Gene Ack3 (Sea Urchin)
Ack3
Sequence
Protein domains of Ack3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Ack3.AA | Ack | 195-283 | 73 | 1.3e-70 | 237.45 | In-house | 178-266 (266) | Show / Hide |
Range on Protein: 195-283 Range on HMM: 178-266/266 Sequence Identity: 73% (65 aa) CAPESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL ||||.|...|||||||.||||||||||||.|||||.|.||.||||||.||||||||||.||..||..|..|||..|.|||.||...||| CAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | Ack3.AA | Pkinase_Tyr | 195-283 | 43 | 4.5e-43 | 146.49 | Pfam | 181-270 (270) | Show / Hide |
Range on Protein: 195-283 Range on HMM: 181-270/270 Sequence Identity: 43% (39 aa) CAPESLKTKQFSHASDMWMFGVTLWEMFSFGEEP-WLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL .|||..... |...|| |.|||..||.|..||.| . | ......|...|.|.|.|..||. ||.|| ||...||||| || . || MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Ack3.AA | TK | 195-283 | 28 | 3.2e-38 | 125.19 | In-house | 352-486 (486) | Show / Hide |
Range on Protein: 195-283
Range on HMM: 352-486/486
Sequence Identity: 28% (38 aa)
CAPESLK---------TKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNG----------AQILQKIGKE-----------GERLPRP--DHCP-------
.|||.|. .. |...||.|.|||..||.|..|.||. |. ....... .. |.|...| .|||
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM
-------PGIYSLMEICWQANPEDRPMFSSVKDQL
. .| || ||...||||| || ...||
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| SAM_Ack | Ack3.AA | SAM_Ack | 1-65 | 53 | 2.6e-36 | 126.38 | In-house | 1-65 (65) | Show / Hide |
Range on Protein: 1-65 Range on HMM: 1-65/65 Sequence Identity: 53% (35 aa) EGAQWLEELLEETQLQKFLTKIHDDLQVSRLDHFQYVRTEDLEKIGMGRPAARRLLEAVKRRRRR |..|||.|.|.|.||......|.|.|.| |||||.||..||||.|||.||. ||| ||.|..... EECQWLYEFLREAQLEQYYNQIRDHLKVTRLDHFDYVKDEDLECIGMSRPEQRRLWEAYKKMCPH |
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| Kinase | Ack3.AA | UTK | 195-283 | 36 | 3.5e-36 | 121.28 | In-house | 206-296 (296) | Show / Hide |
Range on Protein: 195-283 Range on HMM: 206-296/296 Sequence Identity: 36% (33 aa) CAPESLKTK-QFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEG-ERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL .|||.| .|...||.| |||..||....| |. |.. .|... ... | |.|.|..|| .| || ||...|..|| | . .|. MAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | Ack3.AA | Syk | 196-277 | 43 | 1.3e-35 | 120.06 | In-house | 177-257 (257) | Show / Hide |
Range on Protein: 196-277 Range on HMM: 177-257/257 Sequence Identity: 43% (36 aa) APESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFS |||. |||.|| | ||||.||||| | | . |. ... | . |.|...|. ||. .|.|| || ..||| |. APECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFI-ENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | Ack3.AA | TK-Unique | 195-283 | 41 | 2.9e-35 | 119.08 | In-house | 203-294 (294) | Show / Hide |
Range on Protein: 195-283 Range on HMM: 203-294/294 Sequence Identity: 41% (39 aa) CAPESLK--TKQF-SHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHC-PPGIYSLMEICWQANPEDRPMFSSVKDQL .|||||| .... . || |.|||..||.|..|. | |. ..|...| ..| |.|.|.|| .. .|.||. ||| .||.|| |...|..| MAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | Ack3.AA | FAK | 196-288 | 41 | 2e-32 | 105.86 | In-house | 194-285 (285) | Show / Hide |
Range on Protein: 196-288 Range on HMM: 194-285/285 Sequence Identity: 41% (39 aa) APESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQLDKMKP .||| | ||| ||||| .|| ..| | . . .| . ||||| |. ||| |||| || .| .|| | .| || ... SPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIEN-GERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ |
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| Kinase | Ack3.AA | Musk | 196-283 | 39 | 7.6e-31 | 98.98 | In-house | 196-282 (282) | Show / Hide |
Range on Protein: 196-283 Range on HMM: 196-282/282 Sequence Identity: 39% (35 aa) APESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL .|||. ||. .|| | .|| |||.||... |..| .. | ..| .| |. || .| || |||.|| ||| | .... . PPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYI-RQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
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| Kinase | Ack3.AA | CTKA | 196-283 | 41 | 9.6e-29 | 93.6 | In-house | 202-290 (290) | Show / Hide |
Range on Protein: 196-283 Range on HMM: 202-290/290 Sequence Identity: 41% (37 aa) APESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEG--ERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL ||| |.. || ||| | ||| |||..|.|| ||.. . | . . .||| | || .|..|. ||. | || | .. | APEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAY-TSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
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| Kinase | Ack3.AA | Fer | 196-284 | 36 | 2.9e-28 | 93.44 | In-house | 186-283 (283) | Show / Hide |
Range on Protein: 196-284 Range on HMM: 186-283/283 Sequence Identity: 36% (36 aa) APESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLG----YNGAQI----LQKIGKEGERLPRPDHCPPGIYSLME-ICWQANPEDRPMFSSVKDQLD |||...|. .|...|.| |||..|| |. |.||..| ... ..| |.| ..| |.|.|| |...|. |||..||||| ..... .| APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | Ack3.AA | MLK | 196-283 | 33 | 6.7e-28 | 93.94 | In-house | 201-291 (291) | Show / Hide |
Range on Protein: 196-283 Range on HMM: 201-291/291 Sequence Identity: 33% (31 aa) APESL---KTKQFSHASDMWMFGVTLWEMFSFGEEPWL-GYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKDQL ||| . . ..| ..|.| .|| ||||.. .|.| .|....|. ... .|.|.| | ||... .||..||...|..|| |... .| APEVIQQFRCEKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| TyrKc | Ack3.AA | TyrKc | 39-283 | 15 | 8.2e-12 | -31.67 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-283
Range on HMM: 1-280/280
Sequence Identity: 15% (52 aa)
TEDLEKIGMG------RPAARRLLEAVKRRRRRSGSQ------SILGRV------------AVV---------KRLTVRYPTAHN---KSFNRKPSGFDR
. ..|.| | . .. . ||| . . . .|. .. ... . | . . . |.. ||. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
RLNGIGDIRDVTALIAEREEERERKSGRAKFGMVKHEKWSLCTGSFSTVSMRCLRYEVA------GSEE-----------LVDGFL-----------PNF
... . . .| | ||. .
---------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIY
SY--------MYLVE---PEE--LIRFWGYEVXCAPESLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLG-----YNGAQILQKIGKEGERLPRPDH---
.. .| . . | | .|||..... |...|| |.|||..||.|..|..|. | . ....... |.|.|.|.|..
DDDQQGESKDYYRKKEHKGGKTMLPIRW-----MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYP
-----CPPGIYSLMEICWQANPEDRPMFSSVKDQL
||. .|..|. ||...||||| || .....
MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Sam7 | Ack3.AA | sam7 | 1-63 | 21 | 5.5e-11 | 36.97 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 1-63 Range on HMM: 1-70/70 Sequence Identity: 21% (15 aa) EGAQWLEELLEETQL---QKFLTKIHDDLQ---VSRLDHFQYVRTEDLEKIGMGRPA-ARRLLEAVKRRR ... | ||. .. |.. ...| . |. .||.... |||...|. || .......... | WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR |
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| Kinase | Ack3.AA | GTPase_binding | 345-383 | 41 | 1.2e-10 | 39.08 | Pfam | 1-41 (71) | Show / Hide |
Range on Protein: 345-383 Range on HMM: 1-41/71 Sequence Identity: 41% (17 aa) SGITGEDISKPIKYSFIHTGHGGVDGN-T-WGHPDKIDELY |. ||..| | .|||.||| . . . || ||..|..| AGVSAQDIRVPLKHGFIHNGHGMSNMRHCYWGFPDEFDNNY |
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| Kinase | Ack3.AA | SH3_2 | 290-344 | 20 | 7.6e-10 | 37.37 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 290-344 Range on HMM: 1-68/68 Sequence Identity: 20% (14 aa) EMRVTKDFDE---PDK-----LECEEGQIITII---DGKPEENWWLG-QNIHTHKI--GRIPRKLLAPM .||..|.. .. | ...|..|..| | ... |||.. .| ... |..|.. .... YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-NWWWCWETIWGGRRMRGWFPSQWVEEC |
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| Kinase | Ack3.AA | Pkinase | 195-283 | 17 | 9.6e-09 | 32.0 | Pfam | 178-293 (293) | Show / Hide |
Range on Protein: 195-283 Range on HMM: 178-293/293 Sequence Identity: 17% (21 aa) CAPESLK-TKQFSHASDMWMFGVTLWEMFSFGEEPWLGY------NGAQILQKIGKEGERLPRPDHCP-------------------PGIYSLMEICWQA .||| .. . ....||| .|..|.||.. |. |. | . |....|.. . ..| |. . .... |.. MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK NPEDRPMFSSVKDQ--L .|..|| . .. . DPKKRPTAEQILQHPWF |
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| Kinase | Ack3.AA | SH3 | 289-345 | 25 | 7.4e-08 | 33.35 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 289-345 Range on HMM: 1-58/58 Sequence Identity: 25% (15 aa) LEMRVTKDFDE--PDKLECEEGQIITIIDGKPEENWWLGQNIHTHKIGRIPRKLLAPMS ..|. |.. || | ..|.|||... ...|| |.. .| ..| .| .... PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID |
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| S_TKc | Ack3.AA | S_TKc | 39-289 | 14 | 4.5e-07 | -73.17 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 39-289
Range on HMM: 1-231/231
Sequence Identity: 14% (45 aa)
TEDLEKIGMGRPAARRLLEAVKRRRRRSGSQSILGRVAVVKRLTVRYPTAHNKSFNRKPSGFDRRLNGIGDIRDVTALIAEREEERERKSGRAKFGMVKH
| |.||| | . .. .| ||. .|.. . .||.. . .|
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------------------------------------EHIRREIQILKK-----HH
EKWSLCTGSFSTVSMRCLRYEVAGS--EELVDGFLPNFS-YMYLVEPEELIRFWGYEVXC----------------------------------------
. . ..| . . .. | .. .| | . . . . || .||. |.. |
PNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTF
-------APESLKTKQFSH-ASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKEGERLPRPDHCPPGIYSLMEICWQANPEDRPMFSSVKD---QLD
||| | .... ..|.| .|..|.||.. |. |. . .....||| .| .... |.| .||.|| .
CGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK
KMKPL
.. .
CHPWF
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| Kinase | Ack3.AA | SH3_1 | 306-338 | 30 | 0.000449 | 16.93 | Pfam | 17-49 (49) | Show / Hide |
Range on Protein: 306-338 Range on HMM: 17-49/49 Sequence Identity: 30% (10 aa) EEGQIITIIDGKPEENWWLGQNIHTHKIGRIPR ..| ||..|. ... .|| |... |.. | .| KKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS |
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