Spk377

Species: Sea Urchin
Alias: SPU_013806, Spk377
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchA

Sequence

Name Sequence Type Origin Length Description Download
Spk377.AA Protein None 734 None Fasta, JSON
Spk377.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of Spk377.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk377.AA urchA 479-673 56 1.2e-152 495.63 In-house 1-208 (208) Show / Hide
Range on Protein: 479-673
Range on HMM: 1-208/208
Sequence Identity: 56% (117 aa)

LGRGVAGTVYLFRHAVSKIPVAAKLVEYPG---------ECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLEKSMLK
|||||.|||.|.||.....|||.|..|.|.         |||.||..|||.....||||||||...|..|. ..||||.|.|....|||||.||.|.|..
LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM

TGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVE-ESGLWRAKIIDLGWASAIATPF---VMPLDEEQIDFYRSGRGCCHIAPECVLDARP
..|.||||.|..|....|||||..|.||||||||||||.||.. |.|.|||||||.|||. ...||   .|..|..|..|||....||||||||.|||.|
RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP

CSTSSDVY
||||||||
CSTSSDVY

Kinase Spk377.AA urch 479-676 43 9.79999999999e-113 380.83 In-house 1-217 (217) Show / Hide
Range on Protein: 479-676
Range on HMM: 1-217/217
Sequence Identity: 43% (94 aa)

LGRGVAGTVYLFRHAVSKIPVAAKLVEYPG-----------------ECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITD
.|||..|.|.|.||. .|.||| | ...|                  |.|..|...||..|| |.||.||| .||| |. .|.|||.|......||....
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW

CLEKS-MLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVE-ESGLWRAKIIDLGWASAIATPF-VMPLDEEQIDFYRSGRGCCHIAPE
|..|| |....|.|....|. ... ...|..|.|..|||.|||||||||... ..| |.|.|||.||.. ...|| .|....|....|..|.|.||||||
CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE

CVLDARPCSTSSDVYSLG
||||..|||..|||||.|
CVLDGQPCSIASDVYSVG

Kinase Spk377.AA urch-unclassified 514-676 30 2e-36 127.15 In-house 52-215 (215) Show / Hide
Range on Protein: 514-676
Range on HMM: 52-215/215
Sequence Identity: 30% (51 aa)

EVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLEKSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEE
|...|.. .. | ||  ||  .. .. . ..||| |  .  . |.  . .     |  | | . .|. ..  . .|..|.|... | |||| .|.|.   
EAMVHRLFADHPYFPRCYGMVKHEDCPC-IVMEFLGDKQTYTVYPLCQWIHERH-KSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWC

SG--LWRAKIIDLGWASAIATP---FVMPLDEEQIDFYRSGRGCCHIAPECVLDARPCSTSSDVYSLG
.    |.|.|||.| .| .. |   .  .. |..   |..|    |.||| ||.  | |  ||.||||
DHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMRE--YMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG

Kinase Spk377.AA urchC 511-679 30 6e-21 64.39 In-house 54-223 (223) Show / Hide
Range on Protein: 511-679
Range on HMM: 54-223/223
Sequence Identity: 30% (52 aa)

FRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLE-KSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVL
.. | |. | .|. |.|| .||   ||..  .   ||.|.    ..|   | .. .      |..       .   . .|  ..|. | | || | ||||
CEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVT-EFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVL

VVEESGLWRAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCHIAPECVLD--ARPCSTSSDVYSLGRLL
       | . |||.|  | .| |  .      .   . . |  ||||| |||      | .||.|| | .|
LEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAPE-VLDIDGCQVSVASDIYSVGVIL

Kinase Spk377.AA urchB 586-676 39 1.1e-13 45.7 In-house 121-212 (212) Show / Hide
Range on Protein: 586-676
Range on HMM: 121-212/212
Sequence Identity: 39% (36 aa)

VAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATPFVM-PLDEEQIDFYRSGRGCCHIAPECVLDARPCSTSSDVYSLG
.  |.  .|  | | |||| ||||       . | ||| | .| |  |  |  . .|    |  |     |||| .|.  . | ||||.| |
IVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG

S_TKc Spk377.AA S_TKc 473-717 18 3.4e-11 -12.77 SMART 1-231 (231) Show / Hide
Range on Protein: 473-717
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVEYPGECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGS--ESEDRSYTITDCLEKSMLKT
 .   ..|.|  |.||. ||  ..  || | .    | .|.|..|..   . |.  ..|..|.   |   . ||...    .          | . . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD----------LFDYIKKR

GPD-----LTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCH----IAPECVL
|.      ..  .  ...  ....|. .||.|..  ||| .|.|. |     . ||.| | |  .                   . .|     .||| . 
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-

DARPCST-SSDVYSLG--------------RLLAMVGRAMRYDDFECFGTQIYLADEDQRPTVQEIID--------QLY
   . .. ..|..|.|               . .|  . .  ...  |  ..   | ..|||. |.          .  
---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk377.AA urchB 517-549 54 2e-06 19.11 In-house 62-93 (212) Show / Hide
Range on Protein: 517-549
Range on HMM: 62-93/212
Sequence Identity: 54% (18 aa)

IHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVG
||| .|. |.|| |.|  ||| |   .| ||||
IHQLMSDSPYFPKFWGTLDIDNDL-CQAQEFVG

Kinase Spk377.AA TKL 585-676 21 3e-06 18.35 In-house 140-276 (364) Show / Hide
Range on Protein: 585-676
Range on HMM: 140-276/364
Sequence Identity: 21% (29 aa)

GVAEGLKALHS--------KGFLCNDLKEDNVLVVEES-----------GLWRAKIIDLGWASAIATPFVMPLDEEQID------FYR--SGRGC---CH
..| |.  |||        .. .  ||| .|.|| |               |..|| |.| .  . . . |   .  .        .|  ... |   ..
DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW

IAPECVLDA---------------RPCSTSSDVYSLG
 |||.  ..               .. |...|||| |
MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

Kinase Spk377.AA LISK-DD1 585-627 40 6e-06 17.74 In-house 131-174 (290) Show / Hide
Range on Protein: 585-627
Range on HMM: 131-174/290
Sequence Identity: 40% (18 aa)

GVAEGLKALHSKGFLCNDLKEDNVLVVEE-SGLWRAKIIDLGWA
..|..   ||||. .  |||  | || |  ...||.|..|.| |
DIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFA

Kinase Spk377.AA Dicty5 585-625 39 7e-06 16.19 In-house 112-149 (260) Show / Hide
Range on Protein: 585-625
Range on HMM: 112-149/260
Sequence Identity: 39% (16 aa)

GVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLG
..| ... |||..    |||  |.|. |.   | .|||| |
DIAQSMRHLHSMNIIHRDLKSMNFLITEN---WKIKIIDFG

Kinase Spk377.AA C8 588-679 21 1e-05 15.99 In-house 134-226 (226) Show / Hide
Range on Protein: 588-679
Range on HMM: 134-226/226
Sequence Identity: 21% (21 aa)

EGLKALHSKGFLCNDLKEDNVLVVEESGLW-RAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCHIAPECVLD----ARPCSTSSDVYSLGRLL
.|.  .|.| ..  |.| .| || ..       |. |.| ||..       .. .             .|||   .     .  .  ||..|.| .|
DGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase Spk377.AA Ciliate-C7 586-609 54 1.5e-05 14.3 In-house 111-134 (164) Show / Hide
Range on Protein: 586-609
Range on HMM: 111-134/164
Sequence Identity: 54% (13 aa)

VAEGLKALHSKGFLCNDLKEDNVL
.|.||   |||... |||| || |
IAQGLYYIHSKNCVVNDLKMDNIL

TyrKc Spk377.AA TyrKc 473-716 19 0.000681 -159.68 SMART 1-280 (280) Show / Hide
Range on Protein: 473-716
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVE--YPGECFRNEVRIHQAISGL-PWFP---TFYGSFDIDG------DQSVLAMEFVGSESEDRSYTIT
 .   .||.|  |.||. .     |.|| | .      | |..| ||    . | .  |    .||    .|      ..  . ||..            
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARI---MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG---------

DCLEKSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATP-FVMPLDEEQIDFYRSGRGCCH-----
 .| .   |..|.|. ..  .    .|.|   ||||..   ||   |.|| |.    ..|| | | . .|          |..     .......     
-DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPI

--IAPECVLDARPCSTSSDV----------YSLGRLLA-------MVGRAMRYDDFECFGTQIYLA-----------------------DEDQRPTVQEI
   ||||  . . ..| |||          ...|           |  . .. .  . .   .                          | ..||| .||
RWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IDQL
....
HECF

Kinase Spk377.AA TKL 704-716 46 0.029376 3.95 In-house 352-364 (364) Show / Hide
Range on Protein: 704-716
Range on HMM: 352-364/364
Sequence Identity: 46% (6 aa)

DQRPTVQEIIDQL
..||. |||...|
EKRPSFQEILKRL

Kinase Spk377.AA urchB 478-502 48 0.05021 3.46 In-house 6-30 (212) Show / Hide
Range on Protein: 478-502
Range on HMM: 6-30/212
Sequence Identity: 48% (12 aa)

ELGRGVAGTVYLFRHAVSKIPVAAK
| |||  | | . ||   |.| | |
EIGRGTYGRVVIARHRQTKVPLAIK

Kinase Spk377.AA urch-unclassified 479-500 36 0.137135 1.82 In-house 1-22 (215) Show / Hide
Range on Protein: 479-500
Range on HMM: 1-22/215
Sequence Identity: 36% (8 aa)

LGRGVAGTVYLFRHAVSKIPVA
.| |  | |.. ||    .||.
IGKGTFGKVFMMRHQREAVPVK

Kinase Spk377.AA Pkinase 586-625 34 0.166849 6.4 Pfam 117-157 (293) Show / Hide
Range on Protein: 586-625
Range on HMM: 117-157/293
Sequence Identity: 34% (14 aa)

VAEGLKALHSKGFLCNDLKEDNVLVVEESGL-WRAKIIDLG
...||. .||.|..  ||| .|.|....  .  . ||.| |
ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG

Pkinase Spk377.AA Pkinase 473-509 27 0.258114 5.73 Pfam 1-37 (293) Show / Hide
Range on Protein: 473-509
Range on HMM: 1-37/293
Sequence Identity: 27% (10 aa)

SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVEYPGE
 ..   .|.|  |.||. .|  . . || | .....|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE

Kinase Spk377.AA Pkinase 655-676 27 1.651286 2.88 Pfam 178-199 (293) Show / Hide
Range on Protein: 655-676
Range on HMM: 178-199/293
Sequence Identity: 27% (6 aa)

IAPECVLDARPCSTSSDVYSLG
.||| ...... ....|..|.|
MAPEVIRGGQYYGPKVDMWSCG