Gene SMG1 (Sea Urchin)

SMG1

Species: Sea Urchin
Alias: SPU_016754, SMG1, Spk336
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
SMG1.AA Protein None 77 None Fasta, JSON

Protein domain

Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SMG1.AA SMG1 2-57 76 2.6e-38 124.44 In-house 187-242 (242) Show / Hide 
Range on Protein: 2-57
Range on HMM: 187-242/242
Sequence Identity: 76% (43 aa)

TQAFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFEKGKNLRVPE
||.. |||||.||.|||||||||||||||.   |||||||||..|||||| |.|||
TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase SMG1.AA PIKK 1-77 51 4.3e-38 132.87 In-house 185-262 (290) Show / Hide 
Range on Protein: 1-77
Range on HMM: 185-262/290
Sequence Identity: 51% (40 aa)

LTQAFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFE-KGKNLRVPERVPFRMTQNVQAALGITGVE
..... ||.|| .| |||.||||||..|....  |||.||||...||| ... |.||| ||||.|.|   |.|..|||
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVE
Kinase SMG1.AA ATR 3-77 49 9.3e-32 105.18 In-house 165-239 (267) Show / Hide 
Range on Protein: 3-77
Range on HMM: 165-239/267
Sequence Identity: 49% (37 aa)

QAFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFEKGKNLRVPERVPFRMTQNVQAALGITGVE
... ||.||..|.|||||||||| ||.|.. ..||.||.|||. | .|. . ||| ||||.|.|.. ..|  . .
ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTY
Kinase SMG1.AA ATM 4-77 55 3.3e-29 90.14 In-house 139-212 (304) Show / Hide 
Range on Protein: 4-77
Range on HMM: 139-212/304
Sequence Identity: 55% (41 aa)

AFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFEKGKNLRVPERVPFRMTQNVQAALGITGVE
|. || |  |..|||.||||||  |.|.|    |.||||  | ||.|| |  || ||||.|  .   .||||||
AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVE
Kinase SMG1.AA PI3_PI4_kinase 7-77 36 2.7e-22 84.11 Pfam 169-255 (300) Show / Hide 
Range on Protein: 7-77
Range on HMM: 169-255/300
Sequence Identity: 36% (32 aa)

RSTAVLSMIGYIIGLGDRHLDNVLV--NFVTGEVVHIDYNVCFE--KGKNLRVPERVPFRMTQ------NVQAAL------GITGVE
|| |......||.|.||||.|| .|  .  ||...|||.. ||.  |.| . .||||||| |.      . . |.      . .| .
RSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDY
Kinase SMG1.AA FRAP 7-77 45 1.8e-19 68.31 In-house 142-213 (251) Show / Hide 
Range on Protein: 7-77
Range on HMM: 142-213/251
Sequence Identity: 45% (33 aa)

RSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFEKG-KNLRVPERVPFRMTQNVQAALGITGVE
|| |..||.|||.||||||. |.. .  || .||||.  |||   .  . ||..|||.|     |. ..|.|
RSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIE
Kinase SMG1.AA DNAPK 1-64 41 1.8e-14 48.9 In-house 186-250 (301) Show / Hide 
Range on Protein: 1-64
Range on HMM: 186-250/301
Sequence Identity: 41% (27 aa)

LTQAFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFE-KGKNLRVPERVPFRMT
|   | |. ||    ..| | |||||.| .||. .|... ||.   |   .  | |||  |||.|
LREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLT