Spk376

Species: Sea Urchin
Alias: Spk376, SPU_012859
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk376.AA Protein None 759 None Fasta, JSON
Spk376.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of Spk376.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk376.AA urchC 40-258 70 1e-183 600.09 In-house 1-223 (223) Show / Hide
Range on Protein: 40-258
Range on HMM: 1-223/223
Sequence Identity: 70% (158 aa)

QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYM
|||||..||||||||||||||||||||.|||..|.|..|.|.|||..||.|.|||||||.|.||||.|||||..||||.|...|.||||||||.|||.||
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM

LMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP-HLSGSNGSMSTHAKGY-FIHTAP
|.||.||||||||.|.|||||.|||.|||||||...|...||||||||||||||.||.||...|||.|||||..|| |..|.|..|..|.|.| |||.||
LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP

EVLK--GCATSVASDVYSVGIIL
|||.  ||..|||||.||||.||
EVLDIDGCQVSVASDIYSVGVIL

Kinase Spk376.AA urch 46-255 46 1.9e-123 416.4 In-house 1-217 (217) Show / Hide
Range on Protein: 46-255
Range on HMM: 1-217/217
Sequence Identity: 46% (100 aa)

VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLT--AELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYMLMDA
.|.|.||.|.|.|....|.|| ||.....||.|  .|.|....|... |..|||. ...||..||||.|.|.|. |.|.|||.||||||..||.|.|...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

ICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKN-RWVAVIIDLGMVSTVTYP-HLSGS-NGSMSTHAKGY-FIHTAPEV
|.....|.| |...|||...|.|||..|. |.|. ..||||.|.||||||.|.. ||.|||||.|.|.|.|.| ..... ...|.....|. ..|.|||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

LK-GCATSVASDVYSVG
.. |...|.||||||||
VLDGQPCSIASDVYSVG

Kinase Spk376.AA urch-unclassified 46-216 36 7e-46 158.74 In-house 1-172 (215) Show / Hide
Range on Protein: 46-216
Range on HMM: 1-172/215
Sequence Identity: 36% (64 aa)

VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRK---QCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYMLMD
 |||..| | ..|. .|  || .|   ...|  .. .|  ..     . |  |||.  . .. .||||| .| |   .. |.| ||.|||  ...| | .
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHN--DYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

AICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKN--RWVAVIIDLGMVSTVTYPH
.|  |      | . | .   | .||. |  |.|   |||||.| .|.||. .    || | |||.||.||.|.||
WIHERHKSN--PALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPH

Kinase Spk376.AA urchB 41-215 41 2.5e-33 116.89 In-house 2-168 (212) Show / Hide
Range on Protein: 41-215
Range on HMM: 2-168/212
Sequence Identity: 41% (73 aa)

TILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQ--CNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTY
  |  .| |.|| |.. |    | |  ||      |     |  |  .     |  |||    .|| |||||.|.||   | | |.  ||.| |  |  |
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY

MLMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP
 |             |     | | | |||..|.  .|   ||||| | |||||| |  |. ||||| |||||.| |
PLHEP----------PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAP

Kinase Spk376.AA TKL 46-258 16 3.2e-20 69.52 In-house 1-279 (364) Show / Hide
Range on Protein: 46-258
Range on HMM: 1-279/364
Sequence Identity: 16% (51 aa)

VGKGSYGEVMLGRLNGEK--------DPVVIKRALVKQNLTAELEESD-------------RKQCNIRCEKEARAGLMMST--SPYFPRFLGTVMTDGD-
.|.|..|||  |...|.          .|..|.  ....   .. . .              .     ...| .  .|||    |   .|.| ..  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HCLVTEFI-----GDKIQGKTYMLMDAICPRKGCDPVPDVQKWNL-VAIGEDIIRGVIALHGLS--------LLHNDIKDDNVLLE--
            .|.|.|..      . ..                        |.. . .  || ||.  ||           ..| |.| .|.|.   
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN

---------FRKNRWVAVIIDLGMVSTVTYPH--------------LSGSNGSMSTHAKGYFIHTAPEVLKGC----------------ATSVASDVYSV
          ... |.. | |.|   ...                 .. .|.... .  | . . |||||.|                   | ..|||| 
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF

GIIL
||.|
GIVL

Kinase Spk376.AA urchA 95-252 25 1.5e-17 53.29 In-house 44-208 (208) Show / Hide
Range on Protein: 95-252
Range on HMM: 44-208/208
Sequence Identity: 25% (44 aa)

KEARAGLMMSTSPYFPRFLGTVMTDGDHC-LVTEFIGDKIQGKTYMLMDAICP----RKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDN
.|..   . . .|.|| |.|    ..|   .  ||.||  .|. | ... .      |.     |.  .    ..  ||  |  ..|    | || |.||
NEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQ-----PALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDN

VLLEF-RKNRWVAVIIDLGMVSTVTYPH------LSGSNGSMSTHAKGYFIHTAPE-VLKGCATSVASDVY
.|.      || |.|||.|  . .  |       ..          ...  | ||| .|..   | .||||
CLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRC-CHIAPECALDAQPCSTSSDVY

Kinase Spk376.AA S_TKc 40-297 18 1e-12 9.56 SMART 1-231 (231) Show / Hide
Range on Protein: 40-297
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYM
 .||...|||..|.|...| .. .  | ||.                    .. ..| .   .    |.  .....  . .. ..|.|...    | .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCD----GDLGD

LMDAICPRKG---CDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPHLSGSNGSMSTHAKGYFIHT-
|.| |. |..   . | |  . . ...    |....  .| .  .| |.| .|.||       .  |.| |.   .                   |. | 
LFDYIKKRGRHGLRFPFPE-HARFYMY---QICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTP

---APEVLKGCATSV-ASDVYSVGIIL-------------DCIGDFIKDDDLCTLVEVCCKEDPKERPGDMEEML-------PGVV
   |||||     .  ..|..|.|.||             . . . |...... ... |.. ||..||.  | .           .
WYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk376.AA C8 168-258 26 1.5e-10 32.9 In-house 132-226 (226) Show / Hide
Range on Protein: 168-258
Range on HMM: 132-226/226
Sequence Identity: 26% (26 aa)

IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRW-VAVIIDLGMVSTVTYPHLSGSNGSMSTHAK---GYFIHTAPEVLKG-----CATSVASDVYSVGIIL
.| ||  .|    .| ||| .| |. . .|      . |.|. |.|.      .  .. ..     | .   |||..|.        .  ||..|||..|
MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSK-----NKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL





Kinase Spk376.AA Ciliate-E3 161-261 31 6.2e-10 27.46 In-house 105-202 (202) Show / Hide
Range on Protein: 161-261
Range on HMM: 105-202/202
Sequence Identity: 31% (32 aa)

LVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPHLSGSNGSMSTHAKG-YFIHTAPEVLKGCATSVASDVYSVG-IIL
.  |   ||.|.||.|   . | ||| || |.  ..|. .. | |.|         |.  .|  .| . | . .  |||...  . |  || |||| ...
IYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESK-----QLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFC

DCI
. .
QLC

Kinase Spk376.AA Ciliate-C8 168-258 26 4.4e-09 29.02 In-house 128-238 (238) Show / Hide
Range on Protein: 168-258
Range on HMM: 128-238/238
Sequence Identity: 26% (29 aa)

IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVII-------DLGMVSTVTYPHL----SGSNGSMST--HA-KGYFIHTAPEVLKG------CATSV
.| .|  ||    .| ||| .| |. | ..    . .       |.|  | ...       .  .|.  .  ..  | .  .||||.|.         | 
MIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSK

ASDVYSVGIIL
 ||.||||..|
KSDSYSVGLVL

Kinase Spk376.AA Ciliate-E2-Unclassified 168-258 23 1e-07 22.9 In-house 152-260 (352) Show / Hide
Range on Protein: 168-258
Range on HMM: 152-260/352
Sequence Identity: 23% (27 aa)

IIRGV-IALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVS--------------------TVTYPHLSGSNGSMSTHAKGYFIHTAPEVLKGCATS
|. |     | .  .| ||| .|.|.   ...    |||.|  .                       . . .|... |.         ||||||.|.  .
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYD

----VASDVYSVGIIL
     ..|..|.|.||
HSKAYKCDIWSLGVIL

Kinase Spk376.AA urch-unclassified 234-255 65 1e-06 20.06 In-house 193-215 (215) Show / Hide
Range on Protein: 234-255
Range on HMM: 193-215/215
Sequence Identity: 65% (15 aa)

HTAPE-VLKGCATSVASDVYSVG
| ||| || |  |||.||.|| |
HMAPEIVLYGQPTSVYSDIYSLG

Kinase Spk376.AA TyrKc 40-314 14 2e-06 -117.95 SMART 1-280 (280) Show / Hide
Range on Protein: 40-314
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTS-PYFP---RFLGTVMTD-------GDHCLVTE-
 | ... | | .|||..|...    .| .|                         .|||   .|.   .  |   |..| ....       . ...|.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREAR---IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

--------FIGDKIQGKTYMLMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPH---
        .. ..                       ..   |. .  .| .|   ||   . | |.   |.|.  ..   .. | | |. |   | .   
MPHGDLKDYLRKHRPK--------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGL-SRDIYDDDQQ

-LSGSNGSMST--HAK--GYFIHTAPEVLKGCATSVASDVYSVGIIL-----DCIGDF-------IKDDDLCTLVEVCCKEDPKER---------PGDME
  |..  ....  ..|       .|||... .  . .|||.| |. .     ..           ......  .|.     .. .          | .| 
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY

EMLPGVVDIKEKHRTVARLAGESL
..     . . . |   .   | .
QIMKQCWHEDPEDRPTFSEIHECF

Kinase Spk376.AA urchB 236-255 66 3e-06 18.97 In-house 192-212 (212) Show / Hide
Range on Protein: 236-255
Range on HMM: 192-212/212
Sequence Identity: 66% (14 aa)

APEV-LKGCATSVASDVYSVG
|||| | | .||..|||.|||
APEVILHGQSTSISSDVFSVG

Kinase Spk376.AA Pkinase 168-258 27 6e-06 22.21 Pfam 117-202 (293) Show / Hide
Range on Protein: 168-258
Range on HMM: 117-202/293
Sequence Identity: 27% (26 aa)

IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVA----VIIDLGMVSTVTYPHLSGSNGSMSTHAKGYFIHTAPEVLK-GCATSVASDVYSVGIIL
|.||.  .|  . .| |.| .|.|.  ...  .      |.| |    .        |.|  |.  |     ||||.. |   . ..|..|.|.||
ILRGLEYCHSMGIIHRDLKPENILID-NNG--HIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

Kinase Spk376.AA Pkinase 40-128 16 0.000125 17.45 Pfam 1-81 (293) Show / Hide
Range on Protein: 40-128
Range on HMM: 1-81/293
Sequence Identity: 16% (15 aa)

QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEF
 .|....|.||.|.| ...  |. . |..|.  .. .   ....  |         |..  ...  .|.  |.......... ..|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEY

Kinase Spk376.AA Ciliate-E2-Unclassified 41-76 22 0.001697 8.02 In-house 2-37 (352) Show / Hide
Range on Protein: 41-76
Range on HMM: 2-37/352
Sequence Identity: 22% (8 aa)

TILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQN
.|... |.|..|.| . . . .|   ..| . ..|.
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI

Kinase Spk376.AA Pkinase_Tyr 41-69 33 0.004209 11.13 Pfam 2-34 (270) Show / Hide
Range on Protein: 41-69
Range on HMM: 2-34/270
Sequence Identity: 33% (11 aa)

TILETVGKGSYGEVMLGRLN----GEKDPVVIK
|.... |.|..|||..|...    ..| || .|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK

Kinase Spk376.AA Pkinase_Tyr 235-253 36 0.174699 5.65 Pfam 181-199 (270) Show / Hide
Range on Protein: 235-253
Range on HMM: 181-199/270
Sequence Identity: 36% (7 aa)

TAPEVLKGCATSVASDVYS
.|||... .  ...|||.|
MAPECINYGKFTTKSDVWS

Kinase Spk376.AA TKL 267-286 30 0.204975 0.87 In-house 336-355 (364) Show / Hide
Range on Protein: 267-286
Range on HMM: 336-355/364
Sequence Identity: 30% (6 aa)

DDDLCTLVEVCCKEDPKERP
..... | . |...||..||
PPSMKKLMQDCWDHDPEKRP