VPS15

Species: Sea Urchin
Alias: VPS15, Spk359, SPU_017786
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
VPS15.AA Protein None 1403 None Fasta, JSON
VPS15.kin_dom Protein Kinase Domain None 166 None Fasta, JSON

Protein domain

Protein domains of VPS15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VPS15.AA VPS15 208-318 46 1.2e-68 234.38 In-house 162-296 (296) Show / Hide
Range on Protein: 208-318
Range on HMM: 162-296/296
Sequence Identity: 46% (63 aa)

FVEGSSSRPVDNATSETVEGLQVRQDVKG--------------------GELTPAMDIFSVGCVIAELFTEG-NAPFDLSQLLAYCSGAYSP--DAVLEQ
|...|..|....|....|......||...                    |||||||||||.||||||||.|| ..|||.|||..|.||.|.|  ....|.
FFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEK

IEDEHIKDLCKHMLQKD-PSKRMSAEQYLVKGRGT
|.||||..||.||.||| |.||||.|.||.|.||.
IQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF

Kinase VPS15.AA VPS15 26-138 56 7.2e-65 221.83 In-house 1-115 (296) Show / Hide
Range on Protein: 26-138
Range on HMM: 1-115/296
Sequence Identity: 56% (65 aa)

YEFDHSLGSTRFFKVARAKYKEGLAVVKVFVIHDPSLPLRSFKEKIEDIKTRLSNGS--NCLPFLRSTLSDKAALLFRQYVRNNLYDRISTRPFLISIEK
 ... .||||||.||..|| .||. ||||||.||. ..|...|..||.||  |.  .  ||.|. .  ..|||| ..||||..|||||||||||| .|||
CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIEK

KWIAFQLLCALNQAH
||||||.||||.|.|
KWIAFQTLCALEQCH

Kinase VPS15.AA VPS15 142-169 89 9e-18 58.14 In-house 154-181 (296) Show / Hide
Range on Protein: 142-169
Range on HMM: 154-181/296
Sequence Identity: 89% (25 aa)

DNPADFSFFFDTSRRRTCYIAPERFVEG
||||||.|||||||||||||||||||..
DNPADFTFFFDTSRRRTCYIAPERFVSN

Kinase VPS15.AA VPS15 170-207 31 2.3e-12 39.19 In-house 166-223 (296) Show / Hide
Range on Protein: 170-207
Range on HMM: 166-223/296
Sequence Identity: 31% (18 aa)

SSSRPVDSATSETVEGLQVRQDVKG--------------------GELTPAMDIFSVG
|..|... |....|......||...                    |||||||||||.|
SRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDSIDRQQNPWLFGELTPAMDIFSAG

Kinase VPS15.AA S_TKc 26-324 14 2.5e-09 -40.24 SMART 1-231 (231) Show / Hide
Range on Protein: 26-324
Range on HMM: 1-231/231
Sequence Identity: 14% (47 aa)

YEFDHSLGSTRFFKVARAKYKE--GLAVVKVFVIHDPSLPLRSFKEKIEDIKTRLSNGSNCLPFLRSTLSDKAALLFRQYVRN---NLYDRISTRPF---
||.   .|.  | || ... |.   .  .|.          ....  |.  |    .  |   .. .  . .   ..  |. .   .|.|.|  |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LISIEKKWIAFQLLCALNQAH--------------LVGDNPA-----DFSFFFDTSRRRTC----YIAPERFVEGSSSRPVDSATSETVEGLQVRQD
   .   . . .. |..|||.  |              |. .         .. ..    .  |    |.||| .                         
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL-------------------------

VKGGELTPAMDIFSVGFVEGSSSRPVDNATSETVEGLQVRQDVKGGELTP-AMDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYSPDAVLEQIEDEHI
                                                .. . |. |.||...|... |  ||.  . . .               ..  
----------------------------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG-----------SPEA

KDLCKHMLQKDPSKRMSAEQYLVKGRGTAFPEFF
||. ...|||||.||..| . |  ..  .  ..|
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase VPS15.AA Ciliate-E2 240-310 23 3.9e-08 23.99 In-house 274-358 (365) Show / Hide
Range on Protein: 240-310
Range on HMM: 274-358/365
Sequence Identity: 23% (24 aa)

TPAMDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYSPDAVLEQIEDEHIK----------------------------DLCKH----MLQKDPSKRMS
. . ||.|.|... |. . |. ||                  ..||..  |.                            ||.|     ||||||.||..
DYKCDIWSLGVILYEMLF-GKPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT

-AEQ
 .||
GWEQ

Kinase VPS15.AA KIS 289-324 36 7.5e-07 16.24 In-house 445-473 (473) Show / Hide
Range on Protein: 289-324
Range on HMM: 445-473/473
Sequence Identity: 36% (13 aa)

HIKDLCKHMLQKDPSKRMSAEQYLVKGRGTAFPEFF
| .|| | ||. |...| .||  |          ||
HLRDLIKSMLHCDIARRIPAEMILCHP-------FF

Kinase VPS15.AA IRE 239-310 30 9e-07 19.05 In-house 209-285 (292) Show / Hide
Range on Protein: 239-310
Range on HMM: 209-285/292
Sequence Identity: 30% (25 aa)

LTPAMDIFSVGCVIAELFTEGNAPFD---LSQLLAYCSGAYSPDAVLEQIE-DEHIK-----DLCKHMLQKDPSKRMSAEQ
.| . |||| |||.  ..|.|. ||    |.      .|.|.    |.|.. . |..     || . |...||.|| ....
KTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYN----LDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKE

Kinase VPS15.AA Pkinase 240-310 25 2e-06 23.75 Pfam 190-286 (293) Show / Hide
Range on Protein: 240-310
Range on HMM: 190-286/293
Sequence Identity: 25% (25 aa)

TPAMDIFSVGCVIAELFTEGNAPFD-L------SQLLAYCSGAYSPDAVLEQIED--------------------EHIKDLCKHMLQKDPSKRMSAEQ
.|. |..|.||...|... |. ||.        .|.  .|   . |    .. ..                    |  ||..| .|.|||.|| .|||
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

Kinase VPS15.AA CAMK1 291-312 59 3e-06 14.21 In-house 250-271 (276) Show / Hide
Range on Protein: 291-312
Range on HMM: 250-271/276
Sequence Identity: 59% (13 aa)

KDLCKHMLQKDPSKRMSAEQYL
||. |||| .||.|| ..|| |
KDFIKHMLEVDPKKRYTCEQCL

Kinase VPS15.AA CDPK 291-310 65 7e-06 14.31 In-house 245-264 (271) Show / Hide
Range on Protein: 291-310
Range on HMM: 245-264/271
Sequence Identity: 65% (13 aa)

KDLCKHMLQKDPSKRMSAEQ
||| . ||..|| |||||.|
KDLIRKMLCYDPKKRMSAQQ

Kinase VPS15.AA Ciliate-E2a 291-310 65 1.2e-05 12.6 In-house 249-268 (275) Show / Hide
Range on Protein: 291-310
Range on HMM: 249-268/275
Sequence Identity: 65% (13 aa)

KDLCKHMLQKDPSKRMSAEQ
||| | ||.|||.|| .|.|
KDLMKKMLEKDPKKRITAQQ

Kinase VPS15.AA CMGC 240-257 50 2.4e-05 12.54 In-house 313-330 (513) Show / Hide
Range on Protein: 240-257
Range on HMM: 313-330/513
Sequence Identity: 50% (9 aa)

TPAMDIFSVGCVIAELFT
|...|. ||||..||..|
TTPIDMWSVGCIFAEMYT

Kinase VPS15.AA CDK8 240-257 55 0.000192 9.26 In-house 203-220 (329) Show / Hide
Range on Protein: 240-257
Range on HMM: 203-220/329
Sequence Identity: 55% (10 aa)

TPAMDIFSVGCVIAELFT
|.| || ..||. ||| |
TKAIDIWAIGCIFAELIT

Kinase VPS15.AA RCK 243-255 61 0.00033 8.93 In-house 195-207 (298) Show / Hide
Range on Protein: 243-255
Range on HMM: 195-207/298
Sequence Identity: 61% (8 aa)

MDIFSVGCVIAEL
|||..|||...||
MDIWAVGCIMYEL

Kinase VPS15.AA CMGC 283-310 50 0.000362 8.57 In-house 479-506 (513) Show / Hide
Range on Protein: 283-310
Range on HMM: 479-506/513
Sequence Identity: 50% (14 aa)

EQIEDEHIKDLCKHMLQKDPSKRMSAEQ
.  .|.   || | ||| ||.||..|||
RKCCDPQAIDLLKKMLQYDPDKRITAEQ

Kinase VPS15.AA RCK 292-312 52 0.000794 7.7 In-house 273-293 (298) Show / Hide
Range on Protein: 292-312
Range on HMM: 273-293/298
Sequence Identity: 52% (11 aa)

DLCKHMLQKDPSKRMSAEQYL
.|.. ||| ||.|| .|.| |
ELMEKMLQWDPQKRITAQQAL

Kinase VPS15.AA CDK8 286-310 44 0.001367 6.54 In-house 298-322 (329) Show / Hide
Range on Protein: 286-310
Range on HMM: 298-322/329
Sequence Identity: 44% (11 aa)

EDEHIKDLCKHMLQKDPSKRMSAEQ
.| |  .|  .||  ||.||...||
RDSHAYHLLYKMLTMDPTKRITCEQ

Kinase VPS15.AA KIS 238-257 50 0.011938 2.79 In-house 370-389 (473) Show / Hide
Range on Protein: 238-257
Range on HMM: 370-389/473
Sequence Identity: 50% (10 aa)

ELTPAMDIFSVGCVIAELFT
| | | || | ||.| . .|
ECTHAVDIWSLGCIIVRMYT

HEAT VPS15.AA HEAT 422-452 29 0.000291 18.62 Pfam 1-31 (31) Show / Hide
Range on Protein: 422-452
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

IIPCILHFVHDPFPRVRAEAIRTITQTLMLV
|.|..|.  .|| ..||. |.....| .  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15.AA HEAT 467-497 32 0.006416 13.97 Pfam 1-31 (31) Show / Hide
Range on Protein: 467-497
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

ILPNLSNIAQDPIDMVRMVYAENIAVLAETA
||| | .  .|| . ||.  .. ...|.| .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15.AA HEAT 580-611 25 0.770039 6.77 Pfam 1-31 (31) Show / Hide
Range on Protein: 580-611
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LLSHMITFLNDKEDWHLRGSFFDSIVGVAAYV
.|.|... |||. ||. | . . ... .. ..
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC

HEAT VPS15.AA HEAT 619-649 22 0.102681 9.8 Pfam 1-31 (31) Show / Hide
Range on Protein: 619-649
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LKPLLQQGLTDHEEQVICKALKSVTGLVQLG
. |.| ..|.| ...| . |..... |..  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15.AA HEAT 659-689 12 1.979582 5.35 Pfam 1-31 (31) Show / Hide
Range on Protein: 659-689
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

MAYELVPYVCHPNLWIRQATVGFIAAIARSL
.   |.   ..|.  .|.|..  ...... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

WD40 VPS15.AA WD40 1080-1118 22 1.8e-11 35.6 Pfam 1-39 (39) Show / Hide
Range on Protein: 1080-1118
Range on HMM: 1-39/39
Sequence Identity: 22% (9 aa)

GLLIAHLHEHKGAVNRLQVSYD-HTLFSTCSDDGTVKVWD
. ... . .|...|. . .. |  ... ..|.|||...||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 VPS15.AA WD40 1079-1118 20 2.7e-10 41.44 SMART 1-46 (46) Show / Hide
Range on Protein: 1079-1118
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

RGLLIAHLHEHKG--AVNRLQVSYDH------TLFSTCSDDGTVKVWD
   ... .. |.|  .|. .... |.      ... ..| |||...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15.AA WD40 1128-1167 22 0.000217 21.83 SMART 1-46 (46) Show / Hide
Range on Protein: 1128-1167
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

TNKSRQTYNRQPG--KIKTLTFCQSS------HSIASGSDDGSIHVNR
| |  .|..   |   . ........      . .|||| ||.|..  
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15.AA WD40 1129-1167 25 0.000436 14.38 Pfam 1-39 (39) Show / Hide
Range on Protein: 1129-1167
Range on HMM: 1-39/39
Sequence Identity: 25% (10 aa)

NKSRQTYNRQPGKIKTLTFCQS-SHSIASGSDDGSIHVNR
 |  .|.    ...  . .... .| .||||.||.|..  
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 VPS15.AA WD40 1224-1265 16 0.108865 6.44 SMART 1-46 (46) Show / Hide
Range on Protein: 1224-1265
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

EAFRLRNQQRHGA--LVRRVRLHPSQ-----QSLVISAVQGNNEVSMWD
.   ..  . | .   |. |. ||.       ....|.   .. . .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS--DGTIRIWD

WD40 VPS15.AA WD40 1225-1265 17 6.350908 2.4 Pfam 1-39 (39) Show / Hide
Range on Protein: 1225-1265
Range on HMM: 1-39/39
Sequence Identity: 17% (7 aa)

AFRLRNQQRHGALVRRVRLHPSQQSLVISAVQGNNEVSMWD
   ..    | . |. .. ||.......|.    . . .||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGS-RDGTIRIWD

WD40 VPS15.AA WD40 1280-1318 12 0.084639 7.13 SMART 1-46 (46) Show / Hide
Range on Protein: 1280-1318
Range on HMM: 1-46/46
Sequence Identity: 12% (6 aa)

HPPLSQTQH------AIHALYCIPSM---EQTPCFLTAGSDQRIRYWN
   . .| .      .....   |.     .. ...... |  || |.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15.AA WD40 1287-1318 18 0.192451 6.77 Pfam 10-39 (39) Show / Hide
Range on Protein: 1287-1318
Range on HMM: 10-39/39
Sequence Identity: 18% (6 aa)

QHAIHALYCIPSMEQTPCFLTAGSDQRIRYWN
.|.. .. . |.  . ....... |  || |.
THWVTCCAWHPD--MGHYLASGSRDGTIRIWD