Gene Ack1 (Sea Urchin)
Ack1
Sequence
Protein domains of Ack1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Ack1.AA | Ack | 1-197 | 54 | 7.4e-134 | 451.0 | In-house | 28-221 (266) | Show / Hide |
Range on Protein: 1-197 Range on HMM: 28-221/266 Sequence Identity: 54% (108 aa) IPVAVKCLSPEKLSLDKCQQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPAFP-ITLLLDFSVQITDAMRYLHMSN |.||||||...|.....|..|||.|.||||||.|.|||.|||||||... ||.|||.||..||...... ....||. |..|.||..||...||||.|.. IQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM-LMMVTELAPCGSLLDCLRK-HCRTAFFLIHTLCDFCMQIAMGMRYLEMKR IIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGEN-YRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPFAHLSGEEVI .|||||||||||||.|| .|.||.||||.|.|...|. ||.|...|||.|.||...|.|....|..|||||.||||.|||||||..|.|...|.... CIHRDLAARNILLFSDD---RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQIL |
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| Kinase | Ack1.AA | Pkinase_Tyr | 1-197 | 40 | 5.1e-77 | 261.46 | Pfam | 29-225 (270) | Show / Hide |
Range on Protein: 1-197 Range on HMM: 29-225/270 Sequence Identity: 40% (83 aa) IPVAVKCLSPEKLSLDK-CQQDFLKEAAIMHSL-NHEHLVKLYGVVLDVDSS--LMLVTEFAPLRSLAENMKQE-ALKPAFPITLLLDFSVQITDAMRYL ||||||.| .|. . . |..||..||.||..| .|...|.||||..| . . ...|.|..|. .| . .. |..... ||....|| ..| || IPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYL HMSNIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKP-FAHLSGE . |.|||||||||.|. |...||.||||.| . ..| . .| . ||| ||. |.. || .||||||||.|||.|.||..| .. .| | ESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE EVI ||. EVY |
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| Kinase | Ack1.AA | TK | 1-197 | 20 | 1.8e-66 | 221.59 | In-house | 53-414 (486) | Show / Hide |
Range on Protein: 1-197
Range on HMM: 53-414/486
Sequence Identity: 20% (74 aa)
IPVAVKCLSPEKLSLDKCQQD--------------FLKEAAIMHS--LNHEHLVKLYGVVLDVDSS-----------LMLVTEFAPLRS----LAENMKQ
.|||||.| .. . .. ..| .. |...|.. ..|...|.||||....... .|.|.|..|. . | . ..
TPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRK
EALKPA-------------------------------------------------------------------------FPITLLLDFSVQITDAMRYLH
| .. || ...|| ..|.|||
CRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
MS------NIIHRDLAARNILLFVDDEGNKK-------AKISDFG--------LSRRLLLGENYRS---EMRP-------------------NLKLPLAW
|..||||||||.|.. .. .. .||.||| |.|.. ...|.. . .. . |||. |
SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW
MPVESLT---------KLTFTKASDVWSFGVTMWEMFSYGRKPFAH-LSG---------EEVI
|. |.|. . .|| .||||||||.|||.|.||..|.. .| .||.
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVM
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| Kinase | Ack1.AA | UTK | 3-199 | 30 | 5.6e-61 | 207.33 | In-house | 32-252 (296) | Show / Hide |
Range on Protein: 3-199 Range on HMM: 32-252/296 Sequence Identity: 30% (69 aa) VAVKCLSPEKLSLDKCQQ-----DFLKEAA---IMHSLN-HEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPA-----FPITLLLDFSVQI |||| .. . |. |. ||..||. .| .. |.....|.||... .. .|.|||... .|. . . .| . . .|.....| VAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQ-EEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDI TDAMRYLHMSNIIHRDLAARNILLFVD----DEGNKKAKISDFG---LSRRLL-------LGENYRSEMRPNLKLPLAWMPVESLTKL-TFTKASDVWSF ..| ||| ...||||||||.|.. . ..||.||| .|||. .| | . .... ..|..|| |.||. .|| .|||||| ARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSF GVTMWEMFSYGRKPFAHLSGEEVITS ||..||....||.|....| ..|... GVVCWEIWTWGRLPYPGMSNMQVWHQ |
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| Kinase | Ack1.AA | EGFR | 1-196 | 36 | 1.3e-46 | 152.66 | In-house | 29-212 (258) | Show / Hide |
Range on Protein: 1-196 Range on HMM: 29-212/258 Sequence Identity: 36% (71 aa) IPVAVKCLSPEKLSLDKCQQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPAFPITLLLDFSVQITDAMRYLHMSNI ||||.| | .. . | ....| || .| |..|.|||.| || . . ..||| . |. .| . ..| | . .|| ..||| | || . IPVAIKVL--REQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQH--KDNIGSQHLLNWCVQIAKGMQYLEEHRM IHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPFAHLSGEEV .||||||||.|. .. || ||||.. || . . |.| || .|.. . .| .|||||.|||.||. .| ||.. .. .|. VHRDLAARNVLV----KSPNHVKITDFGLAK--LLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREI |
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| Kinase | Ack1.AA | Fer | 2-189 | 34 | 2.6e-46 | 155.76 | In-house | 34-220 (283) | Show / Hide |
Range on Protein: 2-189 Range on HMM: 34-220/283 Sequence Identity: 34% (66 aa) PVAVKCLSP-EKLSLDKCQQDFLKEAAIMHS-LNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPAFPITLLLDFSVQITDAMRYLHMSN .|||| . .. .. ...|..|| || . ..| . ||.||| | . .|.| ||.. || . .| . | . .. ..... |. . |.||| | KVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVD-EQPIMIVMEFCNGGSLDSYLKKNKNK-TVSDNEKIRMCYQAACGMEYLHSKN IIHRDLAARNILLFVDDEGNKKAK--ISDFGLSRRLLLGENYRSEMR-PNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPFA .||||.||||.|. .... | | |||||.|| . .. |...|. . |.| |.. |.... ......|||||||..|| |. | .|.. CIHRDIAARNCLY---HKDKVKKKCKISDFGMSRQCS-DYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYP |
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| Kinase | Ack1.AA | TyrKc | 1-201 | 28 | 9.1e-46 | 159.29 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-201 Range on HMM: 1-280/280 Sequence Identity: 28% (84 aa) I---------------------PVAVKCLSPEKLSLDKCQQDFLKEAAIMHSL--NHEHLVKLYGVVLDV------DSSLMLVTEFAPLRSLAENMKQEA | .||||.| ... ..||..|| ||..| .|...|.||||... . ||.|.|..|. .| . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR LKPAFPITLLLDFSVQITDAMRYLHMSNIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLG-------ENYRSEMRPNLK--LPLAWMPVESLTKL | .. ||.|..|| . |.||| |.|||||||||.|. . .||||||||| . . . ||. . . | ||. ||. |.. . PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG TFTKASDVWSFGVTMWEMFSYGRKPFAH-----LSGEEVI-------------T-----------------------------------SSM .|| .||||||||.|||.|.|| .| .| .||| . . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Ack1.AA | TK-Unique | 19-198 | 32 | 1.4e-44 | 151.66 | In-house | 47-250 (294) | Show / Hide |
Range on Protein: 19-198 Range on HMM: 47-250/294 Sequence Identity: 32% (67 aa) QQDFLKEAAIMHSLN-HEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEA-----------LK------PAFP----IT--LLLDFSVQITDAMRY .||||||...| .| |...|...|. . | . |.. |..| .| .. . || |..| |. .|. | .|| .| | KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEY LHM--SNIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLT--KLTF-TKASDVWSFGVTMWEMFSYGRKPFA |. .|.||||.|||.|| .|..||.|||..|.. .. | .. . . ..|..||. ||| . .. | ||||||||.|||.|..| |. LASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQG-RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP HLSGEEVIT .. ..... GMPWKDIME |
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| Kinase | Ack1.AA | Syk | 1-197 | 36 | 4.3e-44 | 149.68 | In-house | 32-219 (257) | Show / Hide |
Range on Protein: 1-197 Range on HMM: 32-219/257 Sequence Identity: 36% (72 aa) IPVAVKCLSPEKLSLDKC-QQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQE--ALKPAFPITLLLDFSVQITDAMRYLHM |.||.| |. . ... .| |. || .|. | | . |.. |. . ..|.| | |.| .. ..|. . . |. |. | || IKVAIKMLKADH--NQPADKQEFMREAQVMCQLDHPCIVRMIGICH--AEMMMMVMEMAELGPMHKYLQQHRHEITANNVLELWH---TQVAMGMCYLEE SNIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPFAHLSGEEVI .. .||||||||.|| . |||||||.|. | ....| . | |. | |. . .| .||||||||||||||||| || . .| ||. KHFVHRDLAARNVLL----VNRHYAKISDFGMSKALGADSQYY-QATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVM |
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| Kinase | Ack1.AA | Src | 1-198 | 37 | 4.5e-44 | 147.59 | In-house | 24-211 (255) | Show / Hide |
Range on Protein: 1-198 Range on HMM: 24-211/255 Sequence Identity: 37% (75 aa) IPVAVKCLSPEKLSLDKCQQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPAFPITLLLDFSVQITDAMRYLHMSNI ..|||| |.| .| ...||.|| || .| ||.||.|| |. . . |||. || . |.. . ... |.|.. |. . | || |. TKVAVKTLKPGTMS----PEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNY IHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLL--GENYRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPFAHLSGEEVIT |||||||||.| .|.| .|. |||| | |. ..| ..| |.| |. | .. .|| |||||||. ..|...||| | . .||.. IHRDLAARNVLV---GENN-VCKVADFGLAR-LIKEDDDEY--CARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQ |
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| Kinase | Ack1.AA | TKL | 2-182 | 19 | 2e-41 | 143.91 | In-house | 28-284 (364) | Show / Hide |
Range on Protein: 2-182
Range on HMM: 28-284/364
Sequence Identity: 19% (52 aa)
PVAVKCLSPEKLSL----------------------DKCQQDFLKEAAIMHSLN--HEHLVKLYGVVLDVDS------------SLMLVTEFAPLRSLAE
.|||| .. . .. . .. | .| ||. .. |...|...|.... .. |..|.|..| || .
DVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLH
NMKQEALKPAFPITLLLDFSVQITDAMRYLHMSN--------IIHRDLAARNILLFVDDE----------GNKKAKISDFGLSRRLLLGEN---------
.. . ...... .| .| |||..| |||||| .|||.. . . . ..||.||||||.. .|
YLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMM
------YRSEMRPNLKLPLAWMPVESLTKL----------------TFTKASDVWSFGVTMWEMFS
..... . ..||. | | . ......||.|||. .||...
ESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
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| Kinase | Ack1.AA | Csk | 3-188 | 36 | 4.6e-40 | 134.41 | In-house | 25-198 (251) | Show / Hide |
Range on Protein: 3-188 Range on HMM: 25-198/251 Sequence Identity: 36% (67 aa) VAVKCLSPEKLSLDKCQQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPAFPITLLLDFSVQITDAMRYLHMSNIIH |||||.. . | || ||..| | |. ||.| ||.|. .| .|.|. .| . . . .. || |.. . .| || ...| VAVKCIKCDG---NGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRH-VITRRQLLKFAMDVCEGMCYLEQKKFVH RDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLTKLTFTKASDVWSFGVTMWEMFSYGRKPF |||||||||. |. ||.|||||.. |.. .. |.| | | | . |. |||||||. .|| .|.|| |. RDLAARNILVSEDCV----AKVSDFGLAKE----ECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPY |
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| Kinase | Ack1.AA | Pkinase | 3-197 | 24 | 2.3e-25 | 90.75 | Pfam | 27-227 (293) | Show / Hide |
Range on Protein: 3-197 Range on HMM: 27-227/293 Sequence Identity: 24% (54 aa) VAVKCLSPEKLSLDKCQQDFL-KEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPLR----SLA----ENMKQEALKPAF--PITLLLDFSVQITDA ||||... .. . .|.|.... |..||..|||.. |.||... | .... .|.|... .|. . .| . . .. || . VAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKFYMYQILRG MRYLHMSNIIHRDLAARNILLFVDDEGNKKA----KISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLT-KLTFTKASDVWSFGVTMWEMFSYGRK . |.| .|||||| |||. | | ||.||||.. . . ... . . .|. | . ....|.||.|....||.. || LEYCHSMGIIHRDLKPENILI---D-NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRP PFAHL------SGEEVI || . . ..| PFPGHCWHDNHDQMQMI |
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| Kinase | Ack1.AA | S_TKc | 1-202 | 20 | 2.6e-14 | 33.0 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-202
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)
I------------------------PVAVKCLSPEKLSLDKCQQDFLKEAAIMHSLNHEHLVKLYGVVLDVDSSLMLVTEFAPL--RSLAENMKQEALKP
||.|... .....| .|... .|...||||.| | ..| .|.|... .| . .|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG
A---FPITLLLDFSVQITDAMRYLHMSNIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYRSEMRPNLKLPLAWMPVESLTKLTFTK-ASDV
|| . || .|. |.| .|||||| |||| ||.||||.|.| . . .|. | | ..| ..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDW
WSFGVTMWEMFSYGRKPFA----------------------H------LSGEEVIT-------SSMK
||.|....||.. |. || . .. |. .
WSCGCILYEMLC-GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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