Gene CG8878 (Fruit Fly)

CG8878

Species: Fruit Fly
Alias: VRK, CG8878
External Links: Flybase Link
Annotation:

Classification

Group: CK1
Family: VRK

Sequence

Name Sequence Type Origin Length Description Download
CG8878.AA Protein None 1004 None Fasta, JSON
CG8878.kin_dom Protein Kinase Domain None 291 None Fasta, JSON

Protein domain

Protein domains of CG8878.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG8878.AA VRK 123-284 46 4.4e-108 347.06 In-house 1-165 (284) Show / Hide 
Range on Protein: 123-284
Range on HMM: 1-165/284
Sequence Identity: 46% (77 aa)

WRLGRPIGKGNFGEIFLASDDTVCPASSETAKYVVKIEP-HSNGPLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASGTHYFG
||||.|||.|.||.|.|||.. .|......|.||||||| |.|||||.|.|...................||||||||||||.|..|||.....|.|.|.
WRLGKPIGQGGFGCIYLASPN-TCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN

DVRYRFLVLPRFDRDLHSLIK-NS--RVQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSK
...|||.|.|||.|||..... ..  |...|..|.||.....|||.||...|.|.||||.|.....
GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGF
Kinase CG8878.AA VRK 519-631 50 2.7e-83 266.6 In-house 170-284 (284) Show / Hide 
Range on Protein: 519-631
Range on HMM: 170-284/284
Sequence Identity: 50% (58 aa)

EHVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRDAHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQ
..|.|.|.|||......|.||....|.||.|.||.||||.|||.| |.|||||||.|||....|..|||||.|..|||..|||..||..||...|||...
DQVYLVDYGLAYRYCPNGKHRQYKEDPRRCHNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQK

FYG-KQVPKYLGEFL
... |||....|...
CFPWKQVCCEIGKYM
Kinase CG8878.AA CK1 123-648 14 2.6e-69 236.6 In-house 1-339 (339) Show / Hide 
Range on Protein: 123-648
Range on HMM: 1-339/339
Sequence Identity: 14% (80 aa)

WRLGRPIGKGNFG-EIFLASDD--TVCPASS--ETAKYVVKIEP-HSNGPLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTHVLSRGPPSGIPSFIASG
|.....||.| || .|......  .  . ..  .. .|..|.|| .|.|........ .     ... .. . | .|    .| ..  ...|.| ... .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-K-ASIL----KHKHFCKKHCGCPHPCMYW

THYFGDVRYRFLVLPRFDRDLHSLIK---N-SR-VQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGYEDHYEEKQQTTD
 | ..| .|...|.... ..| .| |   .  |    |. | .|. ....|| .||.|. | |||..|....  . .                       
YHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESF-----------------------

SGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNSNNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYL
                                                                                                    
----------------------------------------------------------------------------------------------------

RPTKRISYREEFNEDGYPKETAENSDESPESSDNESDEFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQKLRSRGSKHLDNNPTEY
                                                                                                  .|
--------------------------------------------------------------------------------------------------KY

KFLPT-----EEEHVFLIDFGLAS-KFQDRGVHR----------PFIMDQR----RAHDG-TLEFTSRDAHLGAH-SRRSDLECLGYNLLYWSEGY--LP
    .     |. .|..||||.|  |. |.. |.            ..  .    . . | |....|...|||   .|| ||....| |..|  |   ||
GKH-HHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLP

WKDVAQQQQQEK---VHRAKELFMTDVPEMLRQFYGKQV------PKYLGEFLLQIGQLAYQERPNYERY
|... .. .. |   |...|. |... .  ...| ..        |... ...  | .| |..||.||  
WQNMKDEMKP-KDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CG8878.AA CK1-D 521-648 30 3.8e-17 56.9 In-house 137-261 (261) Show / Hide 
Range on Protein: 521-648
Range on HMM: 137-261/261
Sequence Identity: 30% (39 aa)

VFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRDAHLG-AHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQFY
|..|||||| ...|   |.       .   ||  . |   |.|   ||| ||| ||| |.|.  | |||. .    ...|  |  |  |    . | . |
VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGY

GKQVPKYLGEFLLQIGQLAYQERPNYERY
    |.   ...    .| ....|.|   
----PSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CG8878.AA CK1-A 520-648 30 2.7e-16 53.93 In-house 136-261 (261) Show / Hide 
Range on Protein: 520-648
Range on HMM: 136-261/261
Sequence Identity: 30% (40 aa)

HVFLIDFGLASKFQDRGVHRPFIMDQRRAHDGTLEFTSRDAHLGA-HSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQF
..|||||||| |..|   ..     . .   ||  . | .||||   ||| |.| .|| ..|.  | |||. .  . .. |  .  |  |.   |.|   
KLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQL---

YGKQVPKYLGEFLLQIGQLAYQERPNYERY
  |  |  .  ..  . .| ..| |.|   
-CKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CG8878.AA CK1-Unclassified 258-616 13 3.2e-15 41.4 In-house 113-244 (244) Show / Hide 
Range on Protein: 258-616
Range on HMM: 113-244/244
Sequence Identity: 13% (50 aa)

IINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGYEDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATS
.|  .|.|| |.. | |||  | .. |                                                                         
MIQRIEYLHNKNFIHRDIKPDNFLMGK-------------------------------------------------------------------------

NSNNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKETAENSDESPESSDNESDEFIPPSSRR
                                                                                                    
----------------------------------------------------------------------------------------------------

SVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQKLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDR---GVHRPFIMDQRRAHDGTLE
                                                        |  .  .|..|||||. .. |.   | | |.  .      ||  
--------------------------------------------------------LGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLT--GTAR

FTSRDAHLGA-HSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLR
..|  ||||   ||| ||| ||| |.|   |.||| ..  . ..||  . .|. |.  .|.| 
YASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase CG8878.AA CK1 520-646 33 4.3e-10 31.13 In-house 147-271 (271) Show / Hide 
Range on Protein: 520-646
Range on HMM: 147-271/271
Sequence Identity: 33% (43 aa)

HVFLIDFGLASKF-QDR-GVHRPFIMDQRRAHDGTLEFTSRDAHLGA-HSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLR
.|..|||||| .. .|. . | |.  .      ||  ..|  .|||   ||| |.| ||| |.|   | ||| ..  . ...|  . .|  |.  .|.| 
QVYIIDFGLAKRYRDDKTHQHIPYRENKNLT--GTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQL-

QFYGKQVPKYLGEFLLQIGQLAYQERPNYE
 . |.  |... ..|  . || ..|.|.|.
-CKGN-FPNEFAMYLNYCRQLHFEEKPDYM
Kinase CG8878.AA CK1-G 249-648 10 2.7e-08 24.15 In-house 96-266 (266) Show / Hide 
Range on Protein: 249-648
Range on HMM: 96-266/266
Sequence Identity: 10% (42 aa)

KSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQVVPKGNGYEDHYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDD
|. . .|. .|. .| .|..     |.|  | ....                                                                
KTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGR----------------------------------------------------------------

EDFDDGATSNSNNSNSLDVFHTPVNKKRSARNAIQFSGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKETAENSDESPESSDNESD
                                                                                                    
----------------------------------------------------------------------------------------------------

EFIPPSSRRSVIKRGRSAQIATPKKTPVSTRASRQEKVKKEPNGDQKLRSRGSKHLDNNPTEYKFLPTEEEHVFLIDFGLASKFQDRGVHRPFIMDQRRA
                                                                    ... ...||||.| .. |    .      .. 
----------------------------------------------------------------PSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKS

HDGTLEFTSRDAHLGA-HSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTDVPEMLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYER
  ||  . |   |||   ||| |.| ||   .|   | |||         |.  .  .      .| | |  .. .|. .. .|  . .| ..| | |. 
LTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQ--NNAFPEQFATYLRYVRRLDFFECPDYDY

Y
 
L
Kinase CG8878.AA Worm6 517-648 23 9.1e-08 24.3 In-house 147-279 (279) Show / Hide 
Range on Protein: 517-648
Range on HMM: 147-279/279
Sequence Identity: 23% (32 aa)

EEEHVFLIDFGLAS--KFQDRGVHRPFIMDQR-RAHD--GTLEFTSRDAHLGA-HSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQEKVHRAKELFMTD
|.  ....|||..   |. ..|     .  .|  |.   ||. . .. .| |  ..|. |.|.  | .. .  | |||. .   ...||.....    . 
EHHTIYMLDFGMCRRKKYCNKGNE---LRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRR--RT

VPEMLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERY
 ..| |.|.|.  .. . . .  | |..|..||.|.  
RAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CG8878.AA Worm8 258-283 50 1e-06 15.1 In-house 108-133 (261) Show / Hide 
Range on Protein: 258-283
Range on HMM: 108-133/261
Sequence Identity: 50% (13 aa)

IINVLENLHDKGYCHNDIKAQNLMVS
.. .|   | .|  | |||| |||||
LVKILQDIHSFGIVHGDIKADNLMVS
Kinase CG8878.AA CK1 123-142 50 2e-06 18.46 In-house 1-20 (271) Show / Hide 
Range on Protein: 123-142
Range on HMM: 1-20/271
Sequence Identity: 50% (10 aa)

WRLGRPIGKGNFGEIFLASD
 |.|| || |.||.|.|. .
YRVGRKIGQGSFGDIYLGIN
Kinase CG8878.AA S_TKc 123-468 9 2e-06 -81.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 123-468
Range on HMM: 1-231/231
Sequence Identity: 9% (37 aa)

WRLGRPIGKGNFGEIFLASDDTVCPASSETAKYVVKIEPHSNGPLFVEIHCLINTSRNNDLSDAAEDAASLPAPQTH----VLSRGPPSGIPSFIASGTH
....|.|||| ||. ... .           .. .|| .                                   ..     .|..     |  .. .  .
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK----------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD

YFGDVRYRFLVLPRFDR---DLHSLIKNSR-------VQQKSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLR-------RQVVPKGNGYED
      . ..|.   |    ||...||. .               ..  |.. || .|..| .| |.| .|.....   .        ||.         
-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------

HYEEKQQTTDSGNSSEQETNDDDYFLKSEKFALKKIVDIKQDEDEDDEDFDDGATSNSNNSNSLDVFHTP-------VNKKRSARNAIQF----------
                                                                 .  ||       .           .          
---------------------------------------------------------------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGC

------SGSNPVRACRREKRNSMYEEMVKSHYLRPTKRISYREEFNEDGYPKETAENSDESPESSDNESDEFI---------PPSSRRSVIKRGR-----
      .|  | .       . |.. ..                                        |.|..          |. | .. .  .     
ILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--SAQI
     .
KCHPWF
Kinase CG8878.AA CK1-G 123-139 58 6.5e-05 12.48 In-house 1-17 (266) Show / Hide 
Range on Protein: 123-139
Range on HMM: 1-17/266
Sequence Identity: 58% (10 aa)

WRLGRPIGKGNFGEIFL
.| |. || |||||.|.
YRVGKKIGCGNFGELFE
Kinase CG8878.AA CK1-Unclassified 123-142 40 7.5e-05 10.27 In-house 1-20 (244) Show / Hide 
Range on Protein: 123-142
Range on HMM: 1-20/244
Sequence Identity: 40% (8 aa)

WRLGRPIGKGNFGEIFLASD
 |... || | ||||... .
YRVIEKIGQGSFGEIYKCIN
Kinase CG8878.AA TTBK 123-142 50 7.9e-05 13.04 In-house 1-20 (257) Show / Hide 
Range on Protein: 123-142
Range on HMM: 1-20/257
Sequence Identity: 50% (10 aa)

WRLGRPIGKGNFGEIFLASD
|.  . || | ||||. | |
WKVVKKIGGGGFGEIYEAKD
Kinase CG8878.AA CK1-D 123-139 52 8.9e-05 12.59 In-house 1-17 (261) Show / Hide 
Range on Protein: 123-139
Range on HMM: 1-17/261
Sequence Identity: 52% (9 aa)

WRLGRPIGKGNFGEIFL
.|.|| || | ||.|..
YRIGRKIGSGSFGDIYH
Kinase CG8878.AA Worm6 123-144 31 0.000315 11.46 In-house 1-22 (279) Show / Hide 
Range on Protein: 123-144
Range on HMM: 1-22/279
Sequence Identity: 31% (7 aa)

WRLGRPIGKGNFGEIFLASDDT
| ....||.| || .....|..
WKVTKKIGEGGFGAVYKVEDKS
Kinase CG8878.AA Worm8 123-143 33 0.000735 6.97 In-house 1-21 (261) Show / Hide 
Range on Protein: 123-143
Range on HMM: 1-21/261
Sequence Identity: 33% (7 aa)

WRLGRPIGKGNFGEIFLASDD
. |..  |.| .|.. |. ||
YTLEKVLGRGMYGDVHLCQDD
Kinase CG8878.AA CK1-A 123-140 55 0.001775 7.95 In-house 1-18 (261) Show / Hide 
Range on Protein: 123-140
Range on HMM: 1-18/261
Sequence Identity: 55% (10 aa)

WRLGRPIGKGNFGEIFLA
.|| |.|| | ||.|.|.
YRLVRKIGSGSFGDIYLG
Kinase CG8878.AA CK1-A 249-282 38 0.003416 6.93 In-house 95-128 (261) Show / Hide 
Range on Protein: 249-282
Range on HMM: 95-128/261
Sequence Identity: 38% (13 aa)

KSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMV
|  |.||  .|  .| .| |.. | |||  | ..
KTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLM
Kinase CG8878.AA TTBK 621-648 32 0.005717 6.37 In-house 230-257 (257) Show / Hide 
Range on Protein: 621-648
Range on HMM: 230-257/257
Sequence Identity: 32% (9 aa)

KQVPKYLGEFLLQIGQLAYQERPNYERY
| .|. .  |.  |  | |..||.|   
KHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CG8878.AA TTBK 250-292 30 0.007585 5.93 In-house 98-140 (257) Show / Hide 
Range on Protein: 250-292
Range on HMM: 98-140/257
Sequence Identity: 30% (13 aa)

SLLVLAVHIINVLENLHDKGYCHNDIKAQNLMVSKCKYLRRQV
. | | | |.. .|  |. |. | |||  |  . .  . .|..
TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKC
Kinase CG8878.AA CK1-D 249-282 35 0.026621 3.73 In-house 95-128 (261) Show / Hide 
Range on Protein: 249-282
Range on HMM: 95-128/261
Sequence Identity: 35% (12 aa)

KSLLVLAVHIINVLENLHDKGYCHNDIKAQNLMV
|  |.||  .|  .| .| . . | |||  | ..
KTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLM
Kinase CG8878.AA CK1 249-276 39 0.069584 2.51 In-house 105-132 (271) Show / Hide 
Range on Protein: 249-276
Range on HMM: 105-132/271
Sequence Identity: 39% (11 aa)

KSLLVLAVHIINVLENLHDKGYCHNDIK
|  | .|  .|  .| .| |.. | |||
KTVLMIADQMIQRIEYVHNKNFIHRDIK
Kinase CG8878.AA TTBK 514-532 31 0.12021 1.63 In-house 133-151 (257) Show / Hide 
Range on Protein: 514-532
Range on HMM: 133-151/257
Sequence Identity: 31% (6 aa)

LPTEEEHVFLIDFGLASKF
.| .   ....||||| ..
NPSTCRKCYMLDFGLARQY
Kinase CG8878.AA Worm6 262-279 44 0.374476 0.31 In-house 117-134 (279) Show / Hide 
Range on Protein: 262-279
Range on HMM: 117-134/279
Sequence Identity: 44% (8 aa)

LENLHDKGYCHNDIKAQN
.| ||  |. | |.|..|
IEDLHNCGFIHRDVKPGN