Spk378

Species: Sea Urchin
Alias: SPU_014245, Spk378
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urch-unclassified

Sequence

Name Sequence Type Origin Length Description Download
Spk378.AA Protein None 770 None Fasta, JSON
Spk378.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of Spk378.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk378.AA urch-unclassified 513-720 54 4.5e-154 518.14 In-house 1-215 (215) Show / Hide
Range on Protein: 513-720
Range on HMM: 1-215/215
Sequence Identity: 54% (118 aa)

IGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKANEEDVKRV-ISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKAI
|||||||.|||.|...|||.|||..|||............ ..|.|.|..||..||||...||.||||.|..||..||..|.||||||.|.|||||...|
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI

KTKN---PALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR---DDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYIL
....   ||||...|.||..||..|.|||||.||||||.|.||.||..   |.||.|||||.|...|.|||||.||..||||..|..|..|.|.|||..|
HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL

YGEYSSIQSDIFSLG
||...|..|||.|||
YGQPTSVYSDIYSLG

Kinase Spk378.AA urch 513-720 40 1.5e-117 396.83 In-house 1-217 (217) Show / Hide
Range on Protein: 513-720
Range on HMM: 1-217/217
Sequence Identity: 40% (89 aa)

IGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKAN--EEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKA
||.||.| |...|.......|... ....|...  .|..   ...||.|. ||. ||.|...|| ||...|.... ....||.||.||| |...|||...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

IKT-----KNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR---DDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPE
|..     .||.||...||||..||..|..|||....||||.|..||||..   . ||.|.|||.|.|.|.|||.|.....|.||. |. | .|.|.|||
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHG-RWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE

YILYGEYSSIQSDIFSLG
..|.|...||.||..|.|
CVLDGQPCSIASDVYSVG

Kinase Spk378.AA urchC 507-723 35 1e-36 116.28 In-house 1-223 (223) Show / Hide
Range on Protein: 507-723
Range on HMM: 1-223/223
Sequence Identity: 35% (81 aa)

TVDTKPIGKGTFGVVFMKRLGAE--AVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHG--YTKHASCPGLVVEFLGDKGTR
    . |||| .| | . || .|   ||.|   .   ...  |   .    |  |. ||  |  ..   | |||  |   .    |  .| || ||| . 
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQ--NNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMC--IVTEFIGDKQQG

TVYPLSKAIK---TKNPALSDQEW--LNIVVDITEGIHAMHERDLLHNDIKPNNVLLR-RDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVY
 ||.|  |..     .| .  | |  . |  || .|.|.|| . |||||||  ||||  | .|| . ||||| |.|.. |   |   |  |.  . .  .
KVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDV-MPDHQKLYGF

QHLAPEYIL-YGEYSSIQSDIFSLGRII
 | ||| .   |   |  |||.| | | 
IHIAPEVLDIDGCQVSVASDIYSVGVIL

Kinase Spk378.AA urchA 562-717 33 9.3e-28 86.67 In-house 44-208 (208) Show / Hide
Range on Protein: 562-717
Range on HMM: 44-208/208
Sequence Identity: 33% (55 aa)

KEVAVHRLLGEHPAFPRCHGYTK-HASCPGLVVEFLGDKGTRTV----YPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR
.|. .| .||  | ||   |  .      |.  || ||  |         |.||.  ..|||. ..|.|. .|| ||  .|||.  | || |  |.|.| 
NEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRK

--DDRWKAYIIDMGNVTTVTMPH--KNRNLTDHEMEGYRLGVVYQHLAPEYILYGEYSSIQSDIF
    ||.| |||.|    . ||       ..  . . || .  . | ||| .| .   |. ||..
TEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQPCSTSSDVY

Kinase Spk378.AA urchB 559-720 38 5.9e-20 68.43 In-house 55-212 (212) Show / Hide
Range on Protein: 559-720
Range on HMM: 55-212/212
Sequence Identity: 38% (62 aa)

RTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLL-RRD
|  ||  .| |. . | ||.  |         . .|| | | | . |||        | ||    . |  ||  |.  .|   ||||| |  |||| .| 
RVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGYPLHEP-----PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRG

DRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYILYGEYSSIQSDIFSLG
 |. | ||| | | |.| | |   ..      |  |      ||| || |   || ||.|| |
HRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG

Kinase Spk378.AA TKL 513-720 14 3.8e-14 47.34 In-house 1-276 (364) Show / Hide
Range on Protein: 513-720
Range on HMM: 1-276/364
Sequence Identity: 14% (42 aa)

IGKGTFGVVFMKRLGA----------EAVAVKVQGIHEDQKANEEDVKRVI--------------SLNHSRTVKEVAVHRLLGE-HPAFPRCHGYTKHAS
||.|.||.|.  ..            . ||||.  .....  ....  . .               . . |  .|. .  ..   ||   .. || .  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK--FKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

C-------------PGLVVEFLGDKGT-RTVYPLSKAIKTKNPALSDQEW-LNIVVDITEGIHAMHERD--------LLHNDIKPNNVLLRRDDR-----
|             ...| |.  ..|. . ..                .  .... ||  |.. .| ..        ..| |.|..|.|. .. .     
CGCVCMHPVGPWGQLCIVMEYC-PGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

-------WKAYIIDMGNVTTVTMPHKNRNLTDHEMEGY---------RLGVV--YQHLAPEYILYGEY---------------SSIQSDIFSLG
       |.. | |.|  .....  ..     ..||           .  ..  ....||| .   ..                | ..|..| |
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME-SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

Kinase Spk378.AA Ciliate-E2 612-725 17 9.7e-13 40.04 In-house 138-288 (365) Show / Hide
Range on Protein: 612-725
Range on HMM: 138-288/365
Sequence Identity: 17% (29 aa)

KTKNPALSDQEWLNIVVDITE---------------GIHAMHERD-LLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGV-
| .   ....| ..|   |..               ... .|..   .| ||||.|.|.         |||.|. . .. ...||     ... |     
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KN

-----------------------VYQHLAPEYILYGEY--------SSIQSDIFSLGRIIHY
                        .  .||| . ...|         . ..||.||| |...
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

Kinase Spk378.AA S_TKc 507-762 14 8.1e-12 -3.58 SMART 1-231 (231) Show / Hide
Range on Protein: 507-762
Range on HMM: 1-231/231
Sequence Identity: 14% (43 aa)

TVDTKPIGKGTFGVVFMKRLGA--EAVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLG-DKGTRT
    ..||||.||.|.  |     . ||.|.                       .. .|.....    ||   .....  . ..  .| |... |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGD-----

VYPLSKAIKTKNPA-----LSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQH
.  | . || ...      ..  .   ..  | ...  .|..  .| |.|| |.|| .       |.| |  . .                . . .    
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------------TTFCGTPWY

LAPEYILYGEYSSIQSDIFSLG-----------------RIIHYVSRVIHNSDLFNLATLMIDSHPHLRPSWKEINR-------VKQA
.||| .    |.   .|. |.|                 .... .      ... ..   . .  |  ||.  |. .           
MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk378.AA Ciliate-A1 618-668 39 1.6e-11 35.4 In-house 98-146 (301) Show / Hide
Range on Protein: 618-668
Range on HMM: 98-146/301
Sequence Identity: 39% (20 aa)

LSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMG
..  |   | . |.||. ..|..  || |.|| |.|.  ||.||  |.|.|
MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWK--ICDLG

Kinase Spk378.AA WEE 614-720 29 1.1e-10 32.11 In-house 104-223 (297) Show / Hide
Range on Protein: 614-720
Range on HMM: 104-223/297
Sequence Identity: 29% (39 aa)

KNPALSDQEWLNIVVDITEGIHAMHER-DLLHNDIKPNNVLLRRDD--------------------RWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRL
.|..|....  .| ||| .|.| .|.. ...|.|||| |... ...                    . |  | | | ||...    |.| . .| || . 
WNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCK--IGDFGHVTDMNS---NNNNPHQEQEGDS-

GVVYQHLAPEYILYG--EYSSI-QSDIFSLG
      .||| || |  .|.    .||||||
----RYMAPE-ILQGYYHYTHLYKADIFSLG

Kinase Spk378.AA C8 609-723 22 8.6e-09 26.76 In-house 111-226 (226) Show / Hide
Range on Protein: 609-723
Range on HMM: 111-226/226
Sequence Identity: 22% (28 aa)

KAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWK--AYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYILY
.  ..|.  .|... ..| . . .|.  .|    .| ||||.| |.. |        . |.|  ..|.   .     ..      .|   . .||| |..
DERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----CGTW-AYFAPE-IEK

G-----EYSSIQSDIFSLGRII
.       ..||||.||.| . 
KQDNQYKQYRIQSDLFSVGLVL

Kinase Spk378.AA Pkinase 507-654 22 2e-06 23.83 Pfam 1-141 (293) Show / Hide
Range on Protein: 507-654
Range on HMM: 1-141/293
Sequence Identity: 22% (34 aa)

TVDTKPIGKGTFGVVFMKRLGAEA--VAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTK-HASCPGLVVEFLGDKGTRT
 .  ..||.|.||.|.  .   .   ||||.    ...| ...  .| .         |..... |  ||   |....   . ..  .| |.. ..|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI-IKKRHEKSWKDQTHRRL--------SEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYC-EGGLY-

VYPLSKAIK-TKNPAL--SDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLL
|  |.  |.  .. ..  |..|  ...  | .|.  .|..  .| |.|| |.|.
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI

Kinase Spk378.AA TyrKc 507-762 17 2e-06 -120.17 SMART 1-280 (280) Show / Hide
Range on Protein: 507-762
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

TVDTKPIGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLG-EHPAFPRCHGYTKHA-------SCPGLVVEFLGD
 .  | .| | ||.|.  ..  . ||||.  ..||               .    .|  . . || .||   |..|.  .          . .|.|.   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKM--LKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

KGTRTVYPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEG---------
 |      | . .. . | |. .. |.. ..| .|    |.. . | |.   |.|. ..    . | | |             |.    ..         
-G-----DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFG-------------LSRDIYDDDQQGESKDY

YR-----LG---VVYQHLAPEYILYGEYSSIQSD----------IFSLGRIIHYV---------------------SRVIH---------NSDLFNLATL
||      |   . .  .||| | ||.... .||          ||..|   ..                       .  .          ...... . 
YRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ

MIDSHPHLRPSWKEINRVKQA
  .  |. ||. .||  ... 
CWHEDPEDRPTFSEI--HECF

Kinase Spk378.AA WEE 733-756 25 0.103008 1.61 In-house 268-291 (297) Show / Hide
Range on Protein: 733-756
Range on HMM: 268-291/297
Sequence Identity: 25% (6 aa)

SDLFNLATLMIDSHPHLRPSWKEI
..| .|  .|..  | .||.. ..
QELKQLIKWMMHPDPEQRPTCQQL

Kinase Spk378.AA Ciliate-A1 713-723 72 0.249791 0.2 In-house 208-218 (301) Show / Hide
Range on Protein: 713-723
Range on HMM: 208-218/301
Sequence Identity: 72% (8 aa)

QSDIFSLGRII
|||..||| ||
QSDMYSLGCII

Kinase Spk378.AA Pkinase 699-726 35 3.977286 1.53 Pfam 178-205 (293) Show / Hide
Range on Protein: 699-726
Range on HMM: 178-205/293
Sequence Identity: 35% (10 aa)

LAPEYILYGEYSSIQSDIFSLGRIIHYV
.||| |. |.| .  .|..|.| |....
MAPEVIRGGQYYGPKVDMWSCGCILYEM