Gene NKF1 (Sea Urchin)

NKF1

Species: Sea Urchin
Alias: SPU_014253, NKF1, Spk180
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
NKF1.AA Protein None 389 None Fasta, JSON
NKF1.kin_dom Protein Kinase Domain None 331 None Fasta, JSON

Protein domain

Protein domains of NKF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NKF1.AA NKF1 31-292 49 8.10000000001e-180 603.68 In-house 1-269 (269) Show / Hide 
Range on Protein: 31-292
Range on HMM: 1-269/269
Sequence Identity: 49% (134 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNNIKFKDFHREIVLSCELSVHAAVVATLPDTFESTD--AYMMLQEYAPYGDLLEAIPP--QRGLDE
|..|..|.||.||||.|.....||.|.|||...|...|.||||||....|.||.|...|.|....|...|  .|...|||||.|||.|.|.|  ||||.|
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

IRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDK-DLTVAKLSDFSRTRRRGSLVRKNARSIPYSPPEVSQALE-NESFALEPSQDSWHFGVMLFCV
...|.|.||.|.||.|.||..|||.|.||||||.||. |....||.||..||.||..||......||..|||.|.|. ||.|...||.|.|.|||..||.
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

LTGMFPWEIADSTRSSCFEEFTRWQKRK-VTVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYI
|||.|||..||.....|.|.|..||.|| ....|..||.|||......||||.|..|||..|...|||.
LTGCFPWQKADWMCDPCYEWFMWWQRRKQPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase NKF1.AA S_TKc 31-297 22 5.9e-33 116.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 31-297
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNNIKFKDFHREIVLSCELSVHAAVVATLPDTFESTDAYMMLQEYAPY--GDLLEAIPPQRG-----
|. . .. .| .||  . ..|..| ..|.|.||      ... ||| .  .   |   . .| |.|.. | . |  ||..   |||.. |  ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDKDLTVAKLSDFSRTRRRGSLVRKNARSIPYSPPEVSQALENESFALEP-SQDSWHFGVML
 ..| .... ..|.. || ..||.. .| |.||||.|| .    . |..||   |.     .    .  | .|||            . . | | .|..|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

FCVLTGMFPWEIADSTRSSCFEEFTRWQKRKVTVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYIG----DSWL
.  |.|  |..    .    |.                    .| .. . ||.|.   |.| .. .. ..      . |.
YEMLCGYPPFP----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NKF1.AA Pkinase 31-292 20 1.1e-27 98.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 31-292
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNNIKFKDFHR-----EIVLSCELSVHAAVVATLPDTFESTDAYMMLQEYAPYG----DLLEAIP--
|. .... .|..|.  . ..| .| ..|.|.||| ..| .   .     || .  .|. |  .| .. |.||. | . | .||.. |    || . |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLY-DWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PQRGL--DEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDKDLTVA---KLSDF--SRT--RRRGSLVRKNARSIPYSPPEVSQALENESFALEP
 ....  .|  .|... |.. .| ..||.. .| |.||||.|.  .. ...   |..||  ..     ..|     . ...| .||| .    ..    |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGP

SQDSWHFGVMLFCVLTGMFPWEIA--DSTRSSCFEEFTRWQKRKVTVAPPAWRNFT-----------------PKLLKLCRKLLEPKAERRGSVSQIHKY
. | | .|..|...|.| .|.  .  . .  .  . . |  ....    | |..                   . ........|... ..| .  || . 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--I
  .
PWF
Kinase NKF1.AA CAMK 36-173 17 2.4e-20 61.63 In-house 1-240 (425) Show / Hide 
Range on Protein: 36-173
Range on HMM: 1-240/425
Sequence Identity: 17% (43 aa)

VLKEGNYGKIELIVDKRSG------------VRYALKQIKKNNIK-----------------------------FKDFHREIVLSCELS-----VHAAVV
.| .|..||  | ..|...            ...| | |.|. .|                              | . ||| .   |.     ..   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ATLPDTFES-------------------TDAYMMLQ---EYAPYG----DLLEAI--PPQ-------------RGLDEIRVKSCLAQVAAALSFLHSKRL
  | ...|.                   .. . |     ||.. |    ||.. |   ..             . ..|  .. .  |.. |. ..||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHGDVKPENVLLFDKDL---------------TVAKLSDF
|| | ||||.|| |..                   |..||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase NKF1.AA Ciliate-E2 31-292 15 6.4e-20 65.05 In-house 1-365 (365) Show / Hide 
Range on Protein: 31-292
Range on HMM: 1-365/365
Sequence Identity: 15% (59 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNN---------IKFKDFHREIV----LSCELSVHAAV-----------------------VATLPD
|  | .. .||.|.. .  ... . ..|.|.|. ..          | | .  .|.    .   ...                           .  . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TFE--STDAYMMLQEYAPYGDLLE------AIPPQR-----GLDEIRVKSCLAQVAA---------------ALSFLHSKR-LVHGDVKPENVLLFDKDL
.|.  ... . .  ||. .|||..         ..       ..|  .|   .|..                || .||||   .| | ||||.|.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

TVAKLSDFS--------RTRRRGSLVRKN---------------------------ARSIPYSPPEVSQALENE----SFALEPSQDSWHFGVMLFCVLT
   |..||         . .|.. ... .                           . . .| .||. .  ...    .     . | | .||.|.. |.
--IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GMFPWEIADSTRSSCFEEFTRWQKRKVTVAPP--------------AWRNFTPKLLKLCRK----LLEPKAERRGS-VSQI--HKYI
| .|.             .   .. |.   .|               | . ...   |..|    .|. . | | .  .||  |...
GKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NKF1.AA CAMKL 31-173 23 8.2e-18 53.29 In-house 1-173 (297) Show / Hide 
Range on Protein: 31-173
Range on HMM: 1-173/297
Sequence Identity: 23% (41 aa)

YTPIGVLKEGNYGKIELIVD-KRSGVRYALKQIKKNNIKFKDFHR----------------EIVLSCELS--VHAAVVATLPDTFESTDA------YMML
|. . .| .|..||  | .. .  |...| | |.|. |. ... .                || .   |.   |  ..  | ...|  .       . . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIK-LYEVIETPEHDIETKKIYLV

QEYAPYGD--LLEAI--PPQRG--LDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDKDLTVAKLSDF
 ||.. |.  |.. |   . |.  ..|   .    |. .|....||.. || | ||||.|| ...  ..|..||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF
Kinase NKF1.AA Ciliate-E2-Unclassified 31-292 18 9.2e-18 58.2 In-house 1-352 (352) Show / Hide 
Range on Protein: 31-292
Range on HMM: 1-352/352
Sequence Identity: 18% (67 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNNIKF-KDF---HREIVLS----CELS-----------------VHAAVVATLPDTFESTDAYMML
|. | .. .|..||. . ..|  .  ||.|..||..|.  |     . ||...    ....                     ..  . ..|....   . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

QEYAPYGDLLEAIPPQRG-----------------LDEIRVK-----SCLAQVAAALSFLHSK-RLVHGDVKPENVLLFDKDLT--VAKLSDFSRTRRRG
 ||...|||.. |  . .                 ..|  .|       .||.  .|..||.|   .| | ||||. |||..      |..||.  .. .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENI-LFDNNGKNYYIKIIDFGISKKYQ

SL------------------VRKNARSIPYS----PPEVSQA-LENESFALEPSQDSWHFGVMLFCVLTGMFPWEIADSTRSSC----------FEEFTR
.                      .. .. |     .||| |    ..| |   . | | .|| |.. |.| .| .  ... . .          .... .
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

WQKRKVTVAPPAW-----RNFTPKLLKLCR----KLLEPKAERRGSVSQI--HKYI
..| | .  |...      .  |.   ...    |.|. . . | . .||  | ..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NKF1.AA MSK 112-297 25 9.8e-18 56.53 In-house 86-277 (277) Show / Hide 
Range on Protein: 112-297
Range on HMM: 86-277/277
Sequence Identity: 25% (49 aa)

GDLLEAIPPQRGLDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDK--DLTVAKLSDF--SRTRRRGSLVRKNA--RSIPYSPPEVSQALENES
| |.. |   .  || ..   ....  |....|.|. .|.| ||||.|. |.  . .| ||.||  .| . ..   | .    .. | .||. .  . . 
GELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHV-KLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQD

FALEPSQDSWHFGVMLFCVLTGMFPWE-IADSTR---SSCFEEFTRWQKRKVTVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYIGDSWL
    .. | |  || |.  |||  |    .|. .   .|  |   | .| ..     || |. |.   | ..||. . ..| ... . .   ..|.
GGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRA---HEWK
Kinase NKF1.AA CAMK-Unique 31-160 18 6.4e-17 52.19 In-house 1-190 (363) Show / Hide 
Range on Protein: 31-160
Range on HMM: 1-190/363
Sequence Identity: 18% (36 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKK---NNIKFKD------------------FHREIVLSCELSVHAAVVATLPDT----FESTD-----
|. . ....||.|..    |.  |. .| | .||    |.| |                   . ||...   .. |   .  | |.    |.  .     
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVD-HPNIIK-LYDWNNPIFCDRKYPLCD

----------AYMMLQEYAPYGDLLEAIPP--------------------QRGLDE--IRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLL
          .. ...||.. |||...|                      |. . |    . .  .... |....||.  ||.| |.||...
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMV
Kinase NKF1.AA STE 31-173 18 5.2e-15 49.54 In-house 1-191 (359) Show / Hide 
Range on Protein: 31-173
Range on HMM: 1-191/359
Sequence Identity: 18% (36 aa)

YTPIGVLKEGNYGKIELIVDKR---------------SGVRYALKQIKKNNI------------------KFKDFHREIVLSCELSV-HAAVVATLPDTF
.. |... .|..|.  . ...                .|...| ||....|                   ..... .|| .  ...  |  .|  . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY-GCY

E-------STDAYMMLQEYAPYGDLLEAIP----PQRGLD----------EIRVKSCLAQVAAA-LSFLHSKRLVHGDVKPENVLLFDKDLTVAKLSDF
.       . |   .  || ..| | . |     ....|.          |  ..  . |.  . |..|||.. .| |.|| |.||       .||.||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDF
Kinase NKF1.AA Ciliate-A7 129-173 38 6.7e-14 46.88 In-house 133-182 (360) Show / Hide 
Range on Protein: 129-173
Range on HMM: 133-182/360
Sequence Identity: 38% (19 aa)

VKSCLAQVAAALSFLHS-KRLVHGDVKPENVLLFDKDLTV----AKLSDF
...|. |.| ||  ||. | ..|.|.||||...|..  .     .||.||
MRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADF
Kinase NKF1.AA Aur 105-160 41 3.2e-13 30.72 In-house 77-134 (257) Show / Hide 
Range on Protein: 105-160
Range on HMM: 77-134/257
Sequence Identity: 41% (24 aa)

LQEYAPYGDLLEAIPPQ--RGLDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLL
..|||| |.| . .  |  . .||.|     .|.. || ..|||  .| | ||||.||
ILEYAPGGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILL
Kinase NKF1.AA TyrKc 31-292 20 5.6e-11 -45.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 31-292
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKNNIKFKDFHREIVLSCEL-SVHAAVVATLPDTFEST------DAYMMLQEYAPYGDLLEAIPPQRG
 | . .| ||..|.. . . |   .  | | .|..    .||.||. . |.|   |  .|. .    ..       . .|.. ||.|.|||.. .   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDKDLTVAKLSDF--SRTRRRG-------SLVRK----NARS-IPY--SPPEVSQALENESF
 |      |   |.|.  ..||||...| |    |.|. ..   ..| |||  ||    .       .  ||    .... .|.   .||.        .
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------N

ALEPSQDS--WHFGVMLFCVLT-GMFPWE------IADSTRSSCFEEFTRWQKRKV-----TVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYI
  . .  |  | |||... ..| |. |..      . ..    . ..  |  . .                .... .. ..  . ..| | . |.||...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase NKF1.AA Pkinase_Tyr 102-173 27 4.8e-08 27.87 Pfam 82-155 (270) Show / Hide 
Range on Protein: 102-173
Range on HMM: 82-155/270
Sequence Identity: 27% (21 aa)

YMMLQEYAPYGDLLEAIPP----QRGLDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDKDLTVAKLSDF
...  ||.|.||||.        .. |.  .  .  .|.|.....|.||...| |.   |.|. . .. |.| .||
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NN-VVKICDF
Kinase NKF1.AA Aur 39-68 33 1e-06 13.05 In-house 9-38 (257) Show / Hide 
Range on Protein: 39-68
Range on HMM: 9-38/257
Sequence Identity: 33% (10 aa)

EGNYGKIELIVDKRSGVRYALKQIKKNNIK
.| .|.  |. .| .. ..|||...|..||
KGKFGNVYLARHKKTHFIFALKVMFKEQIK
Kinase NKF1.AA CAMKL 210-297 23 0.014763 3.81 In-house 215-297 (297) Show / Hide 
Range on Protein: 210-297
Range on HMM: 215-297/297
Sequence Identity: 23% (21 aa)

PSQDSWHFGVMLFCVLTGMFPWEIADST--RSSCFEEFTRWQKRKVTVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYIGDSWL
|  | |  ||.|.  ..| .|.. ..      ...    .|....    || |      .  | ||.|... |.| .. || .   . |.
PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI--YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN---HPWM