLKQELQKIQKQQKCFNN DEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGISKRLNSDSSNTNDISGLTFKYSSPEQYKHYENQDQLLSC--KTDIFSVG . .| | .| |.. | |.| ||||||||... |.|..|||||| . | .. . |.|.|.|| |||| . .|| . . ||.| | QKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK-DNQQIK-IKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 4856.AA | Ciliate-E5 | 50-250 | 24 | 4.2e-33 | 104.95 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 50-250
Range on HMM: 1-271/271
Sequence Identity: 24% (66 aa)
LINLEFLQESRQTVILKAYSKKLKQNVALKV-SNYIKGSLEHLKREYDIIKGIKEASSIVKIYDFIYFE--KYLISVLVMEYCEMSLYEEMELYKQLNKW
.| .| ...|..|. ... .| |. . . .| ..||..| | .. |.| |... .. . . ..||.|. | . . .||
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFN-SPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKW
YSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGIS---------KRLNSDSS--------------------------------
. .| | | . | .|| ||| |||| ||| | | | |.||| |.. ..
QKHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKN
---------NTNDISGLTFKYSSPEQYKHYENQD------------------QLLSCKTDIFSVGLVFLELL
|.. |.| |||||||. | ||. . . ||.| |.|||||
RKKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
|
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| Kinase | 4856.AA | CMGC | 66-211 | 16 | 2.2e-24 | 76.21 | In-house | 17-287 (513) | Show / Hide |
Range on Protein: 66-211
Range on HMM: 17-287/513
Sequence Identity: 16% (46 aa)
KAYSKKLKQN--------------VALKVSNYIKGSLEHLK-------------REYDIIKGIK----------------EASSIVKIYDFIYFEK----
|.. |. .|. ||.| . |. | || | | .. |||.||..|...
KCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGN
-----------YLISVLVMEYCEMSLYEEMELYKQL-----NKWYSQDE------------ITSII------IQISYALS--QIHCYK--IIHADIKPQN
. ||.||....||. .. .... .. |. . | ... || .| .| . ||| |.||.|
EYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPEN
ILKTKDGKY--------------------KLCDFGISKRLNSDSS----------------------NTNDIS
|| ...... |.|||| .. ... |. .|....
ILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV
|
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| Kinase | 4856.AA | Ciliate-C8 | 59-246 | 26 | 8.7e-24 | 82.28 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 59-246
Range on HMM: 1-238/238
Sequence Identity: 26% (64 aa)
SRQTVILKAYSKKLKQNVALKVSNY----IKGSLEHLKREYDIIKGIKEASSIVKIYDFIYFE---------------------KYLISVLVMEYCE--M
..|||. || .. ||||. | ||.. || | .|. ||. | . | . .|. ||.|.
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC
SLYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKY----KLCD------FGISKRLNSDSS--------NTNDI-SG
.| . . ... .. ||.. | ||. .. .|| |.| ||||.|.| | .| |||| || . | . | .| . .
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM
L---TFKYSSPEQYKH-YENQDQLLSCKTDIFSVGLVF
. .. |. ||..| ...| .. | | |..|||||.
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
|
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| Kinase | 4856.AA | C8 | 50-246 | 26 | 2.5e-23 | 77.86 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 50-246 Range on HMM: 1-226/226 Sequence Identity: 26% (60 aa) LINLEFLQESRQTVILKAYSKKLKQNVALKVSNYIKG----SLEHLKREYDIIKGIKEASSIVKIYDFIYFEKYLI------------------SVLVME . | ..| ..|||. | .....||. . .| ...|| . . .. ..| || | .. . .| || FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME YCEMSLYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKY----KLCDFGISKRLNSDSSNTNDIS----GLTFKYSS || | . . .. .. .|... | ||. .. ||| .|.| ||||.|.| |..| ||||||.. . .. | .. | |..|. LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG-TWAYFA PEQYKHYENQDQLLSCKTDIFSVGLVF ||. | .|| . . . |.|||||| PEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 4856.AA | Ciliate-A1 | 108-249 | 28 | 1e-22 | 74.12 | In-house | 60-221 (301) | Show / Hide |
Range on Protein: 108-249
Range on HMM: 60-221/301
Sequence Identity: 28% (47 aa)
VKIYDFIYFEKY--LISVLVMEYCEMSLYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGISKRLNSDS-
.| |. .|.. .. ..||||. . .. .| |.. . .|| | || .. || |.| |.|||||| | |.|.||.|.|| |
IKNYQQLYYNTNNKECMFIIMEYCQYGNL--FNYCYQ-NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQD
---------------SNTNDIS-GLTFKYSSPEQYK-HY---ENQDQLLSCKTDIFSVGLVFLEL
. .. |.. | |||||. || . .. . |..|.|.....|
CCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
|
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| Kinase | 4856.AA | Ciliate-E3 | 107-250 | 38 | 3.2e-22 | 66.32 | In-house | 64-202 (202) | Show / Hide |
Range on Protein: 107-250 Range on HMM: 64-202/202 Sequence Identity: 38% (58 aa) IVKIYDFIYFEKYLISVLVMEYCEM-SLYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDG---KYKLCDFGISKRLNS .||..| .| ... .|.|||. .|| . .||.|| .| .| |.||| . || .||| ||||.||| | | |||| || | VVKCHDQYYDQQNKMIFIVQEYCSNGDLY---HYIKQQNK--TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK DS--SNTNDISGLTFKYSSPEQYKHYENQDQLLSCKTDIFSVGLVFLELL . . | . |.| |..||| |. |. | |. ||| ||..| NKGHTHTQY-QGWTPFYAAPEQ-----NDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 4856.AA | Pkinase | 107-250 | 31 | 1.9e-20 | 73.42 | Pfam | 62-206 (293) | Show / Hide |
Range on Protein: 107-250 Range on HMM: 62-206/293 Sequence Identity: 31% (49 aa) IVKIYDFIYFEKYLISVLVMEYCEMSLYEEMELY----KQLNKWY--SQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKY----KLCDFGI ||..||. . .... .||||||. || |.|. . .... | .|. ... || .| .| .||| |.||.||| ..| |.||||. IVRLYDWFEDKDHIY--MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL SKRL-NSDSSNTNDISGLTFKYSSPEQYKHYENQDQLLSCKTDIFSVGLVFLELL .| . . .| .... | | | .|| . .| . | |..|.|... |.| AKQFDY-NNS-MTTFCG-TPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEML |
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| Kinase | 4856.AA | S_TKc | 50-314 | 23 | 4.4e-20 | 73.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 50-314 Range on HMM: 1-231/231 Sequence Identity: 23% (65 aa) LINLEFLQESRQTVILKAYSKKLKQNVALKVSNYIKGSLEHLKREYDIIKGIKEASSIVKIYDFIYFEKYLISVLVMEYCEM---SLYEEMELYKQ--LN |. . . . |.. || .. ||.|. . ||..|| .| | |||.||... .|||||. .|.. .. .. |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR KWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGISKRLNSDSSNTNDISGLTFKYSSPEQYKHYENQDQLLSC-KTDIFSVG .... .. ... || || .| .||| |.||.||| .. |.||||....| . | | .|| .. | |. |.| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCG LVFLELLK----FPLNESTAKKIRENNYKELKSIDYLQNSGIFKILRQKLFKIDPSNRISSYELIY--SLVGELQFS .. |.| || .. . |. | .| . .|... ||..|.. |. ... .. CILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4856.AA | WEE | 124-249 | 26 | 2.1e-17 | 55.03 | In-house | 82-229 (297) | Show / Hide |
Range on Protein: 124-249 Range on HMM: 82-229/297 Sequence Identity: 26% (39 aa) LVMEYCEMS---LYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCY-KIIHADIKPQNILKTKDG--------------------KYKLCDFGISKR ..||||. . |. . .. |.| . ..| |. .|. .|. || . ..| |||| ||. .|.. ..|. ||| ... IQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD LNSDSSNTNDISGLTFKYSSPEQYKHYENQDQLLSCKTDIFSVGLVFLEL .||...|..... ..| .|| . . . | |||| |....|| MNSNNNNPHQEQEGDSRYMAPEILQG--YYHYTHLYKADIFSLGITIYEL |
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| Kinase | 4856.AA | Ciliate-C6 | 147-247 | 35 | 7e-17 | 56.37 | In-house | 132-244 (306) | Show / Hide |
Range on Protein: 147-247 Range on HMM: 132-244/306 Sequence Identity: 35% (40 aa) YSQDEITSIIIQISYALSQIHC-YKIIHADIKPQNILKTKD-GKYKLCDFGISKRLNSDS-SNTNDISGLTFKYSSPE--QYKH--YENQ-----DQLLS ....|| . .|| | .|. .| | ||||.||| .| .|.| |||....|. . ||| | | ||| . | .. | .|. FDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQIDY CKTDIFSVGLVFL | |||| |.. | FKCDIFSLGMILL |
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| TyrKc | 4856.AA | TyrKc | 35-307 | 17 | 8.9e-08 | -96.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 35-307 Range on HMM: 1-280/280 Sequence Identity: 17% (55 aa) LNLCEKL---------EGLLKKQQLINLEFLQESRQTVILKAYSKKLKQNVALKVSNYIKGSLEHLKREYDIIKGI-KEASSIVKIYDFIYFE------- . | .|| .| .| ..|| |. . . .| . || | . . .. ||..| . . ITLGKKLGEGAFGEVYKGTWK---------------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYI KYLISVLVMEYCEM-SLYEEMELYKQLNKWYSQDEITSIIIQISYALSQIHCYKIIHADIKPQNILKTKDGKYKLCDFGISKRLNSD-----SSNTNDI- . | .||||.. .| . .. . .. |. .||. . .| ..|| |. |.| .... | .||| |. . .| |. . . EPLM--IVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK ---SG---LTFKYSSPEQYKHYENQDQLLSCKTDIFSVGLVFLELLKF------------PLNESTAKKIRENNYKELKSIDYLQ------NSGIFKILR .| | . .|| .. . |.|..| | . |.. . |. ..... .. . || . ...| . EHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMK QKLFKIDPSNRISSYELIYSL | . ||..| . |.. . Q-CWHEDPEDRPTFSEIHECF |
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| TPR | 4856.AA | TPR | 433-466 | 17 | 1.147375 | 0.06 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 433-466 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) GDALSNCSLICEQLGKFNKAILLRGNAIKNYQKV .|..| ......|....|| |.. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 4856.AA | TPR_2 | 433-453 | 23 | 10.246094 | 3.08 | Pfam | 1-21 (34) | Show / Hide |
Range on Protein: 433-453 Range on HMM: 1-21/34 Sequence Identity: 23% (5 aa) GDALSNCSLICEQLGKFNKAI .|. | ......|.. .|| AEAWYNLGQCYYKQGDYDEAI |
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| TPR_1 | 4856.AA | TPR_1 | 433-453 | 23 | 56.282555 | 0.41 | Pfam | 1-21 (34) | Show / Hide |
Range on Protein: 433-453 Range on HMM: 1-21/34 Sequence Identity: 23% (5 aa) GDALSNCSLICEQLGKFNKAI .|..| ......|....|| AEAWYNLGNCYYKMGNYDEAI |
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| TPR | 4856.AA | TPR | 475-508 | 20 | 0.883018 | 1.06 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 475-508 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) AKQLQQLCWNYYQLKDYYKSVQYGLKSIDMFRYL |. . .| ||...|| . ... |.... . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 4856.AA | TPR_2 | 475-508 | 23 | 7.596333 | 3.54 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 475-508 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AKQLQQLCWNYYQLKDYYKSVQYGLKSIDMFRYL |. . .| . ||...|| . ..| |.. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 4856.AA | TPR | 518-551 | 26 | 0.276675 | 5.49 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 518-551 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AECYRQLAWSYQQINKRYLGLESAQKALNIYIQI ||.. .|. .| . .. .| |||| . . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 4856.AA | TPR_2 | 518-551 | 23 | 0.534153 | 7.62 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 518-551 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AECYRQLAWSYQQINKRYLGLESAQKALNIYIQI ||....|...| . .. .| .||| .. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 4856.AA | TPR_1 | 518-545 | 32 | 20.544445 | 1.94 | Pfam | 1-28 (34) | Show / Hide |
Range on Protein: 518-545 Range on HMM: 1-28/34 Sequence Identity: 32% (9 aa) AECYRQLAWSYQQINKRYLGLESAQKAL || . .|.. | . .. .| |||| AEAWYNLGNCYYKMGNYDEAIECYQKAL |
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| TPR | 4856.AA | TPR | 561-594 | 20 | 0.237047 | 6.08 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 561-594 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) AYTLNTLGYIHSGVKNYSKELEYKLQSLEMFQQL | ... || .. ..| . .|. ..||. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 4856.AA | TPR_1 | 561-579 | 26 | 37.419141 | 1.03 | Pfam | 1-19 (34) | Show / Hide |
Range on Protein: 561-579 Range on HMM: 1-19/34 Sequence Identity: 26% (5 aa) AYTLNTLGYIHSGVKNYSK | ... ||... .|| . AEAWYNLGNCYYKMGNYDE |
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| TPR_1 | 4856.AA | TPR_1 | 604-637 | 26 | 5.7e-05 | 21.34 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 604-637 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AAQLNNVGVAYFNTNQLDKAQMYYQQSLQMKKSI | ..| |..|.. ...|.| .||. |.. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 4856.AA | TPR | 604-637 | 26 | 0.000163 | 22.24 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 604-637 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AAQLNNVGVAYFNTNQLDKAQMYYQQSLQMKKSI | ..| |..|.. ...|.| .||..|.. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 4856.AA | TPR_2 | 604-637 | 26 | 0.002021 | 16.19 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 604-637 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AAQLNNVGVAYFNTNQLDKAQMYYQQSLQMKKSI |. ..| |..|.. ...|.| ||...|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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