Gene 24887 (Tetrahymena)

24887

Species: Tetrahymena
Alias: TTHERM_00389910, 74, 24887, PreTt24887, 41.m00294
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
24887.AA Protein None 1715 None Fasta, JSON
24887.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
24887.NA RNA None 5148 None Fasta, JSON

Protein domain

Protein domains of 24887.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24887.AA ULK 71-330 36 1e-132 447.22 In-house 1-324 (324) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-324/324
Sequence Identity: 36% (120 aa)

FCLSDLVGKGASG-TVYLGENSVT---KDLVAIKVID---LHQVKD----EYTWGLICSEIDIMKKLK---CEN--VVKLIDVFQTQ--NNAYIITELCE
.||..  |||. | .|| |.|  |   . .||.|.||   . . |     .| | |...|| ||||||   ..|  .|||.|.|.|.  || |||.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLVDFMKRNAG--------KIRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKD------------VFKITDFGFARMVE---KTDYLMTS
.||| ...|.| .        .. ...|.... .|. |..|| ||.|||||.||.||||....            |.||.|||||..|.   . . ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPLYMSPQILK----RQMYT-SKCDVWSIGLIFYELIYGQTP---WPSNSVI----DLVNN-------MFSNPLKFPNVGQAGDVILEDVK
.|      ||||||.||||.    .. |. .|||.||.| ||||..||..|   |  |. .    .|.||       .  .|..||... ....| ...|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECK

DFIKGCLKFEEADRLGWEEVYRHSLF
|.|...|...| ||  |||.. | .|
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24887.AA ULK 71-330 37 1.2e-131 443.68 In-house 1-329 (329) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-329/329
Sequence Identity: 37% (125 aa)

FCLSDLVGKGASGTVYLGENSVTK----DLVAIKVID---LHQVKD----EYTWGLICSEIDIMKKLK--------CENVVKLIDVFQTQ--NNAYIITE
.||..  |||. |.|| |.|  ||     .||.|.||   . | ..    .| | |...||.||||||        ..|.|||.|.|.|.  || |||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCEDGDLVDFMKRNAG---------KIRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKD------------VFKITDFGFARMVEKT---DY
.|..||| ...|.| .         .. ...|.... .|| |..|| ||.|||||.||.||||....            |.||.|||||..|..    . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LMTSLV------GTPLYMSPQILK----RQMYT-SKCDVWSIGLIFYELIYGQTP---WPSNSVI-----DLVNN-------MFSNPLKFPNVGQAGDVI
.|.. |      ||||||.||||.    .. |. .|||.||.| ||||..||..|   |  |. .     .|.||       . ..||.||..| ....|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG-NDPQI

LEDVKDFIKGCLKFEEADRLGWEEVYRHSLF
 ...||.|...|...| ||  |||.. | .|
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 24887.AA S_TKc 71-330 32 4.7e-83 283.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FCLSDLVGKGASGTVYLGENSVTKDLVAIKVIDLHQVKDEYTWGLICSEIDIMKKLKCENVVKLIDVFQTQNNAYIITELCED--GDLVDFMKRNAGK--
. . ...|||| |.||.. .  |. .||||.|.            |..||.|.|| ...|.|||.||||. .. |...|.|.   ||| |..|.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKDVFKITDFGFARMVEKTDYLMTSLVGTPLYMSPQILKRQMYTS-KCDVWSIGLIFYE
   .   .| ...  |...|. . .||||||||||.|||...  . ||.|||.|| .       |...||| ||.| .|    |.  |||.||.| |.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LIYGQTPWPSNSVIDLVNNMFSNPLKFPNVGQAGDVILEDVKDFIKGCLKFEEADRLGWEEVYR-------HSLF
...|..|.|   .  . ...                  ...||||..||... ..|..  |. .       |  |
MLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24887.AA Pkinase 71-330 31 5.2e-82 283.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-293/293
Sequence Identity: 31% (92 aa)

FCLSDLVGKGASGTVYLGENSVTKDLVAIKVIDLHQVKDEYTWGLIC-SEIDIMKKLKCENVVKLIDVFQTQNNAYIITELCEDG----DLVDFMK-RNA
...   .|.|..|.||.. .  | ..||.|.|...  |..    ..  ||| |||.|...|.|.|.|.|.. .. |...|.|| |    || |... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKI--RQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKDVF----KITDFGFARMV-EKTDYLMTSLVGTPLYMSPQILK-RQMYTSKCDVWSI
|..    ... .... |||||. . ..|||||||||.||||.....     ||.|||.|. . .  .  ||...||| ||.| ... .|.|..|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GLIFYELIYGQTPWPSN------SVIDLVNNMFSNPLKFPNVGQ----------------AGDVILEDVKDFIKGCLKFEEADRLGWEEVYRHSLF
|.|.||.. |..|.|.       . . ....  . ||.|.                      . . |. |||||.||..  ..|...|..  |  |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 24887.AA AGC 71-330 19 8.6e-74 189.28 In-house 1-395 (395) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-395/395
Sequence Identity: 19% (79 aa)

FCLSDLVGKGASGTVYLGENS------VTKDLVAIKVIDLHQ-VKDEY--TWGLICSE------------IDIMKKLK----------CENVVK-LIDVF
| .  ..|||. |.||| .         |... |.||..    ...    .   . .|             .|..|..          . ..|| |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTQNN--AYIITELCE----------DGDLVDFMK-R-NAGKIRQNQAVKIITD-------ILRGLQELAK-HGIIHRD-LKPANILISKKDVFKITDFG
|....   |.. |...          ...|   .. | . |.   ..|  ..         |. .|. | . .|||||| ||| |||. ..   |.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARMVEKTD--------------------------------------------------YLMTSLVG--TPLYMSPQILKRQMYTSKCDVWS--IGLIFY
.. .. . .                                                   . ....|  || ||.| ||    |.  || ||   | ..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELIYGQTPWPSNS----------VIDLVNNMF------SNPLKFPN----VGQAGDVILEDVKDFIKGCLKFEEADRLG----------WEEVYRHSLF
|...|..|  ...            .. ..        ....|||.      .. . . .. ||.||..|. . ..|||           ||. .|  |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 24887.AA Ciliate-E2 71-330 21 4.7e-69 235.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

FCLSDLVGKGASGTVYLGENSVTKD-----------------------LVAIKVIDLHQVKDEYTWGLICSEID----------IMKKLKCENVVKLIDV
. .  . |.|. |.||....  ..                        ..|.|..   |..       |. ||.          |...|.. |..|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TQNNAYIITELCEDGDLVDFMKRNAGK----------IRQNQAVKIITDILR---------------GLQELAKHG-IIHRDLKPANILISKKDVF
||  ..|| |...|.|. ||| |..| |  |          .  ... .|.. ||.               .|..| . . |||||.|| |||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGFAR--------------MVEKTDYL------------------MTSLVGTPLYMSPQILKRQM---------YTSKCDVWSIGLIFYELIYGQT
||.|||...              . ....                      ...||| ||.|.||...          |. |||.||.| |.||...|..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PWPSNSVIDLVNNMFSN-PLKFPNVGQ------------AGDVILEDVKDFIKG----CLKFEEADRLG-WEEVYRHSLF
|.          .   . ...||.                 . . ...||.||     .|. ..  |.. ||..  |  |
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24887.AA CAMK 76-330 19 1.5e-67 216.47 In-house 1-425 (425) Show / Hide 
Range on Protein: 76-330
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

LVGKGASGTVYLGENSVTK------------DLVAIKVIDLHQVKD-------------------------EYTWGLICSEIDIMKK-------LKCENV
  |.|. |.|.|...  |.              ||||.||  ..||                         ...   . .||.||||       |. .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLIDVFQ------------TQNN--------AYIIT---ELCEDG----DLVDFMKRN--------------AGKIRQNQAVKIITDILRGLQELAKHG
.||..|..            | ..         |...   |.|. |    || |. ...               |..   .| ...  |. ... . .|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPANILISKKD-----------------VFKITDFGFARMVEK-----------------------TDYLMTSLVGTPLYMS-PQILKR----Q
|.|||||| |||.....                   ||.|||||.....                       .. .|.  .||| ||. | .|..    .
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

M----------YTSKCDVWSIGLIFYELIYGQTPWPSNSVIDLV---------NNMFSNPL--KFPNVGQAGDVIL--------------------EDVK
|          |. |||.||.| | | .  |  |. . .  . .         ...| . .  |.       . |                     ...|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFIKGCLKFEEADRLGWEEVYRHSLF
|.|...|. .  .|.  |.. .|  .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24887.AA Ciliate-E2-Unclassified 71-330 23 7.9e-63 215.04 In-house 1-352 (352) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

FCLSDLVGKGASGTVYLGENSVTKDLV-----AIKVIDLHQVKDEYTWGLICSEIDIMKKLK-------------------CENVVKLIDVFQTQNNAYI
. .    |.|. |.||. ... .| ..     ..|... .| . ..    |  |...|...|                   ....||....||...| ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITELCEDGDLVDFMK----------------RNAGKIRQNQAV-----KIITDILRGL-QELAKHGIIHRDLKPANILISKKD---VFKITDFGFARMVE
..|.||.||| ...|                ..  ..  .||.     ...  || || .   |..|||||.|| |||....      ||.|||...  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

KT---------------DYLMTSLVGTPLYM----SPQILKRQMYT----SKCDVWSIGLIFYELIYGQTPWPSNSVID----------------LVNNM
.                . .|.. .||| ||    .| .|..| |      |||.|| | |.||...|. | ..|. ..                | .| 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

FSNPLKFPNVGQ--AGDVILEDVKDFIK----GCLKFEEADRLGWEEVYRHSLF
. ....||.  .  . . . . .||||.     .||     |...|..  | .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24887.AA STE 71-330 22 2.1e-58 200.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-359/359
Sequence Identity: 22% (82 aa)

FCLSDLVGKGASGTVYLGENSV---------------TKDLVAIKVIDLHQV--------------KDEYTWGLICSEIDIMKKLK--CENVVKLIDVFQ
. . . .||||.||||.. |                 |....|||...| .               |..  .  |  ||.||||..  ..|.|| .. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TQ-------NNAYIITELCEDGDLVDFMKRNAGKIR-------------QNQAVKIITDILRG-LQELAKHGIIHRDLKPANILISKKDVFKITDFGFAR
         .. .|. |... | | |..|.. |. .              .|  .|. .||.| |. | .|.|||||.||||||.      |..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MVEK----------------TDYLMTSLVGTPLYMSPQILKRQM------YTSKCDVWSIGLIFYELIYGQTPW---PSNSVIDLVNNMF----------
 ...                ..   ...|||| .|.| .....       |. |||.||.|.   |.. |. ||   .  ... . ....          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---SNPLKFPNVGQAG-------------DVILEDVKDFIKGCLKFEEADRLGWEEVYR--HSLF
    .| ..|.  . .             .   .. ||||. ||. .  .|   ..  .  |. .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24887.AA Ciliate-E2c 71-330 25 1.6e-57 197.44 In-house 1-310 (310) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-310/310
Sequence Identity: 25% (79 aa)

FCLSDLVGKGASGTVYLG------ENSVTK---------DLVAIKVIDLHQVKDEYTWGLICSEIDIMKKLKCENVVKLIDVFQTQNNAYIITELCEDGD
.     .|.|  |.||..       |.  .            . |..|.|. ..      |  ||..||...  ...| .| .|| .. |.|.| |..|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LVDFMKRNAGKIRQNQAVKIITDILRGLQELAKH-GIIHRDLKPANILISKKDVFKITDFGFARMVEKTDYLMTS----LVGTPLYMSPQILKR-QMYTS
| .. . .  |.   | .     |......| |  .|.|||.||.|||| .... || ||||.. .    .  |.     .|||.||.||||.. . ||.
LEQYIYHKP-KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILI-HNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KCDVWSIGLIFYELIYGQTPWP------------------SNSVIDLVNNMF---------------SNPLKFPNVGQAGDVILEDVKDFIKGCLKFEEA
| |.|| |   |. ..   ||                    |..  |. .                   ...||.  .    | ..||..|.  | ..|.
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPE--NYEQNISQEVKQLIHKMLQVDEE

DRLGWEEVYRHSLF
.|. |.|.  |...
KRIDWDEIFNHECI
Kinase 24887.AA Ciliate-B1 71-267 32 4e-50 172.83 In-house 1-226 (290) Show / Hide 
Range on Protein: 71-267
Range on HMM: 1-226/290
Sequence Identity: 32% (74 aa)

FCLSDLVGKGASGTVYLGE---NSVTKDL-VAIKVIDLHQVKDEYTWGLICSEIDIMKKLK--------------CENVVKLIDVFQTQNNAYIITELCE
  .  . |.|| . |..|.   |. ..   ...|...  |  |.    .. .|..| ..|               |....  .||.|.|  .|||.|.||
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

DGDLVDFMKRNAGKIRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKD------------VFKITDFGFARMVEKTDYLMTSLVGTPLYMSPQ
.||| ..  ..  .  .  .. ... |  |.| | ||.|.|||||| ||||.||             .|||||||   | .     | |.|||. ||.| 
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEY--MMQSCVGTINYMAPE

ILK-RQMYTSKCDVWSIGLIFYELIYGQ
||. .| |. | | ||.|.| ||.|...
ILNFNQQYDKKVDIWSFGCIMYEIITNE
Kinase 24887.AA NEK 71-263 26 1.1e-47 164.76 In-house 1-217 (286) Show / Hide 
Range on Protein: 71-263
Range on HMM: 1-217/286
Sequence Identity: 26% (59 aa)

FCLSDLVGKGASGTVYLGENSVTKDL-----VAIKVIDLH----QVKDE--YTWGLICSEIDIMKKLKCENVVKLIDVFQTQN--NAYIITELCE-DGDL
. .   .|.|. |.||. .   ...      ...| |..     . |..         .|. | |.||..|.|| .| |. ..    .|. | ||  |||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN------NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDL

VDF---MKRNAG---KIRQNQAVKIITDILRGLQELAKH-----GIIHRDLKPANILISKKDV----FKITDFGFARMVEKTDYLMTS-LVGTPLYMSPQ
 ..    |.. .    .  .| ... . .. .|... ..      |.|||.||.|| ..|..      || ||| ... ..|  . .. .|||| |||| 
YQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPE

ILKRQMYTSKCDVWSIGLIFYEL
... . |..|.|.||.| . ||.
VCQNKPYNNKSDIWSLGCVLYEM
Kinase 24887.AA Pkinase_Tyr 71-280 28 2.9e-34 116.67 Pfam 1-226 (270) Show / Hide 
Range on Protein: 71-280
Range on HMM: 1-226/270
Sequence Identity: 28% (65 aa)

FCLSDLVGKGASGTVYLGENS----VTKDLVAIKVIDLHQVKDEY-TWGLICSEIDIMKKL-KCENVVKLIDVFQ-TQNN--AYIITELCEDGDLVDFMK
  .    |.|| |.||.|.       ||  ||.|..  ..  .|   .    .|. |||.| ...|.|.|. |    .     ||..|... ||| |. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RN---AGKIRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKDVFKITDFGFARMVEKTDYLMTSLVGTPL---YMSPQILKRQMYTSKCDVWS
..    ...   . ... ..| .|.. |. ...|||||   |.|.... | ||.||| || ....|| ...  |..|    |.|  ..   .|.| ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

IGLIFYELIY-GQTP-WPSNSVIDLVN
 |   .|..  |..| .|  |  ....
FGVLMWEIFTYGEQPTYPGMSNEEVYE
Kinase 24887.AA TyrKc 71-330 24 5.1e-30 106.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FCLSDLVGKGASGTVYLGENSVTKDLVAIKVIDLHQVKDEYTWGLICSEIDIMKKL--KCENVVKLIDVFQTQ-------NNAYIITELCEDGDLVDFMK
  | .  | || |.||.|. .     ||.|..  .          ...|. ||.||  . .|.|.|. |  .|          .|..|... ||| |. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RNAGKIRQNQAVKIITDILRGLQELAKHGIIHRDLKPANILISKKDVFKITDFGFARMVEKT-------DYLMTSL-VGTP--L---YMSPQILKRQMYT
.. .|.   . ... ..| .| . |.....|||||   |.|.... . ||.||| .| ..         || ...   |.   |    |.|  ..  ..|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKCDVWSIGLIFYELI-YGQTPWPS-----NSVIDLVNNMFSN-PLKFPNVGQAGDV----ILEDVKDFIKGCLKFEEADRLGWEEVYRHSLF
.| |||| |   .|.  |||.|.|       | ......  .   .. |  .    .      ... . .| | ... .||   .|.  |..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF