Gene Cdc7 (Sea Urchin)

Cdc7

Species: Sea Urchin
Alias: Spk157, SPU_000046, Cdc7
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: CDC7

Sequence

Name Sequence Type Origin Length Description Download
Cdc7.AA Protein None 591 None Fasta, JSON
Cdc7.kin_dom Protein Kinase Domain None 510 None Fasta, JSON

Protein domain

Protein domains of Cdc7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdc7.AA CDC7 78-587 42 0.0 1071.7 In-house 1-522 (522) Show / Hide 
Range on Protein: 78-587
Range on HMM: 1-522/522
Sequence Identity: 42% (230 aa)

FTVLDKIGEGTFSSVYRATLKKTP-----------DCNQEFALKHIIPTSHPSRILSELSCLVRIGGCHNVMGVKLTVREKDNIVIVMPHFKHNKFQDFY
..|.||||||||||||.||....|           .|...||.||.||||||.||..||.||.|.||.|||||.. ..|..|...||||.|.|..|||||
YKVHDKIGEGTFSSVYKATCQRQPHVNKFASHFWNYCRRKFAIKHHIPTSHPERIMNELQCLTRMGGHHNVMGMCCCFRYNDHVHIVMPYFPHCSFQDFY

HDMT--VKEVQDYLRALFIALRRVHKFNVIHRDVKPGNFLYNRHSRKYALVDFGLAQAVPTRSSAKTTVKPSTVGGVLHHDTPRPPQARKNTRRAVSTSE
..|.  ..|...|...||.|||.||.|..|||||||.||||||...|..||||||||..............|...           |.|.|.....|.|.
FHMNRDMEEIKHYMYNLFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLAQHMMDYNECSRSHQQSKMQ-----------QERCNQNKYHSISG

NKALTRVEPKRTQSESHSKVPKLVELDPNTFHSTDKSSRDRSNHRLDSVNEDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKPVILTRNCAAIAT
||||.|..|..||...||..........|..|.......|...|...||...........|....|.|..................|.....|.|...|.
NKALLRRPPPKTQDQQHSNKNNVKRNYNNNQHHIKQGKDDKNDHNNFSVMRNVFGNRNFNMHSNNSHNNPNNKNMKQNNNVDNNNRKNNTQKRICSTKAM

RGVTRRLQDMPKTPQGICGCYGLPRVCDVCMAKKNQVAPRAGTPGFRSPEVLLKCPDQTTAVDMWAAGVIFLSILSGRYPFFRAPDDFTALAQIMSIMGT
. .|.|...|...||..|.||.....|..||..|.|.|.||||||||.|||||||||||||.|.|..||||||.||||||||.||||.|||||||.|.|.
N-GTMRKNAMSCDPQCCCCCYKSDKCCNCCMCPKQQHANRAGTPGFRAPEVLLKCPDQTTAIDIWSCGVIFLSLLSGRYPFFMAPDDMTALAQIMTIFGS

EETTEAAKVNGKNLLCNVKLPAMELKTMCRQLR------------LGAVQRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQRSVGSVGSEEGL
||....|...||...|....||......||...            .|..|....||.|.....| |..||.||.||.......|.|..............
EEIIKMAHFFGKKIECSHEFPAQDWRELCRCYWYMDSLPNRTSDIQGHAQHQPAKSKQTDHKAS-RVQRSQNQHSPDSFYKRDSDECWHCGPICSKHMWK

VDQFPDTAYDLLGRLLELDPHKRITAEQALKHPFL
...|||.|||||.|.||..||||||||.||||||.
WEEFPDEAYDLLDRCLEMNPHKRITAEEALKHPFF
Kinase Cdc7.AA S_TKc 78-587 12 3.7e-53 183.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-587
Range on HMM: 1-231/231
Sequence Identity: 12% (67 aa)

FTVLDKIGEGTFSSVYRATLKKTPDCNQEFALKHIIPTSHPSRILSELSCLVRIGGCHNVMGVKLTVREKDNIVIVMPHFKH--NKFQDFYHD-------
...|.|||.|.|..||... ||    ....|.| |       .|..|...| .  .. |.   . . .. |.. .|| .  .      |. ..       
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MTVKEVQDYLRALFIALRRVHKFNVIHRDVKPGNFLYNRHSRKYALVDFGLAQAVPTRSSAKTTVKPSTVGGVLHHDTPRPPQARKNTRRAVSTSENK
  ..  ... |.. .. ||   |. ..||||.|| | | ..      . |||||  .                                           
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------------------------------

ALTRVEPKRTQSESHSKVPKLVELDPNTFHSTDKSSRDRSNHRLDSVNEDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKPVILTRNCAAIATRG
                                                                                                    
----------------------------------------------------------------------------------------------------

VTRRLQDMPKTPQGICGCYGLPRVCDVCMAKKNQVAPRAGTPGFRSPEVLLKCPDQTT-AVDMWAAGVIFLSILSGRYPFFRAPDDFTALAQIMSIMGTE
                                       ||| ...||||      .. ..|.|. |.|.   |.|. ||         ..... ..|  
-----------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--

ETTEAAKVNGKNLLCNVKLPAMELKTMCRQLRLGAVQRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQRSVGSVGSEEGLVDQFPDTAYDLLG
                                                                                           .. | |.. 
-------------------------------------------------------------------------------------------SPEAKDFIR

RLLELDPHKRITAEQALK-------HPFL
..|. || ||.|| .||.       ||..
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdc7.AA CMGC 411-587 17 9.1e-30 94.25 In-house 292-513 (513) Show / Hide 
Range on Protein: 411-587
Range on HMM: 292-513/513
Sequence Identity: 17% (46 aa)

RSPEVLLKCPDQT---------TAVDMWAAGVIFLSILSG-------RYPFFR-----------APDDFTALAQIMSIMG--T---------------EE
|.||.|| ... |         |..|||..| ||  .. |       ..|.|              ..   |..|. ..|  |               ||
RAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEE

--------------------------TTEAAKVNGKNLLCNVKLPAMELKTMCRQLRLGAVQRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQ
                           .| |.   .. .   . |   .| ..  .. ..  . . |  ...  . .    .                  
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK-AMVF-NW-IY---E------------------

RSVGSVGSEEGLVDQFP--------------DTAYDLLGRLLELDPHKRITAEQALKHPFL
              .|.              . | ||| ..|..||.|||||||||.||..
-------------EKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase Cdc7.AA CAMK 83-445 10 1.7e-26 81.79 In-house 1-334 (425) Show / Hide 
Range on Protein: 83-445
Range on HMM: 1-334/425
Sequence Identity: 10% (55 aa)

KIGEGTFSSVYRATLKKTP----------DCNQEFALKHIIPTSHP------------------------------SRILSELSCLVRIGG------CHN
..|.|.|. |.... |.|.          . .|..| | |  . ..                               ....|.... .. |        |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VMGVKL---------------TVRE-----KDNIVIVM-------PH------FKHNKFQDFY------------HDMTVKEVQDYLRALFIALRRVHKF
.                    | .      ......||               | . . .  |            . .| .|.. | | .  |..  |. 
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NVIHRDVKPGNFLYNRHS----------------RKYALVDFGLAQA---------------------VPTRSSAKTTVKPSTVGGVLHHDTPRPPQARK
|..||| || | |.. ..                 .  ..|||.|.                      .                               
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW-------------------------------

NTRRAVSTSENKALTRVEPKRTQSESHSKVPKLVELDPNTFHSTDKSSRDRSNHRLDSVNEDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKPVI
                                                                                                    
----------------------------------------------------------------------------------------------------

LTRNCAAIATRGVTRRLQDMPKTPQGICGCYGLPRVCDVCMAKKNQVAP--------RAGTPGFRS-PEVLLK-------------CPDQTTAVDMWAAG
                                                |        . |||.. . ||||..              |  . ..|||..|
----------------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG

VIFLSILSGRYPF
||    |.|..||
VILYIMLCGYPPF
Kinase Cdc7.AA Ciliate-E2-Unclassified 147-587 11 2.3e-24 81.46 In-house 93-352 (352) Show / Hide 
Range on Protein: 147-587
Range on HMM: 93-352/352
Sequence Identity: 11% (57 aa)

KDNIVIVMPHFKHNKFQDFYHD--------------------MTVKEVQ-----DYLRALFIALRRVHKFN-VIHRDVKPGNFLYNRHSR--KYALVDFG
|.|| |||  ..... ...  .                     | ....     .|.. .  .|   |. | .|||| || | |..   .  .  . |||
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

LAQAVPTRSSAKTTVKPSTVGGVLHHDTPRPPQARKNTRRAVSTSENKALTRVEPKRTQSESHSKVPKLVELDPNTFHSTDKSSRDRSNHRLDSVNEDDL
..    . .  . |                                                                                      
ISKKYQQNNNCD-TNQ------------------------------------------------------------------------------------

KKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKPVILTRNCAAIATRGVTRRLQDMPKTPQGICGCYGLPRVCDVCMAKKNQV-----APRAGTPGFR--
                                                                             .|...        ..|||..   
----------------------------------------------------------------------------QQKMQIWKQQMMWTFCGTPNYMPQ

--SPEVLLKCPDQT---TAVDMWAAGVIFLSILSGRYPFF---RAPDDFTALAQIMSIMGTEETTEAAKVNGKNLLCN--VKLPAMELKTMCRQLRLGAV
  .|||| ..   .    ..|.|. |||.  .| |.|||.   .  ....  ..|  .        | . . ..  ..  .. | .. .           
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NN--------AYRKQLYQNIKQKNIQFPKFPWQQ----------

QRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQRSVGSVGSEEGLVDQFPDTAYDLLG----RLLELDPHKRITAEQALKHPFL
                                                    .. ...| |..     ..|. .| ||||.||.|.||..
--------------------------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Cdc7.AA CK2 78-220 27 1.4e-22 63.52 In-house 1-143 (288) Show / Hide 
Range on Protein: 78-220
Range on HMM: 1-143/288
Sequence Identity: 27% (41 aa)

FTVLDKIGEGTFSSVYRATLKKTPDCNQEF--ALKHIIPTSHPSRILSELSCLVRIGGCHNVMGVKLTVREKDNIVI--VMPHFKHNKFQDFYHDMTVKE
. |  ||| | .| |. .  .|.   |..     | . |     .|  |.. |  . |  |..    .|. ..  |   | .. .   |.  |. .|  .
YEVIRKIGRGKYSEVFEGINIKN---NEKCKIVIKILKPVKK-KKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYD

VQDYLRALFIALRRVHKFNVIHRDVKPGNFLYNRHSRKYALVDFGLA
.. |.. | .||   |.  ..|||||| | . . . ||  |.| |||
IRYYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLA
Kinase Cdc7.AA Ciliate-E2 397-587 15 4.1e-21 69.19 In-house 240-365 (365) Show / Hide 
Range on Protein: 397-587
Range on HMM: 240-365/365
Sequence Identity: 15% (35 aa)

KKNQVAPRAGTPGFRSPEVLLKCPD--------QTTAVDMWAAGVIFLSILSGRYPFFRAPDDFTALAQIMSIMGTEETTEAAKVNGKNLLCNVKLPAM-
. |..   .||||. .||.| . ..         ....|.|..|||.   |.|..||                              ... |....|   
QQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------------QQQIKQCKIDFPCPE

--------------------ELKTMCRQLRLGAVQRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQRSVGSVGSEEGLVDQFPDTAYDLLGRL
                    | | .... . |                                                                  |.
WQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GK-----------------------------------------------------------------RM

LELDPHKRIT-AEQALKHPFL
|. || |||| .||.|.||..
LQKDPEKRITGWEQILNHPWF
Kinase Cdc7.AA Pkinase 78-233 23 1.3e-18 66.85 Pfam 1-171 (293) Show / Hide 
Range on Protein: 78-233
Range on HMM: 1-171/293
Sequence Identity: 23% (42 aa)

FTVLDKIGEGTFSSVYRATLKKTPDCNQEFALKHIIPTSHPSRIL------SELSCLVRIGGCHNVMGVKLTVREKDNIVIVMPHFKHN----KFQ----
.... |||.|.|..||... |.|..   ..|.| |   .  |  .      ||.. . |. .. |.   . ....||.| .||..  .            
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-DFYHDM--TVKEVQDYLRALFIALRRVHKFNVIHRDVKPGNFLYNRHSRK---YALVDFGLAQAV-PTRSSAKTTV
 . .  .  . .|...|.. .. .|   |. ..||||.|| |.|....        . |||||  .   ..|  ||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF
Kinase Cdc7.AA CMGC 78-220 16 1.6e-18 56.66 In-house 1-251 (513) Show / Hide 
Range on Protein: 78-220
Range on HMM: 1-251/513
Sequence Identity: 16% (41 aa)

FTVLDKIGEGTFSSVYRATLKKTP-----------DCNQEFALKHII-PTSHPS-------------RILSELSCLVRIG----------------GCHN
.....||||||.. ||... |.|            . |.. |.| |  |  ..              |.| |...| ..                   .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VMGVKLTVREKD-----------------NIVIVMPHFKHNKFQDFYHD------------------------------MTVKEVQDYLRALFIALR--R
. . .  .. |.                 .. .|. .  |. .|  ..                               ...  .. | . .. .|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

VHKFN--VIHRDVKPGNFLYNRHSRKY-------------------ALVDFGLA
 |. .  .|||| || | | |   . .                    . |||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase Cdc7.AA Ciliate-E2a 555-587 48 3.2e-17 47.25 In-house 243-275 (275) Show / Hide 
Range on Protein: 555-587
Range on HMM: 243-275/275
Sequence Identity: 48% (16 aa)

QFPDTAYDLLGRLLELDPHKRITAEQALKHPFL
.... ..||. ..|| || |||||.|||.||. 
KCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase Cdc7.AA Ciliate-E2 78-221 17 2.7e-15 48.94 In-house 1-204 (365) Show / Hide 
Range on Protein: 78-221
Range on HMM: 1-204/365
Sequence Identity: 17% (36 aa)

FTVLDKIGEGTFSSVYRATLKKTP--------------------DCNQEFALKHIIPT--SHPSRILSELSCLV------------RIGGCHNVMGVKLT
. .. |||.|.|.|||... .|..                    . ....|.| ...    . ....... ..             ..  . |..  . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VR--EKDNIVIVMPHFKHNKFQD---------------FYHDMTVKEVQDYLRALF---------------IALRRVHKFN-VIHRDVKPGNFLYNRHSR
     ..|| .||  ....  .|                 . .| ||.... . ..                ||.  |. | .|||| || | |.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

KYALVDFGLAQ
   ..||||..
-IKIIDFGLSK
Kinase Cdc7.AA CDK 482-587 17 4.1e-15 44.65 In-house 253-284 (284) Show / Hide 
Range on Protein: 482-587
Range on HMM: 253-284/284
Sequence Identity: 17% (19 aa)

VKLPAMELKTMCRQLRLGAVQRRQSKSSQSNGESSKRRRRSINQTSPPKEETVGSPESQRSVGSVGSEEGLVDQFPDTAYDLLGRLLELDPHKRITAEQA
.|||                                                                            ||| ..| .||.|||.||||
TKLPDY--------------------------------------------------------------------------DLLNKMLCYDPKKRISAEQA

LKHPFL
|.||..
LQHPYF
Kinase Cdc7.AA CAMK1 562-587 50 2.8e-14 37.87 In-house 251-276 (276) Show / Hide 
Range on Protein: 562-587
Range on HMM: 251-276/276
Sequence Identity: 50% (13 aa)

DLLGRLLELDPHKRITAEQALKHPFL
|..  .||.|| ||.|.||.|.||..
DFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase Cdc7.AA PITSLRE 558-587 53 6.6e-14 47.2 In-house 266-295 (295) Show / Hide 
Range on Protein: 558-587
Range on HMM: 266-295/295
Sequence Identity: 53% (16 aa)

DTAYDLLGRLLELDPHKRITAEQALKHPFL
||..||| ..|...| .||||..|||||. 
DTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Cdc7.AA Pkinase 404-460 32 3.4e-13 47.72 Pfam 171-232 (293) Show / Hide 
Range on Protein: 404-460
Range on HMM: 171-232/293
Sequence Identity: 32% (20 aa)

RAGTPGFRSPEVLLKCPDQTTAVDMWAAGVIFLSILSGRYPFFRA-----PDDFTALAQIMS
..|||....|||...... ...||||..|.|.   |.|| ||  .      |.   ...||.
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMG
Kinase Cdc7.AA CK2 404-466 30 7e-13 34.03 In-house 155-217 (288) Show / Hide 
Range on Protein: 404-466
Range on HMM: 155-217/288
Sequence Identity: 30% (19 aa)

RAGTPGFRSPEVLLKCPDQTTAVDMWAAGVIFLSILSGRYPFFRAPDDFTALAQIMSIMGTEE
| ..  .. || |.   .   ..|||. |..| |..  . |||.  |  ..| .|. ..|||.
RVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTED
Kinase Cdc7.AA CAMK 560-587 46 9e-12 33.48 In-house 398-425 (425) Show / Hide 
Range on Protein: 560-587
Range on HMM: 398-425/425
Sequence Identity: 46% (13 aa)

AYDLLGRLLELDPHKRITAEQALKHPFL
. ||. ..|. || ||.|.||.|.||..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Cdc7.AA CAMK1 78-113 35 4.1e-11 28.5 In-house 1-36 (276) Show / Hide 
Range on Protein: 78-113
Range on HMM: 1-36/276
Sequence Identity: 35% (13 aa)

FTVLDKIGEGTFSSVYRATLKKT-PDCNQEFALKHII
. . ..||.|.|| ||..| |.|    ....|.| |.
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCID
Kinase Cdc7.AA Pkinase 557-587 41 5.8e-11 39.84 Pfam 263-293 (293) Show / Hide 
Range on Protein: 557-587
Range on HMM: 263-293/293
Sequence Identity: 41% (13 aa)

PDTAYDLLGRLLELDPHKRITAEQALKHPFL
.... |.. ..|..||.||.||||.|.||..
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Cdc7.AA CAMK1 189-446 12 9.1e-11 27.46 In-house 125-217 (276) Show / Hide 
Range on Protein: 189-446
Range on HMM: 125-217/276
Sequence Identity: 12% (32 aa)

HKFNVIHRDVKPGNFLYNRHSRKY--A--LVDFGLAQAVPTRSSAKTTVKPSTVGGVLHHDTPRPPQARKNTRRAVSTSENKALTRVEPKRTQSESHSKV
|. .. ||| || | ||   .     .  . ||||.. .   .                                                         
HSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--------------------------------------------------------

PKLVELDPNTFHSTDKSSRDRSNHRLDSVNEDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKPVILTRNCAAIATRGVTRRLQDMPKTPQGICGC
                                                                                                    
----------------------------------------------------------------------------------------------------

YGLPRVCDVCMAKKNQVAPRAGTPGFRSPEVLLK--CPDQTTAVDMWAAGVIFLSILSGRYPFF
                   . ||||.  ||||          |.||| .|||.  .| |  ||.
---------------LMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFY
Kinase Cdc7.AA CDK 411-464 34 9.1e-10 27.25 In-house 186-243 (284) Show / Hide 
Range on Protein: 411-464
Range on HMM: 186-243/284
Sequence Identity: 34% (20 aa)

RSPEVLLKCPDQT--TAVDMWAAGVIFLSILS--GRYPFFRAPDDFTALAQIMSIMGT
|.||.|| . . .  |..|||..| ||  ..    | |.|    .   |  |  |.||
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT
Kinase Cdc7.AA Ciliate-E2a 166-234 25 3.1e-09 23.38 In-house 92-170 (275) Show / Hide 
Range on Protein: 166-234
Range on HMM: 92-170/275
Sequence Identity: 25% (20 aa)

YHD-MTVK--EVQDYLRALF-IALRRVHKFNVIHRDVKPGNFLYN---RHS---RKYALVDFGLAQAVPTRSSAKTTVK
... .. .  |. |... |.  .|  .|. |..||| || |.|..     |    .  ..|||||. ... .  .  .|
QCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQK
Kinase Cdc7.AA CK2 560-587 42 3.9e-09 22.64 In-house 261-288 (288) Show / Hide 
Range on Protein: 560-587
Range on HMM: 261-288/288
Sequence Identity: 42% (12 aa)

AYDLLGRLLELDPHKRITAEQALKHPFL
| |.| ..|  |. .||||  |..||. 
AIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase Cdc7.AA Ciliate-E2a 397-445 38 4.5e-09 22.89 In-house 163-216 (275) Show / Hide 
Range on Protein: 397-445
Range on HMM: 163-216/275
Sequence Identity: 38% (21 aa)

KKNQVAPRAGTPGFRSPEVLLKCP---DQ--TTAVDMWAAGVIFLSILSGRYPF
.|... .. ||||.  ||||       ..  .| .||| .||||   |.|. ||
EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPF
Kinase Cdc7.AA CDK 78-207 25 6.9e-09 24.39 In-house 1-143 (284) Show / Hide 
Range on Protein: 78-207
Range on HMM: 1-143/284
Sequence Identity: 25% (39 aa)

FTVLDKIGEGTFSSVYRATLKKTP--DCNQEFALKHIIPTS-----H----PSRILSELSCLVRIGGCHNVMGVKLTVREK-----------DNIVIVMP
.  |.||||||.  ||.|  |.|     .|  ||| |.  .     .    |.  . | |.|  .  ..|.  ..  .  |            ....|..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

HFKHN--KFQDFYHDMTVKEVQDYLRALFIALRRVHKFNVIHRDVKPGNFLYNR
.  |   |. |         .. |.. |  .|   |. ...||| || | |.|.
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINN
Kinase Cdc7.AA Ciliate-E2a 78-102 44 3.7e-08 20.14 In-house 1-25 (275) Show / Hide 
Range on Protein: 78-102
Range on HMM: 1-25/275
Sequence Identity: 44% (11 aa)

FTVLDKIGEGTFSSVYRATLKKTPD
. ...|||.|.| ||| |..|.|..
YKFIKKIGKGNFGSVYLAQHKQTGK
Kinase Cdc7.AA PITSLRE 411-435 56 3.2e-07 22.58 In-house 173-197 (295) Show / Hide 
Range on Protein: 411-435
Range on HMM: 173-197/295
Sequence Identity: 56% (14 aa)

RSPEVLLKCPDQTTAVDMWAAGVIF
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RAPELLLGCKKYSTPVDMWSVGCIF
Kinase Cdc7.AA Ciliate-E2-Unclassified 78-100 34 2e-06 18.01 In-house 1-23 (352) Show / Hide 
Range on Protein: 78-100
Range on HMM: 1-23/352
Sequence Identity: 34% (8 aa)

FTVLDKIGEGTFSSVYRATLKKT
.... .||.| |..||..  ||.
YKIIKQIGQGGFGKVYKCQHKKQ
Kinase Cdc7.AA PITSLRE 78-100 52 1.2e-05 16.77 In-house 1-23 (295) Show / Hide 
Range on Protein: 78-100
Range on HMM: 1-23/295
Sequence Identity: 52% (12 aa)

FTVLDKIGEGTFSSVYRATLKKT
|  |..|.|||.  ||||  |.|
FQCLNRIHEGTYGVVYRAKDKRT
Kinase Cdc7.AA TyrKc 78-287 13 3.2e-05 -138.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 78-287
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

FTVLDKIGEGTFSSVYRATLKKTPDCNQEFALKHIIPTSHPSRILSELSCLVRIG-GCHNVMGVKLTVREK-------DNIVIVMPHFKHNKFQDFYHDM
 | ..|.||| |  ||..|.|      .. | | . . .    ...|.. . ..|    |.      ....       . . ||| . .|   .|. .. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

TVKEVQDYLRALFIALRRVHKF--------------NVIHRDVKPGNFLYNRHSRKYALV---DFGLAQAVPTR----SSAKTTVKPSTVGGV-------
  |          . ..  ..|              |.||||    | |...       |   ||||. ..        | .. .| .. ||        
RPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

------LHH----------------------DTPRPPQAR--KNTRRAVSTSENK-ALTRVEP--------------------------KRTQSESHSKV
       ..                      ..| | ..   .. ....   ..   . . .                           .|   .    .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

PKL
 ..
ECF
Kinase Cdc7.AA PITSLRE 189-220 43 0.031558 4.17 In-house 123-153 (295) Show / Hide 
Range on Protein: 189-220
Range on HMM: 123-153/295
Sequence Identity: 43% (14 aa)

HKFNVIHRDVKPGNFLYNRHSRKYALVDFGLA
|.  ..||| |  | ||. |.    . |||||
HDNWIMHRDLKTSNLLYS-HKGILKICDFGLA