DNAPK

Species: Sea Urchin
Alias: DNAPK, Spk040, SPU_015529
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: DNAPK

Sequence

Name Sequence Type Origin Length Description Download
DNAPK.AA Protein None 2555 None Fasta, JSON

Protein domain

Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
NUC194 DNAPK.AA NUC194 222-630 36 5.8e-153 519.26 Pfam 1-446 (446) Show / Hide
Range on Protein: 222-630
Range on HMM: 1-446/446
Sequence Identity: 36% (164 aa)

KEIRKAAIQRVCIPLLRQASRDATVTFYKGHIHDIISVLEARLTK--NPVPAFENQLVSKICYFELIEVLYSRLSKDDLNSKDSALNREYRHGNVE----
 ..| . . |.|..||. .| |. |.|.. || ||......| ||   . ..|| |...|.|.. .|||.||||.||...|.|.  | .|.         
NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA

--KGNEMSTALTKAALGARNEDC-RGETVAVELR--RQFHCAAFNCSAAIISCVQDNIKFYNAFLFSENHAKGQFLLDNLVDPKKEY---GFAIEMDAPV
  .||| ..||.|.. .|. |.  .|.....|.|  |..||||.|| .|.|||..   |||..|||.||  |......||.| . .|    | .|   |.
PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM

ERKKRFVAIRTQAR-ETNTPEESGYVSGPAHYLSSQ--YLSDSSLSEDVNQFDFSSSVRHFGSSMESQR-----DGGSQGSQGSQRPGS-MASRQDSKPV
||||. ||||  ||   .  ...   ..  .|||||  |. |||||... ||||| .|     .. ||.      ..||    .| ... |.  ||    
ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQD----

FSPGGEYLEMEEDALNQHECMAAMTGVLK-HMTNNKINPDI-----TKATKAE----EMPQWMSGLQKKLSSQSTEHNIKLFIVRLVINAQDVFQPYARF
     .  | | | .|||||||.|.|..| ||  |.| | .      .   .     .|| ||. | .||  |..  || |||  ..||  ..|.|||.|
-----DVMELEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKF

WLSPLMQFLA-----GGQQG-GINYMVLDIMLVMLDWSTLAVPE-------DDEE
|..||||        .|  | |..||| ||    | |...| |         || 
WIGPLMQLIVKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH

MIT DNAPK.AA MIT 1363-1394 33 0.000612 16.64 Pfam 1-33 (71) Show / Hide
Range on Protein: 1363-1394
Range on HMM: 1-33/71
Sequence Identity: 33% (11 aa)

ALIKTKDVTQEAIQAES-RGDYESALELYSKAI
.| | ... ..|..|.   |.|| |...| .||
YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAI

FAT DNAPK.AA FAT 1457-1688 16 4.6e-08 27.22 Pfam 18-237 (408) Show / Hide
Range on Protein: 1457-1688
Range on HMM: 18-237/408
Sequence Identity: 16% (41 aa)

YLPYMMRSKLKRLMEGSEDDSLLGFIDSSAKDQEKRVILESRYTEELAALSILKEDYN--RAKYYLANSTSSFLQEWSG-LGPLMLTSRLSKLQDIQKLT
|.... ... | |  |  |  |  |||.. .|.   . ..  . ... .| ... ..   .|..|  .  . ...||.  |  .   ....... .| |.
YMDEYISVMKK-LL-GE-DQ-L-TFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLA

EAEQFLQLANKPFSE------GLKSSATRLVSDWSRNLPDPKRDPISVWDDVTQYRCLYMD----KLCNLLGDSGGGGGGGGDSMETEDQKFDDLVRREK
| | . |  ..  .       .  ..  ... .| . ||. | ....||..  . |....     ..                      . |  .  .| 
ELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM---------------------NSFCYRGPHED

VLLSMKMADSACQQANFCVAAKHLKSTHRGLVEFEDL----RPAWTHSY
   ..|.|...  . .. .. |.||. ..   . ||      | ||..|
MWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAY

FAT DNAPK.AA FAT 1865-1884 28 0.653518 3.28 Pfam 388-408 (408) Show / Hide
Range on Protein: 1865-1884
Range on HMM: 388-408/408
Sequence Identity: 28% (6 aa)

LQAMNLNSP-EARQHFPRLLQ
...  |..  ..|| ..|||.
FHSIALSQGSNSRQDTLRLLW

Kinase DNAPK.AA DNAPK 2139-2440 49 2.4e-158 532.32 In-house 1-301 (301) Show / Hide
Range on Protein: 2139-2440
Range on HMM: 1-301/301
Sequence Identity: 49% (149 aa)

HVKIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDF
||.|||||| |  . |||.|| | ||| || . ||..| .||||.|||||||| .|| |...| .|.|| | | || ..||| ||| .||| .| .||| 
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI

ITRSMTEAE-HKVYTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLC
  . | . .  | | |    |      ||..     .  .  .   |. .| ... ..||..| | | |..|| |  .| ..|..| || ||.|..|| |
LNNEMQQKMGKKEYISQDREPPCMYRDWLKQMDRKHD--VAEYHIMYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVIC

ICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVFVKEPSLD
|  .||||||||| ||.|  |.|. ..|||||||||||||||.||| ||| ||. ||||.|||| |.. . |.| ..|.|.   .|.|..|||...||.|
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WKC
|| 
WKN

Kinase DNAPK.AA PIKK 2141-2430 36 1.1e-116 393.9 In-house 1-290 (290) Show / Hide
Range on Protein: 2141-2430
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

KIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFIT
 |...|. |  . ...||| |.||| |.  ||.|.| .|||| |||..||| .|| .|..|..|..| |...|| |.||..|.|..|||  ..|||....
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

RSMTEAE-HKVYTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLCIC
. . ...  . . .    .      ||..   .  .. .     |.... .|. ..|||.. . | |.... |.. . .||.....| ...||.|| |. 
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS-YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV

QYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVF
 ||||.||||..|...  .||. |.||||..|.||.|.|| ||..||| ||...|.| ||...||. ....|.....||. | | ....||
GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase DNAPK.AA PI3_PI4_kinase 2170-2440 23 4.8e-75 260.41 Pfam 1-300 (300) Show / Hide
Range on Protein: 2170-2440
Range on HMM: 1-300/300
Sequence Identity: 23% (76 aa)

DYPFLVKVGEDLR--MDQRIEQLF-----------------------CIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFITRSMT
.|||..|.|.|||   |.|..|..                       ..|| .. .|... .| .....| ..|. |. |..|||...||..  .   |.
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

EAEHKV--------YTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASP-EAFLTLRAHFARSHAV
. .||         . .... . ..                            ... . |..|..| | . |.. |.  . .. |.... | .|.||.|.
KCKHKHFNKEHKMWMKMWPDWWHLM---------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAG

LCICQYILGIGDRHLSNFLV--SLETGGMVGIDFGHSFG-SATQFLPIPELIPFRVTR------QIINLM------LPMKIDGVLQSTMVHTLRALRQNH
.|.  ||||.||||..|..|    .|| ...|||||.|. ....... ||..||| |.      .....|       |.. .| ......|..||||...
MCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHM

ELLVNTM-------DVFVKEPSLDWKC
.|..|..       . .|. ....|. 
NLCMNLLKKAVMRGECMVHDGLPMWRS

Kinase DNAPK.AA PI3Kc 2172-2491 24 2.6e-66 227.54 SMART 1-336 (336) Show / Hide
Range on Protein: 2172-2491
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)

PFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFITRSMTEAE------HKVY------TSRTAGPG
....|.|.||| |.|. |.| .|| |...|..|..| |....| ..|. |. |..|||. ..||      .....       . ..       ..     
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

ALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASP-EAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLE
.  . |.|. |.            |. .. .|..| |..  .. . . |.  |.. . .| |.. . | .|.||.|. |.  |||||||||..|...  .
Y-MMIWHQQACHW--------MMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMK

TGGMVGIDFGHSFGSATQFLPIP-----ELIPFRVTRQIINLML----PMKIDGVLQSTMVHTLRALRQNHELLVNTMDVFVKEPS-LDWKCF-AVKQAD
|| ...||||| ||.. ...| .     |. ||| |......|     |.. .|  ........||.|....|..|.. ..|. |   .|. .   ..  
TGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYL

YQKLSED--SREDISWYPKK--KIKFAEMKLQGVNSTYITKAELEMGP
 |.. .|  | |... | ..  ..|. |  ... ...... ... ...
RQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase DNAPK.AA ATR 2285-2430 30 8.9e-26 84.47 In-house 123-267 (267) Show / Hide
Range on Protein: 2285-2430
Range on HMM: 123-267/267
Sequence Identity: 30% (45 aa)

KKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELI
| ..| |  |.|||        . .  | .    |. . . |  . || ||.|.  ||.|.||||  | |.   .| .| .|.   |.|  ||  .||..
KSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIV

PFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVF
|||.|. ... | ||| .|.    .. ... .|.. . ..  .| |
PFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase DNAPK.AA FRAP 2316-2440 35 3.8e-25 89.38 In-house 127-251 (251) Show / Hide
Range on Protein: 2316-2440
Range on HMM: 127-251/251
Sequence Identity: 35% (44 aa)

SASPEAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRA
| . |  .  |  . || |.. .  ||||.||||.|| .    || .| ||||  |  | .   .||.|||| || ..| |    |.|    |    .. 
SPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKV

LRQNHELLVNTMDVFVKEPSLDWKC
.| . | ..  .. ||  | . |. 
IREHKESVMAVLEAFVYDPLFYWRL

Kinase DNAPK.AA ATR 2140-2249 33 3.1e-20 65.26 In-house 1-110 (267) Show / Hide
Range on Protein: 2140-2249
Range on HMM: 1-110/267
Sequence Identity: 33% (37 aa)

VKIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFI
  |||||. |  |.||.||| |...| |   |  . |  .||| | |  .   ..| .. .|.   .| . . || |.|.  . .|.|||  | ||.  .
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

TRSMTEAEHK
..   | . .
DKLWKEKKQY

Kinase DNAPK.AA ATM 2326-2457 34 2.1e-19 58.3 In-house 137-267 (304) Show / Hide
Range on Protein: 2326-2457
Range on HMM: 137-267/304
Sequence Identity: 34% (46 aa)

RAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVN
|  . || |   |  ||||.||||  | |.      .| || |  |    . || || .|||.|| |.  |    ..||       |.  .|   | |. 
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLT

TMDVFVKEPSLDWKCFAVKQADYQKLSEDSRE
 ..| . .|  ||    .|    |.  ||  |
IVEVLLYDPLFDWTMNPLKALYLQQRPEDETE

Kinase DNAPK.AA FRAP 2170-2239 32 1.7e-14 49.83 In-house 1-70 (251) Show / Hide
Range on Protein: 2170-2239
Range on HMM: 1-70/251
Sequence Identity: 32% (23 aa)

DYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFI
.| || |  ||.| | |. ||| ..| .|. ..   ...| .. | ..|.  . |.. ||.   ||.  |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILI

Kinase DNAPK.AA ATM 2174-2228 43 5.5e-13 37.42 In-house 3-57 (304) Show / Hide
Range on Protein: 2174-2228
Range on HMM: 3-57/304
Sequence Identity: 43% (24 aa)

LVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEW
|||  .||| |  . | | . | .|       .| ||. ||.|||.  | |.|||
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW

Kinase DNAPK.AA SMG1 2329-2367 51 7.4e-10 28.67 In-house 190-228 (242) Show / Hide
Range on Protein: 2329-2367
Range on HMM: 190-228/242
Sequence Identity: 51% (20 aa)

FARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDF
.||| ||. .  ||.|.||||| | |. . || .| ||.
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase DNAPK.AA SMG1 2149-2235 33 1.3e-09 27.89 In-house 1-87 (242) Show / Hide
Range on Protein: 2149-2235
Range on HMM: 1-87/242
Sequence Identity: 33% (29 aa)

VLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTL
.  |    ||| .   | |   ||.| |  ||| .| || |   |.| . |              | | |.  | |.. ||   | |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL

FATC DNAPK.AA FATC 2523-2555 54 1.4e-16 56.1 Pfam 1-33 (33) Show / Hide
Range on Protein: 2523-2555
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

KGLSVEDQVACLIDQATDPRILGKTYQGWEPWV
..||||.|| .||..||||. | . |.|| ||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW