Gene Spk379 (Sea Urchin)
Spk379
Sequence
Protein domains of Spk379.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk379.AA | urchC | 203-421 | 67 | 7.2e-181 | 590.73 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 203-421 Range on HMM: 1-223/223 Sequence Identity: 67% (151 aa) QNILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQRNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSYE |.|||..||||||||||||||||||||.|||..|.|..|.|.|||..||.|.|||||||||.||||.|||||..||||.....|.||||||||.|||.|. QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM LYDAICPSEGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP-YISGSNGSMSTHAKGY-LIRTAP |.||.||..||||.|.|||||.|||.|||||||...|...||||||||||||||.||.||...|||.|||||..|| ...|.|..|..|.|.| .|..|| LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP EVLK--GCETSVASDVYSVGIIL |||. ||..|||||.||||.|| EVLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk379.AA | urch | 209-418 | 47 | 2.7e-123 | 415.93 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 209-418 Range on HMM: 1-217/217 Sequence Identity: 47% (102 aa) VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLT--AELEESDGKQRNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSYELYDA .|.|.||.|.|.|....|.|| ||.....||.| .|.|... |... |..|||.|...||..||||.|.|.|.... ||||.||||||..|||| |... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC ICPSEGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKN-RWVAVIIDLGMVSTVTYPY-ISGS-NGSMSTHAKGY-LIRTAPEV |..|..|.| |...|||...|.|||..|.||.|....||||.|.||||||.|.. ||.|||||.|.|.|.|.|. ... ...|.....|. . .|||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC LK-GCETSVASDVYSVG .. |...|.|||||||| VLDGQPCSIASDVYSVG |
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| Kinase | Spk379.AA | urch-unclassified | 209-378 | 35 | 4.2e-48 | 166.11 | In-house | 1-171 (215) | Show / Hide |
Range on Protein: 209-378 Range on HMM: 1-171/215 Sequence Identity: 35% (63 aa) VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQRNIRCE-----KEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSYEL |||..| | ..|. .| || .| ...| .... .. |. . |||.| . .. .||||| .| | . . .|.| ||.||| .. | | IGKGTFGKVFMMRHQREAVPVKVKMIHEHHN----DYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPL YDAICPSEGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKN--RWVAVIIDLGMVSTVTYP ...| | | . | . | .||. | .|.| . |||||.| .|.||. . || | |||.||.||.|.| CQWI--HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMP |
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| Kinase | Spk379.AA | urchB | 204-378 | 41 | 8.9e-38 | 131.82 | In-house | 2-168 (212) | Show / Hide |
Range on Protein: 204-378 Range on HMM: 2-168/212 Sequence Identity: 41% (74 aa) NILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQ--RNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSY | | .| |.|| |.. | | | || | | | . | ||| . .|| |||||.|.|| . ||. ||.| | | | NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY ELYDAICPSEGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP |. | | | | |||..|.| .| ||||| | |||||| | |. ||||| |||||.| | PLHEP----------PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAP |
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| Kinase | Spk379.AA | TKL | 209-421 | 17 | 2.5e-20 | 69.91 | In-house | 1-279 (364) | Show / Hide |
Range on Protein: 209-421
Range on HMM: 1-279/364
Sequence Identity: 17% (53 aa)
VGKGSYGEVMLGRLNGEK--------DPVVIKRALVKQNLTAELEESD---------------GKQRNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGG-
.|.|..||| |...|. .|..|. .... .. . . ... .|.| . . . | .|.| .. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LCLVTEFIGDKIQGKS-YELYDAICPSEGCDPVPDVQKWNL-VAIGEDIIRGVMALHG--------RSLLHNDIKDDNVLLE------
||.|.|.. .| | .... |.. . . || ||. || . ..| |.| .|.|.
CVCMHPVGPWGQLCIVMEYC----PGGSLLHYLH----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV
-----FRKNRWVAVIIDLGMVSTVTYPY--------------ISGSNGSMSTHAKGYLIRTAPEVLKGC----------------ETSVASDVYSVGIIL
... |.. | |.| ... .. .|.... . | . |||||.| | | ..|||| ||.|
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
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| Kinase | Spk379.AA | urchA | 258-379 | 28 | 2.4e-17 | 52.57 | In-house | 44-166 (208) | Show / Hide |
Range on Protein: 258-379
Range on HMM: 44-166/208
Sequence Identity: 28% (36 aa)
KEARVGLMMSTSPYFPRFLGTVMVNGG-LCLVTEFIGDKIQGKSYELYDAICPS-EGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLL
.|... . . .|.|| |.| . .. . ||.|| .|.|| . . . . | | . . | .|.. || | ..| . | || |.||.|.
NEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPALTRDQWMNVML--DIAEGLKVMHEKGFLCNDLKEDNCLV
EF-RKNRWVAVIIDLGMVSTVTYPY
|| |.|||.| . . |.
RKTEFGRWRAKIIDFGWACPCQMPF
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| Kinase | Spk379.AA | S_TKc | 203-460 | 17 | 7.6e-13 | 11.47 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 203-460 Range on HMM: 1-231/231 Sequence Identity: 17% (51 aa) QNILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQRNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSY- ||...|||..|.|...| .. . | ||. .. ..| .. . |. ..... . |..|.|.. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYC-------DGD --ELYDAICPSEG---CDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPYISGSNGSMSTHAKGYLI .|.| |. . . | | . . ... |.... .| . .| |.| .|.|| . |.| |. . |. | . LGDLFDYIKKRGRHGLRFPFPE-HARFYMY---QICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPW RTAPEVLKGCETSV-ASDVYSVGIIL-------------DCIGRVIKDDDLRTLGDMCCKEDPKERPDDMEEML-------PEVL ||||| . ..|..|.|.|| . . ..|...... . . |.. ||..|| | . . . YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk379.AA | C8 | 331-421 | 26 | 6.1e-10 | 30.8 | In-house | 132-226 (226) | Show / Hide |
Range on Protein: 331-421 Range on HMM: 132-226/226 Sequence Identity: 26% (26 aa) IIRGVMALHGRSLLHNDIKDDNVLLEFRKNRW-VAVIIDLGMVSTVTYPYISGSNGSMSTHAK---GYLIRTAPEVLKG-----CETSVASDVYSVGIIL .| || .| .| ||| .| |. . .| . |.|. | ..| . .. .. | . |||..|. . . ||..|||..| MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFAS-----QVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | Spk379.AA | Ciliate-E2 | 331-421 | 20 | 1.4e-08 | 25.59 | In-house | 169-286 (365) | Show / Hide |
Range on Protein: 331-421 Range on HMM: 169-286/365 Sequence Identity: 20% (26 aa) IIRGVMALHGRS-LLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPYIS---GSNGSMSTHAK-----------------------GYLIRTAPEVL || .. || . .| ||| .|.|. |||.|. .. ... .. . . | | . |||.| IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL KGCE---------TSVASDVYSVGIIL .| . . ..|..|.|.|| NGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | Spk379.AA | TyrKc | 203-459 | 16 | 8.8e-08 | -96.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 203-459
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)
QNILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQRNIRCEKEARVGLMMSTS-PYFP---RFLGTVMVN-------GGLCLVTEF
... | | .|||..|... .| .| .. .. | .|. . | |..| .. . |..|.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMRE-----ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY
I-----GDKIQGKSYELYDAICPSEGCDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPY----ISG
| .. . . .. |. . .| .| || . . | |. |.|. .. .. | | |. | | . |.
MPHGDLKDYLRKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGL-SRDIYDDDQQGESK
SNGSMST--HAKG-YLIR-TAPEVLKGCETSVASDVYS----------------------------------VGIILDCIGR------VIKDDDLRTLGD
. .... ..|. || .|||... .. . .|||.| | ... |. |.. ..
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK
MCCKEDPKERPDDMEEMLPEV
.|..|||..|| ..| .
QCWHEDPEDRP-TFSEIHECF
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| Kinase | Spk379.AA | Ciliate-E2-Unclassified | 331-421 | 22 | 2.9e-07 | 21.26 | In-house | 152-260 (352) | Show / Hide |
Range on Protein: 331-421 Range on HMM: 152-260/352 Sequence Identity: 22% (28 aa) IIRGVMALHGRS-LLHNDIKDDNVLLEFRKNRWVAVIIDLGMVS---------------------------TVTYPYISGSNGSMSTHAKGYLIRTAPEV |. | || .| ||| .|.|. ... |||.| . . |. |.. . ||||| ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-------------YTAPEV LKGCETS----VASDVYSVGIIL |.|.. . ..|..|.|.|| LQGQNYDHSKAYKCDIWSLGVIL |
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| Kinase | Spk379.AA | urch-unclassified | 399-418 | 66 | 4e-06 | 18.28 | In-house | 195-215 (215) | Show / Hide |
Range on Protein: 399-418 Range on HMM: 195-215/215 Sequence Identity: 66% (14 aa) APE-VLKGCETSVASDVYSVG ||| || | |||.||.|| | APEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk379.AA | urchB | 399-418 | 66 | 4e-06 | 18.13 | In-house | 192-212 (212) | Show / Hide |
Range on Protein: 399-418 Range on HMM: 192-212/212 Sequence Identity: 66% (14 aa) APEV-LKGCETSVASDVYSVG |||| | | ||..|||.||| APEVILHGQSTSISSDVFSVG |
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| Kinase | Spk379.AA | Ciliate-E3 | 324-370 | 36 | 5e-06 | 15.13 | In-house | 105-151 (202) | Show / Hide |
Range on Protein: 324-370 Range on HMM: 105-151/202 Sequence Identity: 36% (17 aa) LVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLG . | ||.|..|.| . . | ||| || |. ..|. .. | |.| IYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFG |
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| Kinase | Spk379.AA | Pkinase | 203-291 | 15 | 0.000145 | 17.22 | Pfam | 1-81 (293) | Show / Hide |
Range on Protein: 203-291 Range on HMM: 1-81/293 Sequence Identity: 15% (15 aa) QNILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAE------LEESDGKQRNIRCEKEARVGLMMSTSPYFPRFLGTVMVNGGLCLVTEF |....|.||.|.| ... |. . |..|. .. . . | |... ... .|. |...... .. ...|.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEY |
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| Kinase | Spk379.AA | Ciliate-E3 | 399-424 | 37 | 0.000334 | 9.34 | In-house | 176-202 (202) | Show / Hide |
Range on Protein: 399-424 Range on HMM: 176-202/202 Sequence Identity: 37% (10 aa) APEVLKGCETSVASDVYSVG-IILDCI |||... | || |||| .... . APEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | Spk379.AA | Ciliate-E2-Unclassified | 204-239 | 22 | 0.001019 | 8.8 | In-house | 2-37 (352) | Show / Hide |
Range on Protein: 204-239 Range on HMM: 2-37/352 Sequence Identity: 22% (8 aa) NILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQN .|... |.|..|.| . . . .| ..| . ..|. KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI |
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| Kinase | Spk379.AA | Pkinase | 399-421 | 41 | 0.002501 | 12.85 | Pfam | 179-202 (293) | Show / Hide |
Range on Protein: 399-421 Range on HMM: 179-202/293 Sequence Identity: 41% (10 aa) APEVLK-GCETSVASDVYSVGIIL ||||.. | . . ..|..|.|.|| APEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | Spk379.AA | urchA | 399-415 | 50 | 0.003639 | 6.14 | In-house | 191-208 (208) | Show / Hide |
Range on Protein: 399-415 Range on HMM: 191-208/208 Sequence Identity: 50% (9 aa) APE-VLKGCETSVASDVY ||| .|.. | .|||| APECALDAQPCSTSSDVY |
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| Kinase | Spk379.AA | Ciliate-E2 | 203-221 | 21 | 0.066456 | 2.3 | In-house | 1-19 (365) | Show / Hide |
Range on Protein: 203-221 Range on HMM: 1-19/365 Sequence Identity: 21% (4 aa) QNILETVGKGSYGEVMLGR .... |.|..| | ... YKFIKKIGQGNFGSVYKCK |
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| Kinase | Spk379.AA | Pkinase | 331-355 | 36 | 0.173497 | 6.34 | Pfam | 117-141 (293) | Show / Hide |
Range on Protein: 331-355 Range on HMM: 117-141/293 Sequence Identity: 36% (9 aa) IIRGVMALHGRSLLHNDIKDDNVLL |.||. .| .. .| |.| .|.|. ILRGLEYCHSMGIIHRDLKPENILI |
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