Gene TRRAP (Sea Urchin)
TRRAP
Sequence
Protein domains of TRRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TRRAP.AA | PIKK | 401-414 | 50 | 0.145334 | 1.92 | In-house | 277-290 (290) | Show / Hide |
Range on Protein: 401-414 Range on HMM: 277-290/290 Sequence Identity: 50% (7 aa) ANAREILMRMLEVF .. ||.|| .||| RQHRETLMTVCEVF |
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| FAT | TRRAP.AA | FAT | 2818-3165 | 21 | 3.6e-98 | 328.95 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 2818-3165 Range on HMM: 1-408/408 Sequence Identity: 21% (89 aa) PQLVLESAWRVPNWGA--MKEALAQVE------------QSCPREMNWKVNLYRGFIAI--CHPDEKNLTLIERLVEMSSKQALEEWRR-LPHYVTQAHT | .|.|||...| |.| .... ...| |. |. ...... .. .| ..... .|.... . ..||.. ||. ....| APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY PLLQASQRIMELQEASQVHHGLQPTNLG-RNQSLHDMKAIVKTWRNRLPMV-SDDLSHWSDIFMWRQHHYQAIVQAYDNSSSTTQDNQQHNHTMLGVHAS |... | ..||.|..| . .. ..|.. .. |....|....||..|||.. .....|..|..||||....|.|.| .. ..| | PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM-----------NSFCYRGPHED AQSIINYGKVARKHSLIGPALDSLSRIHT------------IPSVPV------------VDCFQKIRQQVKCYLQMA-GTMGKQELQEGL----EVIEST .. .| . ...||| . . . ..|....| .|.. . ...||..|....|..|. |. ..|.. || |||..| MWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVINNT NLKYFSREMTA-EFYALKGMFLAQV----------GRSDEANKTFSAAVQMHDTLVK-AWALWGDYLEQIFCKDK-------------QMSLGESAITCF ||.||.... | ..|...||.... ...||... ...|.. .... | ||. |. | ...| ... .. . |..|| NLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCF LHACRHQNESKSRKYLAKVLW .|.......|.||......|| FHSIALSQGSNSRQDTLRLLW |
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| Kinase | TRRAP.AA | PIKK | 3554-3831 | 24 | 1.7e-93 | 316.89 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 3554-3831 Range on HMM: 1-290/290 Sequence Identity: 24% (71 aa) IARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLD ..|||. ... .|.......||||..||.||||. ..|...||.|.....| | |..|. || |......|...|....|.|. .....| . RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK---GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE IYKKWCSKQQVETDPPINR---------------YYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTSTDYFAFRKMMCGQLALLG |||.||.| . . .... . || ... .| .. |..... .......| ...|. ..|.|.. .||........|.. . ..|. . IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC LAEFVLHLTRLNPEIIQIERNSGLLSVFYFRFDLDETSGELDANRPVPFRLTPNIAEFLTTVGVNGMLNACMISIARCLVQPSFQLPAILKAV ....|.| ...|| |.| . .| . . .|... . |.....||||||.|. ..... ||.| . .|......|. |. . | ...... MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | TRRAP.AA | TRRAP | 3554-3599 | 76 | 2.6e-28 | 97.69 | In-house | 1-46 (46) | Show / Hide |
Range on Protein: 3554-3599 Range on HMM: 1-46/46 Sequence Identity: 76% (35 aa) IARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRR |||||| ||| ||||||||||||| |||||||||.||. ..|| IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR |
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| Kinase | TRRAP.AA | PI3_PI4_kinase | 3597-3744 | 12 | 1.7e-09 | 36.84 | Pfam | 14-181 (300) | Show / Hide |
Range on Protein: 3597-3744 Range on HMM: 14-181/300 Sequence Identity: 12% (22 aa) SRREERVLQVL-----------------------RMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLDIYKKWCSKQQVETDP----- .|...|..| . |. | . |.... .| .|.. .|... .|.....|..|..... | .... | . .. CRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKM PINRYYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTS-TDYFAFRKMMCGQLALLGLAEFVL . ....... . .. . ...| .....|. | .| ....|. ......|. . ..| .. . ..| WMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYIL |
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| Kinase | TRRAP.AA | PI3Kc | 3597-3853 | 15 | 4.3e-07 | -52.4 | SMART | 10-318 (336) | Show / Hide |
Range on Protein: 3597-3853
Range on HMM: 10-318/336
Sequence Identity: 15% (49 aa)
SRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLDIYKKWCSKQQVETDPPINRYYERLAVVQLRGSQASHQVL----
|...|..|..|. |. . | ||...| |... .......|.....|. |.. .| | || . .. .. | . .. .| | . . . .. .
LRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-NMY-MMIWHQ
----------------RDILKEVQTNMVPRTLLKEWALDTFPTS-TDYFAFRKMMCGQLALLGLAEFVL----------HLTRLNPEIIQIE----RNSG
. .. | .|.... |..| ...||.. |....|. . ..| . ..| .|.. . ... | ..|
QACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG
LLSVFYFR-FDLDETSGELDANRPVPFRLTPNIAEFLT----TVGVNGMLNACMISIARCLVQPSFQLPAILKAVLRDEM-IAWSKK-------------
. . |. . . . ||||||... . |. | |. .. | . ..| .. ... . ..|.. . |...
-PKKPGFKHH-H---------RERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRL
--TSLSLRAARV-----------K
.| ..| ..
DHLSDEEAAQYFMQTMCTKLIEHS
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| Kinase | TRRAP.AA | ATR | 3553-3831 | 18 | 4e-06 | 16.31 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 3553-3831 Range on HMM: 2-267/267 Sequence Identity: 18% (53 aa) RIARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLL || | ||| ... ..||.||.| . . |.. | .. ..| . | | .|... |. . | ..| ..| YIAGFDDMVEILASLQ-KPKKISLKGSDGKFYIMMCKPKDDL---RKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR DIYKK-WCSKQQVETDPPINRYYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTSTDYFAFRKMMCGQLALLGLAEFVLHLTRLNP | .| | |.| . . .| .. |.. . .. ...| | . ..| . .|| ...... |. | | . . ... | PILDKLWKEKKQYMQ-------FYQLRQCMDKKSREEWEKQK-VFREFLLPRHP-PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHT EIIQIERNSGLLSVFYFRFDLDETSGE-LDANRPVPFRLTPNIAEFLTTVGVNGMLNACMISIARCLVQPSFQLPAILKAV . | |.. | . . . ||| .. |||||| |. . .. .|. .. | .|. . .. ..... DNILIDKING--ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | TRRAP.AA | PI3_PI4_kinase | 3783-3841 | 15 | 0.06274 | 8.83 | Pfam | 223-300 (300) | Show / Hide |
Range on Protein: 3783-3841 Range on HMM: 223-300/300 Sequence Identity: 15% (12 aa) RPVPFRLTP------NIAEFL------TTVGVNGMLNACMISIARCLVQPSFQLPAIL-------KAVLRDEMIAWSK ..||||.|. .. . . | |.. .. .. | | ... . . | . ..|... |.. ERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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