Gene 14663 (Tetrahymena)
14663
Group:
Other
Family:
Ciliate-Unique
Sequence
Protein domains of 14663.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14663.AA | MSK | 80-194 | 27 | 6.2e-11 | 33.19 | In-house | 86-200 (277) | Show / Hide |
Range on Protein: 80-194 Range on HMM: 86-200/277 Sequence Identity: 27% (32 aa) GDLQTYLDKNPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKELFIYLTDFGGADILSSRNEKIHTPYCYSHKFHPINLLDQ---N | | | . | . .|.|.| . ... | .| .| |.|||||| |. .. . . |.||| | .. . .|. ..|.. . . .|.. . GELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFD--DEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQ HPHFNPFSADCYMLGVIL . ... . | . ||||| DGGYDE-ACDWWSLGVIL |
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| Kinase | 14663.AA | Ciliate-E2c | 79-125 | 35 | 1.4e-09 | 29.89 | In-house | 98-145 (310) | Show / Hide |
Range on Protein: 79-125 Range on HMM: 98-145/310 Sequence Identity: 35% (17 aa) DGDLQTYLDKNPNLSEEEVRLLFVKIIYPVFILHRC-KIYHGDLKPEN .|.|. |. ..|...|... .| ||. . || .|.|.|.|||| GGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPEN |
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| Kinase | 14663.AA | Ciliate-E3 | 80-159 | 31 | 1.8e-09 | 25.97 | In-house | 89-165 (202) | Show / Hide |
Range on Protein: 80-159 Range on HMM: 89-165/202 Sequence Identity: 31% (26 aa) GDLQTYLDKNPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKELFIYLTDFGGADILSSRNEK--IHT |||..|. |...... .. .|| . ..| .| |.|.||.| | . |. | | ||| . | |..| .|| GDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNIL--VDKNNNQLIIKICDFGESKQL--RKNKGHTHT |
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| Kinase | 14663.AA | Ciliate-C8 | 73-194 | 23 | 7.4e-09 | 28.21 | In-house | 91-238 (238) | Show / Hide |
Range on Protein: 73-194 Range on HMM: 91-238/238 Sequence Identity: 23% (35 aa) FKMKKYD--GDLQTYLDK----NPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKELFIYLTD------FGGADILSSRNE----- . |.| . ..|..|.|. . .|... . . .| | ||. | | | ||.|.|. . .. . | | | || |. |. . MEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLV-CFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSK KIHTPYCYSHK--------FHPINLLDQNHPHFNPFS--ADCYMLGVIL |. . . | | | . .|. || | | .|..| KFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 14663.AA | NuaK | 80-127 | 39 | 1.9e-08 | 17.75 | In-house | 84-131 (252) | Show / Hide |
Range on Protein: 80-127 Range on HMM: 84-131/252 Sequence Identity: 39% (19 aa) GDLQTYLDKNPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYL |.| |... |.|.|.| .| |. | |. .| | ||| || | GELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL |
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| Kinase | 14663.AA | Ciliate-E1 | 7-188 | 12 | 3e-08 | 23.45 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 7-188 Range on HMM: 1-202/202 Sequence Identity: 12% (26 aa) LKKGGQAFIIHKGKKSIS----KVFISEKSFQRE----NNIQLNFIQPLNKIFKNKPFAEAYPQKNTKNLNKKEFKMKKYDGDLQTYLD----------- ...|...... . ... . .. | . |... .... . ..... . |... . . .. .... . ... ... |. ||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --KNPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPEN---YLYKICKRTKELFIYLTDFGGADILSSRNEKIHTPYCYSHKFHPINLLD-----QNH .. ....... ... .| . .|| ..|.|.|.||.| . ..... . ||| ...| . ... .| |.. | . . |. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNK PHFNPFSADCY . . | | NQKINYKSDIY |
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| Kinase | 14663.AA | CAMK-Unique | 79-145 | 21 | 4.1e-08 | 22.66 | In-house | 119-218 (363) | Show / Hide |
Range on Protein: 79-145 Range on HMM: 119-218/363 Sequence Identity: 21% (22 aa) DGDLQTYLDK--------------------NPNLSE--EEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTK-------------ELFIYLTD .|||. ...| . .|| ...... .. | .| .| |.|||.|| . .|.. | ..| |.| GGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIM--VCYSFKDNNHHRDFPYDWSNWHIKLCD FG || FG |
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| S_TKc | 14663.AA | S_TKc | 1-231 | 17 | 6.3e-08 | -60.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-231
Range on HMM: 1-231/231
Sequence Identity: 17% (46 aa)
MTKDSLLKKGGQA---FIIHKG--KKSISKVFISEKSFQRENNIQLNFIQPLNKIFKNKPFAEAYPQKNTKNLNKKEFKMKKYDG---DLQTYLDKNPN-
.. .. ||. . .||. .. |. ....|| .| . | | . . . .. . | || || .|..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK---HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKRGRH
-----LSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKELFIYLTDFGGADILSSRNEKIHTPYCYSHKFHPINLLDQNHPHFNPFSAD
..| ..| .. |. . .|. .| | |||||| | | ..||| | .| | .| . . . .| .......|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCD
CYMLGVIL-------------SRMSSHLKDISSDLRILLDLLINYE----LQIEQLIL-------FRWI
. .|.|| .| ... |.... ... . ... . . .. |.
WWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 14663.AA | C8 | 87-194 | 23 | 7.7e-08 | 23.42 | In-house | 115-226 (226) | Show / Hide |
Range on Protein: 87-194 Range on HMM: 115-226/226 Sequence Identity: 23% (27 aa) DKNPNLSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKEL-FIYLTDFGGADILSSRNEKIHTPY---CYSHKFHPINLLDQ--NHPHF .|. .|.|. . ...| | .| .| | |.||.|.| .| ... | | ||| |. .|. ..|.. | .. . . |. . NKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFL--VCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQ NPFSADCYMLGVIL . | . .|..| YRIQSDLFSVGLVL |
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| Kinase | 14663.AA | Ciliate-E2 | 80-145 | 23 | 1.1e-07 | 22.41 | In-house | 119-201 (365) | Show / Hide |
Range on Protein: 80-145 Range on HMM: 119-201/365 Sequence Identity: 23% (22 aa) GDLQTYLDKN-----------PNLSEEEVRLLFVKIIY---------------PVFILHRCK-IYHGDLKPENYLYKICKRTKELFIYLTDFG |||. |. .| ...|.|.. .. .|.. . || . | | |.|||| |. | ..||| GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFG |
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| Kinase | 14663.AA | CAMK | 80-145 | 24 | 1.1e-07 | 20.12 | In-house | 145-241 (425) | Show / Hide |
Range on Protein: 80-145 Range on HMM: 145-241/425 Sequence Identity: 24% (24 aa) G----DLQTYLDKNPN---------------LSEEEVRLLFVKIIYPVFILHRCKIYHGDLKPENYLYKICKRTKE------------LFIYLTDFG | || |. .... ..|.|.| .| |. | .| ..| | |||||| |. .. .. | ..||| GELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG |
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| Kinase | 14663.AA | MSK | 229-244 | 50 | 0.16388 | 0.87 | In-house | 242-257 (277) | Show / Hide |
Range on Protein: 229-244 Range on HMM: 242-257/277 Sequence Identity: 50% (8 aa) RWINCSEKARDLILKL .| | |..|.||| .| AWQNMSPDAKDLIQWL |
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