Gene Spk383 (Sea Urchin)
Spk383
Sequence
Protein domains of Spk383.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk383.AA | urchC | 366-584 | 68 | 2.7e-181 | 592.14 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 366-584 Range on HMM: 1-223/223 Sequence Identity: 68% (152 aa) QTILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSYV |||||..|||.||||||||||||||||||||..|.|..|.|.|||..|..|.|.|||||.|..|||.|||||..|||||....|.||||||||.|||.|. QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM LYDAIIPRKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVAVIIDLGMVSTATYP-YFSGSNGSMSTHAKGY-FIHTAP |.||..|||||||.|.|||||.|||.|||||||...|...||||||||||||||.||.||...|||.|||||..|| ...|.|..|..|.|.| |||.|| LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP EVLK--GCATSVASDVYSVGIIL |||. ||..|||||.||||.|| EVLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk383.AA | urch | 372-581 | 47 | 5.9e-125 | 421.43 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 372-581 Range on HMM: 1-217/217 Sequence Identity: 47% (103 aa) VGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLT--AELEESDRKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSYVLYDA .|.| ||.|.|.|....|.|||||.....||.| .|.|....| .. |..|||. ...||..||||.|.|.|.|..|.|||.||||||..|||| |... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC IIPRKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKN-RWVAVIIDLGMVSTATYPY-FSGS-NGSMSTHAKGY-FIHTAPEV | ....|.|.|...|||...|.|||..|.||.|....||||.|.|||||| |.. ||.|||||.|.|.| |.|. .... ...|.....|. ..|.|||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC LK-GCATSVASDVYSVG .. |...|.|||||||| VLDGQPCSIASDVYSVG |
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| Kinase | Spk383.AA | urch-unclassified | 372-581 | 36 | 2.2e-55 | 190.34 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 372-581 Range on HMM: 1-215/215 Sequence Identity: 36% (81 aa) VGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRK---RRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSYVLYD ||| .| | ..|. .| ||..| ...| .. .| .. . | |||. .... .||||| .| | . .. |.| ||.||| .. | |.. IGKGTFGKVFMMRHQREAVPVKVKMIHEHHN--DYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ AIIPRKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKN--RWVAVIIDLGMVSTATYP--YFSGSNGSMSTHAKGY-FIHTAP .| | | . | . | .||. | .|.| . |||||.| .|.||. . || | |||.||.|| |.| .. | | | | || WIHERHKS--NPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP E-VLKGCATSVASDVYSVG | || | |||.||.|| | EIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk383.AA | urchB | 367-541 | 42 | 7.7e-35 | 122.06 | In-house | 2-168 (212) | Show / Hide |
Range on Protein: 367-541 Range on HMM: 2-168/212 Sequence Identity: 42% (75 aa) TILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKR--RNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSY | .| | || |.. | | | ||| | | | . | ||| || |||||.|.|| | | |. ||.| | | | NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY VLYDAIIPRKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVAVIIDLGMVSTATYP |. | | | | |||..|.| .| ||||| | |||||| | |. ||||| ||||| | | PLHEP----------PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAP |
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| Kinase | Spk383.AA | urchA | 372-578 | 27 | 3.1e-23 | 71.86 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 372-578 Range on HMM: 1-208/208 Sequence Identity: 27% (62 aa) VGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEE--SDRKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHC-LVTEFIGDKIQGKSYVLYD | | || | | | . |||.| . || . ...| .|.. | . .|.|| |.| | .| . ||.|| .|.|| . . LGRGVYGTVHLYRHRQTDHPVALK--------VIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITW AIIP----RKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEY-RKNRWVAVIIDLGMVSTATYPY------FSGSNGSMSTHAKGY . |. |. . .. || | ..| . | || |.||.|. || |.|||.| . |. |. ... CLDKAMEMRQ-----PALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRC FIHTAPE-VLKGCATSVASDVY | ||| .|.. | .|||| -CHIAPECALDAQPCSTSSDVY |
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| Kinase | Spk383.AA | TKL | 372-584 | 16 | 1.4e-21 | 74.43 | In-house | 1-279 (364) | Show / Hide |
Range on Protein: 372-584
Range on HMM: 1-279/364
Sequence Identity: 16% (51 aa)
VGKGGYGEVMLGRLNGEK--------DPVAIKRALVKQNLTAELEESD---------------RKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGD-
.|.||.||| |...|. .||.|. .... .. . . ... |.| . . | .|.| .. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------HCLVTEFI-----GDKIQGKSYVLYDAIIPRKGCDPEPDVQKWNL-VAIGEDIIRGVMALHG--------RSLLHNDIKDDNVLLE--
.|.|.|.. . .. |.. . . || ||. || . ..| |.| .|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN
---------YRKNRWVAVIIDLGMVSTAT---YPYFSG----------SNGSMSTHAKGYFIHTAPEVLKGC----------------ATSVASDVYSVG
.... |.. | |.| . . .. .|.... . | . . |||||.| | ..|||| |
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
IIL
|.|
IVL
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| Kinase | Spk383.AA | S_TKc | 366-623 | 17 | 1.2e-11 | -5.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 366-623 Range on HMM: 1-231/231 Sequence Identity: 17% (52 aa) QTILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSY- .||. .|||..|.|...| .. . ||||. . ..| . |. ..... .. ..|.|.. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYC-------DGD --VLYDAIIPRKG-----CDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVAVIIDLGMVSTATYPYFSGSNGSMSTHAKGY |.| | |.. || .... . |.... .| . .| |.| .|.|| . |.| |. LGDLFDYIKKRGRHGLRFPFPE-HARF-----YMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TT FIHT----APEVLKGCATSV-ASDVYSVGIIL-------------DCIGGFIKDDSLRTLGDMCCKEDPKDRPGDMEEML-------PGVV |. | ||||| . ..|..|.|.|| . . |...... . . |.. ||..||. | . . FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk383.AA | Pkinase | 366-584 | 21 | 2.6e-10 | 37.54 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 366-584 Range on HMM: 1-202/293 Sequence Identity: 21% (48 aa) QTILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKRRNVRYEKEARAGLVMSTSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSYV .|.. .|.|..|.| ... |. . ||.|. .. . . ....|.. |.. . . .|. |...... ... ..|.|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMD LYDAII-PRKGCD--PEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVA----VIIDLGMVSTATYPYFSGSNGSMSTHAKGYF |.| | |.|| .| .... . |.||. .| .. .| |.| .|.|. ... . |.| | . |.| |. | LFDYISTWRHGCFYFSEWECKF-----YMYQILRGLEYCHSMGIIHRDLKPENILID-NNG--HIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTP IHTAPEVLK-GCATSVASDVYSVGIIL ||||.. | . ..|..|.|.|| WYMAPEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | Spk383.AA | STKR | 367-395 | 48 | 5.8e-10 | 28.11 | In-house | 2-32 (312) | Show / Hide |
Range on Protein: 367-395 Range on HMM: 2-32/312 Sequence Identity: 48% (15 aa) TILEFVGKGGYGEVMLGRLNG--EKDPVAIK ...| .||| ||||. |...| ||. ||.| QLIECIGKGRYGEVWKGKWRGNGEKETVAVK |
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| Kinase | Spk383.AA | C8 | 494-584 | 26 | 1.6e-09 | 29.33 | In-house | 132-226 (226) | Show / Hide |
Range on Protein: 494-584 Range on HMM: 132-226/226 Sequence Identity: 26% (26 aa) IIRGVMALHGRSLLHNDIKDDNVLLEYRKNRW-VAVIIDLGMVSTATYPYFSGSNGSMSTHAK---GYFIHTAPEVLKG-----CATSVASDVYSVGIIL .| || .| .| ||| .| |. .| . |.|. | . | . .. .. | . |||..|. . ||..|||..| MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFAS-----QVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | Spk383.AA | Ciliate-E2-Unclassified | 494-584 | 25 | 8.8e-09 | 26.62 | In-house | 152-260 (352) | Show / Hide |
Range on Protein: 494-584
Range on HMM: 152-260/352
Sequence Identity: 25% (29 aa)
IIRGVMALHGRS-LLHNDIKDDNVLLEYRKNRWVAVIIDLGMVS--------------------TATYPYFSGSNGSMSTHAKGYFIHTAPEVLKGCATS
|. | || .| ||| .|.|. ... |||.| . . |.|... |. ||||||.|. .
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYD
----VASDVYSVGIIL
..|..|.|.||
HSKAYKCDIWSLGVIL
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| Kinase | Spk383.AA | TKL-Unique | 492-584 | 31 | 7.3e-08 | 24.01 | In-house | 117-218 (290) | Show / Hide |
Range on Protein: 492-584 Range on HMM: 117-218/290 Sequence Identity: 31% (32 aa) EDIIRGVMALHGRS--LLHNDIKDDNVLLEYR--KNRWVAVIIDLGMVSTATYP---YFSGSNGSMSTHAKGYFIHTAPEVLKG--CATSVASDVYSVGI .|| .| || .. .| |.| |.|. . . | . |.| | . ... .....|. . .|.|. |||||.. | | ||||| || IDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI IL .| VL |
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| Kinase | Spk383.AA | TyrKc | 366-619 | 17 | 4.3e-07 | -107.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 366-619
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)
QTILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKRRNVRYEKEARAGLVMSTS-PYFP---RFLGTVMIN-------GDHCLVTEF
| .. | | .|||..|... .||.| .||| .|. . | |..| .. . ...|.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREAR---IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY
IGDKIQGKSYVLYDAIIPRKGCDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVAVIIDLGMVSTATYPY----FSGSNGSM
|.| . .. |. . .| .| || . . | |. |.|. .. .. | | |. | . | . |.. ..
MPH-GDLKDYLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGL-SRDIYDDDQQGESKDYYRK
ST--HAK--GYFIHTAPEVLKGCATSVASDVYS----------------------------------VGIILDCIGG------FIKDDSLRTLGDMCCKE
.. ..| .|||... . . .|||.| | ... . | . .. .|..|
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
DPKDRP--GDMEEML
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DPEDRPTFSEIHECF
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| Kinase | Spk383.AA | urchB | 562-581 | 66 | 3e-06 | 18.97 | In-house | 192-212 (212) | Show / Hide |
Range on Protein: 562-581 Range on HMM: 192-212/212 Sequence Identity: 66% (14 aa) APEV-LKGCATSVASDVYSVG |||| | | .||..|||.||| APEVILHGQSTSISSDVFSVG |
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| Kinase | Spk383.AA | Ciliate-E2-Unclassified | 367-402 | 27 | 0.004001 | 6.71 | In-house | 2-37 (352) | Show / Hide |
Range on Protein: 367-402 Range on HMM: 2-37/352 Sequence Identity: 27% (10 aa) TILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQN .|.. |.||.|.| . . . .| |.| . ..|. KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI |
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| Kinase | Spk383.AA | TKL-Unique | 368-396 | 41 | 0.009485 | 5.74 | In-house | 1-27 (290) | Show / Hide |
Range on Protein: 368-396 Range on HMM: 1-27/290 Sequence Identity: 41% (12 aa) ILEFVGKGGYGEVMLGRLNGEKDPVAIKR ... .| ||||.| | . ..|||||. FWNKIGEGGYGQVYKGK--WRGYPVAIKQ |
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| Kinase | Spk383.AA | TKL | 593-612 | 35 | 0.2556 | 0.52 | In-house | 336-355 (364) | Show / Hide |
Range on Protein: 593-612 Range on HMM: 336-355/364 Sequence Identity: 35% (7 aa) DDSLRTLGDMCCKEDPKDRP ..|.. | .|...||..|| PPSMKKLMQDCWDHDPEKRP |
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